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, Résumés Influence of CMIP expression on idiopathic nephrotic syndrome evolution Idiopathic nephrotic syndrom (INS) pools two entities: minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). MCD and FSGS are podocyte diseases which share the same pathophysiology: modifications of podocyte cytoskeleton and ultrastructure
, Podocyte foot process effacement is the first step of INS (MCD), the second one is the podocytes loss (FSGS)
, We included all the kidney biopsies, of Aquitaine centralized by two pathology laboratories of
IgA nephropathy (IgAN) or preimplantation tissue (preimp., before kidney allograft) were also included for comparison. Biopsies were secondly read, blindly of the initial diagnosis with a specific nephropathologic interpretation grid. We tested glomerular (podocytes) and tubular CMIP expression by immunohistochemistry, with the final diagnosis was primitive MCD or FSGS. These biopsies were taken from, 2007. ,
, This difference was not significative at M12 (78.5 mL/min/1.73m 2 vs 64.2, p = 0.10). The MDRD slope during the first year after the biopsy was better for glomerular positive CMIP patients (MDRD slope > 40 %: 33.3 % vs 8.7 %, p = 0.041). CMIP positive patients had more vascular chronic lesions in their biopsies than negative CMIP patients, CMIP staining was performed for 120 biopsies: 68.3 % were positive. All the diabN and IgAN had a positive glomerular CMIP staining
, In a multivariate analysis, glomerular CMIP staining was not associated to proteinuria but was related to renal function at M0 (OR 1.02
, But CMIP expression may allow us to distinguish MCD or HSF patients with a better renal course at M12, Glomerular CMIP staining was nonspecific of INS