E. Valassi, H. Franz, T. Brue, R. A. Feelders, R. Netea-maier et al., Diagnostic tests for Cushing's syndrome differ from published guidelines: data from ERCUSYN, Eur J Endocrinol. mai, vol.176, issue.5, pp.613-637, 2017.

S. Petersenn, A. Beckers, D. Ferone, A. Van-der-lely, J. Bollerslev et al., Therapy of endocrine disease: outcomes in patients with Cushing's disease undergoing transsphenoidal surgery: systematic review assessing criteria used to define remission and recurrence, Eur J Endocrinol. juin, vol.172, issue.6, pp.227-239, 2015.

M. Fleseriu, A. H. Hamrahian, A. R. Hoffman, D. F. Kelly, and L. Katznelson, AACE Neuroendocrine and Pituitary Scientific Committee *. American association of clinical endocrinologists and american college of endocrinology disease state clinical review : diagnosis of recurrence in cushing disease, Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol, vol.22, issue.12, pp.1436-1484, 2016.

. Orphanet, Prévalence des maladies rares : données bibliographiques. Classement par prévalence ou incidence décroissante ou par nombre publié de cas. 2018 janv. (Les Cahiers d'Orphanet)

L. K. Nieman, Cushing's syndrome: update on signs, symptoms and biochemical screening, Eur J Endocrinol. oct, vol.173, issue.4, pp.33-41, 2015.

O. Ragnarsson and G. Johannsson, Management of endocrine disease : Cushing's syndrome: a structured short-and long-term management plan for patients in remission, Eur J Endocrinol, vol.169, issue.5, 2013.

L. K. Nieman, B. Biller, J. W. Findling, J. Newell-price, M. O. Savage et al., The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline, J Clin Endocrinol Metab. mai, vol.93, issue.5, pp.1526-1566, 2008.

J. M. Pappachan, C. Hariman, M. Edavalath, J. Waldron, and F. W. Hanna, Cushing's syndrome: a practical approach to diagnosis and differential diagnoses, J Clin Pathol. avr, vol.70, issue.4, pp.350-359, 2017.
DOI : 10.1136/jclinpath-2016-203933

URL : https://jcp.bmj.com/content/jclinpath/70/4/350.full.pdf

A. Tabarin, Diagnostic pitfalls in Cushing's disease, Ann Endocrinol. sept, vol.61, issue.3, pp.224-260, 2000.

L. K. Nieman, Diagnosis of Cushing's Syndrome in the Modern Era, Endocrinol Metab Clin North Am, vol.47, issue.2, pp.259-73, 2018.

V. Guarnotta, M. C. Amato, R. Pivonello, G. Arnaldi, A. Ciresi et al., The degree of urinary hypercortisolism is not correlated with the severity of cushing's syndrome, Endocrine. févr, vol.55, issue.2, pp.564-72, 2017.

S. A. Morgan, Z. K. Hassan-smith, and G. G. Lavery, Mechanisms in endocrinology : Tissue-specific activation of cortisol in Cushing's syndrome, Eur J Endocrinol. août, vol.175, issue.2, pp.83-89, 2016.

M. S. Broder, E. Chang, D. Cherepanov, M. P. Neary, and W. H. Ludlam, Identification of potential markers for cushing disease, Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. mai, vol.22, issue.5, pp.567-74, 2016.

S. Petersenn, J. Newell-price, J. W. Findling, F. Gu, M. Maldonado et al., High variability in baseline urinary free cortisol values in patients with Cushing's disease, Clin Endocrinol (Oxf). févr, vol.80, issue.2, pp.261-270, 2014.

D. A. Vassiliadi and S. Tsagarakis, Diagnosis of endocrine disease : The role of the desmopressin test in the diagnosis and follow-up of Cushing's syndrome, Eur J Endocrinol. mai, vol.178, issue.5, pp.201-215, 2018.

A. Lacroix, R. A. Feelders, C. A. Stratakis, and L. K. Nieman, Cushing's syndrome. The Lancet, août, vol.29, issue.9996, pp.913-940, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01904330

L. K. Nieman, B. Biller, J. W. Findling, M. H. Murad, J. Newell-price et al., Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline, J Clin Endocrinol Metab. août, vol.100, issue.8, pp.2807-2838, 2015.

