A chemical perspective on the anthracycline antitumour antibiotics, Environ. Health Perspect, vol.64, pp.3-18, 1985. ,
DNA base modifications induced in isolated human chromatin by NADH dehydrogenase-catalysed reduction of doxorubicin, Biochemistry, vol.31, pp.3500-3506, 1992. ,
Lower incidence of doxorubicin-induced cardiomyopathy by once a week low-dose administration, American Heart Journal, vol.111, issue.4, pp.755-759, 1986. ,
Intervention of adriamycin induced free radical damage, Biochemistry international, vol.28, issue.4, pp.735-744, 1992. ,
Enhancement of doxorubicin toxicity following activation by NADPH cytochrome-P450 reductase, Biochem. Pharmacol, vol.43, issue.7, pp.1449-1457, 1992. ,
Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells, Biochem. Pharmacol, vol.38, pp.787-793, 1989. ,
Development of mechanisms of protection against oxidative stress in doxorubicin-resistant rat tumoral cells in culture, Free Rad. Res. Comms, vol.11, issue.1-3, pp.137-144, 1990. ,
The physiological role of zinc as antioxidant. Free Rad, Biot. Med, vol.8, pp.281-291, 1990. ,
Human plasma pharmacokinetics of doxorubicin: comparison of bolus and infusional administration, Cancer Treat. Symp, vol.3, pp.77-83, 1984. ,
Mediation of subacute anthracycline cardiotoxicity in rabbits by cardiac histamine release, J. Cardiovasc. Pharmacol, vol.5, pp.913-919, 1983. ,
Reduction of toxicity and increase antitumor effect of adriamycin by N-acyl dehydroalanines, a new family of free radical scavengers, Adv. Exp. Med. Biol, vol.264, pp.339-344, 1990. ,
Detecting DNA damage, Analytical Chemistry, vol.65, issue.15, pp.675-682, 1993. ,
Overexpression of glutathione S-transferase and elevation of thiol pools in a multidrug-resistant human colon cancer cell line, Molecular Pharmacology, vol.41, pp.69-75, 1991. ,
La résistance aux agents antitumoraux cytotoxiques, pp.163-174, 1991. ,
Protective effect of zinc on carbon tetrachloride-induced liver injury in rats, Exp. Mol. Pharmacol, vol.19, pp.186-196, 1973. ,
Effect of zinc deficiency on lipid peroxidation status and infarct size in rat hearts. /nt, J. Cardiology, vol.41, pp.109-113, 1993. ,
Anticancéreux: utilisation pratique. Dossier du CNIMH, hors série, 1992. ,
Pharmacology of adrian1ycin: the message to the clinician ,
, Eur. J. Cancer. Clin. Oncol, vol.24, issue.4, pp.579-582, 1987.
The molecular pharmacology of Doxorubicin in vivo, Eur. J. Cancer, vol.27, issue.5, pp.532-535, 1991. ,
Protein damage and degradation by oxygen radicals: general aspects, J. Biot. Chem, vol.262, issue.20, pp.9895-9901, 1987. ,
Protein damage and degradation by oxygen radicals: modification of amino acids, J. Biol. Chem, vol.262, issue.20, pp.9902-9907, 1987. ,
Protein damage and degradation by oxygen radicals: modification of secondary and tertiary structure, J. Biot. Chem, vol.262, issue.20, pp.9908-9913, 1987. ,
Protein damage and degradation by oxygen radicals: degradation of denatured protein, J. Biot. Chem, vol.262, issue.20, pp.9914-9920, 1987. ,
Vitamin E protects proteins against free radical damage in lipid environments, Biochem. Biophys. Res. Comms, vol.148, issue.3, pp.1277-1282, 1987. ,
Free radicals as mediators of tissue injury, Acta Physiol. Scand, vol.492, pp.43-57, 1980. ,
Binding of transferrin-iron by adriamycin at acidic pH, Febs Lett, vol.196, pp.321-324, 1986. ,
Inactivation of cytochrome c oxidase activity in mitochondrial membranes during redox cycling of doxorubicin, Biochem. Pharmacol, vol.41, issue.4, pp.543-552, 1991. ,
Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis, Arch. Biochem. Biophys, vol.235, issue.2, pp.343-350, 1984. ,
Prevention of doxorubicin cardiac toxicity by N-acetylcysteine, J. Clin. Invest, vol.65, pp.128-135, 1981. ,
Effect of anthracycline antibiotics on oxygen radical formation in rat heart, Cancer Res, vol.43, pp.460-472, 1983. ,
Doxorubicin-induced cardiac toxicity, N. Engt. J. Med, vol.324, issue.12, pp.843-845, 1991. ,
Oxidative destruction of DNA by the adriamycin-iron complex, Biochemistry, vol.23, pp.928-936, 1984. ,
Les radicaux libres dérivés de l'oxygène et la peroxydation lipidique. Rôle en biologie et en physiopathologie. Presse méd, vol.15, pp.751-754, 1986. ,
, Pharmacologie anticancéreuse. In Schorderet M.: Pharmacologie, des concepts fondamentaux aux applications thérapeutiques. FrisonRoche, 1992.
