. .. La-thérapie-cellulaire,

.. .. Principe,

P. A. Mossey, J. Little, R. G. Munger, M. J. Dixon, and W. C. Shaw, ACS : absorbable collagen sponge ; DMB : demineralized bone matrix ; PRP : platelet rich plasma ; MDA : acellular dermal matrix ; HA : hydroxyapatite ; DBB : deproteinized bovine bone 1, Caractéristiques et résultats des différentes études IBG : iliac bone graft, vol.1, pp.1773-85, 2009.

D. A. Kernahan and R. B. Stark, A new classification for cleft lip and palate, Plast. Reconstr. Surg, vol.22, pp.435-441, 1958.

E. J. Curtis and F. C. Fraser, Congenital Cleft Lip and Palate, p.5

G. Murray-jc, Clin Genest, vol.61, 2002.

A. Mc, F. , and S. Df, Epidemiology of lip

, maxilla-palate clefts in the canton of Vaud, Rev. Med. Suisse Romande, vol.123, issue.8, pp.501-506, 2003.

M. J. Dixon, M. L. Marazita, T. H. Beaty, and J. C. Murray, Cleft lip and palate: understanding genetic and environmental influences, Nat Rev Genet, vol.12, pp.167-178, 2011.

M. A. Canfield, M. A. Honein, N. Yuskiv, J. Xing, C. T. Mai et al.,

T. A. Ramadhani and C. A. Hobbs, National estimates and race/ethnic-specific variation of selected birth defects in the United States, Birth Defects Res A Clin Mol Teratol, vol.76, pp.747-756, 1999.

C. La, S. G. Wasserman-cr, and . Tolarova-m, Racial and ethnie variations in the prevalence or orofacial cefts in California, 1983-1992, Am J Med Genet, vol.79, pp.42-47, 1998.

A. C. Allori, J. B. Mulliken, J. G. Meara, S. Shusterman, and J. R. Marcus, Classification of Cleft Lip/Palate: Then and Now, The Cleft Palate-Craniofacial Journal. mars, vol.54, issue.2, pp.175-88, 2017.

T. W. Brophy, Cleft Lip and Palate. Philadelphia: P. Blakiston's Son and Co, 1923.

M. Benoist, Réhabilitation et prothèse maxillo-faciale, pp.137-224, 1978.

V. Veau, Division Palatine: Anatomie, Chirurgie, Phone´tique. Paris: Masson, 1931.

G. Magalon and A. R. Chancholle, Chirurgie plastique de l'enfant

. Paris:-maloine, , pp.31-132, 1987.

D. Kernahan, The striped Y: a symbolic classification for cleft lip and palate, Plast Reconstr Surg, vol.47, pp.469-70, 1971.

M. Larson, R. Hellquist, and O. P. Jakobsson, Classification, recording and cleft palate surgery at the uppsala cleft palate centre, Scand J Plast Reconstr Hand Surg, vol.32, pp.185-92, 1998.

C. Molé and E. Simon, Séquelles de fentes labio-maxillo-palatines : détermination d'un nouveau score alvéolaire par la classification Alveolar Cleft Score (ACS), Revue de Stomatologie

C. Maxillo-faciale and . De-chirurgie-orale, juin, vol.116, issue.3, pp.132-140, 2015.

A. Grenard, M. Fraeyman, B. Vi-fane, and K. Nham, Position des fragments alvéolo-dentaires avant et après gingivopériostoplastie primaire dans les cas de fentes labio-palatines unilatérales

, Rev Orthopédie Dento-Faciale, vol.48, pp.397-406, 2014.

J. Delaire, La cheilo-rhinoplastie primaire pour fente labio-maxillaire congénitale unilatérale, Rev Stomatol, vol.76, issue.3, pp.193-215, 1975.

. Benateau-h, P. Veyssiere-a, C. Brun-c, and . Traore-h,

, Prise en charge chirurgicale primaire des fentes vélaires, vélopalatines et alvéolaires. Rev Stomatoll Chir Maxillofac Chir orale, vol.10, pp.1-13, 2014.

J. C. Talmant, J. C. Talmant, and L. Jp, Une approche fonctionnelle lors du

, Stomatol Chir Maxillofac, vol.108, pp.255-263, 2007.

