Fièvre et portage asymptomatique en zone rurale au Sénégal, étiologies et prévalence

Abstract : Infectious diseases are the leading cause of death in Senegal and remain a major public health problem in sub-Saharan Africa. Malaria and respiratory infections are the leading causes. Nevertheless, in rural areas, the identification of fever etiologies remains unclear, with restricted access to diagnostic tests. Recently, the use of molecular tools in the rural villages of Dielmo and Ndiop has allowed the identification of emerging pathogens that may be responsible for fever. To explore the causes of fever in Senegal and identify reservoir subjects, our study was conducted on a cohort of 377 febrile subjects and 390 asymptomatic controls residing in the rural villages of Dielmo and Ndiop. Nasopharyngeal and blood samples were collected during 2016 to look for 10 bacteria, 7 respiratory viruses and Plasmodium falciparum by molecular biology In 43% of febrile subjects, microorganisms were found in the blood. The nasopharyngeal prevalence in respiratory pathogens was 93%. H. influenzae and S. pneumoniae were the main infectious agents found with prevalences of 88% and 65% respectively. Their association was found in 51% of febrile patients, both in the blood and in the nasopharynx. Asymptomatic carriage was detected in 53% of controls, both for respiratory bacteria and for Rhinovirus and virus Influenzae A. The high prevalence of respiratory infections highlights their major role in the causes of fever in Senegal and encourages the promotion of vaccination campaigns in rural areas. The identification of healthy carriers for all respiratory pathogens investigated could explain their transmission mechanism, which could potentially lead to epidemic
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Anne-Lise Desjacques. Fièvre et portage asymptomatique en zone rurale au Sénégal, étiologies et prévalence. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02170689⟩

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