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, Rapport sur les données de contrôle antidopage | Agence mondiale antidopage
intérêt de la Santé publique ma profession avec conscience et de respecter non seulement la législation en vigueur mais aussi les règles de l'Honneur ,
, De ne jamais oublier ma responsabilité et mes devoirs envers le malade et sa dignité humaine
, De ne dévoiler à personne les secrets qui m'auraient été confiés ou dont j'aurais
, En aucun cas, je ne consentirai à utiliser mes connaissances et mon état pour corrompre les moeurs et favoriser les actes criminels
, Que les hommes m'accordent leur estime si je suis fidèle à mes promesses
, Que je sois méprisé de mes Confrères si je manque à mes engagements
, Dopage : nouveaux médicaments influant sur la biogenèse mitochondriale et musculaire
Dans les molécules antagonistes on retrouve les inhibiteurs de l'histone acétyltransférase GCN5 (par exemple MB-3, CPTH2), un inhibiteur du cycle folate-méthionine (MOTS-c), des inhibiteurs des voies de signalisation de la myostatine (par exemple Stamulumab, PINTA-745, REGN-2477, Ramatercept, BMS-986089, Bimagrumab). Le co-répresseur des récepteurs nucléaires 1 (NCoR-1) a été identifié comme une cible potentielle viable dans l'amélioration de la fonction musculaire mais aucun inhibiteur de cette protéine n'a encore été rapporté à ce jour. Certains de ces composés ont déjà fait l'objet d'utilisations abusives par des sportifs dans le but d'améliorer leurs performances. La nécessité de mettre en place des mesures antidopage préventives et proactives semble indispensable à la lutte contre ces nouvelles substances. Cependant le nombre limité d'informations sur leur métabolisme et leur élimination complique fortement les analyses antidopage, MOTS CLES : Dopage -Mitochondries -Muscles striés squelettiques -Sport _______________________________________________________________________________ JURY : Président : Pr Jean Pierre GOULLÉ, Professeur émérite Membres : Pr Michel GUERBET, Professeur Pr Philippe VÉRITÉ, 2019. ,