P. Garot, J. Garot, and M. Morice, Microcirculation coronaire. EMC -Cardiol. janv

A. R. Pries, L. Badimon, R. Bugiardini, P. G. Camici, M. Dorobantu et al.,

A. Koller, J. J. Piek, and C. De-wit, Coronary vascular regulation, remodelling, and collateralization: mechanisms and clinical implications on behalf of the working group on coronary pathophysiology and microcirculation, Europ Heart J, vol.36, pp.3134-3180, 2015.

A. Yildiz, B. Okcun, T. Peker, C. Arslan, A. Olcay et al., Prevalence of coronary artery anomalies in 12,457 adult patients who underwent coronary angiography, Clin Cardiol. déc, vol.33, issue.12, pp.60-64, 2010.

M. Dauzat, G. Aya, J. P. Bertinchant, J. C. Gris, J. Y. Lefrant et al.,

P. Cardio-vasculaire-intégrée, Sauramps Medical, 2007.

P. Garot, E. Teiger, P. Dupouy, E. Aptecar, L. Hittinger et al., Coronary microcirculation and cardiovascular pathology, Drugs, vol.58, issue.1, pp.23-31, 1999.

R. Coujard, J. Poirier, and J. Racadot, Précis d'histologie humaine, 1980.

R. Levick, Introduction to Cardiovascular Physiology, 2003.

C. De, M. Vasculaire, . De-chirurgie, and . Vasculaire, Référentiel de Médecine Vasculaire et de Chirurgie Vasculaire, Presses universitaires François Rabelais, 2015.

J. E. Deanfield, J. P. Halcox, and T. J. Rabelink, Endothelial function and dysfunction: testing and clinical relevance, Circulation, vol.115, issue.10, pp.1285-95, 2007.

J. M. Canty, Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog, Circulation research, vol.63, pp.821-857, 1988.

F. J. Klocke, Coronary blood flow in man, Prog Cardiovascul Dis, vol.19, pp.117-66, 1976.

P. Croisille, Ischemic heart disease (myocardial perfusion and viability): techniques and results

, J Radiol. oct, vol.85, issue.10, pp.1819-1839, 2004.

K. Thygesen, J. S. Alpert, H. D. White, A. S. Jaffe, and F. S. Apple, Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction, Circulation, vol.116, issue.22, pp.2634-53, 2007.

R. W. Nesto and G. J. Kowalchuk, The ischemic cascade: temporal sequence of hemodynamic, electrocardiographic and symptomatic expressions of ischemia, Am J Cardiol. 9 mars, vol.59, issue.7, pp.23-30, 1987.

W. F. Fearon and Y. Kobayashi, Pries AR, Reglin B. Coronary microcirculatory pathophysiology: can we afford it to remain a black box?, Circ Cardiovasc Interv. 1 déc, vol.10, issue.12, pp.478-88, 2017.

J. A. Panza, Myocardial ischemia and the pains of the heart, N Engl J Med. 20 juin, vol.346, issue.25, pp.1934-1939, 2002.

S. V. Arnold, J. Jang, F. Tang, G. Graham, D. J. Cohen et al., Prediction of residual angina after percutaneous coronary intervention, Eur Heart J -Qual Care Clin Outcomes. 1 juill, vol.1, issue.1, pp.23-30, 2015.

P. Ong, A. Athanasiadis, and U. Sechtem, Pharmacotherapy for coronary microvascular dysfunction, Eur Heart J Cardiovasc Pharmacother. janv, vol.1, issue.1, pp.65-71, 2015.

K. L. Gould, R. L. Kirkeeide, and M. Buchi, Coronary flow reserve as a physiologic measure of stenosis severity, J Am Coll Cardiol. févr, vol.15, issue.2, pp.459-74, 1990.

N. G. Uren, J. A. Melin, B. De-bruyne, W. Wijns, T. Baudhuin et al., Relation between myocardial blood flow and the severity of coronary-artery stenosis, N Engl J Med. 23 juin, vol.330, issue.25, pp.1782-1790, 1994.

K. L. Gould, K. Lipscomb, and G. W. Hamilton, Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve, Am J Cardiol. janv, vol.33, issue.1, pp.87-94, 1974.