E. Valassi, H. Franz, T. Brue, R. A. Feelders, R. Netea-maier et al., Preoperative medical treatment in Cushing's syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN, Eur J Endocrinol. avr, vol.178, issue.4, pp.399-409, 2018.

X. Bertagna, Management of endocrine disease: Can we cure Cushing's disease? A personal view, Eur J Endocrinol. mai, vol.178, issue.5, pp.183-200, 2018.

F. M. Van-haalen, L. Broersen, J. O. Jorgensen, A. M. Pereira, and O. M. Dekkers, Management of endocrine disease : Mortality remains increased in Cushing's disease despite biochemical remission: a systematic review and meta-analysis, Eur J Endocrinol. avr, vol.172, issue.4, pp.143-152, 2015.

B. Khalil, R. Baudry, C. Guignat, L. Carrasco, C. Guibourdenche et al., Sequential hormonal changes in 21 patients with recurrent Cushing's disease after successful pituitary surgery, Eur J Endocrinol, vol.165, issue.5, pp.729-766, 2011.

T. B. Carroll, B. R. Javorsky, and J. W. Findling, Postsurgical recurrent cushing disease: clinical benefit of early intervention in patients with normal urinary free cortisol, Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. oct, vol.22, issue.10, pp.1216-1239, 2016.

M. Danet-lamasou, J. Asselineau, P. Perez, A. Vivot, M. Nunes et al., Accuracy of repeated measurements of late-night salivary cortisol to screen for early-stage recurrence of Cushing's disease following pituitary surgery, Clin Endocrinol (Oxf). févr, vol.82, issue.2, pp.260-266, 2015.

A. Micko, A. Wöhrer, S. Wolfsberger, and E. Knosp, Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification, J Neurosurg. avr, vol.122, issue.4, pp.803-814, 2015.

G. Raverot, E. Dantony, J. Beauvy, A. Vasiljevic, S. Mikolasek et al., Risk of Recurrence in Pituitary Neuroendocrine Tumors: A Prospective Study Using a Five-Tiered Classification, J Clin Endocrinol Metab. 1 sept, vol.102, issue.9, pp.3368-74, 2017.

E. Knosp, E. Steiner, K. Kitz, and C. Matula, Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings, Neurosurgery. oct, vol.33, issue.4, pp.610-618, 1993.

J. Trouillas, P. Roy, N. Sturm, E. Dantony, C. Cortet-rudelli et al., A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up, Acta Neuropathol (Berl). juill, vol.126, issue.1, pp.123-158, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00875723

K. I. Alexandraki, G. A. Kaltsas, A. M. Isidori, H. L. Storr, F. Afshar et al., Long-term remission and recurrence rates in Cushing's disease: predictive factors in a single-centre study, Eur J Endocrinol. avr, vol.168, issue.4, pp.639-687, 2013.

N. El-asmar, A. Rajpal, W. R. Selman, and B. M. Arafah, The Value of Perioperative Levels of ACTH, DHEA, and DHEA-S and Tumor Size in Predicting Recurrence of Cushing Disease, J Clin Endocrinol Metab, vol.01, issue.2, pp.477-85, 2018.

D. A. Vassiliadi, M. Balomenaki, A. Asimakopoulou, E. Botoula, M. Tzanela et al., The Desmopressin Test Predicts Better Than Basal Cortisol the Long-Term Surgical Outcome of Cushing's Disease, J Clin Endocrinol Metab, vol.101, issue.12, pp.4878-85, 2016.

A. Albani, L. G. Pérez-rivas, C. Dimopoulou, S. Zopp, P. Colón-bolea et al., The USP8 mutational status may predict long-term remission in patients with Cushing's disease, Clin Endocrinol (Oxf). 29 juin, vol.89, issue.4, pp.454-462, 2018.

N. Ironside, G. Chatain, D. Asuzu, S. Benzo, M. Lodish et al., Earlier post-operative hypocortisolemia may predict durable remission from Cushing's disease, Eur J Endocrinol. mars, vol.178, issue.3, pp.255-63, 2018.

P. Valderrábano, J. Aller, L. García-valdecasas, J. García-uría, L. Martín et al., Results of repeated transsphenoidal surgery in Cushing's disease. Long-term follow-up, Endocrinol Nutr Organo Soc Espanola Endocrinol Nutr. avr, vol.61, issue.4, pp.176-83, 2014.

