Évaluation quantitative de la réserve coronaire avec les caméras CZT, faisabilité et perspectives

Abstract : Background: cardiac positron emission tomography (PET) is superior to single-photon emission computed tomography (SPECT) thanks to its quantitative analysis capabilities, especially for measuring myocardial blood flow (MBF) and myocardial flow reserve (MFR). The recent development of new cadmium zinc telluride (CZT) gamma cameras has enabled dynamic acquisition, allowing measurement of MBF and MFR. This prospective study aimed to validate a rapid protocol, using régadénoson, and to analyse the standard images from myocardial perfusion imaging (MPI) without any loss of information. Methods and Results: from February to June 2018, 10 patients were referred to our centre. They were prospectively enrolled in our study to evaluate the MBF and MFR, with 5 different reconstruction models. The primary endpoint was the difference between the five models, the secondary endpoint the image quality of the MPI. The 6-min tests highlighted no significant difference in the flow measurement and MFR (p = 0,15), and appears by decreasing acquisition time. The image quality did not differ significantly (p = 0.6). Conclusion: we determined a reliable and reproducible protocol with minimal mobilization of the patient, to flow measurements. This will enable reliable analysis MFR while maintaining both qualitative visual and functional data.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02093090
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Submitted on : Monday, April 8, 2019 - 4:20:15 PM
Last modification on : Saturday, May 25, 2019 - 1:20:18 AM

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Quentin Ceyrat. Évaluation quantitative de la réserve coronaire avec les caméras CZT, faisabilité et perspectives. Médecine humaine et pathologie. 2018. ⟨dumas-02093090⟩

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