, WHO | Effects of human exposure to hormone-disrupting chemicals examined in landmark UN report

S. Desmots, C. Brulez, and E. Lemazurier, Endocrine disrupters and human health: A non-exhaustive review, Environ Risques Santé. 1 mai, vol.4, issue.3, pp.195-204, 2005.

Y. Du, N. Guo, Y. Wang, X. Hua, T. Deng et al., Urinary phthalate metabolites in relation to serum anti-Müllerian hormone and inhibin B levels among women from a fertility center: a retrospective analysis, Reprod Health. 23 févr, vol.15, issue.1, p.33, 2018.

R. S. Carson and . Spring, , 2002.

L. J. Guillette, T. S. Gross, G. R. Masson, J. M. Matter, H. F. Percival et al., Developmental Abnormalities of the Gonad and Abnormal Sex Hormone Concentrations in Juvenile Alligators from Contaminated and Control Lakes in Florida, Environ Health Perspect. août, vol.102, issue.8, p.680, 1994.

P. Mocarelli, P. M. Gerthoux, D. G. Patterson, S. Milani, G. Limonta et al., Dioxin Exposure, from Infancy through Puberty, Produces Endocrine Disruption and Affects Human Semen Quality. Environ Health Perspect, janv, vol.116, issue.1, pp.70-77, 2008.

B. Trabert, M. P. Longnecker, J. W. Brock, M. A. Klebanoff, and K. A. Mcglynn, Maternal Pregnancy Levels of trans-Nonachlor and Oxychlordane and Prevalence of Cryptorchidism and Hypospadias in Boys, Environ Health Perspect. mars, vol.120, issue.3, pp.478-82, 2012.

R. M. Sharpe and N. E. Skakkebaek, Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? The Lancet, vol.341, pp.1392-1398, 1993.

A. Parent, D. Franssen, J. Fudvoye, A. Gérard, and J. Bourguignon, Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents, Front Neuroendocrinol. 1 juill, vol.38, pp.12-36, 2015.

G. Séralini, C. E. Mesnage, R. Gress, S. Defarge, N. Malatesta et al., Republished study: longterm toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize, Environ Sci Eur, vol.26, issue.1

E. Carlsen, A. Giwercman, N. Keiding, and N. E. Skakkebaek, Evidence for Decreasing Quality of Semen During Past 50 Years, Obstet Gynecol Surv. mars, vol.48, issue.3, pp.200-201, 1993.

J. Auger, J. M. Kunstmann, F. Czyglik, and P. Jouannet, Decline in Semen Quality among Fertile Men in Paris during the Past 20 Years, N Engl J Med. 2 févr, vol.332, issue.5, pp.281-286, 1995.

M. Rolland, L. Moal, J. Wagner, V. Royère, D. De-mouzon et al., Decline in semen concentration and morphology in a sample of 26 609 men close to general population between 1989 and 2005 in France, Hum Reprod. févr, vol.28, issue.2, pp.462-70, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01129703

R. Slama, La fertilité des couples en France, p.5

M. E. Thoma, A. C. Mclain, J. F. Louis, R. B. King, A. C. Trumble et al., Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach, Fertil Steril. avr, vol.99, issue.5, pp.1324-1331, 2013.

J. De-cock, K. Westveer, D. Heederik, E. Te-velde, and R. Van-kooij, Time to pregnancy and occupational exposure to pesticides in fruit growers in The Netherlands, Occup Environ Med, vol.51, issue.10, pp.693-702, 1994.

C. Chevrier, C. Warembourg, E. Gaudreau, C. Monfort, L. Blanc et al., Organochlorine Pesticides, Polychlorinated Biphenyls, Seafood Consumption, and Time-to-Pregnancy, Epidemiology. mars, vol.24, issue.2, pp.251-60, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00826533

C. K. Naughton, Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility, Yearb Urol. janv, pp.224-229, 2006.

M. Strazzullo and M. R. Matarazzo, Epigenetic Effects of Environmental Chemicals on Reproductive Biology, Curr Drug Targets, vol.18, issue.10, pp.1116-1140, 2017.

Y. Wei, H. Schatten, and Q. Sun, Environmental epigenetic inheritance through gametes and implications for human reproduction, Hum Reprod Update. 1 mars, vol.21, issue.2, pp.194-208, 2015.

M. D. Anway, A. S. Cupp, M. Uzumcu, and M. K. Skinner, Epigenetic transgenerational actions of endocrine disruptors and male fertility, Science. 3 juin, vol.308, issue.5727, pp.1466-1475, 2005.