K. L. Gould, R. J. Westcott, P. C. Albro, and G. W. Hamilton, Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic coronary vasodilatation. II. Clinical methodology and feasibility, Am J Cardiol. févr, vol.41, issue.2, pp.279-87, 1978.

A. S. Iskandrian, J. Heo, B. Kong, and E. Lyons, Effect of exercise level on the ability of thallium-201 tomographic imaging in detecting coronary artery disease: analysis of 461 patients, J Am Coll Cardiol, vol.14, issue.6, pp.1477-86, 1989.

H. J. Verberne, W. Acampa, C. Anagnostopoulos, J. Ballinger, F. Bengel et al.,

, EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision, Eur J Nucl Med Mol Imaging, vol.42, issue.12, pp.1929-1969, 2015.

A. Manrique, P. Y. Marie, D. Agostini, C. Maunoury, and P. Acar, Recommandations Société Française Cardiologie -Mise à jour des recommandations concernant la pratique des épreuves de provocation d'ischémie en cardiologie nucléaire chez l'adulte et chez l'enfant, Archives des maladies du coeur et des vaisseaux, 2002.

A. Ranhosky and J. Kempthorne-rawson, The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group, Circulation, vol.81, issue.4, pp.1205-1214, 1990.

R. C. Hendel, T. Jamil, and D. K. Glover, Pharmacologic stress testing: new methods and new agents, J Nucl Cardiol, vol.10, issue.2, pp.197-204, 2003.

A. E. Iskandrian, T. M. Bateman, L. Belardinelli, B. Blackburn, M. D. Cerqueira et al., Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging

S. Vasu, W. P. Bandettini, L. Hsu, P. Kellman, S. Leung et al., Regadenoson and adenosine are equivalent vasodilators and are superior than dipyridamole-a study of first pass quantitative perfusion cardiovascular magnetic resonance, J Cardiovasc Magn Reson Off J Soc Cardiovasc Magn Reson. 24 sept, vol.15, p.85, 2013.

Q. Ceyrat, C. Mesguich, L. Janvier, H. Douard, L. Bordenave et al., The impact of

W. Acampa, R. R. Buechel, and A. Gimelli, Low dose in nuclear cardiology: state of the art in the era of new cadmium-zinc-telluride cameras, Eur Heart J -Cardiovasc Imaging. 1 juin, vol.17, issue.6, pp.591-596, 2016.

T. J. Stocker, S. Deseive, J. Leipsic, M. Hadamitzky, M. Y. Chen et al., Reduction in radiation exposure in cardiovascular computed tomography imaging: results from the Prospective Multicenter Registry on RadiaTion Dose Estimates of Cardiac CT AngIOgraphy IN Daily Practice in 2017 (PROTECTION VI), Eur Heart J, vol.25, 2018.

G. Mowatt, J. A. Cook, G. S. Hillis, S. Walker, C. Fraser et al., 64-Slice computed tomography angiography in the diagnosis and assessment of coronary artery disease: systematic review and meta-analysis, Heart, vol.94, issue.11, pp.1386-93, 2008.

N. H. Pijls, B. De-bruyne, K. Peels, P. H. Van-der-voort, H. J. Bonnier et al.,

, Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses, N Engl J Med. 27 juin, vol.334, issue.26, pp.1703-1711, 1996.

P. Tonino, B. De-bruyne, N. Pijls, U. Siebert, F. Ikeno et al., Fractional flow reserve versus angiography for guiding percutaneous coronary intervention, N Engl J Med. 15 janv, vol.360, issue.3, pp.213-237, 2009.

B. De-bruyne, N. Pijls, B. Kalesan, E. Barbato, P. Tonino et al., Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease, N Engl J Med. 13 sept, vol.367, issue.11, pp.991-1001, 2012.

S. Sen, J. Escaned, I. S. Malik, G. W. Mikhail, . Foale-r-a et al., Development and validation of a new adenosine-independent index of stenosis severity from coronary waveintensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study, J Am Coll Cardiol, vol.59, pp.1392-402, 2012.

J. Escaned, M. Echavarría-pinto, H. M. Garcia-garcia, T. P. Van-de-hoef, T. De-vries et al., Prospective Assessment of the Diagnostic Accuracy of Instantaneous Wave-Free Ratio to Assess Coronary Stenosis Relevance: Results of ADVISE II International, Multicenter Study (ADenosine Vasodilator Independent Stenosis Evaluation II), JACC Cardiovasc Interv, vol.8, pp.824-857, 2015.

