Y. Stade-de-hoehn,

C. G. Goetz, The History of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies, Cold Spring Harb Perspect Med, vol.1, 2011.

D. Hirtz, How common are the 'common' neurologic disorders?, Neurology, vol.68, pp.326-337, 2007.

L. Fréquence-de and . Maladie-de-parkinson, , p.9, 2018.

E. R. Dorsey, Projected number of people with Parkinson disease in the most populous nations, Neurology, vol.68, pp.384-386, 2005.

A. Schrag, Y. Ben-shlomo, R. Brown, C. D. Marsden, and N. Quinn,

, Parkinson's disease revisited--clinical features, natural history, and mortality, Mov. Disord, vol.13, pp.885-894, 1998.

L. Hirsch, N. Jette, A. Frolkis, T. Steeves, and T. Pringsheim, The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis, Neuroepidemiology, vol.46, pp.292-300, 2016.

G. F. Wooten, L. J. Currie, V. E. Bovbjerg, J. K. Lee, and J. Patrie, Are men at greater risk for Parkinson's disease than women, Neurosurgery & Psychiatry, vol.75, pp.637-639, 2004.

K. Kalinderi, S. Bostantjopoulou, and L. Fidani, The genetic background of

, Parkinson's disease: current progress and future prospects, Acta Neurol. Scand, vol.134, pp.314-326, 2016.

S. Lubbe and H. R. Morris, Recent advances in Parkinson's disease genetics, J Neurol, vol.261, pp.259-266, 2014.

H. Ahmed, A. I. Abushouk, M. Gabr, A. Negida, and M. M. Abdel-daim, Parkinson's disease and pesticides: A meta-analysis of disease connection and genetic alterations, Biomedicine & Pharmacotherapy, vol.90, pp.638-649, 2017.

C. B. Breckenridge, C. Berry, E. T. Chang, R. L. Sielken, and J. S. Mandel, Association between Parkinson's Disease and Cigarette Smoking, Rural Living, Well-Water Consumption, Farming and Pesticide Use: Systematic Review and Meta-Analysis, PLOS ONE, vol.11, p.151841, 2016.

J. Costa, N. Lunet, C. Santos, J. Santos, and A. Vaz-carneiro, Caffeine exposure and the risk of Parkinson's disease: a systematic review and meta-analysis of observational studies, J. Alzheimers Dis, vol.20, issue.1, pp.221-238, 2010.

J. O. Rinne, Neuronal loss in the substantia nigra in patients with Alzheimer's disease and Parkinson's disease in relation to extrapyramidal symptoms and dementia, Prog. Clin. Biol. Res, vol.317, pp.325-332, 1989.

H. Bernheimer, W. Birkmayer, O. Hornykiewicz, K. Jellinger, and F. Seitelberger, Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations, J. Neurol. Sci, vol.20, pp.415-455, 1973.

D. W. Dickson, Parkinson's disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med 2, 2012.

W. R. Gibb and A. J. Lees, The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease, Neurosurgery & Psychiatry, vol.51, pp.745-752, 1988.

T. G. Beach, Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders, Acta Neuropathol, vol.119, pp.689-702, 2010.

K. Iwanaga, Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases, Neurology, vol.52, pp.1269-1271, 1999.

T. G. Beach, Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders, Acta Neuropathol, vol.117, pp.169-174, 2009.

K. Del-tredici, C. H. Hawkes, E. Ghebremedhin, and H. Braak, Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease, Acta Neuropathol, vol.119, pp.703-713, 2010.

H. Braak, Staging of brain pathology related to sporadic Parkinson's disease, Neurobiology of Aging, vol.24, pp.197-211, 2003.

M. Delong and T. Wichmann, Update on models of basal ganglia function and dysfunction, Parkinsonism & Related Disorders, vol.15, pp.237-240, 2009.


R. M. Zweig, W. R. Jankel, J. C. Hedreen, R. Mayeux, and D. L. Price, The pedunculopontine nucleus in Parkinson's disease, Annals of Neurology, vol.26, pp.41-46, 1989.

N. I. Bohnen, Gait speed in Parkinson disease correlates with cholinergic degeneration, Neurology, vol.81, pp.1611-1616, 2013.

C. Karachi, Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease, J. Clin. Invest, vol.120, pp.2745-2754, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00795787

L. V. Kalia and A. E. Lang, Parkinson's disease, Lancet, vol.386, pp.896-912, 2015.

C. Marras, Predictors of deterioration in health-related quality of life in Parkinson's disease: results from the DATATOP trial, Mov. Disord, vol.23, p.776, 2008.

