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, Résumés Influence of CMIP expression on idiopathic nephrotic syndrome evolution Idiopathic nephrotic syndrom (INS) pools two entities: minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). MCD and FSGS are podocyte diseases which share the same pathophysiology: modifications of podocyte cytoskeleton and ultrastructure

, Podocyte foot process effacement is the first step of INS (MCD), the second one is the podocytes loss (FSGS)

, We included all the kidney biopsies, of Aquitaine centralized by two pathology laboratories of

. Bordeaux, IgA nephropathy (IgAN) or preimplantation tissue (preimp., before kidney allograft) were also included for comparison. Biopsies were secondly read, blindly of the initial diagnosis with a specific nephropathologic interpretation grid. We tested glomerular (podocytes) and tubular CMIP expression by immunohistochemistry, with the final diagnosis was primitive MCD or FSGS. These biopsies were taken from, 2007.

, This difference was not significative at M12 (78.5 mL/min/1.73m 2 vs 64.2, p = 0.10). The MDRD slope during the first year after the biopsy was better for glomerular positive CMIP patients (MDRD slope > 40 %: 33.3 % vs 8.7 %, p = 0.041). CMIP positive patients had more vascular chronic lesions in their biopsies than negative CMIP patients, CMIP staining was performed for 120 biopsies: 68.3 % were positive. All the diabN and IgAN had a positive glomerular CMIP staining

, In a multivariate analysis, glomerular CMIP staining was not associated to proteinuria but was related to renal function at M0 (OR 1.02

, But CMIP expression may allow us to distinguish MCD or HSF patients with a better renal course at M12, Glomerular CMIP staining was nonspecific of INS