P. Brugada and J. Brugada, Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. A multicenter report, J Am Coll Cardiol, vol.20, issue.6, pp.1391-1396, 1992.
DOI : 10.1016/0735-1097(92)90253-j

URL : https://doi.org/10.1016/0735-1097(92)90253-j

R. Dumaine and P. Brugada, Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent, Circ Res, vol.85, issue.9, pp.803-809, 1999.

S. G. Priori, A. A. Wilde, and M. Horie, Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes, J Arrhythmia, vol.30, issue.1, pp.29-47, 2014.

F. Sacher, V. Probst, and P. Maury, Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: A multicenter study-part 2, Circulation, vol.128, issue.16, pp.1739-1747, 2013.

J. Gourraud, J. Barc, A. Thollet, H. Le, and V. Probst, Brugada syndrome : Diagnosis , risk. Arch Cardiovasc Dis, vol.110, pp.188-195, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01832150

J. Sieira and P. Brugada, Brugada Syndrome: Defining the Risk in Asymptomatic Patients, Arrhythmia Electrophysiol Rev, vol.5, issue.3, p.164, 2016.

F. Sacher, F. Arsac, and S. B. Wilton, Syncope in Brugada syndrome patients: Prevalence, characteristics, and outcome. Hear Rhythm, vol.9, pp.1272-1279, 2012.
DOI : 10.1016/j.hrthm.2012.04.013

V. Probst, C. Veltmann, and L. Eckardt, Long-Term Prognosis of Patients Diagnosed With Brugada Syndrome: Results From the FINGER Brugada Syndrome Registry, Circulation, vol.121, issue.5, pp.635-643, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00910144

M. C. Gonzalez-corcia, J. Sieira, and A. Sarkozy, Brugada syndrome in the young: an assessment of risk factors predicting future events, Europace, p.206, 2016.

V. Probst, I. Denjoy, and P. G. Meregalli, Clinical aspects and prognosis of Brugada syndrome in children, Circulation, vol.115, issue.15, pp.2042-2048, 2007.

M. C. Gonzalez-corcia, J. Sieira, and G. Pappaert, A Clinical Score Model to Predict Lethal Events in Young Patients (?19 Years) With the Brugada Syndrome, Am J Cardiol, vol.120, issue.5, pp.797-802, 2017.

G. Conte, C. Asmundis, and D. Ph, Clinical Characteristics , Management , and Prognosis of Elderly Patients with Brugada Syndrome, J Cardiovasc Electrophysiol, vol.25, pp.514-519, 2014.

A. Adler, R. Rosso, E. Chorin, O. Havakuk, C. Antzelevitch et al., Risk stratification in Brugada syndrome: Clinical characteristics, electrocardiographic parameters, and auxiliary testing. Hear Rhythm, 2015.

K. Ezaki, M. Nakagawa, and Y. Taniguchi, Gender Differences in the ST Segment, Circ J, vol.74, issue.11, pp.2448-2454, 2010.

P. Berthome, R. Tixier, and J. Briand, Clinical presentation and follow-up of women affected by Brugada syndrome. Manuscript submitted for publication, 2018.

J. Sieira, G. Conte, and G. Ciconte, Clinical characterisation and long-term prognosis of women with Brugada syndrome, pp.452-458, 2016.

D. Diego, J. M. Cordeiro, J. M. Goodrow, and R. J. , Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males, Circulation, vol.106, issue.15, pp.2004-2011, 2002.

K. Matsuo, M. Akahoshi, S. Seto, and K. Yano, Disappearance of the Brugada-type electrocardiogram after surgical castration: a role for testosterone and an explanation for the male preponderance, Pacing Clin Electrophysiol, vol.26, pp.1551-1553, 2003.

W. Shimizu, K. Matsuo, and Y. Kokubo, Sex hormone and gender difference -Role of testosterone on male predominance in Brugada syndrome, J Cardiovasc Electrophysiol, vol.18, issue.4, pp.415-421, 2007.

S. G. Priori, M. Gasparini, and C. Napolitano, Risk stratification in brugada syndrome: Results of the PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) registry, J Am Coll Cardiol, vol.59, issue.1, pp.37-45, 2012.

S. G. Priori, C. Napolitano, and M. Gasparini, Natural history of Brugada syndrome: Insights for risk stratification and management, Circulation, vol.105, issue.11, pp.1342-1347, 2002.

J. Brugada, R. Brugada, C. Antzelevitch, J. Towbin, K. Nademanee et al., Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3, Circulation, vol.105, issue.1, pp.73-78, 2002.

