, Caractéristiques cliniques confortant ou ne confortant pas le diagnostic d'AMS, p.39

. Correlations and . .. Clinico-pathologiques,

. .. Diagnostics-differentiels,

C. Évolution and . .. De-deces,

. .. Explorations-paracliniques,

, 2.1.1 Exploration par Tomographie par émission monophotonique (TEMP ou SPECT en anglais) des transporteurs de la Dopamine (DAT), Techniques d'exploration du fonctionnement de la synapse neurone dopaminergiquestriatum

, Imagerie du métabolisme cérébral par TEP cérébrale au 18-FDG

.. .. Neuroimagerie,

, 69 10.5.4 Évaluation de la thermorégulation et de la sudation, Exploration des symptômes relevant d'une dysautonomie

. .. Potentiels-nouveaux-biomarqueurs, 72 10.7.1 Biologiques (sang et liquide céphalo-rachidien)

, Left lenticular and putaminal nucleus

, Superior (Brodmann areas 8-9) and middle left frontal gyri (cluster dimensions: 117, x = -28, vol.46

, Anterior cerebellar region: right lobules IV / V (cluster dimensions: 128, x = 38, y= -46, z= -32

, Superior (Brodmann areas 8-9) and middle left frontal gyri (cluster dimensions: 127, x = -28, vol.46

, Right posterior cerebellar region: lobule VIIb (crus 2) (cluster dimensions : 188, x = 20, y= -86, z = -34

, Résultats 1. Caractéristiques générales des patients avec AMS Quatre-vingt-cinq patients diagnostiqués avec une AMS « probable

, 9 %) arrêts respiratoires sur stridor et 1 (2,2 %) embolie pulmonaire ; 5 (10,9 %) l'étaient d'un trouble du rythme ou de la conduction cardiaque ; 1 (2,2 %) l'était d'un sepsis sévère à point de départ urinaire

, Profils cliniques (Figure 1)

, Avec l'analyse LCA, le modèle à deux classes a révélé un profil associant les atteintes extrapyramidale, cérébelleuse, ORL et axiale (profil A : 44 patients, 51,8%) et un profil associant les atteintes cérébelleuse et ORL (profil B : 41 patients, vol.48

, Le modèle à trois classes a révélé un premier profil avec atteintes extrapyramidale, axiale, ORL et cérébelleuse (profil 1 : 46 patients, 54,1%), un second profil avec atteintes cérébelleuse et ORL (profil 2 : 30 patients, 35,3%) et un dernier profil avec atteintes cérébelleuse et cognitive

, Le modèle à quatre classes était non convergent donc non exploitable

, Le modèle à trois classes ayant un niveau de fiabilité statistique élevé

J. Dejerine, L'atrophie olivo-ponto-cerebelleuse, Nouvelle Iconographie Salpêtrière, vol.13, pp.330-370, 1900.

G. M. Shy and D. Ga, A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study, AMA Archives of Neurology, vol.2, pp.511-527, 1960.

R. Adams, L. Van-bogaert, and H. Van-der-eecken, Nigro-striate and cerebello-nigro-striate degeneration. Clinical uniqueness and pathological variability of presenile degeneration of the extrapyramidal rigidity type, Psychiatr Neurol (Basel), vol.142, pp.219-259, 1961.

S. Gilman, G. K. Wenning, . Low, D. J. Brooks, C. J. Mathias et al.,

C. H. Lyoo, Y. Jeong, Y. H. Ryu, S. Y. Lee, T. J. Song et al.,

S. Koga, A. Parks, R. J. Uitti, J. A. Van-gerpen, W. P. Cheshire et al., Profile of cognitive impairment and underlying pathology in multiple system atrophy, Mov. Disord, vol.32, pp.405-413, 2017.

E. Fiorenzato, A. Antonini, G. Wenning, and R. Biundo, Cognitive impairment in multiple system atrophy, Mov. Disord, vol.32, pp.1338-1339, 2017.

N. Auzou, K. Dujardin, R. Biundo, A. Foubert-samier, C. Barth et al., Diagnosing dementia in multiple system atrophy by applying Movement Disorder Society diagnostic criteria for Parkinson's disease dementia, Parkinsonism Relat. Disord, vol.21, pp.1273-1277, 2015.

M. Kitayama, K. Wada-isoe, Y. Irizawa, and K. Nakashima, Assessment of dementia in patients with multiple system atrophy, Eur. J. Neurol, vol.16, pp.589-594, 2009.

I. N. Petrovic, H. Ling, Y. Asi, Z. Ahmed, P. L. Kukkle et al., Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch

, Mov. Disord, vol.27, pp.1186-1190, 2012.

G. Calandra-buonaura, P. Guaraldi, L. Sambati, G. Lopane, A. Cecere et al.,

, Multiple system atrophy with prolonged survival: is late onset of dysautonomia the clue?, Neurol. Sci, vol.34, pp.1875-1878, 2013.

D. Eidelberg, S. Takikawa, J. R. Moeller, V. Dhawan, K. Redington et al., Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson's disease, Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society, vol.33, pp.518-527, 1993.

D. Perani, S. Bressi, D. Testa, F. Grassi, P. Cortelli et al., Clinical/metabolic correlations in multiple system atrophy. A fludeoxyglucose F 18 positron emission tomographic study, Arch. Neurol, vol.52, pp.179-185, 1995.

S. Mattis, Dementia Rating Scale (DRS) Psychological Assessment Resources

F. L. Odessa, , 1988.

B. Dubois, A. Slachevsky, I. Litvan, and B. Pillon, The FAB: a Frontal Assessment Battery at bedside, Neurology, vol.55, pp.1621-1626, 2000.

F. Mahieux-laurent, C. Fabre, E. Galbrun, and A. Dubrulle,

, Rev. Neurol. (Paris), vol.165, pp.560-567, 2009.

H. De-vries, J. Van-'t-riet, M. Spigt, J. Metsemakers, M. Van-den-akker et al., Clusters of lifestyle behaviors: results from the Dutch SMILE study, Prev Med, 2008.

R. Belue, S. T. Lanza, and M. K. Figaro, Lifestyle therapy changes and hypercholesterolemia: identifying risk groups in a community sample of Blacks and Whites, Ethn Dis, vol.19, pp.142-147, 2009.

R. B. Trivedi, B. J. Ayotte, C. T. Thorpe, D. Edelman, and H. B. Bosworth, Is there a nonadherent subtype of hypertensive patient? A latent class analysis approach, Patient Prefer Adherence, vol.4, pp.255-262, 2010.

L. G. Ogden, N. Stroebele, H. R. Wyatt, V. A. Catenacci, J. C. Peters et al., Cluster analysis of the national weight control registry to identify distinct subgroups maintaining successful weight loss, Obesity (Silver Spring), vol.20, pp.2039-2047, 2012.

L. M. Collins and S. T. Lanza, Latent class and latent transition analysis: With applications in the social, behavioral, and health sciences, 2013.

S. T. Lanza and B. L. Rhoades, Latent class analysis: an alternative perspective on subgroup analysis in prevention and treatment, Prev Sci, vol.14, pp.157-168, 2013.

L. K. Muthén and B. O. Muthén, Mplus user's guide 1998-2010 6th ed Los Angeles. CA Author Google Scholar

J. K. Vermunt and J. Magidson, Technical guide for Latent GOLD 4.0: Basic and advanced

. Belmont-massachusetts, , 2005.

I. C. Wurpts and C. Geiser, Is adding more indicators to a latent class analysis beneficial or detrimental? Results of a Monte-Carlo study, Front Psychol, vol.5, p.920, 2014.

S. L. Fitzpatrick, J. W. Coughlin, L. J. Appel, C. Tyson, V. J. Stevens et al., Application of Latent Class Analysis to Identify Behavioral Patterns of Response to

, Behavioral Lifestyle Interventions in Overweight and Obese Adults, Int J Behav Med, 2015.

M. D. Lieberman and W. A. Cunningham, Type I and Type II error concerns in fMRI research: re-balancing the scale, Soc Cogn Affect Neurosci, vol.4, pp.423-428, 2009.

M. Köllensperger, F. Geser, J. Ndayisaba, S. Boesch, K. Seppi et al.,

, Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry, Mov. Disord, vol.25, pp.2604-2612, 2010.

D. Perani, S. Bressi, D. Testa, F. Grassi, P. Cortelli et al., Clinical/metabolic correlations in multiple system atrophy. A fludeoxyglucose F 18 positron emission tomographic study, Arch. Neurol, vol.52, pp.179-185, 1995.
DOI : 10.1001/archneur.1995.00540260085021

T. Eckert, C. Tang, Y. Ma, N. Brown, T. Lin et al., Abnormal metabolic networks in atypical parkinsonism, Mov. Disord, vol.23, pp.727-733, 2008.
DOI : 10.1002/mds.21933

M. F. Nitschke, A. Kleinschmidt, K. Wessel, and J. Frahm, Somatotopic motor representation in the human anterior cerebellum. A high-resolution functional MRI study, Brain, vol.119, pp.1023-1029, 1996.

C. J. Stoodley, J. E. Desmond, and J. D. Schmahmann, Functional topography of the human cerebellum revealed by functional neuroimaging studies, Handbook of the Cerebellum and Cerebellar Disorders, pp.735-764, 2013.

S. Gilman, S. J. May, C. W. Shults, C. M. Tanner, W. Kukull et al., The North American Multiple System Atrophy Study Group, J Neural Transm (Vienna), vol.112, pp.1687-1694, 2005.
DOI : 10.1007/s00702-005-0381-6

URL : https://deepblue.lib.umich.edu/bitstream/2027.42/41653/1/702_2005_Article_381.pdf

D. A. López-mora, V. Camacho, J. Pérez-pérez, S. Martínez-horta, and A. Fernández,

F. Sampedro, Striatal hypometabolism in premanifest and manifest Huntington's disease patients, Eur. J. Nucl. Med. Mol. Imaging, vol.43, pp.2183-2189, 2016.

M. K. Kern, S. Jaradeh, R. C. Arndorfer, and R. Shaker, Cerebral cortical representation of reflexive and volitional swallowing in humans, Am. J. Physiol. Gastrointest. Liver Physiol, vol.280, pp.354-360, 2001.

K. Mosier and I. Bereznaya, Parallel cortical networks for volitional control of swallowing in humans, Exp Brain Res, vol.140, pp.280-289, 2001.

M. L. Harris, P. Julyan, B. Kulkarni, D. Gow, A. Hobson et al., Mapping metabolic brain activation during human volitional swallowing: a positron emission tomography study using [18F]fluorodeoxyglucose, J. Cereb. Blood Flow Metab, vol.25, pp.520-526, 2005.
DOI : 10.1038/sj.jcbfm.9600042

A. Kikuchi, T. Baba, T. Hasegawa, M. Kobayashi, N. Sugeno et al.,

, Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study

, BMJ Open, vol.3, 2013.

A. Jean, Brain stem control of swallowing: neuronal network and cellular mechanisms

, Physiol. Rev, vol.81, pp.929-969, 2001.

S. Krishnan, P. S. Mathuranath, S. Sarma, and A. Kishore, Neuropsychological functions in progressive supranuclear palsy, multiple system atrophy and Parkinson's disease, Neurol India, vol.54, pp.268-272, 2006.

Y. Kawai, M. Suenaga, A. Takeda, M. Ito, H. Watanabe et al., Cognitive impairments in multiple system atrophy: MSA-C vs MSA-P, Neurology, vol.70, pp.1390-1396, 2008.
DOI : 10.1212/01.wnl.0000310413.04462.6a

C. C. Chang, Y. Y. Chang, W. N. Chang, Y. C. Lee, Y. L. Wang et al., Cognitive deficits in multiple system atrophy correlate with frontal atrophy and disease duration, Eur. J. Neurol, vol.16, pp.1144-1150, 2009.
DOI : 10.1111/j.1468-1331.2009.02661.x

L. B. Barcelos, F. Saad, C. Giacominelli, R. A. Saba, P. M. De-carvalho-aguiar et al., Neuropsychological and clinical heterogeneity of cognitive impairment in patients with multiple system atrophy, Clin Neurol Neurosurg, vol.164, pp.121-126, 2018.

R. L. Buckner, The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging, Neuron, vol.80, pp.807-815, 2013.

A. P. Klein, J. L. Ulmer, S. A. Quinet, V. Mathews, and L. P. Mark, Nonmotor Functions of the Cerebellum: An Introduction, AJNR Am J Neuroradiol, vol.37, pp.1005-1009, 2016.

P. H. Lee, Y. An, S. W. Yong, and S. N. Yoon, Cortical metabolic changes in the cerebellar variant of multiple system atrophy: a voxel-based FDG-PET study in 41 patients, Neuroimage, vol.40, pp.796-801, 2008.

S. Gilman, R. A. Koeppe, L. Junck, K. J. Kluin, M. Lohman et al., Patterns of olivopontocerebellar atrophy, Ann. Neurol, vol.36, pp.166-175, 1994.

D. Volder, A. G. Francart, J. Laterre, C. Dooms, G. Bol et al., Decreased glucose utilization in the striatum and frontal lobe in probable striatonigral degeneration

, Ann. Neurol, vol.26, pp.239-247, 1989.

