, , vol.264, p.13005
, Marseille Cedex 05
, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05
, Service d'Oncologie Médicale -Soins palliatifs, p.13385
, Marseille Cedex 05
, Hôpital Sainte Marguerite, 270 boulevard Sainte, vol.14, p.13385
, Marseille Cedex 05
Auteur correspondant : Docteur Anne-Laure COUDERC, Service de Médecine Interne, Gériatrie et Thérapeutique, Pôle GeST, vol.14 ,
Résumé La polymédication de la personne âgée atteinte de cancer peut être à l'origine d'une iatrogénie médicamenteuse et majorer le risque d'effet indésirable et de réduction de doses des chimiothérapies reçues. Pour éviter cela, nous avons développé une collaboration médico-pharmaceutique en complément de l'évaluation gériatrique standardisée (EGS), vol.264 ,
, Mots clés : collaboration médico-pharmaceutique, révision des thérapeutiques, polymédication, cancer, patient âgé
The Impact of Polypharmacy on Patient Outcomes in Older Adults With Cancer, Cancer J, vol.23, pp.211-219, 2017. ,
Alterations in drug disposition in older adults, Expert Opin Drug Metab Toxicol, vol.11, pp.491-508, 2015. ,
Potential drug interactions and chemotoxicity in older patients with cancer receiving chemotherapy, J Geriatr Oncol, vol.5, pp.307-321, 2014. ,
Pharmacist-led medication assessment and deprescribing intervention for older adults with cancer and polypharmacy: a pilot study, Support Care Cancer, vol.26, pp.4105-4118, 2018. ,
Screening for Vulnerability in Older Cancer Patients: The ONCODAGE Prospective Multicenter Cohort Study. Williams BO, éditeur, PLoS One, vol.9, p.115060, 2014. ,
STOPP/ START criteria for potentially inappropriate prescribing in older people: version 2, Age Ageing, vol.44, pp.213-221, 2014. ,
Development of a rapid risk evaluation tool for herbs/drugs interactions in cancer patients: a multicentric experience in south of France, Eur J Cancer Care (Engl), vol.26, p.12752, 2017. ,
Reversible inhibition of three important human liver cytochrome p450 enzymes by tiliroside, Phytother Res, vol.24, pp.1670-1675, 2010. ,
Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity, Biol Pharm Bull, vol.33, pp.1977-82, 2010. ,
Supportive Care Organization in France: a national in-depth survey among patients and oncologists, Support Care Cancer, vol.25, pp.2111-2119, 2017. ,
Supportive care organisation in France: An in depth study by the French speaking association for supportive care in cancer (AFSOS), Eur J Cancer, vol.49, pp.1090-1096, 2013. ,
Addressing the quality of life needs of older patients with cancer: a SIOG consensus paper and practical guide, Ann Oncol, vol.29, pp.1718-1744, 2018. ,
, Journal d'OncoGériatrie ®, vol.186, 2018.
, Révision des thérapeutiques en oncogériatrie par un binôme médecin-pharmacien ? Revision of oncogeriatric therapies by a physician-pharmacist duo
Validation of the G8 screening tool in geriatric oncology: The ONCODAGE project, J Clin Oncol. 20 mai, vol.29, issue.15_suppl, pp.9001-9001, 2011. ,
Les cancers en France -L'essentiel des faits et chiffre -Edition, 2019. ,
Estimations nationales de l'incidence et de la mortalité par cancer en France métropolitaine entre 1990 et 2018. Étude à partir des registres des cancers du réseau Francim, 2019. ,
Les causes médicales de décès en France en 2004 et leur évolution, p.7 ,
,
,
, Centre d'analyse stratégique. Vivre ensemble plus longtemps, 2010.
, Espérance de vie à divers âges en 2018 | Insee
, Haute Autorité de Santé -Prendre en charge une personne âgée polypathologique en soins primaires
État des lieux et perspectives en oncogériatrie, 2009. ,
Cancer and the elderly, Management. Decision patterns, vol.21, 2000. ,
Améliorer la qualité du système de santé et maîtriser les dépenses : Propositions de l'Assurance Maladie pour 2019, 2018. ,
Optimizing cancer care in the elderly: progress in geriatric oncology, Cancer Control J Moffitt Cancer Cent. déc, vol.10, issue.6, pp.440-441, 2003. ,
Geriatric medical oncology in the care of elderly cancer patients, Crit Rev Oncol Hematol. mars, vol.41, issue.3, pp.343-350, 2002. ,
Problèmes pratiques et éthiques des essais cliniques en gériatrie, Rev Med Suisse, 2001. ,
, Plan Cancer 2014-2019 : synthèse, 2014.
