J. C. Jennette, R. J. Falk, P. A. Bacon, N. Basu, M. C. Cid et al., revised international Chapel Hill consensus conference nomenclature of vasculitides, Arthritis Rheum, vol.65, pp.1-11, 2012.
DOI : 10.1002/art.37715

R. A. Lerner, R. J. Glassock, and F. J. Dixon, The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis, J Exp Med, vol.126, pp.989-1004, 1967.

T. Hellmark, C. Johansson, and J. Wieslander, Characterization of anti-GBM antibodies involved in Goodpasture's syndrome, Kidney Int, vol.46, pp.823-829, 1994.

T. Hellmark, M. Segelmark, C. Unger, H. Burkhardt, J. Saus et al., Characterization of a single conformational epitope as a target of pathogenic autoantibodies, J Biol Chem, vol.274, pp.25862-25870, 1999.

B. G. Hudson, K. Tryggvason, M. Sundaramoorthy, and E. G. Neilson, Alport's syndrome, Goodpasture's syndrome and type IV collagen, N Engl J Med, vol.348, pp.2543-2556, 2003.

R. Kalluri, C. B. Wilson, M. Weber, S. Gunwar, A. M. Chonko et al., Identification of the alpha-3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome, J Am Soc Nephrol, vol.6, pp.1178-1185, 1995.

J. Wieslander, P. Bygren, and D. Heinegard, Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome, Proc Natl Acad Sci, vol.81, pp.1544-1548, 1984.

S. P. Mcadoo and C. D. Pusey, Clustering of Anti-GBM Disease. Clues to an Environmental Trigger?, Clin J Am Soc Nephrol, vol.11, issue.8, pp.1324-1326, 2016.

M. Canney, P. V. O'hara, C. M. Mcevoy, S. Medani, D. M. Connaughton et al., Spatial and temporal clustering of anti-glomerular basement membrane disease, Clin J Am Soc Nephrol, vol.11, pp.1392-1399, 2016.

Q. H. Gu, L. J. Xie, X. Y. Jia, R. Ma, Y. H. Liao et al., Fever and prodromal infections in anti-glomerular basement membrane disease, Nephrology, 2017.

M. Donaghy and A. J. Rees, Cigarette smoking and lung haemorrhage in glomerulonephritis caused by autoantibodies to glomerular basement membrane, Lancet, vol.2, pp.1390-1393, 1983.

G. J. Bombassei and A. A. Kaplan, The association between hydrocarbure exposure and anti-GBM antibody-mediated disease, Am J Ind Med, vol.21, pp.141-153, 1992.

M. Fischer, C. D. Pusey, R. W. Vaughan, and A. J. Rees, Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes, Kidney Int, vol.51, pp.222-229, 1997.

J. D. Ooi, J. Chang, K. M. O'sullivan, V. Pedchenko, B. G. Hudson et al., The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN, J Am Soc Nephrol, vol.24, pp.419-431, 2013.

H. Luo, M. Chen, Z. Cui, R. Yang, P. C. Xu et al., The association of HLA-DQB1,-DQA1 and -DPB alleles with anti-glomerular basement membrane disease in Chinese patients, BMC Nephrol, vol.12, p.21, 2011.

R. G. Phelps, V. Jones, A. N. Turner, and A. J. Rees, Properties of HLA class II molecules divergently associated with Goodpasture's disease, Int Immunology, issue.12, pp.1135-1143, 2000.

A. D. Salama, J. B. Levy, L. Lightstone, and C. D. Pusey, Goodpasture's disease, Lancet, vol.358, pp.917-920, 2001.

C. D. Pusey, Antiglomerular basement membrane disease, Kidney Int, vol.64, pp.1535-1550, 2003.

J. Zhao, Y. Yan, Z. Cui, R. Yang, and M. H. Zhao, The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rHalpha3 (IV) NC1 is associated with disease severity

, Hum Immunol, vol.70, pp.425-429, 2009.

M. Segelmark, R. Butkowski, and J. Wieslander, Antigen restriction and IgG subclasses among anti-GBM autoantibodies, Nephrol Dial Transplant, vol.5, pp.991-996, 1990.
DOI : 10.1093/ndt/5.12.991

S. W. Olson, C. B. Arbogast, T. P. Baker, D. Owshalimpur, D. K. Oliver et al.,

, Asymptomatic autoantibodies associate with future anti-glomerular basement membrane disease, J Am Soc Nephrol, vol.22, 1946.