M. Otsuka, Y. Ichiya, Y. Kuwabara, S. Hosokawa, M. Sasaki et al., Glucose metabolism in the cortical and subcortical brain structures in multiple system atrophy and Parkinson's disease: a positron emission tomographic study, J. Neurol. Sci, vol.144, pp.77-83, 1996.

G. Bensimon, A. Ludolph, Y. Agid, M. Vidailhet, C. Payan et al., Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study, Brain, vol.132, pp.156-171, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00603311

J. J. Figueroa, W. Singer, A. Parsaik, E. E. Benarroch, J. E. Ahlskog et al., Multiple system atrophy: prognostic indicators of survival, Mov. Disord, vol.29, pp.1151-1157, 2014.

E. A. Coon, D. M. Sletten, M. D. Suarez, J. N. Mandrekar, J. E. Ahlskog et al.,

, Clinical features and autonomic testing predict survival in multiple system atrophy, Brain, vol.138, pp.3623-3631, 2015.

G. Giannini, G. Calandra-buonaura, F. Mastrolilli, M. Righini, and M. L. Bacchi-reggiani,

A. Cecere, Early stridor onset and stridor treatment predict survival in 136 patients with MSA, Neurology, vol.87, pp.1375-1383, 2016.

N. Quinn, Multiple system atrophy--the nature of the beast, J. Neurol. Neurosurg. Psychiatry, pp.78-89, 1989.

U. Wüllner, T. Schmitz-hübsch, M. Abele, G. Antony, P. Bauer et al.,

, Parkinson's disease, J Neural Transm (Vienna), vol.114, pp.1161-1165, 2007.

Y. Osaki, Y. Ben-shlomo, A. J. Lees, G. K. Wenning, and N. P. Quinn, A validation exercise on the new consensus criteria for multiple sysem atrophy, Mov. Disord, vol.24, pp.2272-2276, 2009.

G. K. Wenning, F. Tison, K. Seppi, C. Sampaio, A. Diem et al., Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)

. Disord, , vol.19, pp.1391-1402, 2004.

J. O. Prochaska, W. F. Velicer, C. Redding, J. S. Rossi, M. Goldstein et al., Stagebased expert systems to guide a population of primary care patients to quit smoking, eat healthier, prevent skin cancer, and receive regular mammograms, Prev Med, vol.41, pp.406-416, 2005.

J. Reedy, P. S. Haines, and M. K. Campbell, The influence of health behavior clusters on dietary change, Prev Med, vol.41, pp.268-275, 2005.

V. Ibáñez, P. Pietrini, G. E. Alexander, M. L. Furey, D. Teichberg et al., Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease, Neurology, vol.50, pp.1585-1593, 1998.

A. L. Bokde, P. Pietrini, V. Ibáñez, M. L. Furey, G. E. Alexander et al., The of neurology, vol.58, pp.480-486, 2001.

P. Martínez-martín, C. Rodríguez-blázquez, M. Alvarez-null, T. Arakaki, and V. C. Arillo,

P. Chaná, Parkinson's disease severity levels and MDS-Unified Parkinson's Disease Rating Scale, Parkinsonism Relat. Disord, vol.21, pp.50-54, 2015.

S. Villeneuve, J. Rodrigues-brazète, S. Joncas, R. B. Postuma, V. Latreille et al.,

, Validity of the Mattis Dementia Rating Scale to detect mild cognitive impairment in

, Parkinson's disease and REM sleep behavior disorder, Dement Geriatr Cogn Disord, vol.31, pp.210-217, 2011.

E. Pirogovsky, D. M. Schiehser, I. Litvan, K. M. Obtera, M. M. Burke et al., The utility of the Mattis Dementia Rating Scale in Parkinson's disease mild cognitive impairment, Parkinsonism Relat. Disord, vol.20, pp.627-631, 2014.

B. Adams, R. Van-bogaert, L. Van-der-eecken, and H. , Nigro-striate and cerebello-nigro-striate degeneration.(Clinical uniqueness and pathological variability of presenile degeneration of the extrapyramidal rigidity type, Psychiatria et neurologia, vol.142, p.219, 1961.

A. Aguzzi, C. Sigurdson, and M. Heikenwaelder, Molecular mechanisms of prion pathogenesis, Annu. Rev. pathmechdis. Mech. Dis, vol.3, pp.11-40, 2008.

Z. Ahmed, Y. T. Asi, A. Sailer, A. J. Lees, H. Houlden et al., The neuropathology, pathophysiology and genetics of multiple system atrophy, Neuropathology and applied neurobiology, vol.38, issue.1, pp.4-24, 2012.

A. Al-chalabi, A. Dürr, N. W. Wood, M. H. Parkinson, A. Camuzat et al., Genetic variants of the ?-synuclein gene SNCA are associated with multiple system atrophy, PloS one, vol.4, issue.9, p.7114, 2009.

T. Anderson, L. Luxon, N. Quinn, S. Daniel, C. David-marsden et al., , 2008.

, Oculomotor function in multiple system atrophy: clinical and laboratory features in 30 patients, Movement Disorders, vol.23, issue.7, pp.977-984

T. J. Anderson and M. R. Macaskill, Eye movements in patients with neurodegenerative disorders, Nature Reviews Neurology, vol.9, issue.2, pp.74-85, 2013.

A. Antonini, J. Schwarz, W. H. Oertel, H. F. Beer, U. D. Madeja et al., 11C] raclopride and positron emission tomography in previously untreated patients with Parkinson's disease Influence of L-dopa and lisuride therapy on striatal dopamine D2-receptors, vol.44, pp.1325-1325, 1994.

A. Antonini, P. Vontobel, M. Psylla, I. Günther, P. R. Maguire et al.,

, Complementary positron emission tomographic studies of the striatal dopaminergic system in Parkinson's disease, Archives of neurology, vol.52, issue.12, pp.1183-1190

A. Antonini, K. L. Leenders, P. Vontobel, R. P. Maguire, J. Missimer et al., Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease, Brain: a journal of neurology, vol.120, issue.12, pp.2187-2195, 1997.

N. Aoki, P. J. Boyer, and C. Lund, Atypical multiple system atrophy is a new subtype of frontotemporal lobar degeneration: frontotemporal lobar degeneration associated with alphasynuclein, Acta Neuropathol, vol.130, issue.1, pp.93-105, 2015.

R. A. Armstrong, Visual signs and symptoms of multiple system atrophy, Clinical and Experimental Optometry, vol.97, issue.6, pp.483-491, 2014.

G. Arnold, K. Tatsch, E. Kraft, W. H. Oertel, and J. Schwarz, Steele-RichardsonOlszewski-Syndrome: Reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: 123IBZM SPECT and MRI study, Movement disorders, vol.17, issue.3, pp.557-562, 2002.

M. Asahina, D. A. Low, C. J. Mathias, Y. Fujinuma, A. Katagiri et al., Skin temperature of the hand in multiple system atrophy and Parkinson's disease, Parkinsonism & related disorders, vol.19, issue.5, pp.560-562, 2013.

R. Ashour, R. Tintner, and J. Jankovic, Striatal deformities of the hand and foot in Parkinson's disease, The Lancet Neurology, vol.4, issue.7, pp.423-431, 2005.

Y. T. Asi, J. E. Simpson, P. R. Heath, S. B. Wharton, A. J. Lees et al.,

, Alpha-synuclein mRNA expression in oligodendrocytes in MSA, Glia, vol.62, issue.6, pp.964-970

N. Auzou, K. Dujardin, R. Biundo, A. Foubert-samier, C. Barth et al., Diagnosing dementia in multiple system atrophy by applying Movement Disorder Society diagnostic criteria for Parkinson's disease dementia, Parkinsonism & related disorders, vol.21, issue.10, pp.1273-1277, 2015.

E. Barca, G. Kleiner, G. Tang, M. Ziosi, S. Tadesse et al., , 2016.

, Decreased coenzyme Q10 levels in multiple system atrophy cerebellum, Journal of Neuropathology & Experimental Neurology, vol.75, issue.7, pp.663-672

L. B. Barcelos, F. Saad, C. Giacominelli, R. A. Saba, P. M. De-carvalho-aguiar et al.,

H. B. Ferraz, Neuropsychological and clinical heterogeneity of cognitive impairment in patients with multiple system atrophy, Clinical neurology and neurosurgery, vol.164, pp.121-126, 2018.

A. Batla, M. Stamelou, K. Mensikova, M. Kaiserova, L. Tuckova et al.,

K. P. Bhatia, Markedly asymmetric presentation in multiple system atrophy, Parkinsonism & related disorders, vol.19, issue.10, pp.901-905, 2013.

S. Baudrexel, C. Seifried, B. Penndorf, J. C. Klein, M. Middendorp et al., The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy, Movement Disorders, vol.29, issue.3, pp.380-387, 2014.

R. O. Beck, C. D. Betts, and C. J. Fowler, Genitourinary dysfunction in multiple system atrophy: clinical features and treatment in 62 cases, The Journal of urology, vol.151, issue.5, pp.1336-1341, 1994.

M. Beekes, A. Thomzig, W. J. Schulz-schaeffer, and R. Burger, Is there a risk of prion-like disease transmission by Alzheimer-or Parkinson-associated protein particles, Acta neuropathologica, vol.128, issue.4, pp.463-476, 2014.

M. Behari, RBD in Parkinson's disease: burden, diagnosis and measures, Journal of the Neurological Sciences, vol.357, p.479, 2015.

H. T. Benamer, J. Patterson, D. J. Wyper, D. M. Hadley, G. J. Macphee et al., Correlation of Parkinson's disease severity and duration with 123I-FP-CIT SPECT striatal uptake, Movement Disorders, vol.15, issue.4, pp.692-698, 2000.

E. E. Benarroch, A. M. As, and J. E. Parisi, Involvement of the ventrolateral medulla in parkinsonism with autonomic failure, Neurology, vol.54, issue.4, pp.963-968, 2000.

E. E. Benarroch, A. M. Schmeichel, P. A. Low, and J. E. Parisi, Depletion of ventromedullary NK-1 receptor-immunoreactive neurons in multiple system atrophy, Brain, vol.126, issue.10, pp.2183-2190, 2003.

E. E. Benarroch, Brainstem in multiple system atrophy: clinicopathological correlations, Cellular and molecular neurobiology, vol.23, issue.4, pp.519-526, 2003.

E. E. Benarroch, A. M. Schmeichel, P. A. Low, and J. E. Parisi, Involvement of medullary serotonergic groups in multiple system atrophy, Annals of neurology, vol.55, issue.3, pp.418-422, 2004.

E. E. Benarroch, A. M. Schmeichel, P. A. Low, B. F. Boeve, P. Sandroni et al., Involvement of medullary regions controlling sympathetic output in Lewy body disease, Brain, vol.128, issue.2, pp.338-344, 2005.

E. E. Benarroch, A. M. Schmeichel, P. Sandroni, P. A. Low, and J. E. Parisi, Involvement of vagal autonomic nuclei in multiple system atrophy and Lewy body disease, Neurology, vol.66, issue.3, pp.378-383, 2006.

E. E. Benarroch, A. M. Schmeichel, P. A. Low, and J. E. Parisi, Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy, Brain, vol.130, issue.2, pp.469-475, 2007.

E. E. Benarroch, Brainstem respiratory control: substrates of respiratory failure of multiple system atrophy, Movement disorders, vol.22, issue.2, pp.155-161, 2007.

E. E. Benarroch, A. M. Schmeichel, B. N. Dugger, P. Sandroni, J. E. Parisi et al., , 2009.

, Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia, Neurology, vol.73, issue.2, pp.106-112

E. E. Benarroch, A. M. Schmeichel, P. A. Low, and J. E. Parisi, Differential involvement of the periaqueductal gray in multiple system atrophy, Autonomic Neuroscience, vol.158, issue.1, pp.111-117, 2010.

E. E. Benarroch, A. M. Schmeichel, J. E. Parisi, and P. A. Low, Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla, Clinical Autonomic Research, vol.25, issue.1, pp.77-80, 2015.

E. E. Benarroch, A. M. Schmeichel, J. E. Parisi, and P. A. Low, Histaminergic tuberomammillary neuron loss in multiple system atrophy and dementia with Lewy bodies, Movement Disorders, vol.30, issue.8, pp.1133-1139, 2015.

G. Bensimon, A. Ludolph, Y. Agid, M. Vidailhet, C. Payan et al., Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study, & NNIPPS Study Group, vol.132, issue.1, pp.156-171, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00603311

D. Berg, C. Siefker, and G. Becker, Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings, Journal of neurology, vol.248, issue.8, pp.684-689, 2001.

S. Behnke, D. Berg, M. Naumann, and G. Becker, Differentiation of Parkinson's disease and atypical parkinsonian syndromes by transcranial ultrasound, Neurosurgery & Psychiatry, vol.76, issue.3, pp.423-425, 2005.

A. Bjornsdottir, G. Gudmundsson, H. Blondal, and E. Olafsson, Incidence and prevalence of multiple system atrophy: a nationwide study in Iceland, J. Neurol. Neurosurg. Psychiatry, vol.84, pp.136-140, 2013.