C. Messerlian, I. Souter, A. J. Gaskins, P. L. Williams, J. B. Ford et al., Urinary phthalate metabolites and ovarian reserve among women seeking infertility care, Hum Reprod Oxf Engl. janv, vol.31, issue.1, pp.75-83, 2016.

D. Li, Z. Zhou, M. Miao, Y. He, J. Wang et al., Urine bisphenol-A (BPA) level in relation to semen quality, Fertil Steril. févr, vol.95, issue.2, pp.625-630, 2011.

M. Sugiura-ogasawara, Y. Ozaki, S. Sonta, T. Makino, and K. Suzumori, Exposure to bisphenol A is associated with recurrent miscarriage, Hum Reprod. 1 août, vol.20, issue.8, pp.2325-2334, 2005.

, Health Outcomes | Agricultural Health Study

D. Sur,

. La-qualité-de-l'eau and F. Assainissement-en, Inserm. Pesticides : Effets sur la santé

. Inserm, , 2013.

F. Santé-publique, Tabagisme en France : 1 million de fumeurs quotidiens en moins

, Baromètre santé -Conduites addictives en Picardie (Les

D. Sur,

R. Künzle, M. D. Mueller, W. Hänggi, M. H. Birkhäuser, H. Drescher et al., Semen quality of male smokers and nonsmokers in infertile couples, Fertil Steril. févr, vol.79, issue.2, pp.287-91, 2003.

M. Knoll, R. Shaoulian, T. Magers, and P. Talbot, Ciliary Beat Frequency of Hamster Oviducts is Decreased in Vitro by Exposure to Solutions of Mainstream and Sidestream Cigarette Smoke1, Biol Reprod. 1 juill, vol.53, issue.1, pp.29-37, 1995.

A. Hyland, K. M. Piazza, K. M. Hovey, J. K. Ockene, C. A. Andrews et al., Associations of lifetime active and passive smoking with spontaneous abortion, stillbirth and tubal ectopic pregnancy: a cross-sectional analysis of historical data from the Women's Health Initiative, Tob Control. juill, vol.24, issue.4, pp.328-363, 2015.

S. Firns, V. F. Cruzat, K. N. Keane, K. A. Joesbury, A. H. Lee et al., The effect of cigarette smoking, alcohol consumption and fruit and vegetable consumption on IVF outcomes: a review and presentation of original data, Reprod Biol Endocrinol [Internet]. déc, vol.13, issue.1, 2015.

F. J. Broekmans, E. Knauff, E. R. Te-velde, N. S. Macklon, and B. C. Fauser, Female reproductive ageing: current knowledge and future trends, Trends Endocrinol Metab. mars, vol.18, issue.2, pp.58-65, 2007.

. Regards-sur-la-parité-en-picardie, Chapitre Santé, Conditions de vie -Maternité, IVG -Insee Picardie Dossier

M. L. Eisenberg and D. Meldrum, Effects of age on fertility and sexual function, Fertil Steril. févr, vol.107, issue.2, pp.301-305, 2017.

N. Andersen, A. Hansen, K. D. Andersen, P. K. , D. Smith et al., Advanced Paternal Age and Risk of Fetal Death: A Cohort Study, Am J Epidemiol. 15 déc, vol.160, issue.12, pp.1214-1236, 2004.

A. S. Herati, B. H. Zhelyazkova, P. R. Butler, and D. J. Lamb, Age-related alterations in the genetics and genomics of the male germ line, Fertil Steril. 1 févr, vol.107, issue.2, pp.319-342, 2017.

, Pesticides et cancer, risques pesticides santé, risque cancer pesticides | Cancer et environnement

M. C. Alavanja, D. P. Sandler, S. B. Mcmaster, S. H. Zahm, C. J. Mcdonnell et al., The Agricultural Health Study, Environ Health Perspect. avr, vol.104, issue.4, pp.362-371, 1996.

R. W. Bretveld, M. Hooiveld, G. A. Zielhuis, A. Pellegrino, I. Van-rooij et al., Reproductive disorders among male and female greenhouse workers, Reprod Toxicol. janv, vol.25, issue.1, pp.107-121, 2008.

D. Whorton, R. Krauss, S. Marshall, and T. Milby, INFERTILITY IN MALE PESTICIDE WORKERS. The Lancet. déc, vol.310, issue.8051, pp.1259-61, 1977.

