Les thérapies anticancéreuses orales dispensées en officine : enjeux et difficultés pour le pharmacien d'officine

Abstract : In a context of more and more ambulatory care for patients suffering from cancer, the oral antineoplastic therapies have grown significantly in the recent years. At present, 20 to 25% of these antineoplastic treatments in studies are oral administration. One of the reasons of this choice is to simplify ambulatory care of the patients to improve their quality of life and comfort. These treatments lengthen the response time and making cancer as a chronic disease in an increasing number of indications. Even if these therapies offer many advantages, they show inconvenience as well: the occurrence of side effects at home, specific handling and administration and also risk of nonadherence. The pharmacist dispenses these therapies and definitely plays a key role for the administration, the onset of side effects and the adherence of the treatment. The adherence has been revealed as similar as other chronic diseases, namely 50%. A poor observance leads to a loss of chance of recovery for the patient. Many factors will influence the therapeutic adherence, they can be categorized into five categories: therapy, patient, disease, healthcare system and socio-economic characteristics. Strategies must be developed to improve the adherence. There are tools which can help the patient: the therapy action notebook and the dose plan. However the development of the therapeutic patient education seems to be an essential work to minimise the risks of the therapy and maximise its accomplishment.
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Master Thesis
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Marie Picot. Les thérapies anticancéreuses orales dispensées en officine : enjeux et difficultés pour le pharmacien d'officine. Sciences pharmaceutiques. 2018. ⟨dumas-02117218⟩

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