, syndromes apparentés : techniques et modalités de la prise en charge non médicamenteuse des troubles moteurs, p.12, 2018.

B. R. Bloem, Measurement instruments to assess posture, gait, and balance in Parkinson's disease: Critique and recommendations, Movement Disorders, vol.31, pp.1342-1355, 2016.

V. E. Kelly, A. J. Eusterbrock, and A. Shumway-cook, A Review of Dual-Task Walking Deficits in People with Parkinson's Disease: Motor and Cognitive Contributions, Mechanisms, and Clinical Implications, Parkinson's Disease, vol.2012, pp.1-14, 2012.

M. Morris, R. Iansek, T. Matyas, and J. Summers, Abnormalities in the stride lengthcadence relation in parkinsonian gait, Mov. Disord, vol.13, pp.61-69, 1998.

M. Morris, R. Iansek, J. Mcginley, T. Matyas, and F. Huxham, Three-dimensional gait biomechanics in Parkinson's disease: Evidence for a centrally mediated amplitude regulation disorder, Mov. Disord, vol.20, pp.40-50, 2005.

O. Blin, A. M. Ferrandez, and G. Serratrice, Quantitative analysis of gait in Parkinson patients: increased variability of stride length, J. Neurol. Sci, vol.98, pp.91-97, 1990.

J. M. Hausdorff, Impaired regulation of stride variability in Parkinson's disease subjects with freezing of gait, Exp Brain Res, vol.149, pp.187-194, 2003.

A. Nieuwboer, Abnormalities of the spatiotemporal characteristics of gait at the onset of freezing in Parkinson's disease, Mov. Disord, vol.16, pp.1066-1075, 2001.

R. Camicioli, B. S. Oken, G. Sexton, J. A. Kaye, and J. G. Nutt, Verbal fluency task affects gait in Parkinson's disease with motor freezing, J Geriatr Psychiatry Neurol, vol.11, pp.181-185, 1998.

J. M. Bond and M. Morris, Goal-directed secondary motor tasks: their effects on gait in subjects with Parkinson disease, Arch Phys Med Rehabil, vol.81, pp.110-116, 2000.

B. Galna, A. T. Murphy, and M. E. Morris, Obstacle crossing in people with

, Parkinson's disease: Foot clearance and spatiotemporal deficits, Human Movement Science, vol.29, pp.843-852, 2010.

A. Burleigh, F. Horak, J. Nutt, and J. Frank, Levodopa Reduces Muscle Tone and Lower Extremity Tremor in Parkinson's Disease, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, vol.22, pp.280-285, 1995.

P. Srivanitchapoom and M. Hallett, Camptocormia in Parkinson's disease: definition, epidemiology, pathogenesis and treatment modalities, J. Neurol. Neurosurg. Psychiatry, vol.87, pp.75-85, 2016.

B. Schoneburg, M. Mancini, F. Horak, and J. G. Nutt, Framework for understanding balance dysfunction in Parkinson's disease, Movement Disorders, vol.28, pp.1474-1482

G. Abbruzzese and A. Berardelli, Sensorimotor integration in movement disorders, Mov. Disord, vol.18, pp.231-240, 2003.

R. Ceravolo, Neuropathy and levodopa in Parkinson's disease: Evidence from a multicenter study, Movement Disorders, vol.28, pp.1391-1397, 2013.

R. S. Weil, Visual dysfunction in Parkinson's disease, Brain, vol.139, pp.2827-2843, 2016.

W. Lv, Vestibulo-ocular reflex abnormality in Parkinson's disease detected by video head impulse test, Neurosci. Lett, vol.657, pp.211-214, 2017.

L. Rocchi, L. Chiari, and F. Horak, Effects of deep brain stimulation and levodopa on postural sway in Parkinson's disease, J Neurol Neurosurg Psychiatry, vol.73, pp.267-274, 2002.

D. Guehl, Evolution of postural stability after subthalamic nucleus stimulation in Parkinson's disease: a combined clinical and posturometric study, Exp Brain Res, vol.170, pp.206-215, 2006.

P. Crenna, Impact of subthalamic nucleus stimulation on the initiation of gait in Parkinson's disease, Exp Brain Res, vol.172, pp.519-532, 2006.

B. R. Bloem, D. J. Beckley, M. P. Remler, R. A. Roos, and J. G. Van-dijk, Postural reflexes in Parkinson's disease during 'resist' and 'yield' tasks, J. Neurol. Sci, vol.129, pp.109-119, 1995.

M. Matinolli, Postural sway and falls in Parkinson's disease: a regression approach, Mov. Disord, vol.22, pp.1927-1935, 2007.