E. G. Fischer and D. J. Lager, Anti-glomerular basement membrane glomerulonephritis: A morphologic study of 80 cases, Am J Clin Pathol, vol.125, pp.445-450, 2006.

J. C. Jennette, Rapidly progressive crescentic glomerulonephritis, Kidney Int, vol.63, pp.1164-1177, 2003.

M. Chen, Z. Cui, and M. Zhao, ANCA-associated vasculitis and anti-GBM disease: the experience in China, Nephrol Dial Transplant, vol.25, pp.2062-2065, 2010.

S. P. Mcadoo, A. Tanna, Z. Hruskova, L. Holm, M. Weiner et al., Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single-seropositive patients, Kidney Int, vol.92, pp.693-702, 2017.

X. Bosch, E. Mirapeix, J. Font, X. Borrellas, R. Rodríguez et al., Prognostic implication of anti-neutrophil cytoplasmic antoantibodies with myeloperoxidase specificity in anti-glomerular basement membrane disease, Clin Nephrol, vol.36, pp.107-113, 1991.

D. R. Jayne, P. D. Marshall, S. J. Jones, and C. M. Lockwood, Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis, Kidney Int, vol.37, pp.965-970, 1990.
DOI : 10.1038/ki.1990.72

URL : https://doi.org/10.1038/ki.1990.72

J. B. Levy, T. Hammad, A. Coulthart, T. Dougan, and C. D. Pusey, Clinical features and outcome of patients with both ANCA and anti-GBM antibodies, Kidney Int, vol.66, pp.1535-1540, 2004.
DOI : 10.1111/j.1523-1755.2004.00917.x

URL : https://doi.org/10.1111/j.1523-1755.2004.00917.x

J. Lindic, A. Vizjak, D. Ferluga, D. Kovac, A. Ales et al., Clinical outcome of patients with coexistent antineutrophil cytoplasmic antibodies and antibodies against glomerular basement membrane, Ther Apher Dial, vol.13, pp.278-281, 2009.

, Kidney Disease Improving Global Outcomes (KDIGO) Glomerulonephritis Wok Group: KDIGO clinical practice guideline for glomerulonephritis, Kidney Int, pp.139-274, 2012.

J. B. Levy, A. N. Turner, A. J. Rees, and C. D. Pusey, Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression, Ann Intern Med, vol.134, pp.1033-1042, 2001.
DOI : 10.7326/0003-4819-134-11-200106050-00009

P. Biesenback, R. Kain, K. Derfler, T. Perkmann, A. Soleiman et al., Long-term outcome of anti-glomerular basement membrane antibody disease treated with immunoadsorption, Plos One, vol.9, p.103568, 2017.

Y. Y. Zhang, Z. Tang, D. M. Chen, D. H. Gong, D. X. Ji et al., Comparison of double filtration plasmapheresis with immunoadsorption therapy in patients with anti-glomerular basement membrane nephritis, BMC Nephrol, vol.15, p.128, 2014.

K. De-groot, L. Harper, D. R. Jayne, F. Suarez, L. F. Gregorini et al., European Vasculitis Study Group): Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial, Ann Intern Med, vol.150, pp.670-680, 2009.

M. Touzot, J. Poisson, S. Faguer, D. Ribes, P. Cohen et al., Rituximab in anti-GBM disease: a retrospective study of 8 patients, J Autoimmun, vol.60, pp.74-79, 2015.

M. Mori, U. Nwaogwugwu, G. R. Akers, and R. L. Mcgill, Anti-glomerular basement membrane disease treated with mycophenolate mofetil, corticosteroids and plasmapheresis, Clin Nephrol, vol.80, pp.67-71, 2013.
DOI : 10.5414/cn107333

C. Garcia-canton, A. Toledo, R. Palomar, F. Fernandez, J. Lopez et al.,

, Goodpasture's syndrome treated with mycophenolate mofetil, Nephrol Dial Transplant, vol.15, pp.920-922, 2000.

B. Alchi, M. Griffiths, M. Sivalingam, J. D. Farrington, and K. , Predictors of renal and patient outcomes in anti-GBM disease: clinicopathologic analysis of two center cohort

, Nephro Dial Transplant, vol.30, pp.814-821, 2015.

