H. Blencowe, S. Cousens, D. Chou, M. Oestergaard, L. Say et al., Born Too Soon: The global epidemiology of 15 million preterm births, Reproductive Health, issue.10, p.2, 2013.

M. Chevallier, T. Debillon, V. Pierrat, P. Delorme, G. Kayem et al., Leading causes of preterm delivery as risk factors for intraventricular hemorrhage in very preterm infants: results of the EPIPAGE 2 cohort study, American Jour of Obstetrics and Gynecology. mai, vol.216, issue.5, pp.518-519, 2017.

N. Gomez-lopez, R. Romero, and Y. Xu, Inflammasome assembly in the chorioamniotic membranes during spontaneous labor at term, Am J Reprod Immunol, vol.77, p.12648, 2017.

T. O'shea, E. N. Michael, K. C. Allred, O. Kuban, N. Dammann et al., Elevated Concentrations of Inflammation-Related Proteins in Postnatal Blood Predict Severe Developmental Delay at 2 Years of Age in Extremely Preterm Infants, The J of Pediatrics, vol.160, issue.3, pp.395-401, 2012.

T. O'shea, B. Michael, E. N. Shah, R. N. Allred, K. C. Fichorova et al., Inflammation-Initiating Illnesses, Inflammation-Related Proteins, and Cognitive Impairment in Extremely Preterm Infants, Brain, Behavior, and Immunity, vol.29, pp.104-116, 2013.

. Kuban, Systemic inflammation and cerebral palsy risk in extremely preterm infants, J Child Neurol, vol.29, issue.12, pp.1692-1700, 2014.

. Kuban, Circulating Inflammatory-Associated Proteins in the First Month of Life and Cognitive Impairment at Age 10 Years in Children Born Extremely Preterm, J Pediatr, vol.180, pp.116-123, 2017.

S. Wikström, D. Ley, I. Hansen-pupp, and I. Rosén, Hellström-Westas. Early amplitude-integrated EEG correlates with cord TNF-alpha and brain injury in very preterm infants, Acta Paediatr, vol.97, issue.7, pp.915-919, 2008.

N. A. Hodyl, N. Aboustate, T. Bianco-miotto, C. T. Roberts, V. L. Clifton et al., Child neurodevelopmental outcomes following prreterm and term birth: what can the placenta tell us?, Placenta, vol.57, pp.79-86, 2017.

M. Nadeau-vallée, Antenatal supression of IL-1 protects against inflammation-induced fetal injury and improves neonatal and developmental outcomes in mice, J. Immunol, vol.198, issue.5, pp.2047-2062, 2017.

C. N. Cordeiro, Y. Savva, D. Vaidya, C. H. Argani, X. Hong et al., Mathematical modeling of the biomarker milieu to characterize to preterm birth and predict adverse neonatal outcomes, Am. J. Reprod. Immunol, vol.75, issue.5, pp.594-601, 2016.

R. Romero, . Gomez-r, F. Ghezzi, B. H. Yoon, M. Mazor et al., A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition, Am J Obstet Gynecol, vol.179, issue.1, pp.186-93, 1998.

P. Pacora, T. Chaiworapongsa, E. Maymon, Y. M. Kim, R. Gomez et al., Funitis and chorionic vascultis : the histological counterpart of the fetal inflammatory response syndrome, J Matern Fetal Neonatal Med, vol.11, issue.1, pp.18-25, 2002.

N. Gomez-lopez, A role for the inflammasome in spontaneous preterm labor with acute histologic chorioamnionitis, Reprod. Sci, vol.24, issue.10, pp.1382-1401, 2017.

B. H. Yoon, R. Romero, C. J. Kim, J. K. Jun, R. Gomez et al., Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity, Am J Obstet Gynecol, vol.172, issue.3, pp.960-70, 1995.

O. Baud, D. Emilie, E. Pelletier, T. Lacaze-masmonteil, V. Zupan et al., Amniotic fluid concentrations of interleukin 1beta, interleukin 6 and TNF-alpha in chorioamnionitis before 32 weeks of gestation: histological associations and neonatal outcome, Br J Obstet Gynaecol, vol.106, issue.1, pp.72-79, 1999.

A. R. Goepfert, W. W. Andrews, C. W. Ramsey, P. S. Cliver, S. P. Goldenberg et al., Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neonatal morbidity, American Journal of Obstetrics and Gynecology, vol.191, issue.4, pp.1375-81, 2004.