H. M. Yang, K. Khush, H. Luikart, K. Okada, H. S. Lim et al.,

H. Valantine and W. F. Fearon, Invasive Assessment of Coronary Physiology Predicts Late Mortality After Heart Transplantation, Circulation, vol.133, pp.1945-50, 2016.

E. Deshayes, J. Collinot, V. Dunet, G. Allenbach, P. Mitsakis et al., L'analyse quantitative en TEP cardiaque. Médecine Nucl. 1 mai, vol.37, pp.181-187, 2013.

V. Dunet and J. Prior, Évaluation de la perfusion myocardique par TEP-TDM. Médecine Nucl, 20 avril, vol.35, pp.336-343, 2011.

K. Yoshinaga, R. Klein, and N. Tamaki, Generator-produced rubidium-82 positron emission tomography myocardial perfusion imaging-From basic aspects to clinical applications, J Cardiol. 1 mars, vol.55, issue.2, pp.163-73, 2010.

C. Jaarsma, T. Leiner, S. C. Bekkers, H. J. Crijns, J. E. Wildberger et al., Diagnostic performance of noninvasive myocardial perfusion imaging using single-photon emission computed tomography, cardiac magnetic resonance, and positron emission tomography imaging for the detection of obstructive coronary artery disease: a meta-analysis, J Am Coll Cardiol. 8 mai, vol.59, pp.1719-1747, 2012.

M. M. Hajjiri, M. B. Leavitt, H. Zheng, A. E. Spooner, A. J. Fischman et al., Comparison of positron emission tomography measurement of adenosine-stimulated absolute myocardial blood flow versus relative myocardial tracer content for physiological assessment of coronary artery stenosis severity and location, JACC Cardiovasc Imaging. juin, vol.2, issue.6, pp.751-759, 2009.

R. Parkash, R. A. Dekemp, T. D. Ruddy, A. Kitsikis, R. Hart et al., Potential utility of rubidium 82 pet quantification in patients with 3-vessel coronary artery disease, J Nucl Cardiol. 1 juill, vol.11, issue.4, pp.440-449, 2004.

M. C. Ziadi, R. A. Dekemp, K. Williams, A. Guo, J. M. Renaud et al., Does quantification of myocardial flow reserve using rubidium-82 positron emission tomography facilitate detection of multivessel coronary artery disease?, J Nucl Cardiol. 1 août, vol.19, issue.4, pp.670-80, 2012.

B. A. Herzog, L. Husmann, I. Valenta, O. Gaemperli, P. T. Siegrist et al., Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve, J Am Coll Cardiol. 7 juill, vol.54, issue.2, pp.150-156, 2009.

R. A. Tio, A. Dabeshlim, H. Siebelink, J. Sutter, . De et al.,

, Comparison Between the Prognostic Value of Left Ventricular Function and Myocardial Perfusion Reserve in Patients with Ischemic Heart Disease, J Nucl Med. 2 janv, vol.50, issue.2, pp.214-223, 2009.

K. Fukushima, M. S. Javadi, T. Higuchi, R. Lautamäki, J. Merrill et al., Prediction of Short-Term Cardiovascular Events Using Quantification of Global Myocardial Flow Reserve in Patients Referred for Clinical 82Rb PET Perfusion Imaging, J Nucl Med. 1 mai, vol.52, issue.5, pp.726-758, 2011.

V. L. Murthy, M. Naya, C. R. Foster, J. Hainer, M. Gaber et al., Improved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow ReserveClinical Perspective, Circulation, vol.124, issue.20, pp.2215-2239, 2011.

M. C. Ziadi, R. A. Dekemp, K. A. Williams, A. Guo, B. Chow et al.,

D. Carli, M. F. Murthy, and V. L. , Cardiac PET/CT for the evaluation of known or suspected coronary artery disease, vol.31, pp.1239-54, 2011.

M. Carli, S. Dorbala, J. Meserve, G. E. Fakhri, A. Sitek et al., Clinical Myocardial Perfusion PET/CT, J Nucl Med. 5 janv, vol.48, issue.5, pp.783-93, 2007.

