X. Duval, F. Delahaye, A. F. Tattevin, P. Obadia, J. et al., Temporal Trends in Infective Endocarditis in the Context of Prophylaxis Guideline Modifications, J Am Coll Cardiol. mai, vol.59, issue.22, pp.1968-76, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00825449

C. Selton-suty, M. Célard, L. Moing, V. Doco-lecompte, T. Chirouze et al., Preeminence of Staphylococcus aureus in Infective Endocarditis: A 1-Year Population-Based Survey, Clin Infect Dis. 1 mai, vol.54, issue.9, pp.1230-1239, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00825451

A. S. Bayer, Infective endocarditis, Clin Infect Dis Off Publ Infect Dis Soc Am. sept, vol.17, issue.3, pp.321-323, 1993.
URL : https://hal.archives-ouvertes.fr/inserm-01519135

P. Brouqui and D. Raoult, New insight into the diagnosis of fastidious bacterial endocarditis, FEMS Immunol Med Microbiol. juin, vol.47, issue.1, pp.1-13, 2006.

N. Benito, J. M. Miró, E. De-lazzari, C. H. Cabell, A. Del-río et al., Health Care-Associated Native Valve Endocarditis in Patients with no History of Injection Drug Use: Current Importance of NonNosocomial Acquisition, Ann Intern Med. 5 mai, vol.150, issue.9, pp.586-94, 2009.

J. J. Federspiel, Increasing US Rates of Endocarditis With Staphylococcus aureus: 1999-2008, Arch Intern Med. 27 févr, vol.172, issue.4, p.363, 2012.

S. Tong, J. S. Davis, E. Eichenberger, T. L. Holland, and V. G. Fowler, Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management, Clin Microbiol Rev. juill, vol.28, issue.3, pp.603-61, 2015.

L. M. Baddour, W. R. Wilson, A. S. Bayer, V. G. Fowler, I. M. Tleyjeh et al., Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association, Circulation, vol.132, issue.15, pp.1435-86, 2015.

L. Moing, V. , A. F. Doco-lecompte, T. Delahaye, F. Piroth et al., Staphylococcus aureus Bloodstream Infection and Endocarditis -A Prospective Cohort Study. Greub G, éditeur, PLOS ONE. 28 mai, vol.10, issue.5, p.127385, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01299980

V. G. Fowler, J. M. Miro, B. Hoen, C. H. Cabell, E. Abrutyn et al., Staphylococcus aureus Endocarditis: A Consequence of Medical Progress, JAMA. 22 juin, vol.293, issue.24, pp.3012-3033, 2005.

H. Asgeirsson, A. Thalme, M. Kristjansson, and O. Weiland, Incidence and outcome of Staphylococcus aureus endocarditis-a 10-year single-centre northern European experience, Clin Microbiol Infect. août, vol.21, issue.8, pp.772-780, 2015.

T. L. Holland, L. M. Baddour, A. S. Bayer, B. Hoen, J. M. Miro et al., Infective endocarditis. Nat Rev Dis Primer, vol.01, p.16059, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01519135

M. Bouaouina and L. Halbwachs-mecarelli, Activation des intégrines et adhérence des leucocytes et des plaquettes, Hématologie. 1 janv, vol.12, issue.1, pp.21-33, 2006.

K. Werdan, S. Dietz, B. Löffler, S. Niemann, H. Bushnaq et al., Mechanisms of infective endocarditis: pathogen-host interaction and risk states, Nat Rev Cardiol. janv, vol.11, issue.1, pp.35-50, 2014.

P. Moreillon and Y. Que, Infective endocarditis. The Lancet, janv, vol.10, issue.9403, pp.139-188, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00465409

Z. Esquer-garrigos and M. R. Sohail, Attachment is the source of all suffering: delineating mechanisms of adhesion in Staphylococcus aureus endocarditis, Eur Heart J, vol.17, issue.2019

D. Sur,

L. Liesenborghs, S. Meyers, M. Lox, M. Criel, J. Claes et al., Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves, Eur Heart J. 3 mars, 2019.

J. P. Remadi, G. Habib, G. Nadji, A. Brahim, F. Thuny et al., Predictors of Death and Impact of Surgery in Staphylococcus aureus Infective Endocarditis, Ann Thorac Surg. avr, vol.83, issue.4, pp.1295-302, 2007.

