Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study, Lancet, vol.364, issue.9451, pp.2097-2105, 2004. ,
Metronomic chemotherapy: new rationale for new directions, Nature Reviews Clinical Oncology, vol.7, issue.8, pp.455-65, 2010. ,
Metastatic breast cancer patients treated with low-dose metronomic chemotherapy with cyclophosphamide and celecoxib: clinical outcomes and biomarkers of response, Cancer Chemother Pharmacol, vol.77, issue.2, pp.365-74, 2016. ,
Phase II trial of metronomic chemotherapy as salvage therapy for patients with metastatic breast cancer ,
, J Egypt Natl Canc Inst, vol.20, issue.2, pp.134-174, 2008.
Oral/metronomic cyclophosphamide-based chemotherapy as option for patients with castration-refractory prostate cancer: review of the literature, Cancer Treat Rev, vol.37, issue.6, pp.444-55, 2011. ,
Metronomic chemotherapy with the COMBAT regimen in advanced pediatric malignancies: a multicenter experience, Oncology, 2012. ,
A feasibility trial of antiangiogenic (metronomic) chemotherapy in pediatric patients with recurrent or progressive cancer, J Pediatr Hematol Oncol, vol.27, issue.11, pp.573-81, 2005. ,
A phase II trial of multi-agent oral anti-angiogenic (metronomic) regimen in children with recurrent or progressive cancer, Pediatr Blood Cancer, vol.61, issue.4, pp.636-678, 2014. ,
,
, Metronomic etoposide/cyclophosphamide/celecoxib regimen given to children and adolescents with refractory cancer: a preliminary monocentric study, Clin Ther, 2008.
Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels, Ann Oncol, vol.13, issue.1, pp.73-80, 2002. ,
Targeting microtubules to inhibit angiogenesis and disrupt tumour vasculature: implications for cancer treatment, Curr Cancer Drug Targets, 2007. ,
Dual therapeutic efficacy of vinblastine as a unique chemotherapeutic agent capable of inducing dendritic cell maturation, Cancer Res, vol.69, issue.17, pp.6987-94, 2009. ,
The anti-angiogenic basis of metronomic chemotherapy, Nat Rev Cancer, vol.4, issue.6, pp.23-36, 2004. ,
Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo, Clin Cancer Res, vol.13, issue.3, pp.1036-1080, 2007. ,
Metronomic therapy can increase quality of life during paediatric palliative cancer care, but careful patient selection is essential, Acta Paediatr, vol.105, issue.8, pp.946-51, 2016. ,
Metronomics during palliative care in paediatric oncology? For sure! But handle me with care, Acta Paediatr, vol.105, issue.8, pp.874-879, 2016. ,
Combined biodifferentiating and antiangiogenic oral metronomic therapy is feasible and effective in relapsed solid tumors in children: single-center pilot study, Onkologie, vol.29, pp.308-313, 2006. ,
Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumors, Pediatr Blood Cancer, vol.50, issue.5, pp.970-975, 2008. ,
Metronomic chemotherapy and radiotherapy as salvage treatment in refractory or relapsed pediatric solid tumours, Curr Oncol, vol.23, issue.3, pp.253-262, 2016. ,
Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors, Pediatr Blood Cancer, vol.59, issue.3, pp.511-518, 2012. ,
Paediatric metronomic four-drug metronomic regimen has anti-tumour activity in pediatric low-grade glioma; the results of a phase II clinical trial, Front. Pharmacol, vol.9, p.950 ,
, World Health Organization (1979) WHO Handbook for reporting results of cancer treatment, vol.48
Reporting results of cancer treatment, Cancer, vol.47, issue.1, pp.207-214, 1981. ,
The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report, J Clin Oncol, vol.27, issue.2, pp.289-297, 2009. ,
Metronomics: towards personalized chemotherapy?, Nat Rev Clin Oncol, vol.11, issue.7, pp.413-444, 2014. ,
Metronomic Chemotherapy vs Best Supportive Care in Progressive Pediatric Solid Malignant Tumors: A Randomized Clinical Trial, JAMA Oncol, vol.3, issue.9, pp.1222-1227, 2017. ,
,
Results of a randomized, prospective clinical trial evaluating metronomic chemotherapy in nonmetastatic patients with high-grade, operable osteosarcomas of the extremities: A report from the Latin American Group of Osteosarcoma Treatment, Cancer, vol.123, issue.6, pp.1003-1010, 2017. ,
Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-based Metronomic Chemotherapy: A Bench to Bedside Study, EBioMedicine, vol.6, p.36, 2016. ,
Phase II study of irinotecan and temozolomide in children with relapsed or refractory neuroblastoma: a Children's Oncology Group study, J Clin Oncol, vol.29, issue.2, pp.208-221, 2011. ,
Phase II study of temozolomide in combination with topotecan (TOTEM) in relapsed or refractory neuroblastoma: a European Innovative Therapies for Children with Cancer-SIOP-European Neuroblastoma study, Eur J Cancer, vol.50, issue.1, pp.170-177, 2014. ,
Irinotecantemozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial, Lancet Oncol, vol.18, issue.7, pp.946-957, 2017. ,
Children Treated With Metronomic Chemotherapy in a Low-income Country: METRO-MALI-01, Pediatr Hematol Oncol, vol.33, issue.1, pp.31-35, 2011. ,
Metronomic Chemotherapy: Seems Prowess to Battle against Cancer in Current Scenario, J Clin Diagn Res, vol.10, issue.11, pp.9-13, 2016. ,
Maintenance chemotherapy in children with ALL exerts metronomic-like thrombospondin-1 associated anti-endothelial effect, Oncotarget, vol.6, issue.26, pp.23008-23022, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01787272
High-dose chemotherapy for children and young adults with stage IV rhabdomyosarcoma, Cochrane Database Syst Rev, issue.12, p.6669, 2010. ,