J. Maddahi, J. Czernin, J. Lazewatsky, S. Huang, M. Dahlbom et al., Phase I, First-in-Human Study of BMS747158, a Novel 18F-Labeled Tracer for Myocardial Perfusion PET: Dosimetry, Biodistribution, Safety, and Imaging Characteristics After a Single Injection at Rest, J Nucl Med. 1 sept, vol.52, issue.9, pp.1490-1498, 2011.

D. S. Berman, J. Maddahi, B. K. Tamarappoo, J. Czernin, R. Taillefer et al., Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: flurpiridaz F 18 positron emission tomography, J Am Coll Cardiol. 29 janv, vol.61, issue.4, pp.469-77, 2013.

N. P. Johnson and K. L. Gould, Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiological severity, JACC Cardiovasc Imaging. avr, vol.5, issue.4, pp.430-470, 2012.

E. Deshayes, J. A. V-m, O. , and J. , Myocardial flow reserve by Rb-82 cardiac PET improves the selection of patients eligible for invasive coronary angiography, 2012.

T. H. Marwick, I. Cho, B. Hartaigh, and J. K. Min, Finding the Gatekeeper to the Cardiac Catheterization Laboratory: Coronary CT Angiography or Stress Testing?, J Am Coll Cardiol. 30 juin, vol.65, issue.25, pp.2747-56, 2015.

P. Gueret and J. Deux, Les nouveautés en scanner coronaire : données cliniques et progrès technologiques. Arch Mal Coeur Vaiss -Prat, vol.2016, pp.2-9, 2016.

J. K. Min, C. A. Taylor, S. Achenbach, B. K. Koo, J. Leipsic et al., Noninvasive Fractional Flow Reserve Derived From Coronary CT Angiography: Clinical Data and Scientific Principles, JACC Cardiovasc Imaging, vol.8, issue.10, pp.1209-1231, 2015.

E. Nagel, C. Klein, I. Paetsch, S. Hettwer, B. Schnackenburg et al., Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease, Circulation, vol.29, issue.4, pp.432-439, 2003.

N. Al-saadi, E. Nagel, M. Gross, A. Bornstedt, B. Schnackenburg et al., Noninvasive detection of myocardial ischemia from perfusion reserve based on cardiovascular magnetic resonance, Circulation, vol.28, issue.12, pp.1379-83, 2000.

P. J. Slomka, J. A. Patton, D. S. Berman, and G. Germano, Advances in technical aspects of myocardial perfusion SPECT imaging, J Nucl Cardiol Off Publ Am Soc Nucl Cardiol. avr, vol.16, issue.2, pp.255-76, 2009.

Y. Takahashi, M. Miyagawa, Y. Nishiyama, H. Ishimura, and T. Mochizuki, Performance of a semiconductor SPECT system: comparison with a conventional Anger-type SPECT instrument

, Ann Nucl Med. 1 janv, vol.27, issue.1, pp.11-17, 2013.

W. L. Duvall, L. B. Croft, E. S. Ginsberg, A. J. Einstein, K. A. Guma et al., Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera, J Nucl Cardiol, vol.18, issue.5, pp.847-57, 2011.

B. Songy, D. Lussato, M. Guernou, M. Queneau, and R. Geronazzo, Comparison of myocardial perfusion imaging using thallium-201 between a new cadmium-zinc-telluride cardiac camera and a conventional SPECT camera, Clin Nucl Med. sept, vol.36, issue.9, pp.776-80, 2011.

E. V. Garcia, Are SPECT measurements of myocardial blood flow and flow reserve ready for clinical use?, Eur J Nucl Med Mol Imaging. 1 déc, vol.41, issue.12, pp.2291-2294, 2014.

B. Hsu, F. Chen, T. Wu, W. Huang, P. Hou et al., Quantitation of myocardial blood flow and myocardial flow reserve with 99mTc-sestamibi dynamic SPECT/CT to enhance detection of coronary artery disease, Eur J Nucl Med Mol Imaging. 1 déc, vol.41, issue.12, pp.2294-306, 2014.

S. Ben-haim, V. L. Murthy, C. Breault, A. R. Sitek, A. Roth et al., Quantification of

, Myocardial Perfusion Reserve Using Dynamic SPECT Imaging in Humans: A Feasibility Study, J Nucl Med. 1 juin, vol.54, issue.6, pp.873-882, 2013.