D. Whorton, T. H. Milby, R. M. Krauss, and H. A. Stubbs, Testicular function in DBCP exposed pesticide workers, J Occup Med Off Publ Ind Med Assoc. mars, vol.21, issue.3, pp.161-167, 1979.

C. A. Easley, J. M. Bradner, A. Moser, C. A. Rickman, Z. T. Mceachin et al., Assessing reproductive toxicity of two environmental toxicants with a novel in vitro human spermatogenic model, Stem Cell Res. mai, vol.14, issue.3, pp.347-55, 2015.

A. J. Wyrobek, G. Watchmaker, L. Gordon, K. Wong, D. Moore et al., Sperm shape abnormalities in carbaryl-exposed employees, Environ Health Perspect. août, vol.40, pp.255-65, 1981.

D. Lerda and R. Rizzi, Study of reproductive function in persons occupationally exposed to 2,4-dichlorophenoxyacetic acid (2,4-D), Mutat Res Lett. janv, vol.262, issue.1, pp.47-50, 1991.

T. Lifeng, W. Shoulin, J. Junmin, S. Xuezhao, L. Yannan et al., Effects of fenvalerate exposure on semen quality among occupational workers, Contraception. janv, vol.73, issue.1, pp.92-98, 2006.

C. Padungtod, D. A. Savitz, J. W. Overstreet, D. C. Christiani, L. M. Ryan et al., Occupational Pesticide Exposure and Semen Quality Among Chinese Workers, J Occup Environ Med, vol.42, issue.10, pp.982-92, 2000.

C. Padungtod, T. J. Hassold, M. E. Ryan, L. M. Savitz, D. A. Christiani et al., Sperm aneuploidy among Chinese pesticide factory workers: scoring by the FISH method, Am J Ind Med. août, vol.36, issue.2, pp.230-238, 1999.

Y. Xia, S. Cheng, Q. Bian, L. Xu, M. D. Collins et al., Genotoxic Effects on Spermatozoa of Carbaryl-Exposed Workers, Toxicol Sci. 1 mai, vol.85, issue.1, pp.615-638, 2005.

R. Recio-vega, G. Ocampo-gómez, V. H. Borja-aburto, J. Moran-martínez, and C. Me, Organophosphorus pesticide exposure decreases sperm quality: association between sperm parameters and urinary pesticide levels, J Appl Toxicol. juill, vol.28, issue.5, pp.674-80, 2008.

Q. Bian, L. C. Xu, S. L. Wang, Y. K. Xia, L. F. Tan et al., Study on the relation between occupational fenvalerate exposure and spermatozoa DNA damage of pesticide factory workers, Occup Environ Med. déc, vol.61, issue.12, pp.999-1005, 2004.

M. Sallmén, J. Liesivuori, H. Taskinen, M. Lindbohm, A. Anttila et al., Time to pregnancy among the wives of Finnish greenhouse workers, Scand J Work Environ Health, vol.29, issue.2, pp.85-93, 2003.

K. M. Curtis, D. A. Savitz, C. R. Weinberg, and T. E. Arbuckle, The Effect of Pesticide Exposure on Time to Pregnancy, Epidemiology. mars, vol.10, issue.2, pp.112-119, 1999.

K. G. Harley, A. R. Marks, A. Bradman, D. B. Barr, B. Eskenazi et al., Work in Agriculture, and Time to Pregnancy Among Farmworkers in California, J Occup Environ Med. déc, vol.50, issue.12, pp.1335-1377, 2008.

S. L. Farr, G. S. Cooper, J. Cai, D. A. Savitz, and D. P. Sandler, Pesticide use and menstrual cycle characteristics among premenopausal women in the Agricultural Health Study, Am J Epidemiol. 15 déc, vol.160, issue.12, pp.1194-204, 2004.

A. J. Idrovo, L. H. Sanìn, D. Cole, J. Chavarro, H. Cáceres et al., Time to first pregnancy among women working in agricultural production, Int Arch Occup Environ Health. juill, vol.78, issue.6, pp.493-500, 2005.

A. Abell, S. Juul, and J. Bonde, Time to pregnancy among female greenhouse workers, Scand J Work Environ Health, vol.26, issue.2, pp.131-137, 2000.

N. M. Grindler, J. E. Allsworth, G. A. Macones, K. Kannan, K. A. Roehl et al., Persistent Organic Pollutants and Early Menopause in U.S. Women. Rosenfeld CS, éditeur, PLOS ONE. 28 janv, vol.10, issue.1, p.116057, 2015.