A. J. Sanfilippo, M. H. Picard, J. B. Newell, E. Rosas, R. Davidoff et al., Echocardiographic assessment of patients with infectious endocarditis: Prediction of risk for complications, J Am Coll Cardiol, vol.18, issue.5, pp.1191-1200, 1991.

M. Rizzi, V. Ravasio, A. Carobbio, I. Mattucci, M. Crapis et al., Predicting the occurrence of embolic events: an analysis of 1456 episodes of infective endocarditis from the Italian Study on Endocarditis (SEI), BMC Infect Dis. 29 avr, vol.14, p.230, 2014.

J. M. Miro, I. Anguera, C. H. Cabell, A. Y. Chen, J. A. Stafford et al., , p.11

B. Iung, S. Tubiana, I. Klein, D. Messika-zeitoun, E. Brochet et al., Determinants of Cerebral Lesions in Endocarditis on Systematic Cerebral Magnetic Resonance Imaging: A Prospective Study, Stroke. nov, vol.44, issue.11, pp.3056-62, 2013.

S. Hubert, F. Thuny, N. Resseguier, R. Giorgi, C. Tribouilloy et al., Prediction of Symptomatic Embolism in Infective Endocarditis, J Am Coll Cardiol, vol.62, issue.15, pp.1384-92, 2013.

V. Pergola, G. D. Salvo, G. Habib, J. Avierinos, P. E. Vailloud et al., Comparison of clinical and echocardiographic characteristics of Streptococcus bovis endocarditis with that caused by other pathogens, Am J Cardiol, vol.88, issue.8, pp.871-876, 2001.

J. M. Steckelberg, Emboli in Infective Endocarditis: The Prognostic Value of Echocardiography, Ann Intern Med. 15 avr, vol.114, issue.8, p.635, 1991.

I. Vilacosta, C. Graupner, J. Sanromán, C. Sarriá, R. Ronderos et al., Risk of embolization after institution of antibiotic therapy for infective endocarditis, J Am Coll Cardiol. 1 mai, vol.39, issue.9, pp.1489-95, 2002.

D. Salvo, G. Habib, G. Pergola, V. Avierinos, J. et al., Echocardiography predicts embolic events in infective endocarditis, J Am Coll Cardiol. mars, vol.37, issue.4, pp.1069-76, 2001.

M. Heiro, J. Nikoskelainen, E. Engblom, E. Kotilainen, R. Marttila et al., Neurologic Manifestations of Infective Endocarditis: A 17-Year Experience in a Teaching Hospital in Finland, Arch Intern Med, vol.160, issue.18, pp.2781-2788, 2000.

F. Thuny, J. Avierinos, C. Tribouilloy, G. R. Casalta, J. Milandre et al., Impact of cerebrovascular complications on mortality and neurologic outcome during infective endocarditis: a prospective multicentre study, Eur Heart J. 1 mai, vol.28, issue.9, pp.1155-61, 2007.

A. Yang, C. Tan, N. Adhikari, N. Daneman, R. Pinto et al., Time-sensitive predictors of embolism in patients with left-sided endocarditis: Cohort study, PloS One, vol.14, issue.4, p.215924, 2019.

F. Thuny, G. Disalvo, O. Belliard, J. Avierinos, V. Pergola et al., Risk of Embolism and Death in Infective Endocarditis: Prognostic Value of Echocardiography: A Prospective Multicenter Study, Circulation. 5 juill, vol.112, issue.1, pp.69-75, 2005.

S. Rohmann, R. Erbel, H. Darius, T. Makowski, and M. Jür, Effect of antibiotic treatment on vegetation size and complication rate in infective endocarditis, Clin Cardiol. févr, vol.20, issue.2, pp.132-172, 1997.

E. García-cabrera, N. Fernández-hidalgo, B. Almirante, R. Ivanova-georgieva, M. Noureddine et al., Neurological complications of infective endocarditis: risk factors, outcome, and impact of cardiac surgery: a multicenter observational study, Circulation. 11 juin, vol.127, issue.23, pp.2272-84, 2013.

D. R. Murdoch, Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century: The International Collaboration on Endocarditis-Prospective Cohort Study, Arch Intern Med. 9 mars, vol.169, issue.5, p.463, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00465395

G. Habib, P. Lancellotti, M. J. Antunes, M. G. Bongiorni, J. Casalta et al., ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC)Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM), Eur Heart J, vol.36, issue.44, pp.3075-128, 2015.