J. Talmant, J. Talmant, and J. Lumineau,

, Annales de Chirurgie Plastique Esthétique, vol.61, pp.348-59, 2016.

M. Hugentobler, I. Dojcinovic, and M. Richter, Techniques de couverture lors d'alvéoloplasties secondaires : comparaison de deux types de lambeaux, Revue de Stomatologie et de Chirurgie Maxillo-faciale. juin, vol.107, issue.3, pp.145-51, 2006.

A. Picard, N. Kadlub, E. Galliani, V. Soupre, S. Cassier et al., Traitement primaire des brèches alvéolaires dans les fentes labio-maxillo-palatines. Rev Orthopédie DentoFaciale, vol.46, pp.275-86, 2009.

F. Boland, S. Drikes, S. Persac, J. Peron, and P. Delcampe, Gingivopériostoplasties associées à une greffe osseuse : évaluation radiologique, Rev Stomatol Chir Maxillofac

J. Godenèche, J. I. Kraft, T. Le, and T. , prise en charge des fentes faciales jusqu'à l'alvéoloplastie secondaire précoce. Rev Orthopédie Dento-Faciale, vol.45, pp.319-356, 2011.

G. Captier, M. Bigorre, L. Mattei, C. Delestan, and P. Montoya, La greffe osseuse secondaire dans les fentes labio-maxillo-palatines totales : modalités techniques et indications à propos de 62

, Annales de Chirurgie Plastique Esthétique. févr, vol.48, issue.1, pp.20-30, 2003.

. Amanat-n and . Langdon-jd, Secondary alveolar bone grafting in clefts of the lip and palate, Cranio Max Fac Surg, vol.19, pp.7-14, 1991.

A. H. Rehrmann, W. R. Koberg, and H. Koch, Long-term postoperative results of primary and secondary bone grafting in complete clefts of lip and palate, Cleft Palate J, vol.7, pp.206-227, 1970.

R. Vanwijck, B. Bayet, J. Roffé, J. Compère, and H. Benateau, Les séquelles labiales dans les fentes uni-et bilatérales, Rev Stomatol Chir Maxillofac. sept, vol.108, issue.4, pp.265-74, 2007.

J. Talmant, J. Talmant, and J. Lumineau, Les séquelles nasales des fentes unilatérales : analyse et prise en charge, Rev Stomatol Chir Maxillofac. sept, vol.108, issue.4, pp.275-88, 2007.

A. De-mey, C. Malevez, A. Mansbach, and M. George, Prise en charge des fentes labio-maxillo

, palatines à l?hôpital des enfants Reine Fabiola de Bruxelles, Annales de chirurgie plastique esthetique, pp.134-137, 2002.

G. Paulin, P. Astrand, J. B. Rosenquist, and L. Bartholdson, Intermediate bone grafting of alveolar clefts, J Craniomaxillof Surg, vol.16, pp.2-7, 1988.

D. E. Tolman, Reconstructive procedures with endosseous implants in grafted bone: a review of the litterature, Int J Oral Maxillofac Implants, vol.10, pp.275-94, 1995.

J. Torres, F. Tamimi, M. Alkhraisat, E. López-cabarcos, J. C. Prados-frutos et al.,

. Tulasne and A. J. Jf, Les greffes osseuses en implantologie, Quintessence international, vol.117, 2004.

M. M. Davarpanah, Manuel d'implantologie clinique

, CdP, p.338, 1999.

A. Seyed-movaghar and R. Movaghar, Osteodistraction of the maxilla in transverse deficiency in adults: Analysis of the literature and clinical case, International Orthodontics. juin, vol.9, issue.2, pp.157-78, 2011.

L. K. Cheung and H. Chua, A meta-analysis of cleft maxillary osteotomy and distraction osteogenesis, Int J Oral Maxillofac Surg, vol.35, issue.1, pp.14-24, 2006.

B. Raphaël, B. Morand, J. Dechamboux, S. Frénea, M. Richard et al., Ostéotomies maxillomandibulaires : techniques. EMC -Techniques chirurgicales -Chirurgie plastique reconstructrice et esthétique, vol.45, p.14, 2003.