I. S. Weidner, H. Møller, T. K. Jensen, and N. E. Skakkebaek, Cryptorchidism and hypospadias in sons of gardeners and farmers, Environ Health Perspect. déc, vol.106, issue.12, pp.793-799, 1998.

N. Nassar, P. Abeywardana, A. Barker, and C. Bower, Parental occupational exposure to potential endocrine disrupting chemicals and risk of hypospadias in infants, Occup Environ Med. 1 sept, vol.67, issue.9, pp.585-594, 2010.

V. Rouiller-fabre, R. Habert, and G. Livera, Effects of endocrine disruptors on the human fetal testis, Ann Endocrinol. mai, vol.75, issue.2, pp.54-61, 2014.

S. H. Swan, R. L. Kruse, F. Liu, D. B. Barr, E. Z. Drobnis et al., Semen Quality in Relation to Biomarkers of Pesticide Exposure, Environ Health Perspect. 18 juin, vol.111, issue.12, pp.1478-84, 2003.

J. W. Dallinga, E. Moonen, J. Dumoulin, J. Evers, J. Geraedts et al., Decreased human semen quality and organochlorine compounds in blood, Hum Reprod Oxf Engl. août, vol.17, issue.8, pp.1973-1982, 2002.

F. O. Owagboriaye, G. A. Dedeke, K. O. Ademolu, O. O. Olujimi, J. S. Ashidi et al., Reproductive toxicity of Roundup herbicide exposure in male albino rat, Exp Toxicol Pathol. sept, vol.69, issue.7, pp.461-469, 2017.

J. D. Meeker, L. Ryan, D. B. Barr, R. F. Herrick, D. H. Bennett et al., The Relationship of Urinary Metabolites of Carbaryl/Naphthalene and Chlorpyrifos with Human Semen Quality, Environ Health Perspect. déc, vol.112, issue.17, pp.1665-70, 2004.

A. Gely-pernot, C. Hao, L. Legoff, L. Multigner, D. Cruz et al., Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males, Sci Rep. 6 juill, vol.8, issue.1, p.10274, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01863035

N. C. Deziel, M. C. Friesen, J. A. Hoppin, C. J. Hines, K. Thomas et al., A Review of Nonoccupational Pathways for Pesticide Exposure in Women Living in Agricultural Areas, Environ Health Perspect. juin, vol.123, issue.6, pp.515-539, 2015.

T. E. Stoker, S. D. Perreault, K. Bremser, R. S. Marshall, A. Murr et al., Acute exposure to molinate alters neuroendocrine control of ovulation in the rat, Toxicol Sci Off J Soc Toxicol. mars, vol.84, issue.1, pp.38-48, 2005.

U. Luderer, J. S. Kesner, J. M. Fuller, E. F. Krieg, J. W. Meadows et al., Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women, Environ Res. févr, vol.121, pp.84-94, 2013.

G. C. Windham, D. Lee, P. Mitchell, M. Anderson, M. Petreas et al., Exposure to organochlorine compounds and effects on ovarian function, Epidemiol Camb Mass. mars, vol.16, issue.2, pp.182-90, 2005.

A. R. Greenlee, T. E. Arbuckle, and P. Chyou, Risk Factors for Female Infertility in an Agricultural Region, Epidemiology. juill, vol.14, pp.429-465, 2003.

M. G. Palmerini, G. Zhurabekova, A. Balmagambetova, S. A. Nottola, S. Miglietta et al., The pesticide Lindane induces dose-dependent damage to granulosa cells in an in vitro culture, Reprod Biol. déc, vol.17, pp.349-56, 2017.

P. Merviel, R. Cabry, K. Chardon, E. Haraux, F. Scheffler et al., Impact of oocytes with CLCG on ICSI outcomes and their potential relation to pesticide exposure, J Ovarian Res, vol.10, issue.2017
URL : https://hal.archives-ouvertes.fr/hal-02050698

W. R. Kelce, C. R. Stone, S. C. Laws, L. E. Gray, J. A. Kemppainen et al., Persistent DDT metabolite p,p'–DDE is a potent androgen receptor antagonist, Nature. juin, vol.375, issue.6532, pp.581-586, 1995.

G. Lemaire, B. Terouanne, P. Mauvais, S. Michel, and R. Rahmani, Effect of organochlorine pesticides on human androgen receptor activation in vitro, Toxicol Appl Pharmacol. avr, vol.196, issue.2, pp.235-281, 2004.

