Skip to Main content Skip to Navigation
Master Thesis

Résultats cliniques de la radiothérapie conformationnelle avec modulation d'intensité accélérée dans les cancers bronchiques non à petites cellules localement avancés

Abstract : Objective: We aimed to evaluate the toxicity, loco‐regional control (LRC) and overall survival (OS) associated with accelerated intensity‐modulated radiotherapy (IMRT) for locally advanced lung cancer. Materials and Methods: Seventy‐three patients were consecutively treated with IMRT from November 2011 to August 2016. A total dose of 66 Gy was delivered using two different schedules of radiotherapy: simultaneous modulated accelerated radiotherapy (SMART) (30 x 2.2 Gy, across 6 weeks) with or without chemotherapy, or moderate hypofractionated radiotherapy (HRT) (24 x 2.75 Gy, across 4 weeks) in patients unfit to receive concomitant chemotherapy. Data on oesophageal and pulmonary toxicities, LRC and OS were prospectively collected. Results: The median follow‐up duration was 44 months. Severe pneumonitis and esophagitis (grade 3‐4) were observed in 7% and 1% of patients respectively, with only one case of grade 4 (pneumonitis). Overall, the 1‐year and 2‐year LRCs were 76% [95 confidence interval (CI)%: 66‐87%] and 62% [95 CI%: 49‐77%] respectively. The 1 and 2‐year OS rates were 72% [95% CI: 63‐83%] and 54% [95 CI%: 43‐68%] respectively. None parameters were correlated with LRC or OS. In particular, no difference was observed between patients treated with SMART and H‐RT (p = 0.26 and 0.6 respectively), with a 1‐year LRC of 74% [95 CI%: 62‐86%] for SMART and 91% [95 CI%: 74 100%] for H‐RT. No significant differences were observed in the toxicity rates associated with each of the RT schedules. Conclusion: Accelerated IMRT for locally advanced lung cancer is associated with low toxicities and high LRC. Moderate hypofractionated RT, by decreasing the total treatment time, may be promising in improving clinical outcomes.
Document type :
Master Thesis
Complete list of metadatas

https://dumas.ccsd.cnrs.fr/dumas-02140305
Contributor : Santé Rennes 1 <>
Submitted on : Monday, May 27, 2019 - 11:01:41 AM
Last modification on : Thursday, July 9, 2020 - 12:30:44 PM

File

JAKSICNicolas.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-02140305, version 1

Collections

Citation

Nicolas Jaksic. Résultats cliniques de la radiothérapie conformationnelle avec modulation d'intensité accélérée dans les cancers bronchiques non à petites cellules localement avancés. Sciences du Vivant [q-bio]. 2018. ⟨dumas-02140305⟩

Share

Metrics

Record views

15

Files downloads

77