,
Clinically guided genetic screening in a large cohort of italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas, J Clin Endocrinol Metab, vol.94, issue.5, pp.1541-1548, 2009. ,
Paragangliomas of the head and neck, Otolaryngol Clin North Am, vol.19, issue.4, pp.755-67, 1986. ,
Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients, J Clin Endocrinol Metab, vol.86, issue.11, pp.5210-5216, 2001. ,
New Insights into the Nuclear Imaging Phenotypes of Cluster 1 ,
, Trends Endocrinol Metab, vol.28, issue.11, pp.807-824, 2017.
SDH mutations establish a hypermethylator phenotype in paraganglioma, Cancer Cell, vol.23, issue.6, pp.739-52, 2013. ,
Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing, Clin Biochem Rev, vol.38, issue.2, pp.69-100, 2017. ,
Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene, J Clin Endocrinol Metab, vol.93, issue.12, pp.4826-4858, 2008. ,
Paragangliomas of the craniocervical region. An immunohistochemical study on tyrosine hydroxylase, Acta Neuropathol, vol.73, issue.3, pp.227-259, 1987. ,
18F-FDG avidity of pheochromocytomas and paragangliomas: a new molecular imaging signature?, J Nucl Med, vol.50, issue.5, pp.711-718, 2009. ,
Staging and functional characterization of pheochromocytoma and paraganglioma by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography, J Natl Cancer Inst, vol.104, issue.9, pp.700-708, 2012. ,
Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma, J Clin Endocrinol Metab, vol.94, issue.12, pp.4757-67, 2009. ,
Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma, J Clin Oncol, vol.25, issue.16, pp.2262-2271, 2007. ,
The Evolving Role of Succinate in Tumor Metabolism: An (18)F-FDG-Based Study, J Nucl Med, vol.58, issue.11, pp.1749-55, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01770170
Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions, Clin Endocrinol (Oxf), vol.79, issue.2, pp.170-177, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00966225
)F-fluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L, Eur J Nucl Med Mol Imaging, vol.44, issue.18, pp.812-833, 2017. ,
Hallmarks of cancer: the next generation, Cell, vol.144, issue.5, pp.646-74, 2011. ,
18F-FDG avidity of pheochromocytomas and paragangliomas: a new molecular imaging signature?, J Nucl Med ,
Staging and functional characterization of pheochromocytoma and paraganglioma by 18Ffluorodeoxyglucose (18F-FDG) positron emission tomography, J Natl Cancer Inst, vol.104, issue.9, pp.700-708, 2012. ,
, Comparison of 18F-Fluoro-L-DOPA, 18F-Fluoro-Deoxyglucose, and 18F-Fluorodopamine PET and 123I
, MIBG Scintigraphy in the Localization of Pheochromocytoma and Paraganglioma, Journal of Clinical Endocrinology and Metabolism, vol.94, issue.12, pp.4757-67, 2009.
Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma, Journal of Clinical Oncology, vol.25, issue.16, pp.2262-2271, 2007. ,
SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma, Cancer cell, vol.23, issue.6, pp.739-52, 2013. ,
The Evolving Role of Succinate in Tumor Metabolism: An (18)F-FDG-Based Study, J Nucl Med, vol.58, issue.11, pp.1749-55, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01770170
New Insights into the Nuclear Imaging Phenotypes of Cluster 1 ,
, Trends Endocrinol Metab, vol.28, issue.11, pp.807-824, 2017.
Quantitative (18)F-DOPA PET/CT in pheochromocytoma: the relationship between tumor secretion and its biochemical phenotype, Eur J Nucl Med Mol Imaging, vol.45, issue.2, pp.278-82, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01876274
,
, Uptake Parameters Correlate with Catecholamine Secretion in Human Pheochromocytomas
, Neuroendocrinology, vol.107, issue.3, 2018.
Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions, Clinical endocrinology, vol.79, issue.2, pp.170-177, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00966225
Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma. Clinical cancer research : an official journal of the American Association for CancerResearch, vol.21, pp.3888-95, 2015. ,
)I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease, Endocr Relat Cancer, vol.19, issue.1, pp.83-93, 2012. ,
Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene, J Clin Endocrinol Metab, vol.93, issue.12, pp.4826-4858, 2008. ,
Ffluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L, Eur J Nucl Med Mol Imaging, vol.44, issue.18, pp.812-833, 2017. ,
Genotype-phenotype correlations in pheochromocytoma and paraganglioma, Endocr Relat Cancer, 2019. ,
Prognosis of malignant pheochromocytoma and paraganglioma (MAPP-Prono study): an ENS@T retrospective study, J Clin Endocrinol Metab, p.23, 2019. ,
,
, Phéochromocytomes et paragangliomes ? PGL : paragangliomes
, Succinate déshydrogènase. ? SDHx : mutations liées au gène SDH ? TCA : cycle de Krebs. ? HIF : facteurs induisant l'hypoxie
,
,
, tomographie par émission de positon/ Tomodensitométrie. ? 18 F-FDG : fluorodésoxyglucose, vol.18
, 123I metaiodobenzylguanidine ? PHDs : prolyl-hydroxylase domain proteins ? LAT : transporteur d'acide aminé neutre du système L ? SUVmax : Valeur de fixation normalisée maximale ? SUVmean : Valeur de fixation normalisée moyenne
, Fixation de la lésion totale ? MTV 42% : Volume métabolique tumoral avec isocontour à 42% ? MBq : MégaBecquerels ? WB: corps entire ? DT: David TAÏEB ? Q1: 1 e quartile ? Q3: 3 e quartile ? SD: Ecart type ? PK : protéine kinase
Hallmarks of cancer: the next generation, Cell, vol.144, issue.5, pp.646-74, 2011. ,
18F-FDG avidity of pheochromocytomas and paragangliomas: a new molecular imaging signature?, J Nucl Med, vol.50, issue.5, pp.711-718, 2009. ,
,
, Staging and functional characterization of pheochromocytoma and paraganglioma by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography, J Natl Cancer Inst
,
Scintigraphy in the Localization of Pheochromocytoma and Paraganglioma, Journal of Clinical Endocrinology and Metabolism, vol.94, issue.12, pp.4757-67, 2009. ,
,
, Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma, Journal of Clinical Oncology, vol.25, issue.16, pp.2262-2271, 2007.
SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma, Cancer cell, vol.23, issue.6, pp.739-52, 2013. ,
The Evolving Role of Succinate in Tumor Metabolism: An (18)F-FDG-Based Study, J Nucl Med, vol.58, issue.11, pp.1749-55, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01770170
New Insights into the Nuclear Imaging Phenotypes of Cluster 1 ,
, Trends Endocrinol Metab, vol.28, issue.11, pp.807-824, 2017.
,
CT in pheochromocytoma: the relationship between tumor secretion and its biochemical phenotype, Eur J Nucl Med Mol Imaging, vol.45, issue.2, pp.278-82, 2018. ,
,
, Uptake Parameters Correlate with Catecholamine Secretion in Human Pheochromocytomas, Neuroendocrinology, vol.107, issue.3, 2018.
Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions, Clinical endocrinology, vol.79, issue.2, pp.170-177, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00966225
,
, Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma
, Clinical cancer research : an official journal of the American Association for Cancer Research, vol.21, pp.3888-95, 2015.
)I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease, Endocr Relat Cancer, vol.19, issue.1, pp.83-93, 2012. ,
,
, Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene, J Clin Endocrinol Metab, vol.93, issue.12, pp.4826-4858, 2008.
)Ffluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L, Eur J Nucl Med Mol Imaging, vol.44, issue.18, pp.812-833, 2017. ,
Genotype-phenotype correlations in pheochromocytoma and paraganglioma, Endocr Relat Cancer, 2019. ,
Prognosis of malignant pheochromocytoma and paraganglioma (MAPP-Prono study): an ENS@T retrospective study, J Clin Endocrinol Metab, 2019. ,