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Master Thesis

Profils cliniques des patients atteints d'Atrophie multi-systématisée et analyse du métabolisme cérébral en TEP 18FDG

Abstract : Introduction: The 2008 diagnostic criteria classify Multiple System Atrophy (MSA) patients in a predominantly parkinsonian (MSA-P) or cerebellar (MSA-C) type. Phenotypic descriptions have since highlighted a clinical heterogeneity among patients (e.g., mixed-type, cognitive impairment, atypical longer survival). Objective: This study attempts to identify different phenotypes of patients with MSA and to describe corresponding brain 18-FDG Positron Emission Tomography (PET) patterns. Methods: Patients with a "probable" MSA diagnosis for whom a brain 18-FDG PET was performed were included. A retrospective analysis (from 2006 to 2017) was conducted using standardized data collection. We used Latent Class Analysis (LCA), an innovative statistical approach, to identify profiles of patients based on common clinical characteristics. Brain metabolism of different groups was studied at rest. Results: Eighty-five patients were included. Three different profiles were revealed (entropy= 0.835): 1. extrapyramidal, axial, laryngeal-pharyngeal involvement (LPI) and cerebellar symptoms (n=46, 54.1%); 2. cerebellar and LPI symptoms (n=30, 35.3%); 3. cerebellar and cognitive symptoms (n=9, 10.6%). Brain metabolism analyses (k>89; p<0.001) showed hypometabolism of the basal ganglia, frontal/prefrontal, temporal cortices and left posterior cerebellum in profile 1. In profile 2 there was hypometabolism of the medulla, prefrontal, temporal, cingular cortices, putamen and bilateral cerebellar hemispheres. In profile 3 there was hypometabolism of bilateral posterior cerebellar hemispheres and vermis. Conclusion: Beyond the two most common phenotypes of MSA, a third and particularly atypical profile with cerebellar and cognitive symptoms but without LPI involvement is described. These profiles are supported by different brain metabolic abnormalities, which could be useful for diagnostic purposes.
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Submitted on : Wednesday, April 3, 2019 - 10:30:26 AM
Last modification on : Friday, July 10, 2020 - 2:59:43 PM


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Stephan Grimaldi. Profils cliniques des patients atteints d'Atrophie multi-systématisée et analyse du métabolisme cérébral en TEP 18FDG. Sciences du Vivant [q-bio]. 2018. ⟨dumas-02088754⟩



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