Y. Benchemam, Distraction alvéolaire Alveolar distraction, p.19

A. Picard, P. Diner, D. Labbé, J. Nicolas, C. Tomat et al., Les séquelles maxillaires dans les fentes labioalvéolopalatovélaires. Place de la distraction ostéogénique. Revue de Stomatologie et de Chirurgie Maxillo-faciale, vol.108, pp.313-333, 2007.

J. Buis, P. Rousseau, V. Soupre, H. Martinez, P. A. Diner et al., Distraction of grafted alveolar bone in cleft case using endosseous implant, Cleft Palate Craniofac J, vol.38, pp.405-409, 2001.

S. L. Yen, J. Gross, P. Wang, and D. D. Yamashita, Closure of a large alveolar cleft bony transport of a posterior segment using orthodontic archwires attached to bone: report of a case, J Oral Maxillofac Surg, vol.59, pp.688-691, 2001.

C. G. Finkemeier, Bone-grafting and bone-graft substitutes, J Bone Joint Surg Am, vol.84, 2002.

J. Torres, F. Tamimi, M. Alkhraisat, E. López-cabarcos, J. C. Prados-frutos et al.,

M. Piattelli, G. A. Favero, and A. Scarano, Bone reactions to anorganic bovine bone

, Oss) used in sinus augmentation procedures: a histologic long-term report of 20 cases in humans

, Int J Oral Maxillofac Implants, vol.14, pp.835-840, 1999.

A. S. Greenwald, S. D. Boden, and V. M. Goldberg, Bone-graft substitutes: facts, fictions, and applications, J Bone Joint Surg Am, vol.83, pp.98-103, 2001.

P. Corre, R. Khonsari, L. B. Elamrani, K. Weiss, P. Mercier et al., Les céramiques phosphocalciques synthétiques dans l'alvéoloplastie secondaire. Revue de Stomatologie et de Chirurgie Maxillo-faciale, avr, vol.113, issue.2, pp.131-136, 2012.

A. Frapsauce, C. Luans, O. Azzis, V. Gicquel, M. E. Benlidayi et al., Intérêt du Glassbone® dans la chirurgie des fentes labio-palatines, Le Pharmacien Hospitalier et Clinicien. déc, vol.51, issue.4, p.p, 2006.

. Jensen and . Ot, La chirurgie pré-implantaire: greffes osseuses, Réal. Clin, vol.19, pp.57-65, 2006.

L. Myon, J. Ferri, F. Chai, N. Blanchemain, and R. G. , Ingénierie du tissu osseux oromaxillofacial par combinaison de biomatériaux, cellules souches, thérapie génique. Revue de Stomatologie et de Chirurgie Maxillo-faciale, vol.112, pp.201-212, 2011.

S. Catros, F. Guillemot, J. Amédée, and J. Fricain, Ingénierie tissulaire osseuse en chirurgie buccale et maxillo-faciale : applications cliniques. Médecine Buccale Chirurgie Buccale, vol.16, pp.227-264, 2010.

S. B. Nicoll, Materials for bone graft substitutes and osseous tissue regeneration, Biomaterials for tissue engineering applications

S. Moussaoui, S. Lucas, P. Zorzi, S. C. Le, and J. H. Trouvin, Regulatory framework of cell therapy products, Bull Cancer, vol.90, pp.779-88, 2003.

N. Fontaine and D. Reynders, Directive 2001/83/CE du Parlement europe´en et du Conseil

W. F. Anderson, Human gene therapy, Nature, vol.392, pp.25-30, 1998.

A. A. Scaduto and J. R. Lieberman, Gene therapy for osteoinduction, Orthop Clin North Am, vol.30, pp.625-658, 1999.

D. B. Spagnoli, The application of recombinant human bone morphogenetic protein on adsorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects, pp.43-70, 2008.

W. K. Tom, M. Chin, T. Ng, S. Bouchoucha, and M. Carstens, Distraction of rhBMP-2-generated mandible: how stable is the engineered bone in response to subsequent surgeries?, J Oral Maxillofac Surg, vol.66, pp.1499-505, 2008.

C. H. Rundle, N. Miyakoshi, Y. Kasukawa, S. T. Chen, M. H. Sheng et al.,

J. Fischer, A. Kolk, S. Wolfart, C. Pautke, P. H. Warnke et al., Future of local bone regeneration -protein versus gene therapy, J Craniomaxillofac Surg, vol.39, pp.54-64, 2011.

