V. Poznyak, A. Fleischmann, D. Rekve, M. Rylett, J. Rehm et al., The World Health organization's Global Monitoring System on Alcohol and Health, Alcohol Res Curr Rev, vol.35, issue.2, pp.244-253, 2014.

F. Santé-publique, Avis d'experts relatif à l'évolution du discours public en matière de consommation d'alcool en France. Saint-Maurice: Santé pub-lique France, 2017.

X. Laqueille, M. Lacombe, and A. Dervaux, Aspects épidémiologiques de l'alcoolodépendance, Presse Médicale. juin, vol.47, issue.6, pp.535-581, 2018.

. World-health and . Organization, International Classification of Disease (ICD-10), World Health Organization, 1991.

, World Health Organization. Country profiles 2024, 2014.

H. U. Wittchen, F. Jacobi, J. Rehm, A. Gustavsson, M. Svensson et al., The size and burden of mental disorders and other disorders of the brain in Europe 2010, Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol. sept, vol.21, issue.9, pp.655-79, 2011.

M. J. Bohn, T. F. Babor, and H. R. Kranzler, The Alcohol Use Disorders Identification Test (AUDIT): validation of a screening instrument for use in medical settings, J Stud Alcohol. 1 juill, vol.56, issue.4, pp.423-455, 1995.

F. Vabret, B. Boudehent, . Lepelleux, . Lannuzel, . Eustache et al., Profil neuropsychologique des patients alcoolo-dépendants. Identification dans un service d'addictologie et intérêt pour leur prise en charge, Alcoologie Addictologie. 15 sept, vol.35, issue.3, pp.215-238, 2013.

A. Dervaux and X. Laqueille, Thiamine (vitamin B1) treatment in patients with alcohol dependence, Presse Medicale Paris Fr, 1983.

A. Pitel, G. Chételat, L. Berre, A. P. Desgranges, B. Eustache et al., Macrostructural abnormalities in Korsakoff syndrome compared with uncomplicated alcoholism, Neurology. 24 avr, vol.78, issue.17, pp.1330-1333, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00652244

N. M. Zahr, Chapter 17 -Structural and microstructral imaging of the brain in alcohol use disorders, Sullivan EV, Pfefferbaum A, éditeurs. Handbook of Clinical Neurology, 2014.

, Disponible sur, Alcohol and the Nervous System, vol.125, pp.275-90

C. Boudehent, H. Beaunieux, A. Pitel, F. Eustache, and F. Vabret, Contribution de la neuropsychologie dans la prise en charge des patients alcoolo-dépendants : compréhension des phénomènes de résistance dans les thérapies motivationnelles et cognitivo-comportementales, Alcoologie et Addictologie, pp.121-128, 2012.

P. J. Eslinger and L. M. Grattan, Frontal lobe and frontal-striatal substrates for different forms of human cognitive flexibility, Neuropsychologia. janv, vol.31, issue.1, pp.17-28, 1993.

P. W. Burgess and T. Shallice, Response suppression, initiation and strategy use following frontal lobe lesions, Neuropsychologia. avr, vol.34, issue.4, pp.263-72, 1996.

C. R. Guillot, J. R. Fanning, J. S. Bullock, M. S. Mccloskey, and M. E. Berman, Effects of alcohol on tests of executive functioning in men and women: A dose response examination, Exp Clin Psychopharmacol, vol.18, issue.5, pp.409-426, 2010.

H. Beaunieux, L. Ritz, S. Segobin, L. Berre, A. Lannuzel et al., Troubles neuropsychologiques dans l'alcoolo-dépendance : l'origine de la rechute ?, Rev Neuropsychol, vol.5, issue.3, pp.159-65, 2013.

B. S. Mccrady and D. E. Smith, Implications of Cognitive Impairment for the Treatment of Alcoholism, Alcohol Clin Exp Res. mars, vol.10, issue.2, pp.145-154, 1986.

A. L. Pitel, H. Beaunieux, T. Witkowski, F. Vabret, B. Guillery-girard et al., Genuine Episodic Memory Deficits and Executive Dysfunctions in Alcoholic Subjects Early in Abstinence, Alcohol Clin Exp Res. juill, vol.31, issue.7, pp.1169-78, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00160876

L. Berre, A. Pinon, K. Vabret, F. Pitel, A. Allain et al., Study of metamemory in patients with chronic alcoholism using a feeling-of-knowing episodic memory task, Alcohol Clin Exp Res, vol.34, issue.11, pp.1888-98, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00538645

F. Vabret, C. Lannuzel, N. Cabe, L. Ritz, C. Boudehent et al., Troubles cognitifs liés à l'alcool : nature, impact et dépistage, Presse Médicale. déc, vol.45, issue.12, pp.1124-1156, 2016.