L. Broersen, M. Jha, N. R. Biermasz, A. M. Pereira, and O. M. Dekkers, Effectiveness of medical treatment for Cushing's syndrome: a systematic review and meta-analysis, Pituitary. déc, vol.21, issue.6, pp.631-672, 2018.

A. Ferriere, C. Cortet, P. Chanson, B. Delemer, P. Caron et al., Cabergoline for Cushing's disease: a large retrospective multicenter study, Eur J Endocrinol, vol.176, issue.3, 2017.
URL : https://hal.archives-ouvertes.fr/dumas-01494157

A. Colao, S. Petersenn, J. Newell-price, J. W. Findling, F. Gu et al., A 12-month phase 3 study of pasireotide in Cushing's disease, N Engl J Med. 8 mars, vol.366, issue.10, pp.914-938, 2012.

J. Young, J. Bertherat, M. C. Vantyghem, O. Chabre, S. Senoussi et al., Hepatic safety of ketoconazole in Cushing's syndrome: results of a Compassionate Use Programme in France, Eur J Endocrinol. mai, vol.178, issue.5, pp.447-58, 2018.

A. Tabarin, Traitements médicaux du syndrome de Cushing, MCED. févr, vol.80, pp.6-12, 2016.

X. Bertagna, R. Pivonello, M. Fleseriu, Y. Zhang, P. Robinson et al., LCI699, a potent 11?-hydroxylase inhibitor, normalizes urinary cortisol in patients with Cushing's disease: results from a multicenter, proof-of-concept study, J Clin Endocrinol Metab. avr, vol.99, issue.4, pp.1375-83, 2014.

C. Baudry, J. Coste, B. Khalil, R. Silvera, S. Guignat et al., Efficiency and tolerance of mitotane in Cushing's disease in 76 patients from a single center, Eur J Endocrinol, vol.167, issue.4, pp.473-81, 2012.

M. Fleseriu, B. Biller, J. W. Findling, M. E. Molitch, D. E. Schteingart et al., Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome, J Clin Endocrinol Metab. juin, vol.97, issue.6, pp.2039-2088, 2012.

R. A. Feelders, C. De-bruin, A. M. Pereira, J. A. Romijn, R. T. Netea-maier et al., Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease, N Engl J Med. 13 mai, vol.362, pp.1846-1854, 2010.

P. Kamenický, P. Chanson, J. Young, S. Brailly-tabard, E. Baudin et al., Metyrapone, and Ketoconazole Combination Therapy as an Alternative to Rescue Adrenalectomy for Severe ACTH-Dependent Cushing's Syndrome, J Clin Endocrinol Metab. 1 sept, vol.96, issue.9, pp.2796-804, 2011.

N. Ironside, C. Chen, C. Lee, D. M. Trifiletti, M. L. Vance et al., Outcomes of Pituitary Radiation for Cushing's Disease, Endocrinol Metab Clin North Am, vol.47, issue.2, pp.349-65, 2018.

K. Ritzel, F. Beuschlein, A. Mickisch, A. Osswald, H. J. Schneider et al., Outcome of Bilateral Adrenalectomy in Cushing's Syndrome: A Systematic Review, J Clin Endocrinol Metab, vol.98, issue.10, pp.3939-3987, 2013.

T. D. Azad, A. Veeravagu, S. Kumar, L. Katznelson, and . Nelson-syndrome, Update on Therapeutic Approaches. World Neurosurg. juin, vol.83, issue.6, pp.1135-1175, 2015.

O. Ragnarsson, D. S. Olsson, E. Papakokkinou, D. Chantzichristos, P. Dahlqvist et al., Overall and disease-specific mortality in patients with Cushing's disease: a Swedish nationwide study, J Clin Endocrinol Metab. 1 févr, 2019.

P. Sarkis, M. Rabilloud, J. Lifante, A. Siamand, E. Jouanneau et al., Bilateral adrenalectomy in Cushing's disease: Altered long-term quality of life compared to other treatment options, Ann Endocrinol. 19 sept, vol.80, issue.1, pp.32-39, 2018.