J. S. Li, D. J. Sexton, M. N. Nettles, R. Fowler, V. G. Ryan et al., Proposed Modifications to the Duke Criteria for the Diagnosis of Infective Endocarditis, Clin Infect Dis. 1 avr, vol.30, issue.4, pp.633-641, 2000.

J. C. Castillo, Long term outcome of infective endocarditis in patients who were not drug addicts: a 10 year study, Heart. 1 mai, vol.83, issue.5, pp.525-555, 2000.

A. S. Bayer, P. M. Sullam, M. Ramos, C. Li, A. L. Cheung et al., Staphylococcus aureus Induces Platelet Aggregation via a Fibrinogen-Dependent Mechanism Which Is Independent of Principal Platelet Glycoprotein IIb/IIIa Fibrinogen-Binding Domains, INFECT IMMUN, vol.63, p.8, 1995.

J. R. Fitzgerald, T. J. Foster, and D. Cox, The interaction of bacterial pathogens with platelets, Nat Rev Microbiol. juin, vol.4, issue.6, pp.445-57, 2006.

A. Loughman, J. R. Fitzgerald, M. P. Brennan, J. Higgins, R. Downer et al., Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A: Platelet activation by Staphylococcus aureus ClfA, Mol Microbiol. 30 juin, vol.57, issue.3, pp.804-822, 2005.

S. W. Kerrigan and D. Cox, Platelet-bacterial interactions, Cell Mol Life Sci. 1 févr, vol.67, issue.4, pp.513-536, 2010.

P. M. Sullam, A. S. Bayer, W. M. Foss, and A. L. Cheung, Diminished Platelet Binding In Vitro by Staphylococcus aureus Is Associated with Reduced Virulence in a Rabbit Model of Infective Endocarditis, INFECT IMMUN, vol.64, p.7, 1996.

J. S. Bennett, Structure and function of the platelet integrin ?IIb?3, J Clin Invest. 1 déc, vol.115, issue.12, pp.3363-3372, 2005.

M. Herrmann, Q. J. Lai, R. M. Albrecht, D. F. Mosher, and R. A. Proctor, Adhesion of Staphylococcus aureus to Surface-Bound Platelets: Role of Fibrinogen/Fibrin and Platelet Integrins, J Infect Dis. 1 févr, vol.167, issue.2, pp.312-334, 1993.

D. Mcdevitt, P. Francois, P. Vaudaux, and T. J. Foster, Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus, Mol Microbiol. janv, vol.11, issue.2, pp.237-285, 1994.

D. N. Eidhin, S. Perkins, P. Francois, P. Vaudaux, M. Höök et al., Clumping factor B (ClfB), a new surfacelocated fibrinogen-binding adhesin of Staphylococcus aureus, Mol Microbiol, vol.30, issue.2, pp.245-57, 1998.

J. I. Flock, G. Fröman, K. Jönsson, B. Guss, C. Signäs et al., Cloning and expression of the gene for a fibronectin-binding protein from Staphylococcus aureus, EMBO J. août, vol.6, issue.8, pp.2351-2358, 1987.

L. Liesenborghs, P. Verhamme, and T. Vanassche, Staphylococcus aureus , master manipulator of the human hemostatic system, J Thromb Haemost. mars, vol.16, issue.3, pp.441-54, 2018.

J. R. Fitzgerald, A. Loughman, F. Keane, M. Brennan, M. Knobel et al., Fibronectin-binding proteins of Staphylococcus aureus mediate activation of human platelets via fibrinogen and fibronectin bridges to integrin GPIIb/IIIa and IgG binding to the FcgammaRIIa receptor, Mol Microbiol. janv, vol.59, issue.1, pp.212-242, 2006.

T. J. Foster, The remarkably multifunctional fibronectin binding proteins of Staphylococcus aureus, Eur J Clin Microbiol Infect Dis. 1 déc, vol.35, issue.12, pp.1923-1954, 2016.

C. Liu, T. Huang, P. Tsai, P. Tsai, C. Chang et al., A segment of Staphylococcus aureus clumping factor A with fibrinogen-binding activity (ClfA221-550) inhibits platelet-plug formation in mice, Thromb Res. janv, vol.121, issue.2, pp.183-91, 2007.

Y. Que, P. Francois, J. Haefliger, J. Entenza, P. Vaudaux et al., Reassessing the Role of Staphylococcus aureus Clumping Factor and Fibronectin-Binding Protein by Expression in Lactococcus lactis, Infect Immun, vol.69, issue.10, pp.6296-302, 2001.