M. Field and W. Cox, Attentional bias in addictive behaviors: A review of its development, causes, and consequences, Drug Alcohol Depend. 1 sept, vol.97, issue.1-2, pp.1-20, 2008.

T. E. Robinson and K. C. Berridge, The neural basis of drug craving: an incentive-sensitization theory of addiction, Brain Res Brain Res Rev. déc, vol.18, issue.3, pp.247-91, 1993.

M. Field, L. Hogarth, D. Bleasdale, P. Wright, G. Fernie et al., Alcohol expectancy moderates attentional bias for alcohol cues in light drinkers: Alcohol expectancy and attentional bias, Addiction. juin, vol.106, issue.6, pp.1097-103, 2011.

E. Shin, J. B. Hopfinger, S. A. Lust, E. A. Henry, and B. D. Bartholow, Electrophysiological evidence of alcoholrelated attentional bias in social drinkers low in alcohol sensitivity, Psychol Addict Behav, vol.24, issue.3, pp.508-523, 2010.

S. Vollstädt-klein, S. Loeber, A. Richter, M. Kirsch, P. Bach et al., Validating incentive salience with functional magnetic resonance imaging: association between mesolimbic cue reactivity and attentional bias in alcohol-dependent patients: Neural cue reactivity triggers attention, Addict Biol. juill, vol.17, issue.4, pp.807-823, 2012.

P. Maurage, D. Grynberg, X. Noël, F. Joassin, P. Philippot et al., Dissociation Between Affective and Cognitive Empathy in Alcoholism: A Specific Deficit for the Emotional Dimension: EMOTIONAL EMPATHY DEFICIT IN ALCOHOLISM, Alcohol Clin Exp Res. mai, 2011.

C. Kornreich, IMPAIRED EMOTIONAL FACIAL EXPRESSION RECOGNITION IS ASSOCIATED WITH INTERPERSONAL PROBLEMS IN ALCOHOLISM, Alcohol Alcohol. 1 juill, vol.37, issue.4, pp.394-400, 2002.

F. D'hondt, P. De-timary, Y. Bruneau, and P. Maurage, Categorical perception of emotional facial expressions in alcohol-dependence, Drug Alcohol Depend, vol.156, pp.267-74, 2015.

J. Uekermann, S. Channon, K. Winkel, P. Schlebusch, and I. Daum, Theory of mind, humour processing and executive functioning in alcoholism, Addiction. févr, vol.102, issue.2, pp.232-272, 2007.

O. Taieb, M. Corcos, G. Loas, M. Speranza, O. Guilbaud et al.,

, Ann Med Interne (Paris). mai, vol.153, issue.3, pp.1-51, 2002.

J. Jacobus and S. F. Tapert, Neurotoxic Effects of Alcohol in Adolescence, Annu Rev Clin Psychol

H. C. Olson, J. J. Feldman, A. P. Streissguth, P. D. Sampson, and F. L. Bookstein, Neuropsychological deficits in adolescents with fetal alcohol syndrome: clinical findings, Conduites addictives chez les adolescents -Une expertise collective de l'Inserm, vol.9, pp.1998-2012, 1998.

D. F. Hermens, J. Lagopoulos, J. Tobias-webb, D. Regt, T. Dore et al., Pathways to alcoholinduced brain impairment in young people: a review, Cortex J Devoted Study Nerv Syst Behav. janv, vol.49, issue.1, pp.3-17, 2013.

A. Topiwala, C. L. Allan, V. Valkanova, E. Zsoldos, N. Filippini et al., Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study, BMJ. 6 juin, vol.357, p.2353, 2017.

M. J. Dry, N. R. Burns, T. Nettelbeck, A. L. Farquharson, and J. M. White, Dose-Related Effects of Alcohol on Cognitive Functioning. Mendelson JE, éditeur. PLoS ONE, vol.7, p.50977, 2012.

L. B. Hassing, Light Alcohol Consumption Does Not Protect Cognitive Function: A Longitudinal Prospective Study, Front Aging Neurosci, vol.10, p.81, 2018.
DOI : 10.3389/fnagi.2018.00081

URL : https://www.frontiersin.org/articles/10.3389/fnagi.2018.00081/pdf

L. Ritz, L. Coulbault, C. Lannuzel, C. Boudehent, S. Segobin et al., Clinical and Biological Risk Factors for Neuropsychological Impairment in Alcohol Use Disorder, Luo J, éditeur. PLOS ONE. 12 sept, vol.11, issue.9, p.159616, 2016.