S. M. Boesch, G. K. Wenning, G. Ransmayr, and W. Poewe, Dystonia in multiple system atrophy, Neurosurgery & Psychiatry, vol.72, issue.3, pp.300-303, 2002.

J. Booij, J. D. Speelman, M. W. Horstink, and E. C. Wolters, The clinical benefit of imaging striatal dopamine transporters with [123 I] FP-CIT SPET in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism, European journal of nuclear medicine, vol.28, issue.3, pp.266-272, 2001.

B. P. Boot, B. F. Boeve, R. O. Roberts, T. J. Ferman, Y. E. Geda et al., Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease: a population-based study, Annals of neurology, vol.71, issue.1, pp.49-56, 2012.

R. Bordet, J. Benhadjali, A. Destee, J. F. Hurtevent, J. L. Bourriez et al., Sympathetic skin response and R-R interval variability in multipele system atrophy and idiopathic Parkinson's disease, Movement disorders, vol.11, issue.3, pp.268-272, 1996.

A. E. Bouwmans, A. M. Vlaar, K. Srulijes, W. H. Mess, and W. E. Weber, Transcranial sonography for the discrimination of idiopathic Parkinson's disease from the atypical parkinsonian syndromes, International review of neurobiology, vol.90, pp.121-146, 2010.

J. H. Bower, D. M. Maraganore, S. K. Mcdonnell, and W. A. Rocca, Incidence of progressive supranuclear palsy and multiple system atrophy in Olmsted County, Neurology, vol.49, pp.1284-1288, 1976.

S. Braune, The role of cardiac metaiodobenzylguanidine uptake in the differential diagnosis of parkinsonian syndromes, Clinical Autonomic Research, vol.11, issue.6, pp.351-355, 2001.

C. Brenneis, K. Seppi, M. F. Schocke, J. Müller, E. Luginger et al., Voxel-based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy, Movement disorders, vol.18, issue.10, pp.1132-1138, 2003.

C. Brenneis, S. M. Boesch, K. E. Egger, K. Seppi, C. Scherfler et al.,

, Cortical atrophy in the cerebellar variant of multiple system atrophy: A voxel-based morphometry study, Movement disorders, vol.21, issue.2, pp.159-165

D. J. Brooks, V. Ibanez, G. V. Sawle, N. Quinn, A. J. Lees et al., Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy, Annals of neurology, vol.28, issue.4, pp.547-555, 1990.

D. J. Brooks and K. Seppi, Proposed neuroimaging criteria for the diagnosis of multiple system atrophy, Movement Disorders, vol.24, issue.7, pp.949-964, 2009.

D. J. Brooks, Molecular imaging of dopamine transporters, Ageing research reviews, vol.30, pp.114-121, 2016.

R. G. Brown, L. Lacomblez, B. G. Landwehrmeyer, T. Bak, I. Uttner et al., Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy, Brain, vol.133, issue.8, pp.2382-2393, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00926779

T. P. Brown, Pure autonomic failure, Practical neurology, p.2016, 2017.

R. G. Burciu, J. W. Chung, P. Shukla, E. Ofori, H. Li et al., Functional MRI of disease progression in Parkinson disease and atypical parkinsonian syndromes, Neurology, vol.87, issue.7, pp.709-717, 2016.

K. Bürk, U. Bühring, J. B. Schulz, C. Zühlke, Y. Hellenbroich et al., Clinical and magnetic resonance imaging characteristics of sporadic cerebellar ataxia, Archives of neurology, vol.62, issue.6, pp.981-985, 2005.

K. Bürk, I. Daum, and U. Rüb, Cognitive function in multiple system atrophy of the cerebellar type, Movement disorders, vol.21, issue.6, pp.772-776, 2006.

D. J. Burn, G. V. Sawle, and D. J. Brooks, Differential diagnosis of Parkinson's disease, multiple system atrophy, and Steele-Richardson-Olszewski syndrome: discriminant analysis of striatal 18F-dopa PET data, Neurosurgery & Psychiatry, vol.57, issue.3, pp.278-284, 1994.

G. Calandra-buonaura, P. Guaraldi, L. Sambati, G. Lopane, A. Cecere et al., Multiple system atrophy with prolonged survival: is late onset of dysautonomia the clue?, Neurological sciences, vol.34, issue.10, pp.1875-1878, 2013.

B. Cao, L. Zhang, Y. Zou, Q. Wei, R. Ou et al., Survival analysis and prognostic nomogram model for multiple system atrophy, Parkinsonism & related disorders, 2018.

C. C. Chang, Y. Y. Chang, W. N. Chang, Y. C. Lee, Y. L. Wang et al., Cognitive deficits in multiple system atrophy correlate with frontal atrophy and disease duration, European journal of neurology, vol.16, issue.10, pp.1144-1150, 2009.

D. L. Choi-lundberg and M. C. Bohn, Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat, Developmental brain research, vol.85, issue.1, pp.80-88, 1995.

V. Chrysostome, F. Tison, F. Yekhlef, C. Sourgen, I. Baldi et al., Epidemiology of multiple system atrophy: A prevalence and pilot risk factor study in, Neuroepidemiology, vol.23, pp.201-208, 2004.

G. Chiaro, G. Calandra-buonaura, A. Cecere, F. Mignani, L. Sambati et al., REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand?, Clinical Autonomic Research, pp.1-15, 2017.

E. J. Chung, W. Y. Lee, W. T. Yoon, B. J. Kim, and G. H. Lee, MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism-predominant multiple system atrophy, Movement Disorders, vol.24, issue.11, pp.1650-1655, 2009.

R. Cilia, G. Marotta, R. Benti, G. Pezzoli, and A. Antonini, Brain SPECT imaging in multiple system atrophy, Journal of neural transmission, vol.112, issue.12, pp.1635-1645, 2005.

C. Colosimo, A. Albanese, A. J. Hughes, V. M. De-bruin, and A. J. Lees, Some specific clinical features differentiate multiple system atrophy (striatonigral variety) from Parkinson's disease, Archives of neurology, vol.52, issue.3, pp.294-298, 1995.

Y. Compta, D. M. Giraldo, E. Muñoz, F. Antonelli, M. Fernández et al., Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy, Parkinsonism & related disorders, vol.46, pp.16-23, 2018.

E. A. Coon, D. M. Sletten, M. D. Suarez, J. N. Mandrekar, J. E. Ahlskog et al., Clinical features and autonomic testing predict survival in multiple system atrophy, Brain, vol.138, issue.12, pp.3623-3631, 2015.

E. A. Coon, A. M. Schmeichel, J. E. Parisi, M. D. Cykowski, P. A. Low et al.,

, Medullary neuronal loss is not associated with ?-synuclein burden in multiple system atrophy, Movement Disorders, issue.12, pp.1802-1809

E. A. Coon, J. E. Ahlskog, M. H. Silber, R. D. Fealey, E. E. Benarroch et al., Do selective serotonin reuptake inhibitors improve survival in multiple system atrophy, Parkinsonism & related disorders, 2017.

E. A. Coon, R. D. Fealey, D. M. Sletten, J. N. Mandrekar, E. E. Benarroch et al., Anhidrosis in multiple system atrophy involves pre-and postganglionic sudomotor dysfunction, Movement Disorders, vol.32, issue.3, pp.397-404, 2017.

E. De-pablo-fernandez, D. Cerdán-santacruz, T. Warner, and J. Holton, No evidence of iatrogenic human transmission in autopsy confirmed multiple system atrophy, Movement Disorders, 2018.

D. Volder, A. G. Francart, J. Laterre, C. Dooms, G. Bol et al., Decreased glucose utilization in the striatum and frontal lobe in probable striatonigral degeneration, Annals of neurology, vol.26, issue.2, pp.239-247, 1989.

K. Deguchi, K. Ikeda, I. Sasaki, M. Shimamura, Y. Urai et al., Effects of daily water drinking on orthostatic and postprandial hypotension in patients with multiple system atrophy, Journal of neurology, vol.254, issue.6, p.735, 2007.

J. Dejerine, L'atrophie olivo-ponto-cérébelleuse, vol.13, pp.330-370, 1900.

P. Desplats, H. J. Lee, E. J. Bae, C. Patrick, E. Rockenstein et al., Inclusion formation and neuronal cell death through neuron-to-neuron transmission of ?-synuclein, Proceedings of the National Academy of Sciences, vol.106, issue.31, pp.13010-13015, 2009.

D. T. Dexter, P. Jenner, A. H. Schapira, and C. D. Marsden, Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia, Annals of neurology, issue.S1, p.32, 1992.

V. Dhawan, T. Ishikawa, C. Patlak, and T. Chaly, Combined FDOPA and 30MFD PET studies in Parkinson's disease, The Journal of Nuclear Medicine, vol.37, issue.2, p.209, 1996.

V. Dhawan, Y. Ma, V. Pillai, P. Spetsieris, T. Chaly et al., Comparative analysis of striatal FDOPA uptake in Parkinson's disease: ratio method versus graphical approach, Journal of Nuclear Medicine, vol.43, issue.10, pp.1324-1330, 2002.

M. Djelloul, S. Holmqvist, A. Boza-serrano, C. Azevedo, M. S. Yeung et al., Alpha-synuclein expression in the oligodendrocyte lineage: an in vitro and in vivo study using rodent and human models, Stem cell reports, vol.5, issue.2, pp.174-184, 2015.

V. Donadio, M. Nolano, M. Elam, P. Montagna, V. Provitera et al., Anhidrosis in multiple system atrophy: a preganglionic sudomotor dysfunction, Movement Disorders, vol.23, issue.6, pp.885-888, 2008.

V. Donadio, A. Incensi, V. Leta, M. P. Giannoccaro, C. Scaglione et al., Skin nerve ?-synuclein deposits A biomarker for idiopathic Parkinson disease, Neurology, vol.82, issue.15, pp.1362-1369, 2014.

K. Doppler, S. Ebert, N. Üçeyler, C. Trenkwalder, J. Ebentheuer et al.,

, Cutaneous neuropathy in Parkinson's disease: a window into brain pathology, Acta neuropathologica, vol.128, issue.1, pp.99-109

K. Doppler, J. Weis, K. Karl, S. Ebert, J. Ebentheuer et al., Distinctive distribution of phospho-alpha-synuclein in dermal nerves in multiple system atrophy, Movement Disorders, vol.30, issue.12, pp.1688-1692, 2015.

R. L. Doty, P. Shaman, and M. Dann, Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function, Physiology & behavior, vol.32, issue.3, pp.489-502, 1984.

R. L. Doty, A. Marcus, and W. William-lee, Development of the 12-item cross-cultural smell identification test (CC-SIT), The Laryngoscope, vol.106, issue.3, pp.353-356, 1996.

R. L. Doty, Olfactory dysfunction in Parkinson disease, Nature Reviews Neurology, vol.8, issue.6, pp.329-339, 2012.

T. Ebendal, A. Tomac, B. J. Hoffer, and L. Olson, Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia, Journal of neuroscience research, vol.40, issue.2, pp.276-284, 1995.

T. Eckert and D. Eidelberg, The role of functional neuroimaging in the differential diagnosis of idiopathic Parkinson's disease and multiple system atrophy, Clinical Autonomic Research, vol.14, issue.2, pp.84-91, 2004.

T. Eckert, C. Tang, Y. Ma, N. Brown, T. Lin et al., Abnormal metabolic networks in atypical parkinsonism, Movement disorders, vol.23, issue.5, pp.727-733, 2008.

D. Eidelberg, J. R. Moeller, V. Dhawan, J. J. Sidtis, J. Z. Ginos et al., The metabolic anatomy of Parkinson's disease: complementary [18F] fluorodeoxyglucose and [18F] fluorodopa positron emission tomographic studies, Movement Disorders, vol.5, issue.3, pp.203-213, 1990.

D. Eidelberg, S. Takikawa, J. R. Moeller, V. Dhawan, K. Redington et al., Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson's disease, Annals of neurology, vol.33, issue.5, pp.518-527, 1993.

D. Eidelberg, J. R. Moeller, T. Ishikawa, V. Dhawan, P. Spetsieris et al.,

, Early differential diagnosis of Parkinson's disease with 18F-fluorodeoxyglucose and positron emission tomography, Neurology, issue.11, p.45

S. E. Fahn, Unified Parkinson's disease rating scale. Recent developments in Parkinson's disease, vol.2, pp.153-164, 1987.

A. Fanciulli and G. K. Wenning, Multiple-system atrophy, New England Journal of Medicine, vol.372, issue.3, pp.249-263, 2015.

L. Farde, L. Eriksson, G. Blomquist, and C. Halldin, Kinetic analysis of central [11C] raclopride binding to D2-dopamine receptors studied by PET-a comparison to the equilibrium analysis, Journal of Cerebral Blood Flow & Metabolism, vol.9, issue.5, pp.696-708, 1989.

J. Y. Feng, B. Huang, W. Q. Yang, Y. H. Zhang, L. M. Wang et al., The putaminal abnormalities on 3.0 T magnetic resonance imaging: can they separate parkinsonism-predominant multiple system atrophy from Parkinson's disease?, Acta radiologica, vol.56, issue.3, pp.322-328, 2015.