W. Pradel, E. Tausche, J. Gollogly, and G. Lauer, Spontaneous tooth eruption after alveolar cleft osteoplasty using tissue-engineered bone: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105: 440e444, 2008.

A. De-ruiter, N. Jansen, and R. Van-es, Micro-structured beta-tricalcium phosphate for repair of the alveolar cleft in cleft lip and palate patients: a pilot study, Cleft Palate Craniofac J, vol.52, pp.336-340, 2015.

N. Alonso, D. Y. Tanikawa, R. S. Freitas, C. Jr, L. Ozawa et al., Evaluation of palate patients, Tissue Eng Part C, vol.16, pp.1183-1192, 2010.

C. Jr, L. W. , S. Freitas, R. D. , A. N. Tanikawa et al.,

, Craniofac Surg, vol.23, pp.1627-1660, 2012.

A. S. Herford, P. J. Boyne, R. Rawson, and R. P. Williams, Bone morphogenetic protein-induced repair of the premaxillary cleft, J Oral Maxillofac Surg, vol.65, pp.2136-2177, 2007.

B. P. Dickinson, R. K. Ashley, K. L. Wasson, C. O'hara, J. Gabbay et al.,

, Plast Reconstr Surg, vol.121, pp.209-226, 2008.

C. S. Francis, S. S. Mobin, M. A. Lypka, E. Rommer, Y. S. Urata et al.,

, Plast Reconstr Surg, vol.131, pp.1107-1122, 2013.

X. She, Q. Zhang, K. Tian, L. Yang, and F. G. Xiong, Clinical research on repairing alveolar cleft with osteoinduction active materials, West China J Stomatol, vol.28, pp.391-395, 2010.

S. M. Balaji, Use of recombinant human bone morphogenetic protein (rhBMP-2) in reconstruction of maxillary alveolar clefts, J Maxillofac Oral Surg, vol.8, pp.211-218, 2009.

W. Pradel and G. Lauer, Tissue-engineered bone graft for osteoplasty in patients with cleft alveolus, Ann Anat, vol.194, pp.545-553, 2012.

H. Behnia, A. Khojasteh, M. Soleimani, A. Tehranchi, A. Khoshzaban et al.,

L. Monfoulet, M. Deschepper, K. Vandamme, M. Manassero, P. Becquart et al., Optimisation des matériaux hybrides à base de cellules souches pour la réparation de grands défauts osseux, IRBM. avr, vol.33, issue.2, pp.73-80, 2012.

T. Oyama, S. Nishimoto, T. Tsugawa, and F. Shimizu, Efficacy of platelet-rich plasma in alveolar bone grafting, Journal of Oral and Maxillofacial Surgery. mai, vol.62, issue.5, pp.555-563, 2004.

C. Lee, K. Nishihara, T. Okawachi, Y. Iwashita, H. J. Majima et al., A quantitative radiological assessment of outcomes of autogenous bone graft combined with platelet-rich plasma in the alveolar cleft, International Journal of Oral and Maxillofacial Surgery. févr, vol.38, issue.2, pp.117-142, 2009.

Z. Q. Li, W. J. Ai, and S. G. Liu, Clinical application of absorbable collagen bio-membrane to the bone graft repair of alveolar cleft, Chin J Pract Stomatol, vol.5, pp.41-44, 2012.

M. Peled, D. Aizenbud, J. Horwitz, and E. E. Machtei, Treatment of osseous cleft palate defects: a preliminary evaluation of novel treatment modalities, Cleft Palate Craniofac J, vol.42, issue.4, pp.344-348, 2005.

H. P. Freihofer, W. A. Borstlap, A. M. Kuijpers-jagt-man, R. A. Voorsmit, and P. A. Van-damme,

K. L. Heidbu¨chel and V. M. Borstlap-engels, Tim-ing and transplant materials for closure of alveolar clefts: a clinical comparison of 296 cases, J Craniomaxillofac Surg, vol.21, pp.143-151, 1993.

L. Vu, . Président, and . Jury, Signature : Vu, la Directrice de l'UFR des Sciences Odontologiques