Y. Que, J. Haefliger, L. Piroth, P. François, E. Widmer et al., Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis, J Exp Med. 16 mai, vol.201, issue.10, pp.1627-1662, 2005.

T. R. Veloso, A. Chaouch, T. Roger, M. Giddey, J. Vouillamoz et al., Use of a Human-Like Low-Grade Bacteremia Model of Experimental Endocarditis To Study the Role of Staphylococcus aureus Adhesins and Platelet Aggregation in Early Endocarditis, Payne SM, éditeur. Infect Immun. mars, vol.81, issue.3, pp.697-703, 2013.

P. Moreillon, J. M. Entenza, P. Francioli, D. Mcdevitt, T. J. Foster et al., Role of Staphylococcus aureus Coagulase and Clumping Factor in Pathogenesis of Experimental Endocarditis, INFECT IMMUN, vol.63, p.6, 1995.

P. Saravia-otten, H. P. Müller, and S. Arvidson, Transcription of Staphylococcus aureus fibronectin binding protein genes is negatively regulated by agr and an agr-independent mechanism, J Bacteriol. sept, vol.179, issue.17, pp.5259-63, 1997.

H. Miajlovic, A. Loughman, M. Brennan, D. Cox, and T. J. Foster, Both Complement-and Fibrinogen-Dependent Mechanisms Contribute to Platelet Aggregation Mediated by Staphylococcus aureus Clumping Factor B, Infect Immun. 1 juill, vol.75, issue.7, pp.3335-3378, 2007.

J. M. Entenza, T. J. Foster, N. Eidhin, D. Vaudaux, P. Francioli et al., Contribution of Clumping Factor B to Pathogenesis of Experimental Endocarditis due to Staphylococcus aureus, Infect Immun. sept, vol.68, issue.9, pp.5443-5449, 2000.

H. Miajlovic, M. Zapotoczna, J. A. Geoghegan, S. W. Kerrigan, P. Speziale et al., Direct interaction of ironregulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets, Microbiology. 1 mars, vol.156, issue.3, pp.920-928, 2010.

H. Hamzeh-cognasse, D. P. Chabert, A. Pozzetto, B. Cognasse, F. Garraud et al., Platelets and infectionscomplex interactions with bacteria, Front Immunol, vol.6, p.82, 2015.

J. S. Bennett, B. W. Berger, and P. C. Billings, The structure and function of platelet integrins, J Thromb Haemost. juill, vol.7, pp.200-205, 2009.

K. J. Clemetson and J. M. Clemetson, Platelet GPIb complex as a target for anti-thrombotic drug development, Thromb Haemost, vol.99, issue.3, pp.473-482, 2008.

D. Cox, S. W. Kerrigan, and S. P. Watson, Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation: Platelets and the innate immune system, J Thromb Haemost. juin, vol.9, issue.6, pp.1097-107, 2011.

M. O'seaghdha, C. J. Van-schooten, S. W. Kerrigan, J. Emsley, G. J. Silverman et al., Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions: Molecular analysis of protein A-vWF interaction, FEBS J. nov, vol.273, issue.21, pp.4831-4872, 2006.

O. A. Hamad, P. H. Nilsson, D. Wouters, J. D. Lambris, K. N. Ekdahl et al., Complement Component C3 Binds to Activated Normal Platelets without Preceding Proteolytic Activation and Promotes Binding to Complement Receptor 1, J Immunol. 1 mars, vol.184, issue.5, pp.2686-92, 2010.

A. Verschoor and H. F. Langer, Crosstalk between platelets and the complement system in immune protection and disease, Thromb Haemost, vol.110, issue.11, pp.910-919, 2013.

E. I. Peerschke, W. Yin, and B. Ghebrehiwet, Complement activation on platelets: Implications for vascular inflammation and thrombosis, Mol Immunol. août, vol.47, issue.13, pp.2170-2175, 2010.

E. Peerschke, A. S. Bayer, B. Ghebrehiwet, and Y. Q. Xiong, gC1qR/p33 Blockade Reduces Staphylococcus aureus Colonization of Target Tissues in an Animal Model of Infective Endocarditis, Infect Immun. 1 août, vol.74, issue.8, pp.4418-4441, 2006.

S. W. Kerrigan, N. Clarke, A. Loughman, G. Meade, T. J. Foster et al., Molecular Basis for Staphylococcus aureus -Mediated Platelet Aggregate Formation Under Arterial Shear In Vitro, Arterioscler Thromb Vasc Biol. févr, vol.28, issue.2, pp.335-375, 2008.