L. Ferini-strambi and S. Marelli, Sleep dysfunction in multiple system atrophy, Current treatment options in neurology, vol.14, issue.5, pp.464-473, 2012.

J. J. Figueroa, W. Singer, A. Parsaik, E. E. Benarroch, J. E. Ahlskog et al., Multiple system atrophy: prognostic indicators of survival, Movement disorders, vol.29, issue.9, pp.1151-1157, 2014.

E. Fiorenzato, A. Antonini, G. Wenning, and R. Biundo, Cognitive impairment in multiple system atrophy, Movement Disorders, vol.32, issue.9, pp.1338-1339, 2017.

R. Freeman, L. Landsberg, and J. Young, The treatment of neurogenic orthostatic hypotension with 3, 4-DL-threo-dihydroxyphenylserine A randomized, placebo-controlled, crossover trial, Neurology, vol.53, issue.9, pp.2151-2151, 1999.

R. Freeman, Neurogenic orthostatic hypotension, New England Journal of Medicine, vol.358, issue.6, pp.615-624, 2008.

R. Freeman, W. Wieling, F. B. Axelrod, D. G. Benditt, E. Benarroch et al., Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome, Autonomic Neuroscience: Basic and Clinical, vol.161, issue.1, pp.46-48, 2011.

H. Fujita, K. Suzuki, A. Numao, Y. Watanabe, T. Uchiyama et al.,

K. Hirata, Usefulness of cardiac MIBG scintigraphy, olfactory testing and substantia nigra hyperechogenicity as additional diagnostic markers for distinguishing between Parkinson's disease and atypical Parkinsonian syndromes, PloS one, vol.11, issue.11, p.165869, 2016.

M. D. Garcia, J. S. Pulido, E. A. Coon, and J. J. Chen, Ocular features of multiple system atrophy, Journal of Clinical Neuroscience, vol.47, pp.234-239, 2018.

O. Gebus, S. Montaut, B. Monga, T. Wirth, C. Cheraud et al., Deciphering the causes of sporadic late-onset cerebellar ataxias: a prospective study with implications for diagnostic work, Journal of neurology, vol.264, issue.6, pp.1118-1126, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01761700

F. Geser, G. K. Wenning, K. Seppi, M. Stampfer-kountchev, C. Scherfler et al., Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group, vol.21, pp.179-186, 2006.

M. Ghaemi, R. Hilker, J. Rudolf, J. Sobesky, and W. D. Heiss, Differentiating multiple system atrophy from Parkinson's disease: contribution of striatal and midbrain MRI volumetry and multi-tracer PET imaging, Neurosurgery & Psychiatry, vol.73, issue.5, pp.517-523, 2002.

I. Ghorayeb, P. O. Fernagut, I. Aubert, E. Bezard, W. Poewe et al., Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration, Movement disorders, vol.15, issue.3, pp.531-536, 2000.

I. Ghorayeb, F. Yekhlef, V. Chrysostome, E. Balestre, B. Bioulac et al., Sleep disorders and their determinants in multiple system atrophy, Neurosurgery & Psychiatry, vol.72, issue.6, pp.798-800, 2002.

G. Giannini, G. Calandra-buonaura, F. Mastrolilli, M. Righini, M. L. Bacchi-reggiani et al., Early stridor onset and stridor treatment predict survival in 136 patients with MSA, Neurology, vol.87, issue.13, pp.1375-1383, 2016.

C. H. Gibbons, P. Schmidt, I. Biaggioni, C. Frazier-mills, R. Freeman et al., The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension, Journal of neurology, vol.264, issue.8, pp.1567-1582, 2017.

S. Gilman, R. A. Koeppe, L. Junck, K. J. Kluin, M. Lohman et al., Patterns of cerebral glucose metabolism detected with positron emission tomography differ in multiple system atrophy and olivopontocerebellar atrophy, Annals of neurology, vol.36, issue.2, pp.166-175, 1994.

S. Gilman, S. J. May, C. W. Shults, C. M. Tanner, W. Kukull et al., , 2005.

, The North American multiple system atrophy study group, Journal of neural transmission, vol.112, issue.12, pp.1687-1694

S. Gilman, G. K. Wenning, P. A. Low, D. J. Brooks, C. J. Mathias et al., Second consensus statement on the diagnosis of multiple system atrophy, Neurology, vol.71, issue.9, pp.670-676, 2008.

S. A. Glasmacher, P. N. Leigh, and R. A. Saha, Predictors of survival in progressive supranuclear palsy and multiple system atrophy: a systematic review and meta-analysis, J Neurol Neurosurg Psychiatry, vol.88, issue.5, pp.402-411, 2017.

P. G. Glass, A. J. Lees, C. Mathias, L. Mason, C. Best et al., Olfaction in pathologically proven patients with multiple system atrophy, Movement Disorders, vol.27, issue.2, pp.327-328, 2012.

D. S. Goldstein, C. Holmes, I. J. Kopin, and Y. Sharabi, Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases, The Journal of clinical investigation, vol.121, issue.8, pp.3320-3330, 2011.

D. S. Goldstein, P. Sullivan, C. Holmes, G. W. Miller, S. Alter et al., Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease, Journal of neurochemistry, vol.126, issue.5, pp.591-603, 2013.

D. S. Goldstein, Dysautonomia in Parkinson disease, Comprehensive Physiology, 2014.

D. S. Goldstein, I. J. Kopin, Y. Sharabi, and C. Holmes, Plasma biomarkers of decreased vesicular storage distinguish Parkinson disease with orthostatic hypotension from the parkinsonian form of multiple system atrophy, Clinical Autonomic Research, vol.25, issue.1, pp.61-67, 2015.

D. S. Goldstein and W. P. Cheshire, Beat-to-beat blood pressure and heart rate responses to the Valsalva maneuver, Clinical Autonomic Research, vol.27, issue.6, pp.361-367, 2017.

J. G. Graham and D. R. Oppenheimer, Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy, Journal of neurology, vol.32, issue.1, p.28, 1969.

K. Hahn and G. Ebersbach, Sonographic assessment of urinary retention in multiple system atrophy and idiopathic Parkinson's disease, Movement disorders, vol.20, issue.11, pp.1499-1502, 2005.

O. Hansson, S. Janelidze, S. Hall, N. Magdalinou, A. J. Lees et al., Blood-based NfL A biomarker for differential diagnosis of parkinsonian disorder, Neurology, vol.88, issue.10, pp.930-937, 2017.

K. Hara, Multiplex families with multiple system atrophy, Arch. Neurol, vol.64, pp.545-551, 2007.

T. K. Hauser, A. Luft, M. Skalej, T. Nägele, T. T. Kircher et al., , 2006.

, Visualization and quantification of disease progression in multiple system atrophy, Movement disorders, vol.21, issue.10, pp.1674-1681

S. Hellwig, F. Amtage, A. Kreft, R. Buchert, O. H. Winz et al., , 2012.

, FDG-PET is superior to [123I] IBZM-SPECT for the differential diagnosis of parkinsonism, Neurology, vol.79, issue.13, pp.1314-1322

C. E. Henderson, H. S. Phillips, R. A. Pollock, A. M. Davies, C. Lemuelle et al., GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle, SCIENCE-NEW YORK THEN WASHINGTON, pp.1062-1062, 1994.

R. Higo, T. Nito, and N. Tayama, Swallowing function in patients with multiple-system atrophy with a clinical predominance of cerebellar symptoms (MSA-C), European Archives of OtoRhino-Laryngology and Head & Neck, vol.262, issue.8, pp.646-650, 2005.

B. Holmberg, B. Johnels, P. Ingvarsson, B. Eriksson, and L. Rosengren, CSFneurofilament and levodopa tests combined with discriminant analysis may contribute to the differential diagnosis of Parkinsonian syndromes, Parkinsonism & related disorders, vol.8, issue.1, pp.23-31, 2001.

T. Homma, Y. Mochizuki, T. Komori, and E. Isozaki, Frequent globular neuronal cytoplasmic inclusions in the medial temporal region as a possible characteristic feature in multiple system atrophy with dementia, Neuropathology, vol.36, issue.5, pp.421-431, 2016.

Y. Horimoto, I. Aiba, T. Yasuda, Y. Ohkawa, T. Katayama et al., , 2000.

, Cerebral atrophy in multiple system atrophy by MRI, Journal of the neurological sciences, vol.173, issue.2, pp.109-112

Y. Horimoto, I. Aiba, T. Yasuda, Y. Ohkawa, T. Katayama et al., , 2002.

, Longitudinal MRI study of multiple system atrophy-when do the findings appear, and what is the course?, Journal of neurology, vol.249, issue.7, pp.847-854

Y. Horimoto, M. Matsumoto, H. Akatsu, H. Ikari, K. Kojima et al.,

K. Kosaka, Autonomic dysfunctions in dementia with Lewy bodies, Journal of neurology, vol.250, issue.5, pp.530-533, 2003.

B. Hoyo, Alternatives to clonazepam in REM behavior disorder treatment, Journal of Clinical Sleep Medicine, vol.12, issue.08, pp.1193-1193, 2016.

A. J. Hughes, C. Colosimo, B. Kleedorfer, S. E. Daniel, and A. J. Lees, The dopaminergic response in multiple system atrophy, Neurosurgery & Psychiatry, vol.55, issue.11, pp.1009-1013, 1992.

A. J. Hughes, S. E. Daniel, S. Blankson, and A. J. Lees, A clinicopathologic study of 100 cases of Parkinson's disease, Archives of neurology, vol.50, issue.2, pp.140-148, 1993.

I. F. Hussain, C. M. Brady, M. J. Swinn, C. J. Mathias, and C. J. Fowler, Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension, Neurosurgery & Psychiatry, vol.71, issue.3, pp.371-374, 2001.

I. Hwang, C. H. Sohn, K. M. Kang, B. S. Jeon, H. J. Kim et al., Differentiation of Parkinsonism-predominant multiple system atrophy from idiopathic Parkinson disease using 3T susceptibility-weighted MR imaging, focusing on putaminal change and lesion asymmetry, American Journal of Neuroradiology, vol.36, issue.12, pp.2227-2234, 2015.

V. Iodice, A. Lipp, J. E. Ahlskog, P. Sandroni, R. D. Fealey et al., Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests, J Neurol Neurosurg Psychiatry, vol.83, issue.4, pp.453-459, 2012.

A. Iranzo, J. Santamaria, E. Tolosa, I. Vilaseca, F. Valldeoriola et al.,

, Long-term effect of CPAP in the treatment of nocturnal stridor in multiple system atrophy, Neurology, vol.63, issue.5, pp.930-932

A. Iranzo, J. Santamaria, D. B. Rye, F. Valldeoriola, M. J. Marti et al., Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD, Neurology, vol.65, issue.2, pp.247-252, 2005.

A. Iranzo, E. Tolosa, E. Gelpi, J. L. Molinuevo, F. Valldeoriola et al., Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eyemovement sleep behaviour disorder: an observational cohort study, The Lancet Neurology, vol.12, issue.5, pp.443-453, 2013.

A. Iranzo, A. Fernández-arcos, E. Tolosa, M. Serradell, J. L. Molinuevo et al., Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients, PLoS One, vol.9, issue.2, p.89741, 2014.

D. J. Irwin, J. Y. Abrams, L. B. Schonberger, E. W. Leschek, J. L. Mills et al., Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone, JAMA neurology, vol.70, issue.4, pp.462-468, 2013.

T. Ishikawa, V. Dhawan, K. Kazumata, and T. Chaly, Comparative nigrostriatal dopaminergic imaging with iodine-123-betaCIT-FP/SPECT and fluorine-18-FDOPA/PET, The Journal of Nuclear Medicine, vol.37, issue.11, p.1760, 1996.

J. Jankovic, J. L. Gilden, B. C. Hiner, H. Kaufmann, D. C. Brown et al., Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine. The American journal of medicine, vol.95, pp.38-48, 1993.

A. Jean, Brain stem control of swallowing: neuronal network and cellular mechanisms, Physiological reviews, vol.81, issue.2, pp.929-969, 2001.

M. Jecmenica-lukic, W. Poewe, E. Tolosa, and G. K. Wenning, Premotor signs and symptoms of multiple system atrophy, The Lancet Neurology, vol.11, issue.4, pp.361-368, 2012.

K. A. Jellinger, Multiple system atrophy: an oligodendroglioneural synucleinopathy, Journal of Alzheimer's Disease, pp.1-38, 2017.

J. Joutsa, M. Gardberg, M. Röyttä, and V. Kaasinen, Diagnostic accuracy of parkinsonism syndromes by general neurologists, Parkinsonism & related disorders, vol.20, issue.8, pp.840-844, 2014.

N. Jozwiak, R. B. Postuma, J. Montplaisir, V. Latreille, M. Panisset et al., REM sleep behavior disorder and cognitive impairment in Parkinson's disease, p.40, 2017.

C. Kaindlstorfer, R. Granata, and G. K. Wenning, Tremor in multiple system atrophy-a review. Tremor and Other Hyperkinetic Movements, p.3, 2013.