Ecole d'été de formation à la biologie des radicaux libres, Defence of the body against free radicals, 1992. ,
, Biological aspect of superoxyde radical and superoxide dismutases, pp.171-181, 1977.
The biology of oxygen radical, Science, vol.201, pp.875-880, 1978. ,
Cardiolipin requirement for electron transfer in complex 1 and III of the mitochondrial respiratory chain, J. Biot. Chem, vol.256, pp.1874-1880, 1981. ,
A new insight into adriamycin-induced cardiotoxicity. /nt, J. of Cardiology, vol.29, pp.15-20, 1990. ,
The oxygen forming oxidase responsible for the respiratory burst in human neutrophils, J. Biot. Chem, vol.254, pp.9070-9074, 1979. ,
Effect of doxorubicin on heart mitochondrial enzymes in rats: a protective role for alpha-tocopherol, Indian J. Experimentat Biology, vol.30, pp.615-618, 1992. ,
The biochemical basis of anthracycline toxicity and antitumor activity, Rev. Biochem. Toxicot, vol.5, pp.1-82, 1983. ,
Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin, Biochem. Biophys. Res. Commun, vol.77, pp.797-803, 1977. ,
Cardiotoxicity of anthracyclines, Eur. J. Cancer Clin. Oncol, vol.20, issue.2, pp.293-296, 1984. ,
Adriamycin induced lipid peroxidation in mitochondria and microsomes, Biochem. Pharmacol, vol.37, pp.3071-3077, 1988. ,
Antioxidant properties of caeruloplasmin toward copper and iron dependant oxygen radical formation, Febs Lett, vol.172, pp.245-249, 1984. ,
Ascorbic acid, metal ions and the superoxide radical, Biochem. J, vol.155, pp.697-700, 1976. ,
, Free radicals in biology and medicine, 1989.
Effect of doxorubicin-enhanced hydrogen peroxide and hydroxyl radical formation on calcium sequestration by cardiac sarcoplasmic reticulum, Biochem. Biophys. Res. Commun, vol.130, pp.739-745, 1985. ,
Adriamycin and its iron(III) and copper(II) complexes, Biochem. Pharmacol, vol.37, issue.19, pp.3663-3669, 1988. ,
Etude de l'effet des antioxydants sur la peroxydation microsomale induite par l'adriamycine. Mémoire du DES de pharmacie hospitalière et des collectivités 1993, Anticancereux et especes reactives de l'oxygene, vol.1 ,
Spectrophotometric assay of thiols, Methods in enzymotogy, vol.143, pp.44-67, 1987. ,
Doxorubicin (Adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity, vol.47, pp.219-231, 1990. ,
Comparaison of the biological alteration elicited in li ver from rats treated with carbon tetrachloric acid, chloroform, 1 '1 '2-trichloroethane and 1 '1 '1-trichloroethane, Biochem. Pharmacol, vol.15, pp.374-384, 1969. ,
Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: correlation with vitamin E content, Lipids, vol.15, issue.5, pp.315-322, 1979. ,
Antioxidant functions of carotenoids. Free Rad, Biol. Med, vol.7, pp.617-635, 1989. ,
Adriamycin-induced myocardial dysfunction in vitro is mediated by free radicals, Am. J. Physiol, vol.261, pp.989-995, 1991. ,
Clinical and pharmacologie investigation of the effects of a-tocopherol on adriamycin cardiotoxicity, Annals New-York Academy of Sciences, pp.411-416, 1982. ,
Protection by salvianolic acid A against adriamycin toxicity on rat heart mitochondria ,
, Biol. Med, vol.12, pp.347-351, 1992.