J. Brugada, R. Brugada, and P. Brugada, Determinants of Sudden Cardiac Death in Individuals with the Electrocardiographic Pattern of Brugada Syndrome and No Previous Cardiac Arrest, Circulation, vol.108, issue.25, pp.3092-3096, 2003.

L. Calò, C. Giustetto, and A. Martino, A New Electrocardiographic Marker of Sudden Death in Brugada Syndrome: The S-Wave in Lead i, J Am Coll Cardiol, vol.67, issue.12, pp.1427-1440, 2016.

A. Sarkozy, A. Sorgente, and T. Boussy, The value of a family history of sudden death in patients with diagnostic type i Brugada ECG pattern, Eur Heart J, vol.32, issue.17, pp.2153-2160, 2011.

P. Delise, G. Allocca, and E. Marras, Risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest: Usefulness of a combined clinical and electrophysiologic approach, Eur Heart J, vol.32, issue.2, pp.169-176, 2011.

J. Sieira, G. Conte, and G. Ciconte, A score model to predict risk of events in patients with Brugada Syndrome, Eur Heart J, vol.38, issue.22, pp.1756-1763, 2017.

K. Lieve and A. Wilde, Inherited ion channel diseases: A brief review, Europace, vol.17, pp.1-6, 2015.

J. Gourraud, J. Barc, and A. Thollet, The Brugada Syndrome: A Rare Arrhythmia Disorder with Complex Inheritance, Front Cardiovasc Med, vol.3, pp.1-11, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01831587

P. G. Meregalli, H. L. Tan, and V. Probst, Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies, Hear Rhythm, vol.6, issue.3, pp.341-348, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00913229

Y. Nakano, H. Ochi, and Y. Onohara, Common variant near HEY2 has a protective effect on ventricular fibrillation occurrence in Brugada syndrome by regulating the repolarization current, Circ Arrhythmia Electrophysiol, vol.9, issue.1, pp.1-2, 2016.

P. Maury, A. Rollin, and F. Sacher, Prevalence and Prognostic Role of Various Conduction Disturbances in Patients With the Brugada Syndrome, Am J Cardiol, vol.112, issue.9, pp.1384-1389, 2013.

J. Sieira, G. Ciconte, and G. Conte, Long-term prognosis of drug-induced Brugada syndrome. Hear Rhythm, vol.133, 2017.

F. Extramiana, P. Maison-blanche, F. Badilini, A. Messali, I. Denjoy et al., Type 1 electrocardiographic burden is increased in symptomatic patients with Brugada syndrome, J Electrocardiol, vol.43, issue.5, pp.408-414, 2010.

N. Behar, B. Petit, and V. Probst, Heart rate variability and repolarization characteristics in symptomatic and asymptomatic Brugada syndrome, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01637189

Y. Mizusawa, H. Morita, and A. Adler, Prognostic significance of fever-induced Brugada syndrome. Hear Rhythm, vol.13, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01831585

H. Morita, K. F. Kusano, and D. Miura, Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome, Circulation, vol.118, issue.17, pp.1697-1704, 2008.

S. Kamakura, T. Ohe, and K. Nakazawa, Long-term prognosis of probands with brugada-pattern STelevation in leads V 1-V 3, Circ Arrhythmia Electrophysiol, vol.2, issue.5, pp.495-503, 2009.

K. Tokioka, K. F. Kusano, and H. Morita, Electrocardiographic parameters and fatal arrhythmic events in patients with brugada syndrome: Combination of depolarization and repolarization abnormalities, J Am Coll Cardiol, vol.63, issue.20, pp.2131-2138, 2014.

H. Morita, A. Watanabe, and Y. Morimoto, Distribution and prognostic significance of fragmented QRS in patients with brugada syndrome, Circ Arrhythmia Electrophysiol, vol.10, issue.3, pp.2-5, 2017.

C. De-asmundis, G. Mugnai, and G. B. Chierchia, Long-Term Follow-Up of Probands With Brugada Syndrome, Am J Cardiol, vol.119, issue.9, pp.1392-1400, 2017.

L. Meng, K. P. Letsas, and A. Baranchuk, Meta-analysis of fragmented QRS as an electrocardiographic predictor for arrhythmic events in patients with Brugada syndrome, Front Physiol, vol.8, pp.1-7, 2017.

P. Rattanawong, T. Riangwiwat, and N. Prasitlumkum, Baseline fragmented QRS increases the risk of major arrhythmic events in Brugada syndrome: Systematic review and meta-analysis, Ann Noninvasive Electrocardiol, pp.1-8, 2017.