C. Kaindlstorfer, K. A. Jellinger, S. Eschlb¨ock, N. Stefanova, G. Weiss et al., The relevance of iron in the pathogenesis of multiple system atrophy: A viewpoint, J Alzheimers Dis, 2017.

T. Kasai, T. Tokuda, T. Ohmichi, R. Ishii, H. Tatebe et al., Serum levels of coenzyme Q10 in patients with multiple system atrophy, PloS one, vol.11, issue.1, p.147574, 2016.

L. Kass-iliyya, C. Kobylecki, K. R. Mcdonald, A. Gerhard, and M. A. Silverdale, Pain in multiple system atrophy and progressive supranuclear palsy compared to Parkinson's disease, Brain and behavior, vol.5, issue.5, 2015.

H. Kaufmann and D. S. Goldstein, Autonomic dysfunction in Parkinson disease, Handbook of clinical neurology, vol.117, pp.259-278, 2013.

H. Kaufmann, R. Freeman, I. Biaggioni, P. Low, S. Pedder et al., Droxidopa for neurogenic orthostatic hypotension A randomized, Neurology, vol.83, issue.4, pp.328-335, 2014.

H. Kaufmann and J. A. Palma, Neurogenic orthostatic hypotension: the very basics, 2017.

H. Kaufmann, L. Norcliffe-kaufmann, J. A. Palma, I. Biaggioni, P. A. Low et al., Natural history of pure autonomic failure: a United States prospective cohort, Annals of neurology, vol.81, issue.2, pp.287-297, 2017.

H. Kaufmann, L. Norcliffe-kaufmann, and J. A. Palma, Reply to "Pure autonomic failure vs. Manifest CNS synucleinopathy: Relevance of stridor and autonomic biomarkers, Annals of Neurology, 2017.

Y. Kawai, M. Suenaga, A. Takeda, M. Ito, H. Watanabe et al.,

K. Ito, , 2008.

, Cognitive impairments in multiple system atrophy MSA-C vs MSA-P. Neurology, vol.70, pp.1390-1396

Y. Kawamoto, I. Akiguchi, Y. Shirakashi, Y. Honjo, H. Tomimoto et al., Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy, Brain research, vol.1136, pp.219-227, 2007.

P. Khemani and S. Vernino, DaTscan in clinical evaluation of Multiple System Atrophy, MOVEMENT DISORDERS, vol.32, 2017.

J. S. Kim, J. J. Yang, D. K. Lee, J. M. Lee, J. Youn et al., Cognitive impairment and its structural correlates in the parkinsonian subtype of multiple system atrophy. Neurodegenerative Diseases, vol.15, pp.294-300, 2015.

H. J. Kim, B. Jeon, and V. S. Fung, Role of magnetic resonance imaging in the diagnosis of multiple system atrophy, Movement Disorders Clinical Practice, vol.4, issue.1, pp.12-20, 2017.

H. W. Kim, M. Oh, J. S. Oh, S. J. Oh, S. J. Lee et al., Striatofrontal Deafferentiation in MSA-P: Evaluation with [18F] FDG Brain PET, PloS one, vol.12, issue.1, p.169928, 2017.

M. Kitayama, K. Wada-isoe, Y. Irizawa, and K. Nakashima, Assessment of dementia in patients with multiple system atrophy, European journal of neurology, vol.16, issue.5, pp.589-594, 2009.

K. J. Kluin, S. Gilman, D. S. Markel, R. A. Koeppe, G. Rosenthal et al., Speech disorders in olivopontocerebellar atrophy correlate with positron emission tomography findings, Annals of Neurology, vol.23, issue.6, pp.547-554, 1988.
DOI : 10.1002/ana.410230604

URL : https://deepblue.lib.umich.edu/bitstream/2027.42/50324/1/410230604_ftp.pdf

G. M. Knudsen, M. Karlsborg, G. Thomsen, K. Krabbe, L. Regeur et al., Imaging of dopamine transporters and D 2 receptors in patients with Parkinson's disease and multiple system atrophy, European journal of nuclear medicine and molecular imaging, vol.31, issue.12, pp.1631-1638, 2004.

S. Koga, N. Aoki, and R. J. Uitti, When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients, Neurology, vol.85, issue.5, pp.404-412, 2015.

S. Koga, K. Kasanuki, and D. W. Dickson, ?-synuclein astrogliopathy: A possible specific feature in ?-synucleinopathy, Neuropathology, 2017.
DOI : 10.1111/neup.12371

S. Koga, A. Parks, R. J. Uitti, J. A. Van-gerpen, W. P. Cheshire et al., Profile of cognitive impairment and underlying pathology in multiple system atrophy, Movement Disorders, vol.32, issue.3, pp.405-413, 2017.
DOI : 10.1002/mds.26874

URL : http://europepmc.org/articles/pmc5359072?pdf=render

S. Koga, W. L. Lin, R. L. Walton, O. A. Ross, and D. W. Dickson, TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and ?-synuclein in glial cytoplasmic inclusions, Neuropathology and applied neurobiology, 2018.

S. Koga and D. W. Dickson, Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy, J Neurol Neurosurg Psychiatry, vol.89, issue.2, pp.175-184, 2018.

M. Köllensperger, F. Geser, K. Seppi, M. Stampfer-kountchev, M. Sawires et al., Red flags for multiple system atrophy, Movement Disorders, vol.23, issue.8, pp.1093-1099, 2008.

M. Köllensperger, F. Geser, J. P. Ndayisaba, S. Boesch, K. Seppi et al., Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry, Movement Disorders, vol.25, issue.15, pp.2604-2612, 2010.

M. Konagaya, Y. Konagaya, M. Sakai, Y. Matsuoka, and Y. Hashizume, Progressive cerebral atrophy in multiple system atrophy, Journal of the neurological sciences, vol.195, issue.2, pp.123-127, 2002.

J. H. Kordower, H. B. Dodiya, A. M. Kordower, B. Terpstra, K. Paumier et al., Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat, Neurobiology of disease, vol.43, issue.3, pp.552-557, 2011.

C. Kouakam, S. Emc-cardiologie-krishnan, P. S. Mathuranath, S. Sarma, and A. Kishore, Neuropsychological functions in progressive supranuclear palsy, multiple system atrophy and Parkinson's disease, Neurology India, vol.54, issue.3, p.268, 2006.

F. Krismer, K. Seppi, F. Tison, C. Sampaio, A. Zangerl et al., The unified multiple system atrophy rating scale: intrarater reliability, vol.27, pp.1683-1685, 2012.
DOI : 10.1002/mds.25181

F. Krismer and G. K. Wenning, Multiple system atrophy: insights into a rare and debilitating movement disorder, Nature Reviews Neurology, vol.13, issue.4, pp.232-243, 2017.
DOI : 10.1038/nrneurol.2017.26

F. Krismer, B. Pinter, C. Mueller, P. Mahlknecht, M. Nocker et al., Sniffing the diagnosis: olfactory testing in neurodegenerative parkinsonism, Parkinsonism & related disorders, vol.35, pp.36-41, 2017.
DOI : 10.1016/j.parkreldis.2016.11.010

K. Kume, H. Iwama, K. Deguchi, K. Ikeda, T. Takata et al., Serum microRNA expression profiling in patients with multiple system atrophy, Molecular medicine reports, vol.17, issue.1, pp.852-860, 2018.
DOI : 10.3892/mmr.2017.7995

URL : http://www.spandidos-publications.com/mmr/17/1/852/download

H. F. Kung, A. Alavi, W. Chang, M. P. Kung, J. W. Keyes et al.,

, In Vivo SPECT Imaging of CNS D.-2, Nucl. Med, vol.31, pp.573-582

D. Kuzdas, S. Stemberger, S. Gaburro, N. Stefanova, N. Singewald et al., , 2013.

, Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: experimental evidence, Experimental neurology, vol.247, pp.531-536

K. Y. Kwon, C. G. Choi, J. S. Kim, M. C. Lee, and S. J. Chung, Diagnostic value of brain MRI and 18F-FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson's disease, European journal of neurology, vol.15, issue.10, pp.1043-1049, 2008.

K. Y. Kwon, J. S. Kim, K. C. Im, M. C. Lee, and S. J. Chung, Comparison of cerebral glucose metabolism between possible and probable multiple system atrophy, Journal of movement disorders, vol.2, issue.1, p.22, 2009.

I. J. Lalich, D. C. Ekbom, S. J. Starkman, D. M. Orbelo, and T. I. Morgenthaler, Vocal fold motion impairment in multiple system atrophy, The Laryngoscope, vol.124, issue.3, pp.730-735, 2014.

K. W. Lange, O. Tucha, G. L. Alders, M. Preier, I. Csoti et al., Differentiation of parkinsonian syndromes according to differences in executive functions, Journal of Neural Transmission, vol.110, issue.9, pp.983-995, 2003.

P. L. Lantos, Neuropathological diagnostic criteria of multiple system atrophy: a review. Neuropathological Diagnostic Criteria for Brain Banking, pp.116-121, 1995.

B. Laurens, R. Constantinescu, R. Freeman, A. Gerhard, K. Jellinger et al., Fluid biomarkers in multiple system atrophy: a review of the MSA Biomarker Initiative, vol.80, pp.29-41, 2015.

B. Laurens, S. Vergnet, M. C. Lopez, A. Foubert-samier, F. Tison et al., Multiple System Atrophy-State of the Art, Current neurology and neuroscience reports, vol.17, issue.5, p.41, 2017.

W. H. Lee, C. C. Lee, W. C. Shyu, P. N. Chong, and S. Z. Lin, Hyperintense putaminal rim sign is not a hallmark of multiple system atrophy at 3T, American journal of neuroradiology, vol.26, issue.9, pp.2238-2242, 2005.

P. H. Lee, Y. S. An, S. W. Yong, and S. N. Yoon, Cortical metabolic changes in the cerebellar variant of multiple system atrophy: a voxel-based FDG-PET study in 41 patients, Neuroimage, vol.40, issue.2, pp.796-801, 2008.

Y. C. Lee, C. S. Liu, H. M. Wu, P. S. Wang, M. H. Chang et al., The 'hot cross bun'sign in the patients with spinocerebellar ataxia, European journal of neurology, vol.16, issue.4, pp.513-516, 2009.

J. Y. Lee, J. Y. Yun, C. W. Shin, H. J. Kim, and B. S. Jeon, Putaminal abnormality on 3-T magnetic resonance imaging in early parkinsonism-predominant multiple system atrophy, Journal of neurology, vol.257, issue.12, pp.2065-2070, 2010.

P. H. Lee, J. E. Lee, H. S. Kim, S. K. Song, H. S. Lee et al., A randomized trial of mesenchymal stem cells in multiple system atrophy, Annals of neurology, vol.72, issue.1, pp.32-40, 2012.

J. H. Lee, Y. H. Han, B. M. Kang, C. W. Mun, S. J. Lee et al., Quantitative assessment of subcortical atrophy and iron content in progressive supranuclear palsy and parkinsonian variant of multiple system atrophy, Journal of neurology, vol.260, issue.8, pp.2094-2101, 2013.

H. J. Lee, E. D. Cho, K. W. Lee, J. H. Kim, S. G. Cho et al., Autophagic failure promotes the exocytosis and intercellular transfer of ?-synuclein, Experimental & molecular medicine, vol.45, issue.5, p.22, 2013.

A. J. Lees and R. O. Bannister, The use of lisuride in the treatment of multiple system atrophy with autonomic failure (Shy-Drager syndrome), Neurosurgery & Psychiatry, vol.44, issue.4, pp.347-351, 1981.

D. J. Lin, K. L. Hermann, and J. D. Schmahmann, The diagnosis and natural history of multiple system atrophy, cerebellar type, The Cerebellum, vol.15, issue.6, pp.663-679, 2016.

J. Linder, H. Stenlund, and L. Forsgren, Incidence of Parkinson's disease and parkinsonism in northern Sweden: a population-based study, Mov. Disord, vol.25, pp.341-348, 2010.

E. Lindersson, D. Lundvig, C. Petersen, P. Madsen, J. R. Nyengaard et al., p25? stimulates ?-synuclein aggregation and is co-localized with aggregated ?-synuclein in ?-synucleinopathies, Journal of Biological Chemistry, vol.280, issue.7, pp.5703-5715, 2005.

A. Lipp, P. Sandroni, J. E. Ahlskog, R. D. Fealey, K. Kimpinski et al.,

K. K. Nickander, Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure, Archives of neurology, vol.66, issue.6, pp.742-750, 2009.

I. Litvan, J. G. Goldman, A. I. Tröster, B. A. Schmand, D. Weintraub et al., Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines, Movement disorders, vol.27, issue.3, pp.349-356, 2012.

P. A. Low and W. Singer, Management of neurogenic orthostatic hypotension: an update, The Lancet Neurology, vol.7, issue.5, pp.451-458, 2008.

P. A. Low, S. G. Reich, J. Jankovic, C. W. Shults, M. B. Stern et al., Natural history of multiple system atrophy in the USA: a prospective cohort study, vol.14, pp.710-719, 2015.