A. R. Vasconcelos, L. M. Yshii, T. A. Viel, H. S. Buck, M. P. Mattson et al., Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment, J. Neuroinflammation, vol.11, p.85, 2014.

R. K. Ohls, B. D. Kamath-rayne, R. D. Christensen, S. E. Wiedmeier, A. Rosenberg et al., Cognitive outcomes of preterm infants randomized to darbepoetin, erythropoietin, or placebo, Pediatrics, vol.133, issue.6, pp.1023-1030, 2014.

K. B. Nelson, J. K. Grether, J. M. Dambrosia, E. Walsh, S. Kohler et al., Neonatal cytokines and cerebral palsy in very preterm infants, Pediatric research, vol.53, issue.4, pp.600-607, 2003.

A. Bashiri, E. Burstein, and M. Mazor, Cerebral palsy and fetal inflammatory response syndrome: a review, Journal of Perinatal Medicine. 1 janv, vol.34, issue.1, 2006.

B. H. Yoon, R. Romero, K. S. Kim, J. S. Park, S. H. Ki et al., A systemic fetal inflammatory response and development of bronchopulmonary dysplasia, Am J Obstet Gynecol, vol.181, issue.4, pp.773-782, 1999.

B. Larroque, P. Y. Ancel, and S. Marret, EPIPAGE Study group. Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study, Lancet, vol.371, pp.813-833, 2008.

L. K. Washburn, R. G. Dillard, D. J. Goldstein, K. L. Klinepeter, R. et al., Survival and major neurodevelopmental impairment in extremely low gestational age newborns born 1990-2000: a retrospective cohort study, BMC Pediatrics. déc, vol.7, issue.1, 2007.

N. S. Wood, N. Marlow, K. Costeloe, A. T. Gibson, and A. R. Wilkinson, EPICure Study Grp. Neurologic and developmental disability after extremely preterm birth, New England Journ Med. 10 août, vol.343, pp.378-84, 2000.

P. Y. Ancel, F. Goffinet, and P. Kuhn, EPIPAGE-2 Writing Group. Survival and morbidity of preterm children born at 22 through 34 weeks' gestation in France in 2011: results of the EPIPAGE-2 cohort study, JAMA Pediatr, vol.169, pp.230-238, 2015.

O. Delmas, P. Garcia, V. Bernard, M. Fabre, R. Vialet et al., Devenir à l'âge de 3ans d'une cohorte d'enfants nés à moins de 26 semaines d'aménorrhée, Arch de Pédiatrie. sept, vol.23, issue.9, pp.927-961, 2016.

Z. Molnár and M. Rutherford, Brain maturation after preterm birth, Sci. Transl. 2013 Med, vol.5, issue.168

B. E. Stephens and B. R. Vohr, Neurodevelopmental outcome of the premature infant, Pediatr. Clin. North Am, vol.56, issue.3, pp.631-646, 2009.

D. B. Selip, L. L. Jantzie, M. Chang, M. C. Jackson, E. C. Fitzgerald et al., Regional differences in susceptibility to hypoxic-ischemic injury in the preterm brain: exploring the spectrum from white matter loss to selective grey matter injury in a rat model, Neurol. Res. Int, 2012.

J. A. Vanderveen, D. Bassler, C. Robertson, and H. Kirpalani, Early interventions involving parents to improve neurodevelopmental outcomes of premature infants: a meta-analysis, Journal of Perinatology. mai, vol.29, issue.5, pp.343-51, 2009.

L. W. Doyle and P. J. Anderson, Adult Outcome of Extremely Preterm Infants, Pediatrics, vol.126, issue.2, pp.342-51, 2010.

S. Saigal, K. L. Day, R. Lieshout, L. A. Schmidt, K. M. Morrison et al., Health, Wealth, Social Integration, and Sexuality of Extremely Low-Birth-Weight Prematurely Born Adults in the Fourth Decade of Life, JAMA Pediatr. 1 juill, vol.170, issue.7, pp.678-86, 2016.

V. Pierrat, L. Marchand-martin, C. Arnaud, M. Kaminski, M. Resche-rigon et al., Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks' gestation in France in 2011: EPIPAGE-2 cohort study, BMJ, p.3448, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01610207

A. G. Wassenaer-leemhuis, . Van, M. Jeukens-visser, J. Hus, D. Van,-meijssen et al., Rethinking preventive post-discharge intervention programmes for very preterm infants and their parents, Developmental Medicine & Child Neurology, vol.58, issue.S4, pp.67-73, 2016.