K. Yoshioka, M. Amino, and W. Zareba, Identification of High-Risk Brugada Syndrome Patients by Combined Analysis of Late Potential and T-Wave Amplitude Variability on Ambulatory Electrocardiograms, Circ J, vol.77, issue.3, pp.610-618, 2013.

A. Takagi, K. Nakazawa, and T. Sakurai, Prolongation of LAS40 (Duration of the Low Amplitude Electric Potential Component (<40?V) of the Terminal Portion of the QRS) Induced by Isoproterenol in 11 Patients With Brugada Syndrome, Circ J, vol.66, pp.1101-1104, 2002.

Z. Huang, C. Patel, and W. Li, Role of signal-averaged electrocardiograms in arrhythmic risk

R. Jain, H. Tandri, and A. Daly, Reader-and instrument-dependent variability in the electrocardiographic assessment of arrhythmogenic right ventricular dysplasia/cardiomyopathy, J Cardiovasc Electrophysiol, vol.22, issue.5, pp.561-568, 2011.

M. De-guillebon, J. B. Thambo, and S. Ploux, Reliability and reproducibility of QRS duration in the selection of candidates for cardiac resynchronization therapy, J Cardiovasc Electrophysiol, vol.21, issue.8, pp.890-892, 2010.

B. Sarubbi, W. Li, and J. Somerville, QRS width in right bundle branch block. Accuracy and reproducibility of manual measurement, Int J Cardiol, vol.75, issue.1, pp.71-74, 2000.

P. Brugada and J. Brugada, Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. A multicenter report, J Am Coll Cardiol, vol.20, issue.6, pp.1391-1396, 1992.

S. G. Priori, A. A. Wilde, and M. Horie, Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes, J Arrhythmia, vol.30, issue.1, pp.29-47, 2014.

J. Steinfurt, J. Biermann, C. Bode, and K. E. Odening, The diagnosis, risk stratification, and treatment of Brugada syndrome, Dtsch Arztebl Int, vol.112, issue.23, pp.394-401, 2015.

V. Probst, C. Veltmann, and L. Eckardt, Long-Term Prognosis of Patients Diagnosed With Brugada Syndrome: Results From the FINGER Brugada Syndrome Registry, Circulation, vol.121, issue.5, pp.635-643, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00910144

O. Nordkamp, L. Postema, P. G. Knops, and R. E. , Implantable cardioverter-defibrillator harm in young patients with inherited arrhythmia syndromes: A systematic review and meta-analysis of inappropriate shocks and complications. Hear Rhythm, vol.13, pp.443-454, 2016.

K. Nademanee and G. Veerakul, Overlapping risks of early repolarization and brugada syndrome, J Am Coll Cardiol, vol.63, issue.20, 2014.

A. Adler, R. Rosso, E. Chorin, O. Havakuk, C. Antzelevitch et al., Risk stratification in Brugada syndrome: Clinical characteristics, electrocardiographic parameters, and auxiliary testing. Hear Rhythm, 2015.

G. Nam, Y. Kim, and C. Antzelevitch, Augmentation of J waves and electrical storms in patients with early repolarization, N Engl J Med, vol.358, pp.2078-2079, 2008.

R. Rosso, E. Kogan, and B. Belhassen, J-Point Elevation in Survivors of Primary Ventricular Fibrillation and Matched Control Subjects. Incidence and Clinical Significance, J Am Coll Cardiol, vol.52, issue.15, pp.1231-1238, 2008.

M. Haïssaguerre, N. Derval, and F. Sacher, Sudden cardiac arrest associated with early repolarization, N Engl J Med, vol.358, pp.2016-2023, 2008.

W. F. Mcintyre, A. R. Pérez-riera, F. Femenía, and A. Baranchuk, Coexisting early repolarization pattern and Brugada syndrome: Recognition of potentially overlapping entities, J Electrocardiol, vol.45, issue.3, pp.195-198, 2012.

C. Antzelevitch, G. Yan, and M. J. Ackerman, Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge Electrophysiology (Sociedad Latinoamericana de Estimulació n Cardíaca y Electrofisiología, vol.32, pp.26-40, 2016.

K. P. Letsas, T. Liu, and Q. Shao, Meta-analysis on risk stratification of asymptomatic individuals with the brugada phenotype, Am J Cardiol, vol.116, issue.1, pp.98-103, 2015.