B. Rolland and M. Naassila, Binge Drinking: Current Diagnostic and Therapeutic Issues, CNS Drugs. mars, vol.31, issue.3, pp.181-187, 2017.
DOI : 10.1007/s40263-017-0413-4

M. Pascual, A. M. Blanco, O. Cauli, J. Miñarro, and C. Guerri, Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats, Eur J Neurosci. janv, vol.25, issue.2, pp.541-50, 2007.
DOI : 10.1111/j.1460-9568.2006.05298.x

T. T. Nguyen-louie, A. Tracas, L. M. Squeglia, G. E. Matt, S. Eberson-shumate et al., Learning and Memory in Adolescent Moderate, Binge, and Extreme-Binge Drinkers, Alcohol Clin Exp Res. sept, vol.40, issue.9, pp.1895-904, 2016.
DOI : 10.1111/acer.13160

URL : http://europepmc.org/articles/pmc5008978?pdf=render

L. M. Squeglia, J. Jacobus, and S. F. Tapert, The effect of alcohol use on human adolescent brain structures and systems, Handbook of Clinical Neurology, 2014.

C. Carbia, E. López-caneda, M. Corral, and F. Cadaveira, A systematic review of neuropsychological studies involving young binge drinkers, Neurosci Biobehav Rev. juill, vol.90, pp.332-381, 2018.

G. Petit, C. Kornreich, P. Maurage, X. Noël, C. Letesson et al., Early attentional modulation by alcohol-related cues in young binge drinkers: an event-related potentials study, Clin Neurophysiol Off J Int Fed Clin Neurophysiol. mai, vol.123, issue.5, pp.925-961, 2012.
DOI : 10.1016/j.clinph.2011.10.042

D. S. Hasin, F. S. Stinson, E. Ogburn, and B. F. Grant, Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions, Arch Gen Psychiatry. juill, vol.64, issue.7, pp.830-872, 2007.

A. Dervaux and X. Laqueille, Comorbidités psychiatriques de l'alcoolodépendance, Presse Médicale. juin, vol.47, issue.6, pp.575-85, 2018.

F. D'hondt, C. Lescut, P. Maurage, O. Menard, B. Gibour et al.,

, Psychiatric comorbidities associated with a positive screening using the Montreal Cognitive Assessment (MoCA) test in subjects with severe alcohol use disorder. Drug and Alcohol Dependence, 2018.

P. Vidailhet,

. L'encephale and . Déc, , vol.36, pp.140-144, 2010.

S. B. Rourke and I. Grant, The interactive effects of age and length of abstinence on the recovery of neuropsychological functioning in chronic male alcoholics: a 2-year follow-up study, J Int Neuropsychol Soc JINS. mars, vol.5, issue.3, pp.234-280, 1999.

R. Alarcon, B. Nalpas, S. Pelletier, and P. Perney, MoCA as a Screening Tool of Neuropsychological Deficits in Alcohol-Dependent Patients, Alcohol Clin Exp Res. juin, vol.39, issue.6, pp.1042-1050, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01916342

N. Ziad, S. Phillips-natalie, A. , B. Valérie, C. Simon et al.,

C. Isabelle, The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment, J Am Geriatr Soc. 30 mars, vol.53, issue.4, pp.695-704, 2005.

L. Ritz, C. Lannuzel, C. Boudehent, F. Vabret, N. Bordas et al., Validation of a Brief Screening Tool for Alcohol-Related Neuropsychological Impairments, Alcohol Clin Exp Res, vol.39, issue.11, pp.2249-60, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-01236103

S. Pelletier, B. Nalpas, R. Alarcon, H. Rigole, and P. Perney, Investigation of Cognitive Improvement in Alcohol-Dependent Inpatients Using the Montreal Cognitive Assessment (MoCA) Score, J Addict, vol.2016, pp.1-7, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01897582

M. L. Copersino, D. J. Schretlen, G. M. Fitzmaurice, S. E. Lukas, J. Faberman et al., Effects of Cognitive Impairment on Substance Abuse Treatment Attendance: Predictive Validation of a Brief Cognitive Screening Measure, Am J Drug Alcohol Abuse. mai, vol.38, issue.3, pp.246-50, 2012.