, Section on Developmental Behavioral Pediatrics. Identifying infants and young children with developmental disorders in the medical home: an algorithm for developmental surveillance and screening, Council on Children With Disabilities, vol.118, pp.405-425, 2006.

C. Flamant, B. Branger, and S. Nguyen-the-tich, Parent-completed developmental screening in premature children: a valid tool for follow-up programs, PLoS One, vol.6, p.20004, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00857600

M. N. Simard, T. M. Luu, and J. Gosselin, Concurrent validity of ages and stages questionnaires in preterm infants, Pediatrics, vol.130, issue.1, pp.108-122, 2012.

L. Schonhaut, I. Armijo, M. Schonstedt, J. Alvarez, and M. Cordero, Validity of the Ages and Stages Questionnaires in Term and Preterm Infants, Pediatrics, vol.131, issue.5, pp.1468-74, 2013.

T. Moore, E. M. Hennessy, J. Myles, S. J. Johnson, E. S. Draper et al., Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies, BMJ, vol.345, pp.7961-7961, 2012.

N. Younge, R. F. Goldstein, and C. M. Bann, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Survival and Neurodevelopmental Outcomes among Perivale Infants, N Engl J Med, vol.376, pp.617-645, 2017.

F. Serenius, G. Sjors, M. Blennow, V. Fellman, G. Holmstrom et al., 204 Regional Differences in peri- and Neonatal Outcomes of Extremely Preterm Infants in Sweden (Express). Archives of Disease in Childhood, vol.97, pp.59-59, 2012.

M. Hack, Poor Predictive Validity of the Bayley Scales of Infant Development for Cognitive Function of Extremely Low Birth Weight Children at School Age, Pediatrics, vol.116, issue.2, pp.333-374, 2005.

D. Bricker and J. Squires, Ages and Stages Questionnaire (ASQ): A Parent-Completed, Child Monitoring System, 1999.

J. Squires, D. Bricker, and L. Potter, Revision of a Parent-Completed Developmental Screening Tool: Ages and Stages Questionnaires, Journal of Pediatric Psychology, vol.22, issue.3, pp.313-341, 1997.

W. Costello, Improved neurodevelopmental outcomes for extremely low birth weight infants in 200-2002 ; Pediatrics, vol.119, pp.37-45, 2001.

C. Sachse, F. Dressler, and E. Henkel, Increased serum procalcitonin in newborn infant without infection, Clin Chem, vol.44, pp.1343-1347, 1998.

G. Monneret, J. M. Labaune, C. Isaac, F. Bienvenu, G. Putet et al., Increased serum procalcitonin levels are not specific to sepsis in neonates, Clinical infectious disease, vol.27, pp.1559-61, 1998.

C. Chirouze, H. Schumacher, C. Rabaud, H. Gil, N. Khayat et al., Low serum procalcitonin level accurately predicts the absence of bacteremia in adults with acute fever, Clin Infect Dis, vol.35, issue.2, pp.156-61, 2002.

C. Balcl, H. Sungutekin, E. Gürses, U. Sungurtekin, and B. Kaptanoglu, Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit, Crit Care, vol.7, issue.1, pp.85-90, 2003.

J. Casado-flores, A. Blanco-quiros, J. Asensio, E. Arranz, J. A. Garrote et al., Serum procalcitonin in children with suspected sepsis: a comparison with C-reactive protein and neutrophil count, Pediatr Crit Care Med, vol.4, issue.2, pp.190-195, 2003.

C. Gras-le-guen, L. Foix-l'hélias, and P. Boileau, Infection néonatale bactérienne précoce (INBP) : quel algorithme de prise en charge en 2017 ?, Archives de Pédiatrie, vol.24, pp.14-21, 2017.

M. Chemsi, A. Habzi, A. Harrak, and S. Benomar, Performances de la procalcitonine dans le diagnostic de l'infection maternofoetale, Journal de Pédiatrie et de Puériculture, vol.25, issue.4, pp.185-92, 2012.

R. Lenclen, G. Ciarlo, A. Paupe, L. Bussieres, and Y. Ville, Neurodevelopmental outcome at 2 years in children born preterm treated by amnioreduction or fetoscopic laser surgery for twin-to-twin transfusion syndrome: comparison with dichorionic twins, American Journal of Obstetrics and Gynecology, vol.201, issue.3, pp.291-292, 2009.

E. Maisonneuve, Impact of chorioamnionitis on neurodevelopmental outcomes and mortality at 2 years in premature infants after preterm labour or preterm premature rupture of membranes, American Journal of Obstetrics and Gynecology. janv, vol.216, issue.1, p.203, 2017.