M. Takagi, K. Aonuma, Y. Sekiguchi, Y. Yokoyama, N. Aihara et al., The prognostic value of early repolarization (J wave) and ST-segment morphology after J wave in Brugada syndrome: Multicenter study in Japan, Hear Rhythm, vol.10, issue.4, pp.533-539, 2013.

K. P. Letsas, F. Sacher, and V. Probst, Prevalence of early repolarization pattern in inferolateral leads in patients with Brugada syndrome, Hear Rhythm, vol.5, issue.12, pp.1685-1689, 2008.

K. Tokioka, K. F. Kusano, and H. Morita, Electrocardiographic parameters and fatal arrhythmic events in patients with brugada syndrome: Combination of depolarization and repolarization abnormalities, J Am Coll Cardiol, vol.63, issue.20, pp.2131-2138, 2014.

S. Kamakura, T. Ohe, and K. Nakazawa, Long-term prognosis of probands with brugada-pattern STelevation in leads V 1-V 3, Circ Arrhythmia Electrophysiol, vol.2, issue.5, pp.495-503, 2009.

H. Kawata, H. Morita, and Y. Yamada, Prognostic significance of early repolarization in inferolateral leads in Brugada patients with documented ventricular fibrillation: A novel risk factor for Brugada syndrome with ventricular fibrillation, Hear Rhythm, vol.10, issue.8, pp.1161-1168, 2013.

P. W. Macfarlane, C. Antzelevitch, and M. Haissaguerre, The early repolarization pattern: A consensus paper, J Am Coll Cardiol, vol.66, issue.4, pp.470-477, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01244027

P. Maury, A. Rollin, and F. Sacher, Prevalence and Prognostic Role of Various Conduction Disturbances in Patients With the Brugada Syndrome, Am J Cardiol, vol.112, issue.9, pp.1384-1389, 2013.

K. Ohkubo, I. Watanabe, and Y. Okumura, Prolonged QRS duration in lead V2 and risk of lifethreatening ventricular Arrhythmia in patients with Brugada syndrome, Int Heart J, vol.52, issue.2, pp.98-102, 2011.

L. Calò, C. Giustetto, and A. Martino, A New Electrocardiographic Marker of Sudden Death in Brugada Syndrome: The S-Wave in Lead i, J Am Coll Cardiol, vol.67, issue.12, pp.1427-1440, 2016.

P. Maury, F. Sacher, and J. B. Gourraud, Increased Tpeak-Tend interval is highly and independently related to arrhythmic events in Brugada syndrome. Hear Rhythm, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01773236

H. Morita, K. F. Kusano, and D. Miura, Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome, Circulation, vol.118, issue.17, pp.1697-1704, 2008.

J. T. Tikkanen, M. J. Junttila, and O. Anttonen, Early repolarization: Electrocardiographic phenotypes associated with favorable long-term outcome, Circulation, vol.123, issue.23, pp.2666-2673, 2011.

S. Georgopoulos, K. P. Letsas, and T. Liu, Ameta-analysis on the prognostic significance of inferolateral early repolarization pattern in Brugada syndrome, Europace, vol.2017, pp.1-6

S. G. Priori, M. Gasparini, and C. Napolitano, Risk stratification in brugada syndrome: Results of the PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) registry, J Am Coll Cardiol, vol.59, issue.1, pp.37-45, 2012.

B. Benito, A. Sarkozy, and L. Mont, Gender Differences in Clinical Manifestations of Brugada Syndrome, J Am Coll Cardiol, vol.52, issue.19, pp.1567-1573, 2008.

J. Sieira, G. Conte, and G. Ciconte, Clinical characterisation and long-term prognosis of women with Brugada syndrome, pp.452-458, 2016.

A. Wilde, P. G. Postema, D. Diego, and J. M. , The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization, J Mol Cell Cardiol, 2010.

M. G. Hoogendijk, M. Potse, and R. Coronel, Critical appraisal of the mechanism underlying J waves, J Electrocardiol, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00906519

F. Sacher, L. Jesel, P. Jais, and M. Haïssaguerre, Insight into the mechanism of Brugada syndrome: Epicardial substrate and modification during ajmaline testing, Hear Rhythm, vol.11, issue.4, pp.732-734, 2014.

J. Zhang, F. Sacher, and K. Hoffmayer, Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in brugada syndrome patients, Circulation, vol.131, issue.22, pp.1950-1959, 2015.

C. Antzelevitch, Brugada Syndrome Clinical, Genetic, Molecular, Cellular, and Ionic Aspects, Curr Probl Cardiol, vol.41, issue.1, pp.7-57, 2016.