Incidence, progression and risk factors for epiretinal membranes in the elderly: the ALIENOR study

Abstract : Purpose: to determine the incidence, progression rate and risk factors for epiretinal membranes (ERMs) in a population of French elderly subjects. Methods: 735 eyes of 413 participants of the ALIENOR study were included between 2009 and 2010. Participants were reevaluated every two-years between 2009 and 2017 (corresponding to 3 follow-up visits). All included eyes had gradable spectral-domain optical coherence tomography (SD-OCT), retinal images at baseline and at least one follow-up data collection point. A classification of ERMs using SD-OCT findings was set up to evaluate ERM incidence and progression. Results: the incidence rate of ERM was 9.42 per 100 eye-years (95% confidence interval (CI), 7.36-12.05) in our population, corresponding to a five-year cumulative incidence of 37.57%. ERM incidence was significantly associated with smoking after 85 years (Hazard Ratio (HR), 4.81; p=0.022), cataract surgery (HR, 1.86; p=0.0108), presence of vitreomacular or vitreopapillary adhesion (HR, 1.64; p=0.038) and decrease in choroidal thickness (HR 1.04; p=0.0094). The five-year cumulative progression rate was 6.86%. Conclusion: due to the systematic use of SD-OCT images, early ERMs were found to be far more frequent in our population than previously described. Incident ERMs were associated with three main ocular risk factors: cataract surgery, vitreous adhesion and interestingly, choroidal thickness.
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Master Thesis
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Caroline Morillon. Incidence, progression and risk factors for epiretinal membranes in the elderly: the ALIENOR study. Human health and pathology. 2018. ⟨dumas-02077082⟩

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