K. C. Luk, V. Kehm, J. Carroll, B. Zhang, P. O'brien et al., , 2012.

, Pathological ?-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice, Science, vol.338, issue.6109, pp.949-953

K. C. Luk, V. M. Kehm, B. Zhang, P. O'brien, J. Q. Trojanowski et al., , 2012.

, Intracerebral inoculation of pathological ?-synuclein initiates a rapidly progressive neurodegenerative ?-synucleinopathy in mice, Journal of Experimental Medicine, p.20112457

C. H. Lyoo, Y. Jeong, Y. H. Ryu, S. Y. Lee, T. J. Song et al., Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy, Brain, vol.131, issue.2, pp.438-446, 2008.

Y. Ma, C. Tang, P. G. Spetsieris, V. Dhawan, and D. Eidelberg, Abnormal Metabolic Network Activity in Parkinson'S Disease: Test-Retest Reproducibility, Journal of Cerebral Blood Flow & Metabolism, vol.27, issue.3, pp.597-605, 2007.

F. Mancini, R. Zangaglia, S. Cristina, M. G. Sommaruga, E. Martignoni et al., Double-blind, placebo-controlled study to evaluate the efficacy and safety of botulinum toxin type A in the treatment of drooling in parkinsonism, Movement Disorders, vol.18, issue.6, pp.685-688, 2003.

M. Mascalchi, A. Vella, and R. Ceravolo, Movement disorders: role of imaging in diagnosis, Journal of magnetic resonance imaging, vol.35, issue.2, pp.239-256, 2012.

L. A. Massey, C. Micallef, D. C. Paviour, S. S. O'sullivan, H. Ling et al., Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy, Movement Disorders, vol.27, issue.14, pp.1754-1762, 2012.

D. Mathias, . Dsc, C. J. Frcp, . Kimber, . Bsc et al., Postural hypotension: causes, clinical features, investigation, and management. Annual review of medicine, vol.50, pp.317-336, 1999.

C. J. Mathias, J. M. Senard, S. Braune, L. Watson, A. Aragishi et al.,

. L-threo-dihydroxyphenylserine, L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure, Clinical Autonomic Research, vol.11, issue.4, pp.235-242

E. Matsusue, S. Fujii, Y. Kanasaki, S. Sugihara, H. Miyata et al., Putaminal lesion in multiple system atrophy: postmortem MR-pathological correlations, Neuroradiology, vol.50, issue.7, p.559, 2008.

S. May, S. Gilman, B. B. Sowell, R. G. Thomas, M. B. Stern et al., Potential outcome measures and trial design issues for multiple system atrophy, Movement Disorders, vol.22, issue.16, pp.2371-2377, 2007.

J. H. Mckay and W. P. Cheshire, First symptoms in multiple system atrophy, Clinical Autonomic Research, pp.1-7, 2018.

J. Mckinley, M. O'connell, M. Farrell, and T. Lynch, Normal dopamine transporter imaging does not exclude multiple system atrophy, Parkinsonism Relat Disord, vol.20, issue.8, pp.933-934, 2014.

C. E. Mendoza-santiesteban, I. Gabilondo, J. A. Palma, L. Norcliffe-kaufmann, and H. Kaufmann, The retina in multiple system atrophy: systematic review and meta-analysis, Frontiers in neurology, vol.8, p.206, 2017.

F. J. Meijer, M. B. Aerts, W. F. Abdo, M. Prokop, G. F. Borm et al., Contribution of routine brain MRI to the differential diagnosis of parkinsonism: a 3-year prospective follow-up study, Journal of neurology, vol.259, issue.5, pp.929-935, 2012.

F. J. Meijer, B. R. Bloem, P. Mahlknecht, K. Seppi, and B. Goraj, Update on diffusion MRI in Parkinson's disease and atypical parkinsonism, Journal of the neurological sciences, vol.332, issue.1, pp.21-29, 2013.

F. J. Meijer, A. Van-rumund, A. M. Tuladhar, M. B. Aerts, I. Titulaer et al., Conventional 3T brain MRI and diffusion tensor imaging in the diagnostic workup of early stage parkinsonism, vol.57, pp.655-669, 2015.

F. J. Meijer, A. Van-rumund, B. A. Fasen, I. Titulaer, M. Aerts et al., Susceptibility-weighted imaging improves the diagnostic accuracy of 3T brain MRI in the work-up of parkinsonism, American Journal of Neuroradiology, vol.36, issue.3, pp.454-460, 2015.

P. T. Meyer, L. Frings, G. Rücker, and S. Hellwig, 18F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment, Journal of Nuclear Medicine, vol.58, issue.12, pp.1888-1898, 2017.

Y. Miki, K. Tanji, F. Mori, J. Utsumi, H. Sasaki et al.,

K. Wakabayashi, Alteration of Upstream Autophagy-Related Proteins (ULK1, ULK2, Beclin1, VPS34 and AMBRA1) in Lewy Body Disease, Brain Pathology, vol.26, issue.3, pp.359-370, 2016.

Y. Miki, K. Tanji, F. Mori, Y. Tatara, J. Utsumi et al.,

K. Wakabayashi, , 2018.

, AMBRA1, a novel ?-synuclein-binding protein, is implicated in the pathogenesis of multiple system atrophy, Brain Pathology, vol.28, issue.1, pp.28-42

D. W. Miller, J. M. Johnson, S. M. Solano, Z. R. Hollingsworth, D. G. Standaert et al., Absence of ?-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia, Journal of neural transmission, vol.112, issue.12, pp.1613-1624, 2005.

J. D. Mills, W. S. Kim, G. M. Halliday, and M. Janitz, Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy, neurogenetics, vol.16, issue.2, pp.107-122, 2015.

J. D. Mills, M. Ward, W. S. Kim, G. M. Halliday, and M. Janitz, Strand-specific RNAsequencing analysis of multiple system atrophy brain transcriptome, Neuroscience, vol.322, pp.234-250, 2016.

P. K. Morrish, J. S. Rakshi, D. L. Bailey, G. V. Sawle, and D. J. Brooks, Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F] dopa PET, Neurosurgery & Psychiatry, vol.64, issue.3, pp.314-319, 1998.

A. L. Mougenot, S. Nicot, A. Bencsik, E. Morignat, J. Verchère et al., Prion-like acceleration of a synucleinopathy in a transgenic mouse model, Neurobiology of aging, vol.33, issue.9, pp.2225-2228, 2012.

H. T. Mount, D. O. Dean, J. Alberch, C. F. Dreyfus, and I. B. Black, Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells, Proceedings of the National Academy of Sciences, vol.92, issue.20, pp.9092-9096, 1995.

J. Müller, G. K. Wenning, M. Verny, A. Mckee, K. R. Chaudhuri et al., Progression of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders, Archives of neurology, vol.58, issue.2, pp.259-264, 2001.

H. Nagayama, M. Yamazaki, M. Ueda, Y. Nishiyama, M. Hamamoto et al.,

, Low myocardial MIBG uptake in multiple system atrophy with incidental Lewy body pathology: an autopsy case report, Movement Disorders, vol.23, issue.7, pp.1055-1057

H. Nagayama, M. Ueda, M. Yamazaki, Y. Nishiyama, M. Hamamoto et al., , 2010.

, Abnormal cardiac [123I]-meta-iodobenzylguanidine uptake in multiple system atrophy, Movement Disorders, vol.25, issue.11, pp.1744-1747

K. Nakamura, F. Mori, T. Kon, K. Tanji, Y. Miki et al., , 2015.

, Filamentous aggregations of phosphorylated ?-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy, Acta neuropathologica communications, vol.3, issue.1

L. E. Nee, M. R. Gomez, J. Dambrosia, S. Bale, R. Eldridge et al., , 1991.

, Environmental-occupational risk factors and familial associations in multiple system atrophy: A preliminary investigation, Clinical Autonomic Research, vol.1, issue.1, pp.9-13

K. Nodaa, S. Katayama, C. Watanabe, Y. Yamamura, and S. Nakamura, Decrease of neurons in the medullary arcuate nucleus of multiple system atrophy: quantitative comparison with Parkinson's disease and amyotrophic lateral sclerosis, Journal of the neurological sciences, vol.151, issue.1, pp.89-91, 1997.

M. Nonaka, T. Imai, T. Shintani, M. Kawamata, S. Chiba et al., Noninvasive positive pressure ventilation for laryngeal contraction disorder during sleep in multiple system atrophy, Journal of the neurological sciences, vol.247, issue.1, pp.53-58, 2006.

L. Norcliffe-kaufmann, H. Kaufmann, J. A. Palma, C. A. Shibao, I. Biaggioni et al.,

R. Freeman, Orthostatic Heart Rate Changes in Patients with Autonomic Failure caused by Neurodegenerative Synucleinopathies, Annals of neurology, 2018.

S. S. O'sullivan, L. A. Massey, D. R. Williams, L. Silveira-moriyama, P. A. Kempster et al., Clinical outcomes of progressive supranuclear palsy and multiple system atrophy, Brain, vol.131, issue.5, pp.1362-1372, 2008.

T. Ogawa, R. Sakakibara, S. Kuno, O. Ishizuka, T. Kitta et al., Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy, Nature Reviews Urology, vol.14, issue.2, p.79, 2017.

D. R. Oppenheimer, Lateral horn cells in progressive autonomic failure, Journal of the neurological sciences, vol.46, issue.3, pp.393-404, 1980.

S. Orimo, T. Oka, H. Miura, K. Tsuchiya, F. Mori et al., Sympathetic cardiac denervation in Parkinson's disease and pure autonomic failure but not in multiple system atrophy, Neurosurgery & Psychiatry, vol.73, issue.6, pp.776-776, 2002.

S. Orimo, T. Kanazawa, A. Nakamura, T. Uchihara, F. Mori et al., Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy, Acta neuropathologica, vol.113, issue.1, pp.81-86, 2007.

S. Orimo, M. Suzuki, A. Inaba, and H. Mizusawa, 123I-MIBG myocardial scintigraphy for differentiating Parkinson's disease from other neurodegenerative parkinsonism: a systematic review and meta-analysis, Parkinsonism & related disorders, vol.18, issue.5, pp.494-500, 2012.

Y. Osaki, Y. Ben-shlomo, A. J. Lees, G. K. Wenning, and N. P. Quinn, A validation exercise on the new consensus criteria for multiple system atrophy, Movement Disorders, vol.24, issue.15, pp.2272-2276, 2009.

M. Otsuka, Y. Ichiya, Y. Kuwabara, S. Hosokawa, M. Sasaki et al.,

K. Masuda, Glucose metabolism in the cortical and subcortical brain structures in multiple system atrophy and Parkinson's disease: a positron emission tomographic study, Journal of the neurological sciences, vol.144, issue.1, pp.77-83, 1996.

T. Ozawa, H. Takano, O. Onodera, H. Kobayashi, T. Ikeuchi et al., No mutation in the entire coding region of the ?-synuclein gene in pathologically confirmed cases of multiple system atrophy, Neuroscience letters, vol.270, issue.2, pp.110-112, 1999.

T. Ozawa, D. Paviour, N. P. Quinn, K. A. Josephs, H. Sangha et al., The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations, Brain, vol.127, issue.12, pp.2657-2671, 2004.

T. Ozawa, Morphological substrate of autonomic failure and neurohormonal dysfunction in multiple system atrophy: impact on determining phenotype spectrum, Acta neuropathologica, vol.114, issue.3, pp.201-211, 2007.

J. A. Palma and H. Kaufmann, Novel therapeutic approaches in multiple system atrophy, Clinical Autonomic Research, vol.25, issue.1, pp.37-45, 2015.

J. A. Palma, L. Norcliffe-kaufmann, and H. Kaufmann, Diagnosis of multiple system atrophy, Autonomic Neuroscience, 2017.

J. A. Palma and H. Kaufmann, Epidemiology, diagnosis and management of neurogenic orthostatic hypotension. Movement disorders clinical practice, 2017.

S. Papapetropoulos, A. Tuchman, D. Laufer, A. G. Papatsoris, N. Papapetropoulos et al., Causes of death in multiple system atrophy, Neurosurgery & Psychiatry, vol.78, issue.3, pp.327-329, 2007.

M. I. Papp, J. E. Kahn, and P. L. Lantos, Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and ShyDrager syndrome), Journal of the neurological sciences, vol.94, issue.1, pp.79-100, 1989.

M. I. Papp and P. L. Lantos, The distribution of oligodendroglial inclusions in multiple system atrophy and its relevance to clinical symptomatology, Brain, vol.117, issue.2, pp.235-243, 1994.

J. Parvizi, J. Joseph, D. Z. Press, and J. D. Schmahmann, Pathological laughter and crying in patients with multiple system atrophy-cerebellar type, Movement Disorders, vol.22, issue.6, pp.798-803, 2007.

A. Patak, J. L. Elghozi, J. O. Fortrat, J. M. Sénard, and O. Hanon, Prise en charge de l'hypotension orthostatique. Consensus d'experts de la Société française d'hypertension artérielle (SFHTA), Société française de gériatrie et gérontologie (SFGG), 2014.

D. C. Paviour, S. L. Price, M. Jahanshahi, A. J. Lees, and N. C. Fox, Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy, vol.129, pp.1040-1049, 2006.