C. Elalouf, Prospective follow-up of a cohort of preterm infants < 33 WG receiving ketamine for tracheal intubation in the delivery room: Neurological outcome at 1 and 2 years, Archives de Pédiatrie. mai, vol.25, issue.4, pp.295-300, 2018.

A. Lautridou, P. Ancel, E. Launay, S. Denizot, J. Orsonneau et al., Umbilical cord blood procalcitonin as a risk factor for mortality in very premature infants, European Journal of Clinical Microbiology & Infectious Diseases. sept, vol.31, issue.9, pp.2407-2419, 2012.

M. Halbwachs, J. B. Muller, S. Nguyen-the-tich, D. La-rochebrochard, E. Gascoin et al., Usefulness of Parent-Completed ASQ for Neurodevelopmental Screening of Preterm Children at Five Years of Age, PLoS ONE, vol.8, issue.8, p.71925, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00874428

T. Charkalukml and . Marchand-martinl, Very preterm children free of disability or delay at age 2: predictors of schooling at age 8: a population- based longitudinal study, Early Hum Dev, vol.87, pp.297-302, 2011.

G. Beaino, B. Khoshnood, M. Kaminski, V. Pierrat, S. Marret et al., Predictors of cerebral palsy in very preterm infants: the EPIPAGE prospective population-based cohort study, Developmental Medicine & Child Neurology, vol.52, issue.6, pp.119-144, 2010.

J. L. Heyden, C. Van-der, A. L. Willekes, A. G. Van-baar, E. Van-wassenaer-leemhuis et al., « Behavioral and Neurodevelopmental Outcome of 2-Year-Old Children after Preterm Premature Rupture of Membranes: Follow-up of a Randomized Clinical Trial Comparing Induction of Labor and Expectant Management, European Journal of Obstetrics & Gynecology and Reproductive Biology, vol.194, pp.17-23, 2015.

. Wassenaer-leemhuise, Rethinking Preventive Post-Discharge Intervention Programmes for Very Preterm Infants and Their Parents, Developmental Medicine & Child Neurology, vol.58, issue.S4, pp.67-73

A. Kordek, A. Torbé, and R. Czajka, Maternal venous procalcitonin levels do not correlate with umbilical cord blood and venous blood concentrations in the neonate, J Perinat Med, vol.34, issue.6, pp.462-467, 2006.

F. Ochi, T. Higaki, M. Ohta, T. Yamauchi, M. Tezuka et al., Procalcitonin as a marker of respiratory disorder in neonates, Pediatrics International, vol.57, issue.2, pp.263-271, 2015.

, Procalcitonin as a Marker of Neonatal Sepsis in Intensive Care Units, Iranian Journal of Medical Sciences, vol.35, issue.3, pp.205-210, 2010.

N. Joram, J. Muller, S. Denizot, J. Orsonneau, J. Caillon et al., Umbilical cord blood procalcitonin level in early neonatal infections: a 4-year university hospital cohort study, European Journal of Clinical Microbiology & Infectious Diseases, vol.30, issue.8, pp.1005-1018, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00669195

S. Lencot, B. Cabaret, G. Sauvage, C. Laurans, E. Launay et al., A new procalcitonin cordbased algorithm in early-onset neonatal infection: for a change of paradigm, European Journal of Clinical Microbiology & Infectious Diseases, vol.33, issue.7, pp.1229-1267, 2014.

B. Cabaret, C. Laurans, and E. Launay, Diagnostic value of a new procalcitonin cord sample guided algorithm to manage newborns suspected of early-onset infection, Arch Pediatr, vol.20, pp.954-62, 2013.

D. Turner, C. Hammerman, B. Rudensky, Y. Schlesinger, C. Goia et al., Procalcitonin in preterm infants during the first few days of life: introducing an age related nomogram, Arch Dis Child Fetal Neonatal Ed, vol.91, pp.283-289, 2006.

M. Cottineau, E. Launay, B. Branger, J. Caillon, J. Muller et al., Valeur diagnostique des critères de suspicion d'infection néonatale précoce : bilan dix ans après les recommandations de l'Anaes. Archives de Pédiatrie, vol.21, pp.187-93, 2014.

C. Didier and P. Kuhn, Late-onset neonatal infections: incidences and pathogens in the era of antenatal antibiotics, Eur J Pediatr, vol.171, pp.681-687, 2012.

