Les bactériocines : en alternative aux traitements antibiotiques

Abstract : The ever-increasing emergence of resistant bacteria faced with the impoverishment of our therapeutic resources and the lack of progress in the antibiotics field, highlight the importance of finding new solutions. Indeed, antimicrobial resistance is increasing at a worrying rate worldwide, and as antibiotics are used, they lose their effectiveness. We are in such a serious situation that even so-called "rescue" antibiotics are becoming ineffective. Bacteriocins are peptide molecules produced by bacteria which can inhibit growth of other bacteria. The objective of my work was to investigate whether bacteriocins are a possible alternative to current antibiotic treatments. To this end, a systematic review of the bibliography on this subject was carried out. It has shown, both in in vitro and in vivo studies, in mouse models, that bacteriocins have a real antibacterial therapeutic potential. They are even active on antibiotic-resistant bacteria and bacterial biofilms, where conventional antibiotics sometimes fail. The results obtained are encouraging, but show the need for further research before these molecules can be prescribed in humans.
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Master Thesis
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Hortense Dillenseger. Les bactériocines : en alternative aux traitements antibiotiques. Sciences pharmaceutiques. 2019. ⟨dumas-02107732⟩

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