H. R. Schelbert, Anatomy and physiology of coronary blood flow, J Nucl Cardiol. août, vol.17, issue.4, pp.545-54, 2010.
DOI : 10.1007/s12350-010-9255-x

URL : https://link.springer.com/content/pdf/10.1007%2Fs12350-010-9255-x.pdf

F. Ben-bouallègue, F. Roubille, B. Lattuca, T. T. Cung, J. Macia et al.,

, Myocardial Perfusion Reserve in Patients with Multivessel Coronary Disease: Correlation with

, Angiographic Findings and Invasive Fractional Flow Reserve Measurements, J Nucl Med Off Publ Soc Nucl Med. nov, vol.56, issue.11, pp.1712-1719, 2015.

D. Agostini, V. Roule, C. Nganoa, N. Roth, R. Baavour et al., First validation of myocardial flow reserve assessed by dynamic99mTc-sestamibi CZT-SPECT camera: head to head comparison with15O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study, Eur J Nucl Med Mol Imaging. 1 mars, 2018.

M. Lortie, R. Beanlands, K. Yoshinaga, R. Klein, J. N. Dasilva et al., Quantification of myocardial blood flow with 82Rb dynamic PET imaging, Eur J Nucl Med Mol Imaging, vol.34, issue.11, pp.1765-74, 2007.
DOI : 10.1007/s00259-007-0478-2

J. A. Leppo and D. J. Meerdink, Comparison of the myocardial uptake of a technetium-labeled isonitrile analogue and thallium, Circ Res. sept, vol.65, issue.3, pp.632-641, 1989.

K. Yoshida, N. Mullani, and K. L. Gould, Coronary flow and flow reserve by PET simplified for clinical applications using rubidium-82 or nitrogen-13-ammonia, J Nucl Med Off Publ Soc Nucl Med, vol.37, issue.10, pp.1701-1713, 1996.

L. J. Shaw, D. S. Berman, D. J. Maron, G. Mancini, S. W. Hayes et al., Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy, Circulation, vol.117, issue.10, pp.1283-91, 2008.

R. Hachamovitch, S. W. Hayes, J. D. Friedman, I. Cohen, and D. S. Berman, Comparison of the computed tomography, Circulation, vol.107, issue.23, pp.2900-2907, 2003.

B. Goudarzi, K. Fukushima, P. Bravo, J. Merrill, and F. M. Bengel, Comparison of the myocardial blood flow response to regadenoson and dipyridamole: a quantitative analysis in patients referred for clinical 82Rb myocardial perfusion PET, Eur J Nucl Med Mol Imaging, vol.38, issue.10, pp.1908-1924, 2011.

R. Nkoulou, T. A. Fuchs, A. P. Pazhenkottil, S. M. Kuest, J. R. Ghadri et al.,

, Myocardial Blood Flow and Flow Reserve Assessed by Gated SPECT with Cadmium-Zinc

, Telluride Detectors Using 99mTc-Tetrofosmin: Head-to-Head Comparison with 13N-Ammonia PET, J Nucl Med. 12 janv, vol.57, issue.12, pp.1887-92, 2016.

R. Assante, W. Acampa, E. Zampella, P. Arumugam, C. Nappi et al., Coronary atherosclerotic burden vs. coronary vascular function in diabetic and nondiabetic patients with normal myocardial perfusion: a propensity score analysis, Eur J Nucl Med Mol Imaging. juill, vol.44, issue.7, pp.1129-1164, 2017.

J. W. Askew, T. D. Miller, R. L. Ruter, L. G. Jordan, D. O. Hodge et al., Early image acquisition using a solid-state cardiac camera for fast myocardial perfusion imaging, J Nucl Cardiol, vol.18, issue.5, p.840, 2011.
DOI : 10.1007/s12350-011-9423-7

C. Meyer and P. Weinmann, Validation of early image acquisitions following Tc-99 m sestamibi injection using a semiconductors camera of cadmium-zinc-telluride, J Nucl Cardiol. 1 août, vol.24, issue.4, pp.1149-56, 2017.

. Task-force-members, G. Montalescot, U. Sechtem, S. Achenbach, F. Andreotti et al., ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology, Eur Heart J. oct, vol.34, issue.38, pp.2949-3003, 2013.

, Annexe 2 : Protocole d'injection

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