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Master Thesis

Utilité et tolérance de la réalisation d’une biopsie hépatique pour l’exploration des anomalies hépatiques après une allogreffe de cellules souches hématopoïétiques

Abstract : Liver blood tests abnormalities are common after allogeneic hematopoietic stem cell transplantation (allo-HSCT) but their cause often remains difficult to identify. Our objective was to evaluate the safety and utility of liver biopsy in patients who underwent allo-HSCT. In a retrospective single center cohort study, we reviewed all cases of patients who underwent liver biopsy between June 2005 and July 2017. During this period, 54 biopsies were performed in 45 patients; 38 patients underwent allo-HSCT for malignant and 7 for non-malignant hematological disorders. Median time between allo-HSCT and liver biopsy was 213 days. Seven biopsies were percutaneous and 47 transjugular. No adverse event related to the biopsy procedure occurred. Graft versus host disease was histologically demonstrated in 16 biopsies (30%), and sinusoidal obstruction syndrome in 3 (5%). Association between clinical, laboratory, imaging and pathological features was poor. Only 34% of physicians’ pre-biopsy hypotheses were confirmed by pathological findings. Patient management was influenced by liver biopsy results in 65% of the cases, allowing to identify a new diagnosis (n=13), ruled out a differential diagnosis (n=14) or confirmed the main hypothesis (n=6). In conclusion, liver biopsy is a safe and useful technique to investigate liver blood test abnormalities following allo-HSCT.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02299131
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  • HAL Id : dumas-02299131, version 1

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Mathilde Ruggiu. Utilité et tolérance de la réalisation d’une biopsie hépatique pour l’exploration des anomalies hépatiques après une allogreffe de cellules souches hématopoïétiques. Médecine humaine et pathologie. 2018. ⟨dumas-02299131⟩

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