Myocardial damage induced by doxorubicins: Hydroperoxide-initiated chemiluminescence and morphology. Free Rad, Biot. Med, vol.8, pp.259-264, 1990. ,
Further studies on the generation of reactives oxygen species from activated anthracyclines and the relationship to cytotoxic action and cardiotoxic effects, Biochem. Pharmacol, vol.31, issue.4, pp.575-581, 1982. ,
, J. Biot. Chem, vol.193, pp.265-275, 1951.
Adriamycin-induced cardiotoxicity (cardiomyopathy and congestive heart failure) in rats, Cancer Res, vol.37, pp.2705-2713, 1977. ,
Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation, Biochem. Pharmacol, vol.30, issue.20, pp.2797-2804, 1981. ,
The role of iron on the initiation of lipid peroxidation, Chem. Phys. Lipids, vol.44, pp.191-208, 1987. ,
Adriamycin-dependent release of iron from microsomal membranes, Arch. Biochem. Biophys, vol.268, pp.398-403, 1989. ,
Reactions of adriamycin with microsomal iron and lipids. Free Rad, Res. Comms, vol.7, issue.3-6, pp.143-148, 1989. ,
Possible sources of iron for lipid peroxidation, Free Rad. Res. Comms, pp.99-106, 1991. ,
Release of iron from ferritin by semiquinone, anthracycline, bipyridyl and nitroaromatic radicals. Free Radie, vol.6, pp.587-591, 1989. ,
Protective effects of spin-trapping agents on adriamycin-induced cardiotoxicity in isolated rat atria, Free Rad. Res. Comms, vol.14, issue.1, pp.41-45, 1991. ,
Hydroxyl radical production and DNA damage induced by anthracycline-iron complex, Febs Lett, vol.172, issue.2, pp.226-230, 1984. ,
Adriamycin: amelioration of toxicity by alphatocopherol, Cancer Treatment Reports, vol.60, issue.7, pp.961-962, 1976. ,
Biochemical determinants of adriamycin toxicity in mouse liver, heart, and intestine, Biochem. Pharmacol, vol.43, issue.4, pp.831-836, 1992. ,
Doxorubicin cardiotoxicity: analysis of prevailing hypotheses, Faseb J, vol.4, pp.3076-3086, 1990. ,
The inhibition of radical-initiated peroxidation of microsomal lipids by both alpha-tocopherol and B-carotène. Free Rad, vol.11, pp.407-414, 1991. ,
The effect of doxorubicin on the transport of pyruvate in rat-heart mitochondria, Biochem. Biophys. Res. Comms, vol.156, pp.1302-1307, 1988. ,
Anthracycline metabolism and free radical formation, Metabolism and action of anticancer drugs, pp.211-260, 1987. ,
Free radical formation by antitumor quinones. Free Rad, Biol. Med, vol.6, pp.63-101, 1989. ,
Inhibition of doxorubicin-initiated membrane damage by Nacetylcysyeine: possible mediation by a thiol-dependent, cytosolic inhibitor of lipid peroxidation, Toxicol. Appt. Pharmacol, vol.96, pp.175-184, 1988. ,
PZ-51 (Ebselen) in vivo protection against adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity, Biochem. Pharmacol, vol.44, issue.4, pp.839-841, 1992. ,
Oxygen radical detoxification enzymes in doxorubicin-sensitive and -resistant P388 murine leukemia cells, Cancer Res, vol.44, 1976. ,
Biochemistry of selenium. A brief overview, Fundam. Appl. Toxicol, vol.3, pp.431-436, 1983. ,
Doxorubicin-dependent lipid peroxidation at low partial pressures of 02, J. Free Rad. Biot. Med, vol.1, pp.43-49, 1985. ,
Ferritin, lipid peroxidation and redoxcycling xenobiotics, Free Rad. Res. Comms, pp.107-114, 1991. ,
, Adriamycine Semiquinone AGPI: Acides gras polyinsaturés AR: Acide 13-cis rétinoïque CA T: Catalase ERO: Espèces réactives oxygénées GPX: Glutathion peroxydase H202: Peroxyde d'hydrogène MDA: Malondialdehyde NA C: N-acétylcystéine NADPH: Nicotinamide adénine dinucléotide phosphate 0 0H: Radical hydroxyle RLO: Radicaux libres oxygénés SOD: Superoxyde dismutase Abréviations