M. D. Latt, S. R. Lord, J. G. Morris, and V. S. Fung, Clinical and physiological assessments for elucidating falls risk in Parkinson's disease, Movement Disorders, vol.24, pp.1280-1289, 2009.

M. W. Creaby and M. H. Cole, Gait characteristics and falls in Parkinson's disease: A systematic review and meta-analysis, Parkinsonism Relat. Disord, 2018.

J. D. Schaafsma, Gait dynamics in Parkinson's disease: relationship to Parkinsonian features, falls and response to levodopa, J. Neurol. Sci, vol.212, pp.47-53, 2003.

G. K. Kerr, Predictors of future falls in Parkinson disease, Neurology, vol.75, pp.116-124, 2010.

R. B. Postuma, Identifying prodromal Parkinson's disease: pre-motor disorders in Parkinson's disease, Mov. Disord, vol.27, pp.617-626, 2012.

P. Ronald and B. , MDS clinical diagnostic criteria for Parkinson's disease, Movement Disorders, vol.30, pp.1591-1601, 2015.

G. Kagi, K. P. Bhatia, and E. Tolosa, The role of DAT-SPECT in movement disorders, Neurosurgery & Psychiatry, vol.81, pp.5-12, 2010.

J. A. Obeso, The origin of motor fluctuations in Parkinson's disease: importance of dopaminergic innervation and basal ganglia circuits, Neurology, vol.62, pp.17-30, 2004.

J. Jankovic, Motor fluctuations and dyskinesias in Parkinson's disease: clinical manifestations, Mov. Disord, vol.20, issue.11, pp.11-16, 2005.

R. Martínez-fernández, E. Schmitt, P. Martinez-martin, and P. Krack, The hidden sister of motor fluctuations in Parkinson's disease: A review on nonmotor fluctuations, Movement Disorders, vol.31, pp.1080-1094, 2016.

M. A. Hely, J. G. Morris, W. G. Reid, and R. Trafficante, Sydney multicenter study of Parkinson's disease: Non-L-dopa-responsive problems dominate at 15 years, Movement Disorders, vol.20, pp.190-199, 2005.

B. S. Connolly and A. E. Lang, Pharmacological Treatment of Parkinson Disease: A Review, JAMA, vol.311, pp.1670-1683, 2014.

K. Seppi, The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease, Mov. Disord, vol.26, pp.42-80, 2011.

K. Léonard, P. Gouilly, and M. Vander-maren, Place de la kinésithérapie dans la maladie de Parkinson : recommandations cliniques et littératures. Kinésithérapie, la Revue 14, pp.30-34, 2014.

S. Sapir, J. L. Spielman, L. O. Ramig, B. H. Story, and C. Fox, Effects of intensive voice treatment (the Lee Silverman Voice Treatment [LSVT]) on vowel articulation in dysarthric individuals with idiopathic Parkinson disease: acoustic and perceptual findings, J. Speech Lang. Hear. Res, vol.50, pp.899-912, 2007.

S. Drapier, Quality of life in Parkinson's disease improved by apomorphine pump: the OPTIPUMP cohort study, J. Neurol, vol.263, pp.1111-1119, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01301510

C. W. Olanow, Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study, Lancet Neurol, vol.13, pp.141-149, 2014.

H. Bergman, T. Wichmann, and M. R. Delong, Reversal of experimental parkinsonism by lesions of the subthalamic nucleus, Science, vol.249, pp.1436-1438, 1990.

S. Little and P. Brown, The functional role of beta oscillations in Parkinson's disease, Parkinsonism Relat. Disord, vol.20, issue.1, pp.44-48, 2014.

A. Eusebio, Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients, J. Neurol. Neurosurg. Psychiatry, vol.82, pp.569-573, 2011.

K. Mueller, Brain connectivity changes when comparing effects of subthalamic deep brain stimulation with levodopa treatment in Parkinson's disease, NeuroImage: Clinical, vol.19, pp.1025-1035, 2018.

T. Sankar, Structural brain changes following subthalamic nucleus deep brain stimulation in Parkinson's disease, Mov. Disord, vol.31, pp.1423-1425, 2016.

V. J. Odekerken, Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial, Lancet Neurol, vol.12, pp.37-44, 2013.

P. Limousin, Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease, New England Journal of Medicine, vol.339, pp.1105-1111, 1998.

A. L. Benabid, S. Chabardes, J. Mitrofanis, and P. Pollak, Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease, The Lancet Neurology, vol.8, pp.67-81, 2009.

