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H. J. Timmers, A. Kozupa, C. C. Chen, J. A. Carrasquillo, A. Ling et al., Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma, J Clin Oncol, vol.25, issue.16, pp.2262-2271, 2007.

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S. Gabriel, E. M. Blanchet, F. Sebag, C. C. Chen, N. Fakhry et al., Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions, Clin Endocrinol (Oxf), vol.79, issue.2, pp.170-177, 2013.
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C. C. Feral, F. S. Tissot, L. Tosello, N. Fakhry, F. Sebag et al., )F-fluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L, Eur J Nucl Med Mol Imaging, vol.44, issue.18, pp.812-833, 2017.

D. Hanahan and R. A. Weinberg, Hallmarks of cancer: the next generation, Cell, vol.144, issue.5, pp.646-74, 2011.

D. Taieb, F. Sebag, A. Barlier, L. Tessonnier, F. F. Palazzo et al., 18F-FDG avidity of pheochromocytomas and paragangliomas: a new molecular imaging signature?, J Nucl Med

H. J. Timmers, C. C. Chen, J. A. Carrasquillo, M. Whatley, A. Ling et al., Staging and functional characterization of pheochromocytoma and paraganglioma by 18Ffluorodeoxyglucose (18F-FDG) positron emission tomography, J Natl Cancer Inst, vol.104, issue.9, pp.700-708, 2012.

H. J. Timmers, C. C. Chen, J. A. Carrasquillo, M. Whatley, A. Ling et al., Comparison of 18F-Fluoro-L-DOPA, 18F-Fluoro-Deoxyglucose, and 18F-Fluorodopamine PET and 123I

, MIBG Scintigraphy in the Localization of Pheochromocytoma and Paraganglioma, Journal of Clinical Endocrinology and Metabolism, vol.94, issue.12, pp.4757-67, 2009.

H. J. Timmers, A. Kozupa, C. C. Chen, J. A. Carrasquillo, A. Ling et al., Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma, Journal of Clinical Oncology, vol.25, issue.16, pp.2262-2271, 2007.

E. Letouze, C. Martinelli, C. Loriot, N. Burnichon, N. Abermil et al., SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma, Cancer cell, vol.23, issue.6, pp.739-52, 2013.

P. Garrigue, A. Bodin-hullin, L. Balasse, S. Fernandez, W. Essamet et al., The Evolving Role of Succinate in Tumor Metabolism: An (18)F-FDG-Based Study, J Nucl Med, vol.58, issue.11, pp.1749-55, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01770170

D. Taieb and K. Pacak, New Insights into the Nuclear Imaging Phenotypes of Cluster 1

P. Pheochromocytoma, Trends Endocrinol Metab, vol.28, issue.11, pp.807-824, 2017.

V. Amodru, C. Guerin, S. Delcourt, P. Romanet, A. Loundou et al., Quantitative (18)F-DOPA PET/CT in pheochromocytoma: the relationship between tumor secretion and its biochemical phenotype, Eur J Nucl Med Mol Imaging, vol.45, issue.2, pp.278-82, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01876274

S. Moog, S. Houy, C. E. Ory, S. Weryha, G. Rame et al.,

, Uptake Parameters Correlate with Catecholamine Secretion in Human Pheochromocytomas

, Neuroendocrinology, vol.107, issue.3, 2018.

S. Gabriel, E. M. Blanchet, F. Sebag, C. C. Chen, N. Fakhry et al., Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions, Clinical endocrinology, vol.79, issue.2, pp.170-177, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00966225

I. Janssen, E. M. Blanchet, K. Adams, C. C. Chen, C. M. Millo et al., Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma. Clinical cancer research : an official journal of the American Association for CancerResearch, vol.21, pp.3888-95, 2015.

J. S. Fonte, J. F. Robles, C. C. Chen, J. Reynolds, M. Whatley et al., )I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease, Endocr Relat Cancer, vol.19, issue.1, pp.83-93, 2012.

H. J. Timmers, K. Pacak, T. T. Huynh, M. Abu-asab, M. Tsokos et al., Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene, J Clin Endocrinol Metab, vol.93, issue.12, pp.4826-4858, 2008.

C. C. Feral, F. S. Tissot, L. Tosello, N. Fakhry, F. Sebag et al., Ffluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L, Eur J Nucl Med Mol Imaging, vol.44, issue.18, pp.812-833, 2017.

J. Crona, A. Lamarca, S. Ghosal, S. Welin, B. Skogseid et al., Genotype-phenotype correlations in pheochromocytoma and paraganglioma, Endocr Relat Cancer, 2019.

S. Hescot, M. Curras-freixes, T. Deutschbein, A. Van-berkel, D. Vezzosi et al., Prognosis of malignant pheochromocytoma and paraganglioma (MAPP-Prono study): an ENS@T retrospective study, J Clin Endocrinol Metab, p.23, 2019.

