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Master Thesis

The Croatian version of the HSCL-25 scale: an external validation study set against scan, in primary care daily practice

Abstract : Depression is a very common disease in Europe. The Hopkins Symptom Checklist in 25 items (HSCL-25) helps to assess anxiety and depression in Primary Care.It was translated it in Croatian language. This study aimed to determine the external validation of the HSCL-25 in its Croatian version (C-HSCL-25) by comparing it to the Schedules for Clinical Assessment in Neuropsychiatry in its Croatian version (C-SCAN). Method : a comparative, non-inferiority, multi-centered, quantitative cross-validation study of C-HCSL-25 in an adult Croatian general practice population was carried out. Two groups were formed: C-HSCL-25+and C-HSCL-25-. A validated cut-off score of > 1.75 was considered to assess depression and anxiety. The C-SCAN was randomly administered to 1 in 2 patients in the C-HSCL-25 ≥ 1.75 group, and to 1 in 16 in the C-HSCL-25 <1.75 group. C-HSCL-25 efficiencies data: Positive (PPV) and Negative (NPV) predictive values, Sensibility (Se), Specificity (Sp), were calculated comparing C-SCAN after prevalence correction. Results : the overall prevalence was 24.75%. 804 patients completed the C-HSCL-25; respectively 605 C-HSCL-25- and 199 C-HSCL-25+. Patients were randomized for C-SCAN interview; respectively 49 in C-HSCL-25- group and 57 in C-HSCL-25+ group. After prevalence correction: efficiencies data were: PPV 59.6%, NPV 81.6%; Se 51.6%, and Sp 86%. Conclusion : the C-HSCL-25 is an efficient tool to diagnose anxiety and depression in primary care. The high NPV add of value the research set in daily practice. Dimensionality and reliability were completed in a complementary study. The whole psychometrics data will be determinate for usability in primary care research.
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Master Thesis
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Submitted on : Tuesday, July 9, 2019 - 11:22:20 AM
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  • HAL Id : dumas-02177621, version 1



Sandrine Blondiau. The Croatian version of the HSCL-25 scale: an external validation study set against scan, in primary care daily practice. Life Sciences [q-bio]. 2019. ⟨dumas-02177621⟩



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