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Master Thesis

Endométriose : état des connaissances des potentialités de la phytothérapie

Abstract : Endometriosis is a chronic gynaecological pathology characterized by the presence of endometrial tissue outside the endometrium. Its large prevalence, its invalidating symptomatology and frequent delays in diagnosis make it a real public health issue. Endometriosis has multifactorial origins and its physiopathology remains poorly known. Although menstrual reflux via the fallopian tubes seems to be the first element, several stages, dependent on genetic, immunological, hormonal and environmental factors are necessary for the endometriosis lesions formation. Estrogen level, inflammation, cell proliferation and angiogenesis play a key role in endometriosis pathogenesis. The treatment of endometriosis includes a medical procedure, based on anti-inflammatory and anti-gonadotropin molecules, as well as a potentially dangerous surgical procedure for patients. These therapies, sometimes heavy, explain the patients’ interest in complementary medicines, including phytotherapy. The Vitex agnus-castus L. chaste-tree (Lamiaceae) and the Curcuma longa L. turmeric (Zingiberaceae) could offer treatment strategies through their anti-estrogenic, anti-inflammatory, analgesic, antiproliferative or antiangiogenesis properties. Other plants are studied in the adjuvant care of endometriosis such as the Tanacetum parthenium L. feverfew (Asteraceae), the Pinus pinaster A. maritime pine (Pinaceae) or the Camellia sinensis L. tea plant (Theaceae). However, these potential treatment options are still being studied and more evidence must be found for therapeutic use. Although they are not subject to formal and validated recommendations to date, some plants seem to offer interesting perspectives in endometriosis treatment.
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Master Thesis
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Pauline Dupont. Endométriose : état des connaissances des potentialités de la phytothérapie. Sciences pharmaceutiques. 2019. ⟨dumas-02117949⟩



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