E. E. Van-daalen, J. C. Jennette, S. P. Mcadoo, C. D. Pusey, M. A. Alba et al., Predicting outcome in patients with anti-GBM glomerulonephritis, Clin J Am Soc Nephrol, vol.13, pp.63-72, 2018.

M. Segelmark, T. Hellmark, and J. Wieslander, The prognostic significance in Goodpasture's disease of specificity, titre and affinity of antiglomerular-basement-membrane antibodies

, Nephron Clin Pract, vol.94, pp.59-68, 2003.

M. K. Shah and S. Y. Hugghins, Characteristics and outcomes of patients with Goodpasture's syndrome, South Med J, vol.95, pp.1411-1418, 2002.

A. Huart, A. G. Josse, D. Chauveau, J. M. Korach, F. Heshmati et al., Outcomes of patients with Goodpasture syndrome: A nationwide cohort-based study from French Society of Hemapheresis, J Autoimmun, vol.73, pp.24-29, 2016.

R. Yang, T. Hellmark, J. Zhao, Z. Cui, M. Segelmark et al., Levels of epitopespecific autoantibodies correlate with renal damage in anti-GBM disease, Nephrol dial Transplant, vol.24, pp.1838-1844, 2009.

P. Liu, . Waheed, L. Boujelbane, and L. J. Maursetter, Multiple reccurences of anti-GBM disease with variable antibody detection: can the laboratory be trusted?, Clin Kidney J, vol.9, pp.657-660, 2016.

B. Gu, A. B. Magil, and S. J. Barbour, Frequently relapsing anti-GBM disease with changing clinical phenotype and antibody characteristics over time, Clin Kidney J, vol.9, pp.661-664, 2016.
DOI : 10.1093/ckj/sfw048

URL : https://academic.oup.com/ckj/article-pdf/9/5/661/8038015/sfw048.pdf

J. B. Levy, R. H. Lachmann, and C. D. Pusey, Recurrent Goodpasture's disease, Am J Kidney Dis, vol.27, pp.573-578, 1996.

B. Y. Choy, T. M. Chan, and K. N. Lai,

, Am J Transplant, vol.6, pp.2535-2542, 2006.

W. Tang, S. P. Mcdonald, C. M. Hawley, S. V. Badve, N. C. Boudville et al., Anti-GBM disease is an uncommon cause of end-stage renal disease, Kidney Int, vol.83, pp.503-510, 2013.

A. E. Berden, F. Ferrario, E. C. Hagen, D. R. Jayne, J. C. Jennette et al., Histopathologic classification of ANCA-associated glomerulonephritis, J Am Soc Nephrol, vol.10, pp.1628-1664, 2010.

Z. Cui, J. Zhao, X. Y. Jia, S. N. Zhu, Q. Z. Jin et al., Anti-Glomerular Basement Membrane Disease Outcomes of Different Therapeutic Regimens in a Large SingleCenter Chinese Cohort Study, Medicine, vol.90, pp.303-311, 2011.

J. A. Tan, N. Dehghan, W. Chen, H. Xie, J. M. Esdaile et al., Mortality in ANCAassociated vasculitis: a meta-analysis of observational studies, Ann Rheum Dis, 2017.

M. Weiner, M. Goh, S. Mohammad, A. J. Hruskova, Z. Tanna et al., Outcome and treatment of Elderly patients with ANCA associated vasculitis, Clin J Am Soc Nephrol, vol.10, pp.1128-1135, 2015.

M. A. Little, P. Nightingale, C. A. Verbugh, T. Hauser, D. Groot et al., Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis, Ann Rheum Dis, vol.69, issue.6, pp.1036-1079, 2010.

A. Haris, K. Polner, J. Aranyi, H. Braunitzer, I. Kaszas et al., Clinical outcomes of ANCA-associated vasculitis in elderly patients, Int Urol Nephrol, vol.46, pp.1595-160, 2014.

. Leucocytes, , p.12

. Hémoglobine, , p.22

C. Complément, , p.22

, Données exprimées en n (%), médiane [Interquartiles Range

, CV, cardiovasculaires ; Anti-MBG, anticorps anti-membrane basale glomérulaire

, ANCA, anticorps anti cytoplasme des polynucléaires neutrophiles

M. Mpo, Protéinase 3 ; SCr, serum creatinine, p.3