M. Dans-l'étude-in-vitro-de, le fer ferreux et ferrique ajouté à la nourriture a diminué l'incidence des caries chez les rats. D'ailleurs, une diminution de la population bactérienne a été notée lors de l'utilisation de ces substrats à base de fer. Le fer aurait donc un rôle cariostatique. De plus, le métabolisme du fer serait plus actif dans les black

, Cela renvoie au rôle des bactéries dans les black-stains, mettant en évidence que tous les éléments cités précédemment sembleraient liés

, Rôle des lactoferrines dans les black-stains

, Deux articles de notre étude ont évoqué le rôle des lactoferrines dans les black-stains, vol.57

. Dans-l'étude-de and . Nordbo, parmi la population d'étudiants, le taux de lactoferrine salivaire était de 2,0 ± 1,9 µg/mL. Ce taux est pourtant plus faible que celui cité par STEIJNS et al. (7-10 µg/mL en moyenne) (44), p.6

, Une augmentation significative du taux de lactoferrine salivaire a ainsi été associée aux black-stains. L'affinité de la lactoferrine pour les macromolécules acides suggère qu'une haute concentration en lactoferrines pourrait contribuer à augmenter l, µg/mL pour les patients atteints de black-stains

. Comme-l'a-montré and . Soares, 53) l'organisation en micelles des lactoferrines dans la salive joue un rôle important dans le maintien de l'homéostasie de l'environnement oral. D'ailleurs, la lactoferrine et le taux de fer influenceraient l'agrégation bactérienne et la formation du biofilm de Streptocoques mutans selon FRANCESCA et al. (74). L'apo-lactoferrine augmenterait l'agrégation bactérienne alors que l'holo-lactoferrine diminuerait l

, D'autres part, le calcium a un effet stimulant sur la formation de ces micelles salivaires

, On peut ainsi mettre en relation l'augmentation du taux de calcium retrouvée dans les black-stains et l'augmentation du taux de lactoferrine salivaire, vol.63, p.55

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L. Vu, . Président, and . Jury, Signature : Vu, la Directrice de l'UFR des Sciences Odontologiques