B. Boylan, C. Gao, V. Rathore, J. C. Gill, D. K. Newman et al., Identification of Fc RIIa as the ITAMbearing receptor mediating IIb 3 outside-in integrin signaling in human platelets, Blood, vol.112, issue.7, pp.2780-2786, 2008.

R. G. Worth, C. D. Chien, P. Chien, M. P. Reilly, S. E. Mckenzie et al., Platelet Fc?RIIA binds and internalizes IgG-containing complexes, Exp Hematol, vol.34, issue.11, pp.1490-1495, 2006.

L. O´brien, S. W. Kerrigan, G. Kaw, M. Hogan, J. Penadés et al., Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A: Multiple mechanisms for stimulating platelet aggregation in S. aureus, Mol Microbiol. 9 mai, vol.44, issue.4, pp.1033-1077, 2002.

S. Bhakdi and J. Tranum-jensen, Alpha-toxin of Staphylococcus aureus, Microbiol Rev. déc, vol.55, issue.4, pp.733-51, 1991.

S. Kerrigan, D. Cox, R. M. Kini, K. J. Clemetson, F. S. Markland et al., The Effect of Bacterial Toxins on Platelet Function, pp.637-51, 2010.

M. Arvand, S. Bhakdi, B. Dahlbäck, and K. T. Preissner, Staphylococcus aureus alpha-toxin attack on human platelets promotes assembly of the prothrombinase complex, J Biol Chem. 25 août, vol.265, issue.24, pp.14377-81, 1990.

J. G. White and G. Rao, Effects of the lonophore A23187 on, Blood Platelets, vol.77, issue.2, p.16, 1974.

M. E. Powers, R. Becker, A. Sailer, J. R. Turner, B. Wardenburg et al., Synergistic Action of Staphylococcus aureus ?-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis, Cell Host Microbe. 10 juin, vol.17, issue.6, pp.775-87, 2015.

T. Parimon, Z. Li, D. D. Bolz, E. R. Mcindoo, C. R. Bayer et al., Staphylococcus aureus ?-hemolysin promotes platelet-neutrophil aggregate formation, J Infect Dis. 1 sept, vol.208, issue.5, pp.761-70, 2013.

M. R. Yeaman, Platelets in defense against bacterial pathogens, Cell Mol Life Sci. févr, vol.67, issue.4, pp.525-569, 2010.

A. S. Bayer, M. D. Ramos, B. E. Menzies, M. R. Yeaman, A. J. Shen et al., Hyperproduction of Alpha-Toxin by Staphylococcus aureus Results in Paradoxically Reduced Virulence in Experimental Endocarditis: a Host Defense Role for, Platelet Microbicidal Proteins. INFECT IMMUN, vol.65, p.9, 1997.

J. D. Fraser and T. Proft, The bacterial superantigen and superantigen-like proteins, Immunol Rev. oct, vol.225, issue.1, pp.226-269, 2008.

D. Haas, C. Weeterings, C. Vughs, M. M. , D. Groot et al., Staphylococcal superantigen-like 5 activates platelets and supports platelet adhesion under flow conditions, which involves glycoprotein Ibα and α IIb Π2

, J Thromb Haemost, vol.7, issue.11, pp.1867-74, 2009.

I. R. Siboo, H. F. Chambers, and P. M. Sullam, Role of SraP, a Serine-Rich Surface Protein of Staphylococcus aureus, in Binding to Human Platelets, Infect Immun. 1 avr, vol.73, issue.4, pp.2273-80, 2005.

T. Nguyen, B. Ghebrehiwet, and E. Peerschke, Staphylococcus aureus Protein A Recognizes Platelet gC1qR/p33: a Novel Mechanism for Staphylococcal Interactions with Platelets, Infect Immun. 1 avr, vol.68, issue.4, pp.2061-2069, 2000.

T. Vanassche, A. Kauskot, J. Verhaegen, W. E. Peetermans, J. Ryn et al., Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation, Thromb Haemost. juin, vol.107, issue.6, pp.1107-1128, 2012.

J. Claes, L. Liesenborghs, M. Peetermans, T. R. Veloso, D. Missiakas et al., Clumping factor A, von Willebrand factor-binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall, J Thromb Haemost JTH. mai, vol.15, issue.5, pp.1009-1028, 2017.