Mechanisms of photodamage of the skin and its functional consequences for skin ageing, Clin Exp Dermatol, vol.26, issue.7, pp.573-580, 2001. ,
Body Composition in Elderly People, Gerontology, vol.31, issue.3, pp.150-157, 1985. ,
Influence of diet and nutritional status on drug metabolism, Clin Pharmacokinet. juill, vol.31, issue.1, pp.47-64, 1996. ,
, Aging Liver. Gerontology, vol.48, issue.6, pp.343-53, 2002.
Liver Function and Phase I Drug Metabolism in the Elderly: A Paradox, Drugs Aging, vol.18, issue.11, pp.837-51, 2001. ,
When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly, Exp Gerontol. août, vol.38, issue.8, pp.843-53, 2003. ,
The Aging Kidney: Physiological Changes, Adv Chronic Kidney Dis. juill, vol.17, issue.4, pp.302-309, 2010. ,
Pharmacokinetics of Indomethacin in the Elderly, Clin Pharmacokinet. mai, vol.24, issue.5, pp.428-462, 1993. ,
Age as a factor affecting lithium therapy, Br J Clin Pharmacol. avr, vol.4, issue.2, pp.201-206, 1977. ,
Mechanisms of Cisplatin nephrotoxicity, Toxins, vol.2, issue.11, pp.2490-518, 2010. ,
The problems of anticholinergic adverse effects in older patients, Drugs Aging. août, vol.3, issue.4, pp.335-383, 1993. ,
Predictors of Early Death Risk in Older Patients Treated With First-Line Chemotherapy for Cancer, J Clin Oncol, vol.30, issue.15, pp.1829-1863, 2012. ,
Adjuvant Chemotherapy in Older and Younger Women With Lymph NodePositive Breast Cancer, JAMA. 2 mars, vol.293, issue.9, p.1073, 2005. ,
Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients, Arch Intern Med. 13 juin, vol.171, issue.11, pp.1013-1022, 2011. ,
Adverse drug events as a cause of hospital admission in the elderly, Intern Med J. juin, vol.31, issue.4, pp.199-205, 2001. ,
Medication and Falls: Risk and Optimization, Clin Geriatr Med. nov, vol.26, issue.4, pp.583-605, 2010. ,
Co-morbidity leads to altered treatment and worse survival of elderly patients with colorectal cancer, Br J Surg. mai, vol.92, issue.5, pp.615-638, 2005. ,
Polypharmacy and potentially inappropriate medication use in geriatric oncology, J Geriatr Oncol, vol.7, issue.5, pp.346-53, 2016. ,
Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people, Pharmacoepidemiol Drug Saf. juin, vol.24, issue.6, pp.637-683, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02006072
Frailty, polypharmacy, and potentially inappropriate medications in old people: findings in a representative sample of the French population, Eur J Clin Pharmacol. sept, vol.73, issue.9, pp.1165-72, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01802861
Patient characteristics associated with polypharmacy and inappropriate prescribing of medications among older adults with cancer, J Geriatr Oncol. juill, vol.3, issue.3, pp.228-265, 2012. ,
, Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults, American Geriatrics Society, vol.67, issue.4, pp.674-94, 2019.
Pharmacist-led medication assessment and deprescribing intervention for older adults with cancer and polypharmacy: a pilot study, Support Care Cancer. déc, vol.26, issue.12, pp.4105-4118, 2018. ,
Implementing a pharmacist-led, individualized medication assessment and planning (iMAP) intervention to reduce medication related problems among older adults with cancer, J Geriatr Oncol. juill, vol.8, issue.4, pp.296-302, 2017. ,
,
, Rev Med Interne. juill, vol.30, issue.7, pp.592-601, 2009.