A. Castrioto, Ten-year outcome of subthalamic stimulation in Parkinson disease: a blinded evaluation, Arch. Neurol, vol.68, pp.1550-1556, 2011.

M. L. Welter, Clinical predictive factors of subthalamic stimulation in Parkinson's disease, Brain, vol.125, pp.575-583, 2002.

A. Collomb-clerc and M. Welter, Effects of deep brain stimulation on balance and gait in patients with Parkinson's disease: A systematic neurophysiological review, Neurophysiol Clin, vol.45, pp.371-388, 2015.

K. A. Follett, Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease, N. Engl. J. Med, vol.362, pp.2077-2091, 2010.

G. Cossu and M. Pau, Subthalamic nucleus stimulation and gait in Parkinson's Disease: a not always fruitful relationship, Gait & Posture, vol.52, pp.205-210, 2017.

C. Maurer, Effect of chronic bilateral subthalamic nucleus (STN) stimulation on postural control in Parkinson's disease, Brain, vol.126, pp.1146-1163, 2003.

B. De-la-casa-fages, F. Alonso-frech, and F. Grandas, Effect of subthalamic nucleus deep brain stimulation on balance in Parkinson's disease: A static posturographic analysis, Gait & Posture, vol.52, pp.374-380, 2017.

H. S. Dafsari, Nonmotor symptoms evolution during 24 months of bilateral subthalamic stimulation in Parkinson's disease, Mov. Disord, vol.33, pp.421-430, 2018.

M. Abbes, Subthalamic stimulation and neuropsychiatric symptoms in

, Parkinson's disease: results from a long-term follow-up cohort study, J. Neurol. Neurosurg. Psychiatry, vol.89, pp.836-843, 2018.

A. Videnovic and L. V. Metman, Deep brain stimulation for Parkinson's disease: prevalence of adverse events and need for standardized reporting, Mov. Disord, vol.23, pp.343-349, 2008.

P. Krack, V. Fraix, A. Mendes, A. Benabid, and P. Pollak, Postoperative management of subthalamic nucleus stimulation for Parkinson's disease, Movement Disorders, vol.17, pp.188-197, 2002.

Y. Wang, Y. Li, X. Zhang, and A. Xie, Apathy following Bilateral Deep Brain Stimulation of Subthalamic Nucleus in Parkinson's Disease: A Meta-Analysis, Parkinson's Disease, pp.1-7, 2018.

J. A. Saint-cyr, L. L. Trépanier, R. Kumar, A. M. Lozano, and A. E. Lang, Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease, Brain, vol.123, pp.2091-2108, 2000.

D. Aldridge, D. Theodoros, A. Angwin, and A. P. Vogel,

, Parkinson's disease after subthalamic nucleus deep brain stimulation: A systematic review, Parkinsonism Relat. Disord, vol.33, pp.3-11, 2016.

J. R. Schlaier, The influence of intraoperative microelectrode recordings and clinical testing on the location of final stimulation sites in deep brain stimulation for Parkinson's disease, Acta Neurochir (Wien), vol.155, pp.357-366, 2013.

R. L. Jacob, J. Geddes, S. Mccartney, and K. J. Burchiel, Cost analysis of awake versus asleep deep brain stimulation: a single academic health center experience, J. Neurosurg, vol.124, pp.1517-1523, 2016.

E. Pirogovsky, The utility of the Mattis Dementia Rating Scale in Parkinson's disease mild cognitive impairment, Parkinsonism & Related Disorders, vol.20, pp.627-631, 2014.

G. Llebaria, Cut-off score of the Mattis Dementia Rating Scale for screening dementia in Parkinson's disease, Mov. Disord, vol.23, pp.1546-1550, 2008.

A. F. Leentjens, F. R. Verhey, G. J. Luijckx, and J. Troost, The validity of the Beck Depression Inventory as a screening and diagnostic instrument for depression in patients with Parkinson's disease, Mov. Disord, vol.15, pp.1221-1224, 2000.

J. L. Palmer, Unified Parkinson's Disease Rating Scale-Motor Exam: inter-rater reliability of advanced practice nurse and neurologist assessments: Neurological assessment inter-rater reliability, Journal of Advanced Nursing, vol.66, pp.1382-1387, 2010.

V. Peto, C. Jenkinson, R. Fitzpatrick, and R. Greenhall, The development and validation of a short measure of functioning and well being for individuals with Parkinson's disease, Qual Life Res, vol.4, pp.241-248, 1995.

P. Auquier, Validation of the French language version of the Parkinson's Disease Questionnaire -PDQ-39, Rev. Neurol, vol.158, pp.41-50, 2002.