J. Higgins, A. Loughman, K. Van-kessel, J. Van-strijp, and T. J. Foster, Clumping factor A of Staphylococcus aureus inhibits phagocytosis by human polymorphonuclear leucocytes, FEMS Microbiol Lett. mai, vol.258, issue.2, pp.290-296, 2006.

H. R. Lijnen, B. V. Hoef, F. D. Cock, K. Okada, S. Ueshima et al., On the mechanism of fibrin-specific plasminogen activation by staphylokinase, J Biol Chem. 25 juin, vol.266, issue.18, pp.11826-11858, 1991.

N. Harraghy, sae is essential for expression of the staphylococcal adhesins, Eap and Emp. Microbiology. 1 juin, vol.151, issue.6, pp.1789-800, 2005.

Y. Chien, A. C. Manna, and A. L. Cheung, SarA level is a determinant of agr activation in Staphylococcus aureus, Mol Microbiol, vol.30, issue.5, pp.991-1001, 1998.

A. L. Cheung, J. M. Koomey, C. A. Butler, S. J. Projan, and V. A. Fischetti, Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr, Proc Natl Acad Sci U S A. 15 juill, vol.89, issue.14, pp.6462-6468, 1992.

A. K. Waller, T. Sage, C. Kumar, T. Carr, J. M. Gibbins et al., Staphylococcus aureus Lipoteichoic Acid Inhibits Platelet Activation and Thrombus Formation via the Paf Receptor, J Infect Dis. 15 déc, vol.208, issue.12, pp.2046-57, 2013.

O. Shannon, A. Uekötter, and J. Flock, Extracellular fibrinogen binding protein, Efb, from Staphylococcus aureus as an antiplatelet agent in vivo, Thromb Haemost, vol.93, issue.5, pp.927-958, 2005.

M. C. Herzberg, K. Gong, G. D. Macfarlane, P. R. Erickson, A. H. Soberay et al., Phenotypic Characterization of Streptococcus sanguis Virulence Factors Associated with Bacterial Endocarditis, INFECT IMMUN, vol.58, p.8, 1990.

S. W. Kerrigan, A role for glycoprotein Ib in Streptococcus sanguis-induced platelet aggregation, Blood. 28 juin, vol.100, issue.2, pp.509-525, 2002.

M. C. Herzberg, K. Gong, N. N. Armstrong, A. R. Witt, P. R. Erickson et al., The Platelet Interactivity Phenotype of Streptococcus sanguis Influences the Course of Experimental Endocarditis, vol.60, p.10, 1992.

C. Plummer, H. Wu, S. W. Kerrigan, G. Meade, D. Cox et al., A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb, Br J Haematol. avr, vol.129, issue.1, pp.101-110, 2005.

M. C. Herzberg, L. K. Krishnan, and G. D. Macfarlane, Involvement of ?2-Adrenoreceptors and G Proteins in the Modulation of Platelet Secretion in Response to Streptococcus sanguis, Crit Rev Oral Biol Med. avr, vol.4, issue.3, pp.435-477, 1993.

I. Ford, C. Douglas, J. Heath, C. Rees, and F. E. Preston, Evidence for the involvement of complement proteins in platelet aggregation by Streptococcus sanguis NCTC 7863, Br J Haematol. sept, vol.94, issue.4, pp.729-768, 1996.

I. Ford, C. Douglas, D. Cox, D. Rees, J. Heath et al., The role of immunoglobulin G and fibrinogen in platelet aggregation by Streptococcus sanguis, Br J Haematol. juin, vol.97, issue.4, pp.737-7446, 1997.

C. Pampolina and A. Mcnicol, Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by Fc?RIIA and ?IIb?3, Thromb Haemost, vol.93, issue.05, pp.932-941, 2005.

M. Arman, K. Krauel, D. O. Tilley, C. Weber, D. Cox et al., Amplification of bacteria-induced platelet activation is triggered by Fc?RIIA, integrin ?IIb?3, and platelet factor 4, Blood. 15 mai, vol.123, issue.20, pp.3166-74, 2014.

K. Krauel, C. Weber, S. Brandt, U. Zahringer, U. Mamat et al., Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes, Blood, vol.120, issue.16, pp.3345-52, 2012.