F. Brucker-davis, K. Wagner-mahler, I. Delattre, B. Ducot, P. Ferrari et al., Cryptorchidism at birth in Nice area (France) is associated with higher prenatal exposure to PCBs and DDE, as assessed by colostrum concentrations, Hum Reprod Oxf Engl. août, vol.23, issue.8, pp.1708-1726, 2008.

I. N. Damgaard, N. E. Skakkebaek, J. Toppari, H. E. Virtanen, H. Shen et al., Persistent Pesticides in Human Breast Milk and Cryptorchidism, Environ Health Perspect. juill, vol.114, issue.7, pp.1133-1141, 2006.

N. Chevalier, F. Brucker-davis, N. Lahlou, P. Coquillard, M. Pugeat et al., A negative correlation between insulin-like peptide 3 and bisphenol A in human cord blood suggests an effect of endocrine disruptors on testicular descent during fetal development, Hum Reprod Oxf Engl. févr, vol.30, issue.2, pp.447-53, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01850487

T. K. Al-hussaini, A. A. Abdelaleem, I. Elnashar, O. M. Shabaan, R. Mostafa et al., The effect of follicullar fluid pesticides and polychlorinated biphenyls concentrations on intracytoplasmic sperm injection (ICSI) embryological and clinical outcome, Eur J Obstet Gynecol Reprod Biol. janv, vol.220, pp.39-43, 2018.

Y. Chiu, P. L. Williams, M. W. Gillman, A. J. Gaskins, L. Mínguez-alarcón et al., Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology, JAMA Intern Med. 1 janv, vol.178, issue.1, pp.17-26, 2018.

M. Manikkam, R. Tracey, C. Guerrero-bosagna, and M. K. Skinner, Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations, Reprod Toxicol. déc, vol.34, issue.4, pp.708-727, 2012.

C. Chevrier, G. Limon, C. Monfort, F. Rouget, R. Garlantézec et al., Urinary Biomarkers of Prenatal Atrazine Exposure and Adverse Birth Outcomes in the PELAGIE Birth Cohort, Environ Health Perspect. 1 juill, vol.119, issue.7, pp.1034-1075, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00682592

E. P. Santos, S. López-costa, P. Chenlo, M. N. Pugliese, S. Curi et al., Impact of spontaneous smoking cessation on sperm quality: case report, Andrologia. déc, vol.43, issue.6, pp.431-436, 2011.

M. S. Neal, E. G. Hughes, A. C. Holloway, and W. G. Foster, Sidestream smoking is equally as damaging as mainstream smoking on IVF outcomes, Hum Reprod. 1 sept, vol.20, issue.9, pp.2531-2536, 2005.

R. Pacifici, I. Altieri, L. Gandini, A. Lenzi, S. Pichini et al., Nicotine, cotinine, and trans-3-hydroxycotinine levels in seminal plasma of smokers: effects on sperm parameters, Ther Drug Monit. oct, vol.15, issue.5, pp.358-63, 1993.

W. Y. Wong, C. M. Thomas, H. Merkus, G. A. Zielhuis, and W. H. Doesburg, Steegers-Theunissen RP. Cigarette smoking and the risk of male factor subfertility: minor association between cotinine in seminal plasma and semen morphology, Fertil Steril, vol.74, issue.5, pp.930-935, 2000.

J. Rubes, X. Lowe, D. Moore, S. Perreault, V. Slott et al., Smoking cigarettes is associated with increased sperm disomy in teenage men, Fertil Steril. oct, vol.70, issue.4, pp.715-738, 1998.

.. S. Zavos-ed, .. D. Ph, . Pm, .. D. Correa-ph, . Jr et al., Effects of Seminal Plasma from Cigarette Smokers on Sperm Viability and Longevity, Fertil Steril. mars, vol.69, issue.3, pp.425-434, 1998.

R. A. Saleh, A. Agarwal, R. K. Sharma, D. R. Nelson, and A. J. Thomas, Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study, Fertil Steril. sept, vol.78, issue.3, pp.491-500, 2002.

S. Sepaniak, T. Forges, H. Gerard, B. Foliguet, M. Bene et al., The influence of cigarette smoking on human sperm quality and DNA fragmentation, Toxicology. juin, vol.223, issue.1-2, pp.54-60, 2006.