C. Schlenstedt, Effect of high-frequency subthalamic neurostimulation on gait and freezing of gait in Parkinson's disease: a systematic review and meta-analysis, European Journal of Neurology, vol.24, pp.18-26, 2017.

M. E. Mcneely and G. M. Earhart, Medication and subthalamic nucleus deep brain stimulation similarly improve balance and complex gait in Parkinson disease, Parkinsonism Relat. Disord, vol.19, pp.86-91, 2013.

M. Ferrarin, Effects of bilateral subthalamic stimulation on gait kinematics and kinetics in Parkinson's disease, Exp Brain Res, vol.160, pp.517-527, 2005.

E. L. Johnsen, P. H. Mogensen, N. A. Sunde, and K. Østergaard, Improved asymmetry of gait in Parkinson's disease with DBS: gait and postural instability in Parkinson's disease treated with bilateral deep brain stimulation in the subthalamic nucleus, Mov. Disord, vol.24, pp.590-597, 2009.

P. Temperli, How do parkinsonian signs return after discontinuation of subthalamic DBS?, Neurology, vol.60, pp.78-81, 2003.

G. Deuschl, A randomized trial of deep-brain stimulation for Parkinson's disease, N. Engl. J. Med, vol.355, pp.896-908, 2006.

G. Kleiner-fisman, Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes, Mov. Disord. 21 Suppl, vol.14, pp.290-304, 2006.

D. Maltête, Subthalamic stimulation in Parkinson disease: with or without anesthesia?, Arch. Neurol, vol.61, pp.390-392, 2004.

M. A. Brodsky, Clinical outcomes of asleep vs awake deep brain stimulation for Parkinson disease, Neurology, vol.89, pp.1944-1950, 2017.

F. Blasberg, Comparison of Awake vs. Asleep Surgery for Subthalamic Deep Brain Stimulation in Parkinson's Disease, Neuromodulation, 2018.

M. Ferrarin, M. Rizzone, L. Lopiano, M. Recalcati, and A. Pedotti, Effects of subthalamic nucleus stimulation and L-dopa in trunk kinematics of patients with Parkinson's disease, Gait Posture, vol.19, pp.164-171, 2004.

G. Tommasi, Freezing and hypokinesia of gait induced by stimulation of the subthalamic region, J. Neurol. Sci, vol.258, pp.99-103, 2007.

C. Moreau, STN-DBS frequency effects on freezing of gait in advanced Parkinson disease, Neurology, vol.71, pp.80-84, 2008.

T. Xie, Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD, Neurology, vol.84, pp.415-420, 2015.

S. Vercruysse, Effects of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease: a prospective controlled study, J. Neurol. Neurosurg. Psychiatry, vol.85, pp.871-877, 2014.

M. J. Mathie, A. C. Coster, N. H. Lovell, and B. G. Celler, Accelerometry: providing an integrated, practical method for long-term, ambulatory monitoring of human movement, Physiol Meas, vol.25, pp.1-20, 2004.

. Serment-d'hippocrate,

, (e) à exercer la médecine, je promets et je jure d'être fidèle aux lois de l'honneur et de la probité?.probité?. Mon premier souci sera de rétablir, de préserver ou de promouvoir la santé dans tous ses éléments, physiques et mentaux

, Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune discrimination selon leur état ou leurs convictions. J'interviendrai pour les protéger si elles sont affaiblies, vulnérables ou menacées dans leur intégrité ou leur dignité. Même sous la contrainte

, Je ne tromperai jamais leur confiance et n'exploiterai pas le pouvoir hérité des circonstances pour forcer les consciences

, Je donnerai mes soins à l'indigent et à quiconque me les demandera. Je ne me laisserai pas influencer par la soif du gain ou la recherche de la gloire

, Admis(e) dans l'intimité des personnes, je tairai les secrets qui me seront confiés

, reçu(e) à l'intérieur des maisons, je respecterai les secrets des foyers et ma conduite ne servira pas à corrompre les moeurs

, Je ferai tout pour soulager les souffrances. Je ne prolongerai pas abusi-vement les agonies. Je ne provoquerai jamais la mort délibérément

, Je n'entreprendrai rien qui dépasse mes compétences. Je les entretiendrai et les perfectionnerai pour assurer au mieux les services qui me seront demandés

, J'apporterai mon aide à mes confrères ainsi qu'à leurs familles dans l'adversité

, Que les hommes et mes confrères m'accordent leur estime si je suis fidèle à mes promesses ; que je sois déshonoré(e) et méprisé(e) si j'y manque