?. Abréviations and . Hnpgl,

?. Pggl, Phéochromocytomes et paragangliomes ? PGL : paragangliomes

?. Sdh, Succinate déshydrogènase. ? SDHx : mutations liées au gène SDH ? TCA : cycle de Krebs. ? HIF : facteurs induisant l'hypoxie

?. Pnmt-:-phenylethanolamine-n-methyltransferase and ?. Emt,

?. ,

?. Tep/tdm, tomographie par émission de positon/ Tomodensitométrie. ? 18 F-FDG : fluorodésoxyglucose, vol.18

, 123I metaiodobenzylguanidine ? PHDs : prolyl-hydroxylase domain proteins ? LAT : transporteur d'acide aminé neutre du système L ? SUVmax : Valeur de fixation normalisée maximale ? SUVmean : Valeur de fixation normalisée moyenne

?. Tl-uptake, Fixation de la lésion totale ? MTV 42% : Volume métabolique tumoral avec isocontour à 42% ? MBq : MégaBecquerels ? WB: corps entire ? DT: David TAÏEB ? Q1: 1 e quartile ? Q3: 3 e quartile ? SD: Ecart type ? PK : protéine kinase

D. Hanahan and R. A. Weinberg, Hallmarks of cancer: the next generation, Cell, vol.144, issue.5, pp.646-74, 2011.

D. Taieb, F. Sebag, A. Barlier, L. Tessonnier, F. F. Palazzo et al., 18F-FDG avidity of pheochromocytomas and paragangliomas: a new molecular imaging signature?, J Nucl Med, vol.50, issue.5, pp.711-718, 2009.

H. J. Timmers, C. C. Chen, J. A. Carrasquillo, M. Whatley, A. Ling et al.,

, Staging and functional characterization of pheochromocytoma and paraganglioma by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography, J Natl Cancer Inst

H. J. Timmers, C. C. Chen, J. A. Carrasquillo, M. Whatley, A. Ling et al.,

-. Comparison-of-18f-fluoro, 1. 18f-fluoro-deoxyglucose, and 1. , Scintigraphy in the Localization of Pheochromocytoma and Paraganglioma, Journal of Clinical Endocrinology and Metabolism, vol.94, issue.12, pp.4757-67, 2009.

H. J. Timmers, A. Kozupa, C. C. Chen, J. A. Carrasquillo, A. Ling et al.,

, Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma, Journal of Clinical Oncology, vol.25, issue.16, pp.2262-2271, 2007.

E. Letouze, C. Martinelli, C. Loriot, N. Burnichon, N. Abermil et al., SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma, Cancer cell, vol.23, issue.6, pp.739-52, 2013.

P. Garrigue, A. Bodin-hullin, L. Balasse, S. Fernandez, W. Essamet et al., The Evolving Role of Succinate in Tumor Metabolism: An (18)F-FDG-Based Study, J Nucl Med, vol.58, issue.11, pp.1749-55, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01770170

D. Taieb and K. Pacak, New Insights into the Nuclear Imaging Phenotypes of Cluster 1

P. Pheochromocytoma, Trends Endocrinol Metab, vol.28, issue.11, pp.807-824, 2017.

V. Amodru, C. Guerin, S. Delcourt, P. Romanet, A. Loundou et al.,

F. Pet/, CT in pheochromocytoma: the relationship between tumor secretion and its biochemical phenotype, Eur J Nucl Med Mol Imaging, vol.45, issue.2, pp.278-82, 2018.

S. Moog, S. Houy, C. E. Ory, S. Weryha, G. Rame et al.,

, Uptake Parameters Correlate with Catecholamine Secretion in Human Pheochromocytomas, Neuroendocrinology, vol.107, issue.3, 2018.

S. Gabriel, E. M. Blanchet, F. Sebag, C. C. Chen, N. Fakhry et al., Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions, Clinical endocrinology, vol.79, issue.2, pp.170-177, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00966225

I. Janssen, E. M. Blanchet, K. Adams, C. C. Chen, C. M. Millo et al.,

, Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma

, Clinical cancer research : an official journal of the American Association for Cancer Research, vol.21, pp.3888-95, 2015.

J. S. Fonte, J. F. Robles, C. C. Chen, J. Reynolds, M. Whatley et al., )I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease, Endocr Relat Cancer, vol.19, issue.1, pp.83-93, 2012.

H. J. Timmers, K. Pacak, T. T. Huynh, M. Abu-asab, M. Tsokos et al.,

, Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene, J Clin Endocrinol Metab, vol.93, issue.12, pp.4826-4858, 2008.

C. C. Feral, F. S. Tissot, L. Tosello, N. Fakhry, F. Sebag et al., )Ffluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L, Eur J Nucl Med Mol Imaging, vol.44, issue.18, pp.812-833, 2017.

J. Crona, A. Lamarca, S. Ghosal, S. Welin, B. Skogseid et al., Genotype-phenotype correlations in pheochromocytoma and paraganglioma, Endocr Relat Cancer, 2019.

S. Hescot, M. Curras-freixes, T. Deutschbein, A. Van-berkel, D. Vezzosi et al., Prognosis of malignant pheochromocytoma and paraganglioma (MAPP-Prono study): an ENS@T retrospective study, J Clin Endocrinol Metab, 2019.