M. G. Hull, K. North, H. Taylor, A. Farrow, and W. C. Ford, Delayed conception and active and passive smoking. The Avon Longitudinal Study of Pregnancy and Childhood Study Team. Fertil Steril, vol.74, pp.725-758, 2000.

T. Freour, D. Masson, S. Mirallie, M. Jean, K. Bach et al., Active smoking compromises IVF outcome and affects ovarian reserve, Reprod Biomed Online. janv, vol.16, issue.1, pp.96-102, 2008.

M. S. Neal, J. Zhu, A. C. Holloway, and W. G. Foster, Follicle growth is inhibited by benzo-[a]-pyrene, at concentrations representative of human exposure, in an isolated rat follicle culture assay, Hum Reprod. 1 avr, vol.22, issue.4, pp.961-968, 2007.

T. Matikainen, G. I. Perez, A. Jurisicova, J. K. Pru, J. J. Schlezinger et al., Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals, Nat Genet. août, vol.28, issue.4, pp.355-60, 2001.

D. Prospero, F. Luzi, S. Iacopini, and Z. , Cigarette smoking damages women's reproductive life, Reprod Biomed Online. janv, vol.8, issue.2, pp.246-253, 2004.

H. Hassa, F. Gurer, H. M. Tanir, M. Kaya, N. B. Gunduz et al., Effect of cigarette smoke and alpha-tocopherol (vitamin E) on fertilization, cleavage, and embryo development rates in mice: An experimental in vitro fertilization mice model study, Eur J Obstet Gynecol Reprod Biol. déc, vol.135, issue.2, pp.177-82, 2007.

S. Alvarez, Do some addictions interfere with fertility?, Fertil Steril. 1 janv, vol.103, issue.1, pp.22-28, 2015.

A. P. Sobinoff, J. M. Sutherland, E. L. Beckett, S. J. Stanger, R. Johnson et al., Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility, Hum Reprod Oxf Engl. déc, vol.29, issue.12, pp.2719-2754, 2014.

J. Thorup, D. Cortes, and B. L. Petersen, The Incidence of Bilateral Cryptorchidism is Increased and the Fertility Potential is Reduced in Sons Born to Mothers who Have Smoked During Pregnancy, J Urol. 1 août, vol.176, issue.2, pp.734-741, 2006.

T. K. Jensen, N. Jørgensen, M. Punab, T. B. Haugen, J. Suominen et al., Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a crosssectional study of 1,770 young men from the general population in five European countries, Am J Epidemiol. 1 janv, vol.159, issue.1, pp.49-58, 2004.

A. Jurisicova, A. Taniuchi, H. Li, Y. Shang, M. Antenos et al., Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri, J Clin Invest. déc, vol.117, issue.12, pp.3971-3979, 2007.

. __________________________________________________________________-_-si-non, préciser la raison : __________________________________________________ 1-J'ai toujours autant de plaisir à faire les choses qui me plaisent habituellement : Oui toujours Pas autant De plus en plus rarement Presque plus du tout

, des sensations de peur et j'ai l'estomac noué : Très souvent Assez souvent Parfois Jamais

-. , ai une sensation de peur, comme si quelque chose d'horrible allait m'arriver : Oui très nettement Oui mais ce n'est pas trop grave Un peu mais cela ne m

J. , intérêt pour mon apparence : Totalement Je n'y fais plus attention J'y fais attention comme d'habitude

, Je sais rire et voir le côté amusant des choses : Toujours autant Plutôt moins De nettement moins Plus du tout

, la bougeotte et je ne tiens pas en place : Oui, c'est tout à fait le cas Plutôt moins qu'avant Beaucoup moins qu

, Je me fais du souci : Très souvent Assez souvent Occasionnellement Très occasionnellement

, Je me réjouis à l'avance de faire certaines choses : Comme d'habitude Plutôt moins qu'avant Beaucoup moins qu

, Methods: A questionnaire was distributed to each member of the couple by a dedicated clinical research officer. Questions concerned life habits, especially occupational and domestic pesticide exposure and smoking. Results: We noted a significantly lower smoking rate in the fertile group of women (17.1% vs 35.8%, p=0.01). We also noted a significantly lower passive smoking rate in the fertile group for both women and men during childhood, adolescence and adulthood, -Je me sens gai(e), de bonne humeur : THESIS TITLE : Endocrine disruptors impact on fertility : a comparative study. Introduction: Environmental endocrine disruptors are frequently found in the human body and are suspected to alter human fertility, 2013.