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Master Thesis

Comparaison du TDM thoracique et de l’IRM pulmonaire UTE dans l’évaluation de l’atteinte du parenchyme pulmonaire chez les patients atteints de mucoviscidose

Abstract : Cystic Fibrosis is the most frequent serious genetic disease in France with more of 7000 people affected in 2017, and a prognostic which depends on respiratory disorder. Life expectancy is still increasing, so it was imperative to develop a non-irradiant imaging technique to limit the impact of radiation on human health. Pulmonary Ultra Short Echo Time Magnetic Resonance imaging (UTE MRI) could allow this technique to have a place in the follow up of the Muscoviscidosis patients. 2 studies by Dournes show a good correlation with Computed Tomography (CT) and a good reproducibility inter and intra observer. The main objective of this work is to study concordance between UTE MRI pulmonary and thoracic CT for lung parenchyma semi-quantitative analysis with Helbich-Bhalla score. Between September 2015 and September 2016, we included 30 patients followed at the adult CRCM in the pneumology service of the CHU of Bordeaux in this prospective, monocentric, pilot study of diagnostic imagery. For one year, 4 visits were planned at M0, M3, M6 and M12. A thoracic CT and a pulmonary UTE MRI was realized at M0 and M12, and the semi-quantitative Helbich-Bhalla score and hyperintensities T2 were analyzed by two double blinded radiologists. At ever visit, there was a medical visit and pulmonary function test was done. 30 patients were included, 2 came out of the study, 8 were on Orkambi®. There was no significant difference between the groups at M0. Pulmonary MRI was comparable to thoracic CT at M0 for semi-quantitative analysis with Helbich-Bhalla score, with and intra-class correlation at 0.98. Forced expiratory volume in 1 second (FEV1) correlate with Helbich-Bhalla sore in CT and MRI at M0. We could see an hyperintensities T2 diminution between M0 and M12 on patients treated by Orkambi®. This study done at the CHU of Bordeaux show that pulmonary MRI is like thoracic CT to appreciate lung parenchyma of Cystic Fibrosis patients with the semi-quantitative Helbich-Bhalla score.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02091022
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Friday, April 5, 2019 - 12:44:41 PM
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Sophie Point. Comparaison du TDM thoracique et de l’IRM pulmonaire UTE dans l’évaluation de l’atteinte du parenchyme pulmonaire chez les patients atteints de mucoviscidose. Médecine humaine et pathologie. 2018. ⟨dumas-02091022⟩

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