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Les patientes porteuses d'une mutation sur les gènes BRCA 1, 2 ont plus de rechute locale (RL) après 5 ans et de rechute controlatérale (RCL) ,
Comparer les taux de RL et RCL après CNA pour tumeur du sein localement avancée, entre une population porteuse ou non de mutation des gènes de prédisposition ,
, Seules les patientes traitées par CNA pour tumeur mammaire localement avancée avec recherche de mutation des gènes BRCA au minimum élargie à un panel de 25 gènes, ont été sélectionnées. Résultats: 122 patientes ont été incluses. 28 patientes sont porteuses d'une mutation, 2007.
, Après chirurgie conservatrice, trois patientes porteuses de mutations ont eu une RL
, BRCA 2) sur 15 et deux patientes non porteuses de mutation sur 67, BRCA1, issue.0403, p.0
,
, Conclusion: Après CNA et chirurgie conservatrice, les patientes porteuses d'une mutation sur les gènes de prédisposition ont plus de rechute locale du cancer du sein avant 5 ans