C. M. Cotten, S. Taylor, and D. K. Benjamin, Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants, Pediatrics, vol.123, issue.1, pp.58-66, 2009.

A. Kordek, M. Ha?asa, and W. Podraza, Early detection of an early onset infection in the neonate based on measurements of procalcitonin and C-reactive protein concentrations in cord blood, Clin Chem Lab Med, vol.46, issue.8, pp.1143-1148, 2008.

N. Joram, C. Boscher, and S. Denizot, Umbilical cord blood procalcitonin and C reactive protein concentrations as markers for early diagnosis of very early onset neonatal infection, Arch Dis Child Fetal Neonatal, vol.91, issue.1, pp.65-66, 2006.

, International Committee for the Classification of Retinopathy of Prematurity The international classification of retinopathy of prematurity revisited, Arch Ophthalmol, vol.123, pp.991-999, 2005.

M. Chevallier, T. Debillon, V. Pierrat, P. Delorme, G. Kayem et al., Leading causes of preterm delivery as risk factors for intraventricular hemorrhage in very preterm infants: results of the EPIPAGE 2 cohort study, American Journal of Obstetrics and Gynecology, vol.216, issue.5, 2017.

A. Leviton, E. N. Allred, R. N. Fichorova, O. Shea, T. M. Fordham et al., Circulating biomarkers in extremely preterm infants associated with ultrasound indicators of brain damage, European Journal of Paediatric Neurology, vol.22, issue.3, pp.440-50, 2018.

J. Gosselin and C. Amiel-tison, Evaluation neurologique de 0 à 6 ans. 2 ème éd, 2008.

. Romero, Fetal cardiac dysfunction in preterm premature rupture of membranes, J Matern Fetal Neonatal Med, vol.16, p.146, 2004.

. Toti, Acute thymic involution in fetuses and neonates with chorioamnionitis, Hum Pathol, vol.31, p.1121, 2000.

N. Hofer, E. Zacharias, and W. Müller, Performance of the definitions of the systemic inflammatory response syndrome and sepsis in neonates, Journ of Perinatal Medicine, vol.40, issue.5, pp.587-590, 2012.

F. H. Bloomfield, J. E. Harding, M. P. Meyer, J. M. Alsweiler, and Y. Jiang, DIAMOND Study Group, The DIAMOND trial. DIfferent Approaches to MOderate & late preterm Nutrition: Determinants of feed tolerance, body composition and development: protocol of a randomised trial, BMC Pediatrics, vol.18, issue.1, 2018.

. Chiesa, C-reactive protein, interleukin-6 and procalcitonin in the immediate post-natal periode: influence of illness severity, risk status, antenatal and perinatal complications, and infection, Clin Chem, vol.49, pp.60-68, 2003.

A. Mitha, Neonatal Infection and 5-Year Neurodevelopmental Outcomes of very Preterm Infants: the Epipage Study, Arch Dis Child, vol.97, issue.2, p.59, 2012.

C. Chiesa, Reliability of Procalcitonin Concentrations for the Diagnosis of Sepsis in Critically Ill Neonates, Clinical Infectious Diseases, vol.26, issue.3, pp.664-72, 1998.

, Pathologies observées Non ! Oui ! (si oui, préciser) : Maladie pulmonaire chronique : Non ! Oui ! (si oui, préciser) : chronique : Non ! Oui ! (si oui

C. Autre-pathologie, Ig anti VRS : Non ! Oui ! Examens et dépistages sensoriels Bilan auditif entre 12 et 15 mois : Non fait ! Normal ! Anormal ! A contrôler !

D. Bilatéral-!-poursuite-visuelle, Normale ! Anormale ! (Si anormale, préciser) : Obtention : Facile ! Difficile ! Absente ! Limitation : Aucune ! Bilatérale ! D ! G ! Bilan visuel : Non fait ! Normal ! Anormal !

!. Strabisme-!-myopie-!-hypermétropie-!-astigmatisme-!-amblyopie, !. Lunettes, and . Nystagmus,

M. Tm,

, ! 0-2 : risque faible ! 3-7 : risque moyen " surveillance et réévaluation par test de suivi ! ? 8 : risque élevé

, Désigne au moins 2 images -Vocabulaire de 10 à 20 mots -Associe 2 mots Comportement : Normal ! Anormal ! (si anormal, préciser) : Endormissement facile : Non ! Oui ! Réveils nocturnes : Non ! Oui ! Participation à l'examen : Normale ! Difficile ! S'oppose : Non ! Oui !, vol.24