A. Pavy-letraon, C. Brefel-courbon, J. Dupouy, F. Ory-magne, O. Rascol et al., Combined cardiovascular and sweating autonomic testing to differentiate multiple system atrophy from Parkinson's disease, Neurophysiologie Clinique, 2017.

M. T. Pellecchia, P. Barone, C. Mollica, E. Salvatore, M. Ianniciello et al., Diffusion-weighted imaging in multiple system atrophy: A comparison between clinical subtypes, Movement Disorders, vol.24, issue.5, pp.689-696, 2009.

D. Perani, S. Bressi, D. Testa, F. Grassi, P. Cortelli et al., , 1995.

, Clinical/metabolic correlations in multiple system atrophy: a fludeoxyglucose F 18 positron emission tomographic study, Archives of neurology, vol.52, issue.2, pp.179-185

I. N. Petrovic, H. Ling, Y. Asi, Z. Ahmed, P. L. Kukkle et al., , 2012.

, Multiple system atrophy-parkinsonism with slow progression and prolonged survival: A diagnostic catch, Movement Disorders, vol.27, issue.9, pp.1186-1190

P. Piccini, J. De-yebenez, A. J. Lees, R. Ceravolo, N. Turjanski et al., Familial progressive supranuclear palsy: detection of subclinical cases using 18F-dopa and 18fluorodeoxyglucose positron emission tomography, Archives of neurology, vol.58, issue.11, pp.1846-1851, 2001.

W. Pirker, S. Asenbaum, G. Bencsits, D. Prayer, W. Gerschlager et al.,

, 123I] ?-CIT spect in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration, Movement disorders, vol.15, issue.6, pp.1158-1167

S. Y. Roh, H. S. Jang, and Y. H. Kim, Hot cross bun sign following bilateral pontine infarction: a case report, Journal of movement disorders, vol.6, issue.2, p.37, 2013.

Z. Rohan, J. Rahimi, and S. Weis, Screening for alpha-synuclein immunoreactive neuronal inclusions in the hippocampus allows identification of atypical MSA (FTLD-synuclein), Acta Neuropathol, vol.130, issue.2, pp.299-301, 2015.

G. Rohrer, G. U. Höglinger, and J. Levin, Symptomatic therapy of multiple system atrophy, Autonomic Neuroscience, 2017.

D. Roncevic, J. A. Palma, J. Martinez, N. Goulding, L. Norcliffe-kaufmann et al., Cerebellar and parkinsonian phenotypes in multiple system atrophy: similarities, differences and survival, Journal of Neural Transmission, vol.121, issue.5, pp.507-512, 2014.

O. A. Ross, A. T. Braithwaite, L. M. Skipper, J. Kachergus, M. M. Hulihan et al.,

C. H. Adler, Genomic investigation of ?-synuclein multiplication and parkinsonism, Annals of neurology, vol.63, issue.6, pp.743-750, 2008.
URL : https://hal.archives-ouvertes.fr/hal-02156834

O. A. Ross, C. Vilariño-güell, Z. K. Wszolek, M. J. Farrer, and D. W. Dickson, Reply to: SNCA variants are associated with increased risk of multiple system atrophy, Annals of neurology, vol.67, issue.3, pp.414-415, 2010.

J. Rosskopf, M. Gorges, H. P. Müller, E. H. Pinkhardt, A. C. Ludolph et al., , 2018.

, Hyperconnective and hypoconnective cortical and subcortical functional networks in multiple system atrophy, Parkinsonism & related disorders, vol.49, pp.75-80

E. K. St-louis, A. R. Boeve, and B. F. Boeve, REM sleep behavior disorder in Parkinson's disease and other synucleinopathies, Movement Disorders, vol.32, issue.5, pp.645-658, 2017.

A. Sailer, S. W. Scholz, M. A. Nalls, C. Schulte, M. Federoff et al.,

, A genome-wide association study in multiple system atrophy, Neurology, vol.87, issue.15, pp.1591-1598

R. Sakakibara, T. Hattori, T. Uchiyama, and T. Yamanishi, Videourodynamic and sphincter motor unit potential analyses in Parkinson's disease and multiple system atrophy, Neurosurgery & Psychiatry, vol.71, issue.5, pp.600-606, 2001.

R. Sakakibara, T. Odaka, T. Uchiyama, R. Liu, M. Asahina et al.,

, Colonic transit time, sphincter EMG, and rectoanal videomanometry in multiple system atrophy, Movement disorders, vol.19, issue.8, pp.924-929

K. Sakushima, N. Nishimoto, M. Nojima, M. Matsushima, I. Yabe et al., Epidemiology of multiple system atrophy in Hokkaido, the northernmost island of Japan, vol.14, pp.682-687, 2015.

H. Sasaki, M. Emi, H. Iijima, N. Ito, H. Sato et al., Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy, Molecular brain, vol.4, issue.1, p.24, 2011.

G. V. Sawle, E. D. Playford, D. J. Brooks, N. Quinn, and R. S. Frackowiak, Asymmetrical pre-synaptic and post-synaptic changes in the striatal dopamine projection in dopa naive parkinsonism: Diagnostic implications of the D2 receptor status, Brain, vol.116, issue.4, pp.853-867, 1993.

G. V. Sawle, E. D. Playford, D. J. Burn, V. J. Cunningham, and D. J. Brooks, Separating Parkinson's disease from normality: discriminant function analysis of fluorodopa F 18 positron emission tomography data, Archives of neurology, vol.51, issue.3, pp.237-243, 1994.

C. H. Schenck, B. F. Boeve, and M. W. Mahowald, Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series, Sleep medicine, vol.14, issue.8, pp.744-748, 2013.

C. Scherfler, G. Göbel, C. Müller, M. Nocker, G. K. Wenning et al.,

K. Seppi, Diagnostic potential of automated subcortical volume segmentation in atypical parkinsonism, Neurology, vol.86, issue.13, pp.1242-1249, 2016.

A. M. Schmeichel, L. C. Buchhalter, P. A. Low, J. E. Parisi, B. W. Boeve et al., Mesopontine cholinergic neuron involvement in Lewy body dementia and multiple system atrophy, Neurology, vol.70, issue.5, pp.368-373, 2008.

C. Schmidt, D. Berg, S. Prieur, S. Junghanns, K. Schweitzer et al., Loss of nocturnal blood pressure fall in various extrapyramidal syndromes, Movement Disorders, vol.24, issue.14, pp.2136-2142, 2009.

S. W. Scholz, H. Houlden, C. Schulte, M. Sharma, A. Li et al., , 2009.

, SNCA variants are associated with increased risk for multiple system atrophy, Annals of neurology, vol.65, issue.5, pp.610-614

L. V. Schottlaender, C. Bettencourt, A. P. Kiely, A. Chalasani, V. Neergheen et al.,

H. &-houlden, Coenzyme Q10 levels are decreased in the cerebellum of multiple-system atrophy patients, PLoS One, vol.11, issue.2, p.149557, 2016.

L. V. Schottlaender, A. Sailer, Z. Ahmed, D. W. Dickson, H. Houlden et al., , 2017.

, Multiple System Atrophy: Clinical, Genetics, and Neuropathology. Neurodegeneration, pp.58-71

A. Schrag, D. Kingsley, C. Phatouros, C. J. Mathias, A. J. Lees et al., Clinical usefulness of magnetic resonance imaging in multiple system atrophy, Neurosurgery & Psychiatry, vol.65, issue.1, pp.65-71, 1998.

A. Schrag, S. Sheikh, N. P. Quinn, A. J. Lees, C. Selai et al., A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy, Movement Disorders, vol.25, issue.8, pp.1077-1081, 2010.

L. Schwarz, O. Goldbaum, M. Bergmann, S. Probst-cousin, and C. Richter-landsberg, Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes, Journal of Molecular Neuroscience, vol.47, issue.2, pp.256-266, 2012.

K. Seppi, M. F. Schocke, K. Prennschuetz-schuetzenau, K. J. Mair, R. Esterhammer et al., Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study, Movement disorders, vol.21, issue.6, pp.847-852, 2006.

T. Shimohata, T. Ozawa, H. Nakayama, M. Tomita, H. Shinoda et al., Frequency of nocturnal sudden death in patients with multiple system atrophy, Journal of neurology, vol.255, issue.10, p.1483, 2008.

T. Shimohata, N. Aizawa, H. Nakayama, H. Taniguchi, Y. Ohshima et al., Mechanisms and prevention of sudden death in multiple system atrophy, Parkinsonism & related disorders, vol.30, pp.1-6, 2016.

G. M. Shy and G. A. Drager, A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study, AMA Archives of Neurology, vol.2, issue.5, pp.511-527, 1960.

M. H. Silber and S. Levine, Stridor and death in multiple system atrophy, Movement disorders, vol.15, issue.4, pp.699-704, 2000.

A. B. Singleton, M. Farrer, J. Johnson, A. Singleton, S. Hague et al., Synuclein locus triplication causes Parkinson's disease, vol.302, pp.841-841, 2003.

C. Siri, S. Duerr, M. Canesi, M. Delazer, R. Esselink et al., A cross-sectional multicenter study of cognitive and behavioural features in multiple system atrophy patients of the parkinsonian and cerebellar type, Journal of neural transmission, vol.120, issue.4, pp.613-618, 2013.

B. J. Snow, I. Tooyama, E. G. Mcgeer, T. Yamada, D. B. Calne et al.,

, Human positron emission tomographic [18F] fluorodopa studies correlate with dopamine cell counts and levels, Annals of neurology, vol.34, issue.3, pp.324-330

S. M. Solano, D. W. Miller, S. J. Augood, A. B. Young, and J. B. Penney, Expression of ?-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease, Annals of neurology, vol.47, issue.2, pp.201-210, 2000.

P. Soliveri, D. Monza, D. Paridi, F. Carella, S. Genitrini et al., , 2000.

, Neuropsychological follow up in patients with Parkinson's disease, striatonigral degeneration-type multisystem atrophy, and progressive supranuclear palsy, Neurosurgery & Psychiatry, vol.69, issue.3, pp.313-318

Y. J. Song, D. M. Lundvig, Y. Huang, W. P. Gai, P. C. Blumbergs et al., p25? relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy, The American journal of pathology, vol.171, issue.4, pp.1291-1303, 2007.

Y. J. Song, G. M. Halliday, J. L. Holton, T. Lashley, S. S. O'sullivan et al., Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression, Journal of Neuropathology & Experimental Neurology, vol.68, issue.10, pp.1073-1083, 2009.

E. Spargo, M. I. Papp, and P. L. Lantos, Decrease in neuronal density in the cerebral cortex in multiple system atrophy, European Journal of Neurology, vol.3, issue.5, pp.450-456, 1996.

M. G. Spillantini, R. A. Crowther, R. Jakes, N. J. Cairns, P. L. Lantos et al., , 1998.

, Filamentous ?-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies, Neuroscience letters, issue.3, pp.205-208

I. Stankovic, F. Krismer, A. Jesic, A. Antonini, T. Benke et al., , 2014.

, Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group, Movement Disorders, vol.29, issue.7, pp.857-867

I. B. Strand, Depression and anxiety in Parkinson s disease and Multiple system atrophyConsequences for treatment, 2016.

E. V. Sullivan, R. De-la-paz, R. B. Zipursky, and A. Pfefferbaum, Neuropsychological deficits accompanying striatonigral degeneration, Journal of clinical and experimental neuropsychology, vol.13, issue.5, pp.773-788, 1991.

M. Tada, O. Onodera, M. Tada, T. Ozawa, Y. S. Piao et al., , 2007.

, Early development of autonomic dysfunction may predict poor prognosis in patients with multiple system atrophy, Archives of neurology, vol.64, issue.2, pp.256-260

M. Tada, A. Kakita, Y. Toyoshima, O. Onodera, T. Ozawa et al., Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death, Brain, vol.132, issue.7, pp.1810-1819, 2009.

S. Takikawa, V. Dhawan, T. Chaly, W. Robeson, R. Dahl et al., Input functions for 6-[fluorine-18] fluorodopa quantitation in parkinsonism: comparative studies and clinical correlations, Journal of Nuclear Medicine, vol.35, issue.6, pp.955-963, 1994.

T. Taniwaki, M. Nakagawa, T. Yamada, T. Yoshida, Y. Ohyagi et al., Cerebral metabolic changes in early multiple system atrophy: a PET study, Journal of the neurological sciences, vol.200, issue.1, pp.79-84, 2002.

K. Tanji, S. Odagiri, A. Maruyama, F. Mori, A. Kakita et al., Alteration of autophagosomal proteins in the brain of multiple system atrophy, Neurobiology of disease, vol.49, pp.190-198, 2013.

D. Testa, V. Fetoni, P. Soliveri, M. Musicco, E. Palazzini et al., Cognitive and motor performance in multiple system atrophy and Parkinson's disease compared, Neuropsychologia, vol.31, issue.2, pp.207-210, 1993.

D. Testa, D. Monza, M. Ferrarini, P. Soliveri, F. Girotti et al., Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy, Neurological Sciences, vol.22, issue.3, pp.247-251, 2001.

