Skip to Main content Skip to Navigation
Master Thesis

Thrombopénies immunologiques liées à des anticorps anti-plaquettes méthylprednisolone-dépendants

Abstract : Introduction: drug-induced immune thrombocytopenia is due to anti-platelet antibodies active only on presence of the suspected treatment. They are usually associated with a unique drug. Materiel and methods: between 2009 and 2017, six adult patients with a suspected methylprednisolone (MP)-induced immune thrombocytopenia for which sera where addressed to the Mondor hospital EFS unit were included. Their medical charts were retrospectively reviewed. Drug-induced anti-platelet antibodies were screened by the MAIPA test and identified by an adsorption-elution method. Results: the six patients presented with acute and profound thrombocytopenia occurring after a MP infusion and resolving in a week. MP-induced antiplatelet antibodies were found in the blood of all the six patients. All had been previously exposed to MP without adverse events. Five out of 6 patients had chemotherapy for neoplasia. Three out of the 5 patients had associated thrombocytopenia induced by oxaliplatin or folinic acid anti-platelets antibodies. Adsorption-elution analysis of 2 patients suggested the presence on 2 different drug-induced anti-platelets antibodies (MP and folinic acid or MP and oxaliplatin). Conclusion: we report 6 cases of MP-induced immune thrombocytopenia. Three of them had associated folinic acid or oxaliplatin-induced thrombocytopenia mediated by different drug-induced anti-platelets antibodies.
Document type :
Master Thesis
Complete list of metadata

Cited literature [57 references]  Display  Hide  Download
Contributor : Université Paris Descartes - Scd Connect in order to contact the contributor
Submitted on : Thursday, September 5, 2019 - 9:42:26 AM
Last modification on : Friday, October 23, 2020 - 4:42:54 PM
Long-term archiving on: : Thursday, February 6, 2020 - 5:52:25 AM


Files produced by the author(s)


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License


  • HAL Id : dumas-02279171, version 1


Marie Dubert. Thrombopénies immunologiques liées à des anticorps anti-plaquettes méthylprednisolone-dépendants. Médecine humaine et pathologie. 2018. ⟨dumas-02279171⟩



Record views


Files downloads