P. M. Sullam, W. C. Hyun, J. Szöllösi, J. Dong, W. M. Foss et al., Physical Proximity and Functional Interplay of the Glycoprotein Ib-IX-V Complex and the Fc Receptor Fc?RIIA on the Platelet Plasma Membrane, J Biol Chem. 27 févr, vol.273, issue.9, pp.5331-5337, 1998.

A. Mcnicol, A. Agpalza, E. Jackson, H. Hamzeh-cognasse, O. Garraud et al., Streptococcus sanguinis-induced cytokine release from platelets: Platelet activation by S. sanguinis and epinephrine, J Thromb Haemost, vol.9, issue.10, pp.2038-2087, 2011.

A. Y. Abdulrehman, E. Jackson, and A. Mcnicol, Platelet activation by Streptococcus sanguinis is accompanied by MAP kinase phosphorylation, Platelets. 1 févr, vol.24, issue.1, pp.6-14, 2013.

P. R. Erickson and M. C. Herzberg, Purification and partial characterization of a 65-kDa platelet aggregationassociated protein antigen from the surface of Streptococcus sanguis, J Biol Chem. 25 août, vol.265, issue.24, pp.14080-14087, 1990.

P. R. Erickson and M. C. Herzberg, The Streptococcus sanguis platelet aggregation-associated protein. Identification and characterization of the minimal platelet-interactive domain, J Biol Chem. 25 janv, vol.268, issue.3, pp.1646-1655, 1993.

M. C. Herzberg, A. Nobbs, L. Tao, A. Kilic, E. Beckman et al., Oral Streptococci and Cardiovascular Disease: Searching for the Platelet Aggregation-Associated Protein Gene and Mechanisms of Streptococcus sanguis -Induced Thrombosis, J Periodontol, vol.76, issue.11-s, pp.2101-2106, 2005.

M. C. Herzberg, Platelet-Streptococcal Interactions in Endocarditis, Crit Rev Oral Biol Med. juill, vol.7, issue.3, pp.222-258, 1996.

H. Flad and E. Brandt, Platelet-derived chemokines: pathophysiology and therapeutic aspects, Cell Mol Life Sci. 1 juill, vol.67, issue.14, pp.2363-86, 2010.

J. Fan, Y. Zhang, C. On, K. L. Frank, B. D. Guenther et al., Ecto-5?-Nucleotidase: A Candidate Virulence Factor in Streptococcus sanguinis Experimental Endocarditis. Beall B, éditeur, PLoS ONE. 7 juin, vol.7, issue.6, p.38059, 2012.

O. L. Moine, P. Stordeur, L. Schandené, A. Marchant, D. Groote et al., Adenosine enhances IL-10 secretion by human monocytes, J Immunol. 1 juin, vol.156, issue.11, pp.4408-4422, 1996.

R. Mercier, R. M. Dietz, J. L. Mazzola, A. S. Bayer, and M. R. Yeaman, Beneficial Influence of Platelets on Antibiotic Efficacy in an In Vitro Model of Staphylococcus aureus-Induced Endocarditis, Antimicrob Agents Chemother. 1 juill, vol.48, issue.7, pp.2551-2558, 2004.

M. A. Armant and M. J. Fenton, Toll-like receptors: a family of pattern-recognition receptors in mammals, Genome Biol, vol.3, issue.8, 2002.

F. Cognasse, H. Hamzeh, P. Chavarin, S. Acquart, C. Genin et al., Evidence of Toll-like receptor molecules on human platelets, Immunol Cell Biol. avr, vol.83, issue.2, pp.196-204, 2005.

G. Zhang, J. Han, E. J. Welch, R. D. Ye, T. A. Voyno-yasenetskaya et al., Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMPDependent Protein Kinase Pathway, J Immunol. 15 juin, vol.182, issue.12, pp.7997-8004, 2009.

A. Ståhl, L. Sartz, A. Nelsson, Z. D. Békássy, and D. Karpman, Shiga Toxin and Lipopolysaccharide Induce PlateletLeukocyte Aggregates and Tissue Factor Release, a Thrombotic Mechanism in Hemolytic Uremic Syndrome, Bereswill S, éditeur. PLoS ONE. 11 sept, vol.4, issue.9, p.6990, 2009.

J. R. Ward, L. Bingle, H. M. Judge, S. B. Brown, R. F. Storey et al., Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor, Thromb Haemost, vol.94, issue.4, pp.831-839, 2005.