E. Valassi, A. Santos, T. Brue, R. T. Netea-maier, R. A. Feelders et al., Diagnostic and therapeutic outcome in ERCUSYN: Preliminary report in over 1000 patients. Endocr Abstr, vol.17

D. Sur,

E. Valassi, A. Santos, M. Yaneva, M. Tóth, C. J. Strasburger et al., The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics, Eur J Endocrinol. 9 janv, vol.165, issue.3, pp.383-92, 2011.

R. V. Lloyd, G. Klöppel, and J. Rosai, Lyon: International Agency for Research on Cancer; 2017. 355 p. (World Health Organization classification of tumours)

G. U. Mehta, D. Ding, M. R. Patibandla, H. Kano, N. Sisterson et al., Stereotactic Radiosurgery for Cushing Disease: Results of an International, Multicenter Study, J Clin Endocrinol Metab, vol.102, issue.11, pp.4284-91, 2017.

G. Raverot, P. Burman, A. Mccormack, A. Heaney, S. Petersenn et al., European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas, Eur J Endocrinol. janv, vol.178, issue.1, pp.1-24, 2018.

A. Mccormack, O. M. Dekkers, S. Petersenn, V. Popovic, J. Trouillas et al., Treatment of aggressive pituitary tumours and carcinomas: results of a European Society of Endocrinology (ESE) survey, Eur J Endocrinol, vol.178, issue.3, pp.265-76, 2016.

. Insee, Populations légales en vigueur à La Réunion à compter du 1er janvier, 2017.

M. Nunes, S. Vattaut, J. Corcuff, A. Rault, H. Loiseau et al., Late-Night Salivary Cortisol for Diagnosis of Overt and Subclinical Cushing's Syndrome in Hospitalized and Ambulatory Patients, J Clin Endocrinol Metab. 1 févr, vol.94, issue.2, pp.456-62, 2009.

A. Barlier and P. Romanet, Réseau Des Laboratoires d'Oncogénétique Tumeurs Endocrines Rares Tengen Adénomes Hypophysaires. Exploration génétique des adénomes hypophysaires, 2016.

A. Albani, M. Theodoropoulou, and M. Reincke, Genetics of Cushing's disease, Clin Endocrinol (Oxf). janv, vol.88, issue.1, pp.3-12, 2018.

A. L. Espinosa-de-los-monteros, E. Sosa-eroza, E. Espinosa, V. Mendoza, R. Arreola et al., Long-term outcome of the different treatment alternatives for recurrent and persistent cushing disease, Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. juill, vol.23, issue.7, pp.759-67, 2017.

Z. K. Hassan-smith, M. Sherlock, R. C. Reulen, W. Arlt, J. Ayuk et al., Outcome of Cushing's disease following transsphenoidal surgery in a single center over 20 years, J Clin Endocrinol Metab. avr, vol.97, issue.4, pp.1194-201, 2012.

L. Broersen, N. R. Biermasz, F. Van, V. F. De, M. Verstegen et al., Endoscopic vs microscopic transsphenoidal surgery for Cushing's disease: a systematic review and metaanalysis. Endocr Abstr, 2018.

D. Sur,

, Au moment d'être admis à exercer la médecine, je promets et je jure d'être fidèle aux lois de l'honneur et de la probité

, Mon premier souci sera de rétablir, de préserver ou de promouvoir la santé dans tous ses éléments, physiques et mentaux

, Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune discrimination selon leur état ou leurs convictions. J'interviendrai pour les protéger si elles sont affaiblies, vulnérables ou menacées dans leur intégrité ou leur dignité. Même sous la contrainte

, Je ne tromperai jamais leur confiance et n'exploiterai pas le pouvoir hérité des circonstances pour forcer les consciences

, Admis dans l'intimité des personnes, je tairai les secrets qui me seront confiés. Reçu à l'intérieur des maisons, je respecterai les secrets des foyers et ma conduite ne servira pas à corrompre les moeurs

, Je ferai tout pour soulager les souffrances. Je ne prolongerai pas abusivement les agonies. Je ne provoquerai jamais la mort délibérément

, Je n'entreprendrai rien qui dépasse mes compétences. Je les entretiendrai et les perfectionnerai pour assurer au mieux les services qui me seront demandés

, J'apporterai mon aide à mes confrères ainsi qu'à leurs familles dans l'adversité

, Que les Hommes et mes confrères m'accordent leur estime si je suis fidèle à mes promesses