H. Font, J. Roelandt, H. Behal, P. Geoffroy, B. Pignon et al., Prevalence and predictors of no lifetime utilization of mental health treatment among people with mental disorders in France: findings from the 'Mental Health in General Population' (MHGP) survey. Soc Psychiatry Psychiatr Epidemiol

D. Sur,

Y. Moriyama, T. Muramatsu, M. Kato, M. Mimura, and H. Kashima, Family history of alcoholism and cognitive recovery in subacute withdrawal, Psychiatry Clin Neurosci. févr, vol.60, issue.1, pp.85-94, 2006.

S. Loeber, T. Duka, W. Márquez, H. Nakovics, H. Heinz et al., Effects of repeated withdrawal from alcohol on recovery of cognitive impairment under abstinence and rate of relapse, Alcohol Alcohol Oxf Oxfs. déc, vol.45, issue.6, pp.541-548, 2010.

M. E. Bates, G. T. Voelbel, J. F. Buckman, E. W. Labouvie, and D. Barry, Short term neuropsychological recovery in substance use disordered clients, Alcohol Clin Exp Res. mars, vol.29, issue.3, pp.367-77, 2005.

K. Mann, A. Günther, F. Stetter, and K. Ackermann, Rapid recovery from cognitive deficits in abstinent alcoholics: a controlled test-retest study, Alcohol Alcohol Oxf Oxfs. août, vol.34, issue.4, pp.567-74, 1999.

S. Zinn, R. Stein, and H. S. Swartzwelder, Executive functioning early in abstinence from alcohol, Alcohol Clin Exp Res. sept, vol.28, issue.9, pp.1338-1384, 2004.

A. L. Pitel, J. Rivier, H. Beaunieux, F. Vabret, B. Desgranges et al., Changes in the episodic memory and executive functions of abstinent and relapsed alcoholics over a 6-month period, Alcohol Clin Exp Res. mars, vol.33, issue.3, pp.490-498, 2009.

A. Pfefferbaum, E. V. Sullivan, D. H. Mathalon, P. K. Shear, M. J. Rosenbloom et al., Longitudinal Changes in Magnetic Resonance Imaging Brain Volumes in Abstinent and Relapsed Alcoholics, Alcohol Clin Exp Res. oct, vol.19, issue.5, pp.1177-91, 1995.

G. B. Kish, J. M. Hagen, M. M. Woody, and H. L. Harvey, Alcoholics' recovery from cerebral impairment as a function of duration of abstinence, J Clin Psychol. avr, vol.36, issue.2, pp.584-593, 1980.

J. R. Yohman, O. A. Parsons, and W. R. Leber, Lack of recovery in male alcoholics' neuropsychological performance one year after treatment, Alcohol Clin Exp Res. avr, vol.9, issue.2, pp.114-121, 1985.

L. Bars, Y. Orcel, S. Balmes, and J. L. , Syndromes de sevrage alcoolique en milieu hospitalier. Enquête nationale, Alcoologie, pp.317-337, 1999.

A. Quigley, C. Connolly, B. Palmer, and S. Helfgott, A brief guide to the assessment and treatment of alcohol dependence, 2015.

, Groupe de travail du COPAAH Troubles de l'usage de l'alcool et troubles cognitifs, Alcoologie et Addictologie, vol.36, issue.4, pp.341-342, 2014.

A. Liberati, D. G. Altman, J. Tetzlaff, C. Mulrow, P. C. Gøtzsche et al., The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration, BMJ. 21 juill, vol.339, p.2700, 2009.

M. Cordovil-de-sousa-uva, O. Luminet, M. Cortesi, E. Constant, M. Derely et al., Distinct Effects of Protracted Withdrawal on Affect, Craving, Selective Attention and Executive Functions among AlcoholDependent Patients, Alcohol Alcohol. 1 mai, vol.45, issue.3, pp.241-247, 2010.

V. Manning, S. Wanigaratne, D. Best, R. G. Hill, L. J. Reed et al., Changes in Neuropsychological Functioning during Alcohol Detoxification, Eur Addict Res, vol.14, issue.4, pp.226-259, 2008.

G. Petit, O. Luminet, C. De-sousa-uva, M. Zorbas, A. Maurage et al., Differential spontaneous recovery across cognitive abilities during detoxification period in alcohol-dependence. VerdejoGarcía A, éditeur, PLOS ONE. 2 août, vol.12, issue.8, p.176638, 2017.

K. Mulhauser, J. Weinstock, P. Ruppert, and J. Benware, Changes in Neuropsychological Status during the Initial Phase of Abstinence in Alcohol Use Disorder: Neurocognitive Impairment and Implications for Clinical Care, Subst Use Misuse. 12 mai, vol.53, issue.6, pp.881-90, 2018.