The Impact of Polypharmacy on Patient Outcomes in Older Adults With Cancer, Cancer J Sudbury Mass. août, vol.23, issue.4, pp.211-219, 2017. ,
Potential drug interactions and chemotoxicity in older patients with cancer receiving chemotherapy, J Geriatr Oncol. juill, vol.5, issue.3, pp.307-321, 2014. ,
, Les unités de coordination et antennes d'oncogériatrie -Oncogériatrie
Use of comprehensive geriatric assessment in older cancer patients, Crit Rev Oncol Hematol. sept, vol.55, issue.3, pp.241-52, 2005. ,
Clinical assessment of elderly people with cancer, Lancet Oncol, vol.6, issue.10, pp.790-797, 2005. ,
A practical approach to geriatric assessment in oncology, J Clin Oncol Off J Am Soc Clin Oncol. 10 mai, vol.25, issue.14, pp.1936-1980, 2007. ,
Comprehensive geriatric assessment for older patients with cancer, J Clin Oncol Off J Am Soc Clin Oncol. 10 mai, vol.25, issue.14, pp.1824-1855, 2007. ,
The Role of Primary Care Physicians in Cancer Care, J Gen Intern Med. sept, vol.24, issue.9, pp.1029-1065, 2009. ,
Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology, J Clin Oncol. août, vol.36, issue.22, pp.2326-2373, 2018. ,
Mini Nutritional Assessment : a practical assessment tool for grading the nutritional state of elderly patients, Facts res gerontol, issue.4, pp.15-59, 1994. ,
« Mini-mental state ». A practical method for grading the cognitive state of patients for the clinician, J Psychiatr Res, vol.12, issue.3, pp.189-98, 1975. ,
CLOX: an executive clock drawing task, J Neurol Neurosurg Psychiatry. 1 mai, vol.64, issue.5, pp.588-94, 1998. ,
Geriatric Depression Scale (GDS): Recent Evidence and Development of a Shorter Version, Clin Gerontol, vol.9, issue.1-2, pp.165-73, 1986. ,
STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION, JAMA. 21 sept, vol.185, pp.914-923, 1963. ,
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living, The Gerontologist. 1 sept, vol.9, issue.3, pp.179-86, 1969. ,
The timed « Up & Go »: a test of basic functional mobility for frail elderly persons, J Am Geriatr Soc. févr, vol.39, issue.2, pp.142-150, 1991. ,
Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale, Psychiatry Res. mars, vol.41, issue.3, pp.237-285, 1992. ,
A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, J Chronic Dis, vol.40, issue.5, pp.373-83, 1987. ,
The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-ofLife Instrument for Use in International Clinical Trials in Oncology, JNCI J Natl Cancer Inst. 3 mars, vol.85, issue.5, pp.365-76, 1993. ,
International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer, Br J Cancer. août, vol.109, issue.4, pp.852-860, 2013. ,
Management of cancer in the older person: a practical approach, The Oncologist, vol.5, issue.3, pp.224-261, 2000. ,
, Initiative des HIGH 5s Medication Reconciliation Rapport d'expérimentation sur la mise en oeuvre de la conciliation des traitements médicamenteux par neuf établissements de santé français, 2015.
, Mettre en oeuvre la conciliation des traitements médicamenteux en établissement de santé, HAS, 2018.
Medication Reconciliation Across Care Transitions in the Pediatric Medical Home, Jt Comm J Qual Patient Saf. mars, 2019. ,
Impact of Pharmacist-Conducted Medication Reconciliation at Discharge on Readmissions of Elderly Patients With COPD, Ann Pharmacother. févr, vol.48, issue.2, pp.203-211, 2014. ,
Fiche mémo -Préconisations pour la pratique des bilans partagés de médication ,
Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review, Cancer. 15 juin, vol.91, issue.12, pp.2214-2235, 2001. ,
Geriatric Factors Predict Chemotherapy Feasibility: Ancillary Results of FFCD 2001-02 Phase III Study in First-Line Chemotherapy for Metastatic Colorectal Cancer in Elderly Patients, J Clin Oncol. 10 avr, vol.31, issue.11, pp.1464-70, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-02088193
Addressing the quality of life needs of older patients with cancer: a SIOG consensus paper and practical guide, Ann Oncol. 1 août, vol.29, issue.8, pp.1718-1744, 2018. ,
soins et protection sociale en, 2000. ,