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T. De and L. A. These, Echec de cathétérisation cervicale en curiethérapie utéro-vaginale : facteurs de risque, complications et valeur pronostique RESUME DE LA THESE EN FRANCAIS : Introduction : La cathétérisation cervicale en vue d'une curiethérapie utéro-vaginale (CUV) peut s'avérer difficile du fait de la distorsion cervicale induite par la tumeur

. Matériel, mais sans impact sur la survie globale. La réalisation de la curiethérapie et la dose totale étaient significativement associées à la survie sans rechute locale. Discussion : On constate que l'échec de cathétérisation ou la perforation utérine en tant que tels n'étaient pas associés à une diminution du contrôle local. Toutefois les patientes redirigées vers une poursuite en radiothérapie externe suite à la survenue d'un tel événement avaient une perte de chance en termes de contrôle local, par défaut d'une escalade de dose suffisante sur la tumeur. Conclusion : Les difficultés de cathétérisation, Les patientes adressées au Centre François Baclesse de 2013 à 2017 en vue d'une CUV et ayant bénéficié d'au moins une tentative de cathétérisation cervicale ont été incluses. Résultats : 184 patientes ont été incluses pour 325 implantations. 101 implantations n'étaient pas correctes

, MOTS-CLES : curiethérapie, perforation utérine, échographie

T. Anglais, ) but without any impact on overall survival. Brachytherapy completion and total dose to the tumor were significantly associated with local relapse-free survival. Discussion : One can see in our cohort that insertion failure or uterine perforation as such weren't associated with decreased local control. Nevertheless, local relapse-free survival was significantly worse after an abortion of brachytherapy procedure due to insertion difficulties if patients were addressed for an external radiotherapy boost, because of suboptimal doses delivered to central pelvis. Conclusion : Intra-uterine tandem insertion failures are a genuine issue in intracavity brachytherapy, Impact of uterine perforation and tandem insertion failures on local control and complications in intracavitary brachytherapy RESUME