D. L. Pennington, T. C. Durazzo, T. P. Schmidt, A. Mon, C. Abé et al., The Effects of Chronic Cigarette Smoking on Cognitive Recovery During Early Abstinence from, Alcohol. Alcohol Clin Exp Res. juill, vol.37, issue.7, pp.1220-1227, 2013.

A. Mon, T. C. Durazzo, S. Gazdzinski, K. E. Hutchison, D. Pennington et al., Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals: The influence of BDNF on brain tissue volumes recovery, Genes Brain Behav. févr, vol.12, issue.1, pp.98-107, 2013.

M. Bendszus, H. Weijers, G. Wiesbeck, M. Warmuth-metz, A. J. Bartsch et al., Sequential MR Imaging and Proton MR Spectroscopy in Patients Who Underwent Recent Detoxification for Chronic Alcoholism: Correlation with Clinical and Neuropsychological Data, vol.7, 2001.

A. J. Bartsch, G. Homola, A. Biller, S. M. Smith, H. Weijers et al., Manifestations of early brain recovery associated with abstinence from alcoholism, Brain, vol.130, issue.1, pp.36-47, 2006.

A. Dervaux, M. Krebs, and X. Laqueille, Cannabis-induced cognitive and psychiatric disorders, Bull Acad Natl Med. mars, vol.198, issue.3, pp.575-577, 2014.

T. C. Durazzo, J. C. Rothlind, S. Gazdzinski, P. Banys, and D. J. Meyerhoff, Chronic smoking is associated with differential neurocognitive recovery in abstinent alcoholic patients: a preliminary investigation, Alcohol Clin Exp Res. juill, vol.31, issue.7, pp.1114-1141, 2007.

G. J. Larrabee, Test validity and performance validity: considerations in providing a framework for development of an ability-focused neuropsychological test battery, Arch Clin Neuropsychol Off J Natl Acad Neuropsychol, vol.29, issue.7, pp.695-714, 2014.

M. F. Green, K. H. Nuechterlein, J. M. Gold, D. M. Barch, J. Cohen et al., Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria, Biol Psychiatry. 1 sept, vol.56, issue.5, pp.301-308, 2004.

O. Godefroy, A. Fickl, M. Roussel, C. Auribault, J. M. Bugnicourt et al., Is the Montreal Cognitive Assessment superior to the Mini-Mental State Examination to detect poststroke cognitive impairment? A study with neuropsychological evaluation, Stroke. juin, vol.42, issue.6, pp.1712-1718, 2011.

L. Beglinger, B. Gaydos, O. Tangphaodaniels, K. Duff, D. Kareken et al., Practice effects and the use of alternate forms in serial neuropsychological testing, Arch Clin Neuropsychol. juin, vol.20, issue.4, pp.517-546, 2005.

A. Federico, S. Tamburin, A. Maier, M. Faccini, R. Casari et al., Multifocal cognitive dysfunction in high-dose benzodiazepine users: a cross-sectional study, Neurol Sci. janv, vol.38, issue.1, pp.137-179, 2017.

S. E. Buffett-jerrott and S. H. Stewart, Cognitive and sedative effects of benzodiazepine use, Curr Pharm Des, vol.8, issue.1, pp.45-58, 2002.

D. W. Loring, S. E. Marino, D. Parfitt, G. R. Finney, and K. J. Meador, Acute lorazepam effects on neurocognitive performance. Epilepsy Behav, vol.25, pp.329-362, 2012.
DOI : 10.1016/j.yebeh.2012.08.019

S. F. Crowe and E. K. Stranks, The Residual Medium and Long-term Cognitive Effects of Benzodiazepine Use: An Updated Meta-analysis, Arch Clin Neuropsychol Off J Natl Acad Neuropsychol, 2017.

C. W. Lejuez, J. F. Magidson, S. H. Mitchell, R. Sinha, M. C. Stevens et al., Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders, Alcohol Clin Exp Res. août, vol.34, issue.8, pp.1334-1379, 2010.

O. A. Parsons, K. W. Schaeffer, and S. W. Glenn, Does neuropsychological test performance predict resumption of drinking in posttreatment alcoholics?, Addict Behav, vol.15, issue.3, pp.297-307, 1990.

J. Weinstock, S. M. Alessi, and N. M. Petry, Regardless of psychiatric severity the addition of contingency management to standard treatment improves retention and drug use outcomes, Drug Alcohol Depend. 16 mars, vol.87, issue.2-3, pp.288-96, 2007.