Étude longitudinale de la dysphonie dans l’Ataxie de Friedreich

Abstract : Objective – The purpose of the present work was to analyze the progression of dysphonia in Friedreich Ataxia (FRDA), and evaluate the effect on the quality of life, and finally to explore the clinical markers affecting the symptoms progression.
Method – Thirty-four patients with Friedreich Ataxia were assessed twice, first at baseline and second at one-year follow-up. A population of 34 paired control subjects was also recorded. An acoustic analysis assessed ten voice parameters by Praat (F0, jitter, shimmer, HNR, unvoiced frames) and Vocalab® (F0, F0 instability, amplitude instability, noise-tosignal ratio, attack deterioration, harmonic poverty). A self-assessment via the Voice Handicap Index was also performed.
Results – Attack alteration, amplitude instability, noise-to-signal ratio and harmonic poverty assessed by Vocalab® decreased significantly in 1 year. The men’s voices were higher pitched than the group control and this increase of F0 impacted their quality of life. An age-effect was found on the progression of the voice handicap of patients.
Conclusion – This study suggests that speech therapy in FRDA needs to focus on the four voice markers most affected after one year. Besides, speech therapy should be based not only on the acoustic analysis but also on the patient experience regarding his vocal handicap.
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Mathilde Sibade. Étude longitudinale de la dysphonie dans l’Ataxie de Friedreich. Sciences cognitives. 2019. ⟨dumas-02168393⟩

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