K. K. Tha, S. Terae, A. Tsukahara, H. Soma, R. Morita et al., , 2012.

, Hyperintense putaminal rim at 1.5 T: prevalence in normal subjects and distinguishing features from multiple system atrophy, N. Engl. J. Med, vol.12, issue.1, pp.233-244, 2013.

S. Thobois, E. Broussolle, L. Toureille, and C. Vial, Severe dysphagia after botulinum toxin injection for cervical dystonia in multiple system atrophy, Movement disorders, vol.16, issue.4, pp.764-765, 2001.

F. Tison, F. Yekhlef, V. Chrysostome, and C. Sourgen, Prevalence of multiple system atrophy, The Lancet, vol.355, issue.9202, pp.495-496, 2000.

F. Tison, F. Yekhlef, V. Chrysostome, E. Balestre, N. P. Quinn et al., Parkinsonism in multiple system atrophy: Natural history, severity (UPDRS-III), and disability assessment compared with Parkinson's disease, vol.17, pp.701-709, 2002.

A. Tomac, J. Widenfalk, L. F. Lin, T. Kohno, T. Ebendal et al., , 1995.

, Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult, Proceedings of the National Academy of Sciences, vol.92, issue.18, pp.8274-8278

J. Q. Trojanowski and T. Revesz, Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy, Neuropathology and applied neurobiology, vol.33, issue.6, pp.615-620, 2007.

P. Trouillas, T. Takayanagi, M. Hallett, R. D. Currier, S. H. Subramony et al., International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome, Journal of the neurological sciences, vol.145, issue.2, pp.205-211, 1997.

K. Tsuchiya, E. Ozawa, C. Haga, S. Watabiki, M. Ikeda et al., Constant involvement of the Betz cells and pyramidal tract in multiple system atrophy: a clinicopathological study of seven autopsy cases, Acta neuropathologica, issue.6, pp.628-636, 2000.

L. C. Tzarouchi, L. G. Astrakas, S. Konitsiotis, S. Tsouli, P. Margariti et al., Voxel-Based Morphometry and Voxel-Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy, Journal of Neuroimaging, vol.20, issue.3, pp.260-266, 2010.

K. Ubhi, C. Inglis, M. Mante, C. Patrick, A. Adame et al., , 2012.

, Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of ?-synucleinopathy, Experimental neurology, vol.234, issue.2, pp.405-416

T. Uchihara, K. Tsuchiya, A. Nakamura, and H. Akiyama, Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type: comparison between Gallyas and Campbell-Switzer methods, Acta neuropathologica, vol.109, issue.5, pp.483-489, 2005.

T. Uchihara, A. Nakamura, Y. Mochizuki, M. Hayashi, S. Orimo et al., Silver stainings distinguish Lewy bodies and glial cytoplasmic inclusions: comparison between Gallyas-Braak and Campbell-Switzer methods, Acta neuropathologica, vol.110, issue.3, pp.255-260, 2005.

D. Uluduz, Ö. Ertürk, G. Kenangil, S. Özekmekçi, S. Ertan et al., , 2010.

, Apraxia in Parkinson's disease and multiple system atrophy, European journal of neurology, vol.17, issue.3, pp.413-418

A. Umemura, T. Oeda, R. Hayashi, S. Tomita, M. Kohsaka et al., Diagnostic accuracy of apparent diffusion coefficient and 123I-metaiodobenzylguanidine for differentiation of multiple system atrophy and Parkinson's disease, PLoS One, vol.8, issue.4, p.61066, 2013.

E. Valera, K. Ubhi, M. Mante, E. Rockenstein, and E. Masliah, Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy, Glia, vol.62, issue.2, pp.317-337, 2014.

N. Vanacore, Smoking habits in multiple system atrophy and progressive supranuclear palsy, European Study Group on Atypical Parkinsonisms. Neurology, vol.54, pp.114-119, 2000.

N. Vanacore, V. Bonifati, G. Fabbrini, C. Colosimo, G. De-michele et al., Case-control study of multiple system atrophy, Movement disorders, vol.20, issue.2, pp.158-163, 2005.

E. Vichayanrat, D. A. Low, V. Iodice, E. Stuebner, E. M. Hagen et al., , 2017.

, Twenty-four-hour ambulatory blood pressure and heart rate profiles in diagnosing orthostatic hypotension in Parkinson's disease and multiple system atrophy, European journal of neurology, vol.24, issue.1, pp.90-97

A. Videnovic, Management of sleep disorders in Parkinson's disease and multiple system atrophy, Movement Disorders, 2017.

B. D. Vieira, R. A. Radford, R. S. Chung, G. J. Guillemin, and D. L. Pountney, Neuroinflammation in multiple system atrophy: response to and cause of ?-synuclein aggregation, Frontiers in cellular neuroscience, p.9, 2015.

F. J. Vingerhoets, M. Schulzer, T. J. Ruth, J. E. Holden, and B. J. Snow, Reproducibility and discriminating ability of fluorine-18-6-fluoro-L-dopa PET in Parkinson's disease, Society of Nuclear Medicine, vol.37, issue.3, pp.421-426, 1996.

N. P. Visanji, J. F. Collingwood, M. E. Finnegan, A. Tandon, E. House et al., Iron deficiency in parkinsonism: region-specific iron dysregulation in Parkinson's disease and multiple system atrophy, Journal of Parkinson's disease, vol.3, issue.4, pp.523-537, 2013.

D. B. Vodu?ek, How to diagnose MSA early: the role of sphincter EMG, Journal of neural transmission, vol.112, issue.12, pp.1657-1668, 2005.

K. Wakabayashi, M. Yoshimoto, S. Tsuji, and H. Takahashi, ?-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy, Neuroscience letters, vol.249, issue.2, pp.180-182, 1998.

U. Walter, D. Dressler, T. Probst, A. Wolters, M. Abu-mugheisib et al.,

, Transcranial brain sonography findings in discriminating between parkinsonism and idiopathic Parkinson disease, Archives of neurology, vol.64, issue.11, pp.1635-1640

H. Watanabe, Y. Saito, S. Terao, T. Ando, T. Kachi et al., Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients, Brain, vol.125, issue.5, pp.1070-1083, 2002.

J. C. Watts, K. Giles, A. Oehler, L. Middleton, D. T. Dexter et al., Transmission of multiple system atrophy prions to transgenic mice, Proceedings of the National Academy of Sciences, vol.110, issue.48, pp.19555-19560, 2013.

G. K. Wenning, Y. B. Shlomo, M. Magalhaes, S. E. Danie, and N. P. Quinn, Clinical features and natural history of multiple system atrophy: an analysis of 100 cases, Brain, vol.117, issue.4, pp.835-845, 1994.

G. K. Wenning, Y. Ben-shlomo, M. Magalhaes, S. E. Daniel, and N. P. Quinn, , 1995.

, Clinicopathological study of 35 cases of multiple system atrophy, Neurosurgery & Psychiatry, vol.58, issue.2, pp.160-166

G. K. Wenning, F. Tison, L. Elliott, N. P. Quinn, and S. E. Daniel, Olivopontocerebellar pathology in multiple system atrophy, Movement disorders, vol.11, issue.2, pp.157-162, 1996.

G. K. Wenning, F. Tison, Y. Ben-shlomo, S. E. Daniel, and N. P. Quinn, Multiple system atrophy: a review of 203 pathologically proven cases, Movement Disorders, vol.12, issue.2, pp.133-147, 1997.

G. K. Wenning, Y. Ben-shlomo, A. Hughes, S. E. Daniel, A. Lees et al., What clinical features are most useful to distinguish definite multiple system atrophy from Parkinson9s disease?, Neurosurgery & Psychiatry, vol.68, issue.4, pp.434-440, 2000.

G. K. Wenning, C. Colosimo, F. Geser, and W. Poewe, Multiple system atrophy, The Lancet Neurology, vol.3, issue.2, pp.93-103, 2004.

G. K. Wenning, F. Tison, K. Seppi, C. Sampaio, A. Diem et al., , 2004.

, Development and validation of the unified multiple system atrophy rating scale (UMSARS), Movement Disorders, vol.19, issue.12, pp.1391-1402

G. K. Wenning, F. Geser, and W. Poewe, Therapeutic strategies in multiple system atrophy, Movement disorders, issue.S12, p.20, 2005.

G. K. Wenning, N. Stefanova, K. A. Jellinger, W. Poewe, and M. G. Schlossmacher, Multiple system atrophy: a primary oligodendrogliopathy, Annals of neurology, vol.64, issue.3, pp.239-246, 2008.

G. K. Wenning and N. Stefanova, Recent developments in multiple system atrophy, Journal of neurology, vol.256, issue.11, pp.1791-1808, 2009.

G. K. Wenning, F. Geser, F. Krismer, K. Seppi, S. Duerr et al., The natural history of multiple system atrophy: a prospective European cohort study, The Lancet Neurology, vol.12, issue.3, pp.264-274, 2013.

G. Wenning, J. Q. Trojanowski, H. Kaufmann, W. A. Rocca, T. Wisniewski et al., , 2018.

, Is Multiple System Atrophy An Infectious Disease, Annals of neurology

K. Winge and C. J. Fowler, Bladder dysfunction in Parkinsonism: mechanisms, prevalence, symptoms, and management, Movement disorders, vol.21, issue.6, pp.737-745, 2006.

Y. Winter, Y. Bezdolnyy, E. Katunina, G. Avakjan, J. P. Reese et al., Incidence of Parkinson's disease and atypical parkinsonism: Russian population-based study, Movement Disorders, vol.25, issue.3, pp.349-356, 2010.

A. L. Woerman, J. Stöhr, A. Aoyagi, R. Rampersaud, Z. Krejciova et al., Propagation of prions causing synucleinopathies in cultured cells, Proceedings of the National Academy of Sciences, vol.112, issue.35, pp.4949-4958, 2015.

A. L. Woerman, J. C. Watts, A. Aoyagi, K. Giles, L. T. Middleton et al., ?-Synuclein: Multiple System Atrophy Prions. Cold Spring Harbor Perspectives in Medicine, 2017.

U. Wüllner, Probable multiple system atrophy in a German family, J. Neurol. Neurosurg. Psychiatry, vol.75, pp.924-925, 2004.

U. Wüllner, T. Schmitz-hübsch, M. Abele, G. Antony, P. Bauer et al., Features of probable multiple system atrophy patients identified among 4770 patients with parkinsonism enrolled in the multicentre registry of the German Competence Network on Parkinson's disease, Journal of Neural Transmission, vol.114, issue.9, pp.1161-1166, 1996.

T. Xie, U. J. Kang, S. H. Kuo, M. Poulopoulos, P. Greene et al., Comparison of clinical features in pathologically confirmed PSP and MSA patients followed at a tertiary center, p.15007, 2015.

I. Yabe, H. Soma, A. Takei, N. Fujiki, T. Yanagihara et al., MSA-C is the predominant clinical phenotype of MSA in Japan: analysis of 142 patients with probable MSA, Journal of the neurological sciences, vol.249, issue.2, pp.115-121, 2006.

T. Yamamoto, R. Sakakibara, T. Uchiyama, Z. Liu, T. Ito et al., When is Onuf's nucleus involved in multiple system atrophy? A sphincter electromyography study, Neurosurgery & Psychiatry, vol.76, issue.12, pp.1645-1648, 2005.

F. Yang, W. J. Li, and X. S. Huang, Alpha-synuclein levels in patients with multiple system atrophy: A meta-analysis, International Journal of Neuroscience, pp.1-10, 2018.

F. Yekhlef, G. Ballan, F. Macia, O. Delmer, C. Sourgen et al., Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD, Journal of neural transmission, vol.110, issue.2, pp.151-169, 2003.

R. G. Yoon, S. J. Kim, H. S. Kim, C. G. Choi, J. S. Kim et al., The utility of susceptibility-weighted imaging for differentiating Parkinsonism-predominant multiple system atrophy from Parkinson's disease: correlation with 18F-flurodeoxyglucose positronemission tomography, Neuroscience letters, vol.584, pp.296-301, 2015.

M. Yoshida, Multiple system atrophy: ?-synuclein and neuronal degeneration, Neuropathology, vol.27, issue.5, pp.484-493, 2007.

K. Yoshida, S. Kuwabara, K. Nakamura, R. Abe, A. Matsushima et al., Idiopathic cerebellar ataxia (IDCA): Diagnostic criteria and clinical analyses of 63, 2018.

, Japanese patients, Journal of the neurological sciences, vol.384, pp.30-35

Z. Zhang and Y. Cheng, miR-16-1 promotes the aberrant ?-synuclein accumulation in parkinson disease via targeting heat shock protein 70, The Scientific World Journal, 2014.

L. Y. Zhang, B. Cao, Y. T. Zou, Q. Q. Wei, R. W. Ou et al., Depression and anxiety in multiple system atrophy, Acta Neurologica Scandinavica, vol.137, issue.1, pp.33-37, 2018.

Q. Zhao, X. Yang, S. Tian, R. An, J. Zheng et al., Association of the COQ2 V393A variant with risk of multiple system atrophy in East Asians: a case-control study and meta-analysis of the literature, Neurological Sciences, vol.37, issue.3, pp.423-430, 2016.