K. Hashimoto, M. Jayachandran, W. G. Owen, and V. M. Miller, Aggregation and Microparticle Production Through Toll-like Receptor 4 Activation in Platelets From Recently Menopausal Women, J Cardiovasc Pharmacol. juill, vol.54, issue.1, pp.57-62, 2009.

J. R. Sheu, C. R. Lee, C. H. Lin, G. Hsiao, W. C. Ko et al., Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets, Thromb Haemost. mai, vol.83, issue.5, pp.777-84, 2000.

Z. Huang, P. Chien, Z. K. Indik, and A. D. Schreiber, Human platelet Fc?RIIA and phagocytes in immune-complex clearance, Mol Immunol. janv, vol.48, issue.4, pp.691-697, 2011.

A. Assinger, M. Laky, G. Schabbauer, A. M. Hirschl, E. Buchberger et al., Efficient phagocytosis of periodontopathogens by neutrophils requires plasma factors, platelets and TLR2: Plasma and platelets enhance clearance of bacteria, J Thromb Haemost. avr, vol.9, issue.4, pp.799-809, 2011.

T. Youssefian, Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation, Blood. 13 mai, vol.99, issue.11, pp.4021-4030, 2002.

C. C. Clawson, Platelet Interaction with Bacteria, vol.70, p.24, 1973.

C. C. Clawson, G. Rao, and J. G. White, Platelet Interaction With Bacteria, vol.81, p.10, 1975.

C. C. Clawson and J. G. White, Platelet Interaction With Bacteria, vol.98, p.15, 1980.

D. Johansson, O. Shannon, and M. Rasmussen, Platelet and Neutrophil Responses to Gram Positive Pathogens in Patients with Bacteremic Infection. Bereswill S, éditeur, PLoS ONE, vol.6, issue.11, p.26928, 2011.

B. F. Kraemer, R. A. Campbell, H. Schwertz, M. J. Cody, Z. Franks et al., Novel Anti-bacterial Activities of ?-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation, PLoS Pathog, vol.7, issue.10, 2011.

R. Mercier, M. J. Rybak, A. S. Bayer, and M. R. Yeaman, Influence of Platelets and Platelet Microbicidal Protein Susceptibility on the Fate of Staphylococcus aureus in an In Vitro Model of Infective Endocarditis, Infect Immun. 1 août, vol.68, issue.8, pp.4699-705, 2000.

E. Guaní-guerra, T. Santos-mendoza, S. O. Lugo-reyes, and L. M. Terán, Antimicrobial peptides: General overview and clinical implications in human health and disease, Clin Immunol. 1 avr, vol.135, issue.1, pp.1-11, 2010.

M. R. Yeaman, Y. Tang, A. J. Shen, A. S. Bayer, and M. E. Selsted, Purification and In Vitro Activities of Rabbit Platelet Microbicidal Proteins, INFECT IMMUN, vol.65, p.9, 1997.

V. K. Dhawan, M. R. Yeaman, A. L. Cheung, E. Kim, P. M. Sullam et al., Phenotypic Resistance to ThrombinInduced Platelet Microbicidal Protein In Vitro Is Correlated with Enhanced Virulence in Experimental Endocarditis Due to Staphylococcus aureus, INFECT IMMUN, vol.65, p.7, 1997.

M. R. Yeaman, D. C. Norman, and A. S. Bayer, Staphylococcus aureus susceptibility to thrombin-induced platelet microbicidal protein is independent of platelet adherence and aggregation in vitro, Infect Immun. juin, vol.60, issue.6, pp.2368-74, 1992.

L. I. Kupferwasser, M. R. Yeaman, S. M. Shapiro, C. C. Nast, and A. S. Bayer, In Vitro Susceptibility to ThrombinInduced Platelet Microbicidal Protein Is Associated With Reduced Disease Progression and Complication Rates in Experimental Staphylococcus aureus Endocarditis: Microbiological, Histopathologic, and Echocardiographic Analyses, Circulation. 12 févr, vol.105, issue.6, pp.746-52, 2002.

P. M. Sullam, U. Frank, M. R. Yeaman, M. G. Tauber, A. S. Bayer et al., Effect of Thrombocytopenia on the Early Course of Streptococcal Endocarditis, J Infect Dis, vol.168, issue.4, pp.910-914, 1993.

R. E. Polonio, L. A. Mermel, G. E. Paquette, and J. F. Sperry, Eradication of Biofilm-Forming Staphylococcus epidermidis (RP62A) by a Combination of Sodium Salicylate and Vancomycin, Antimicrob Agents Chemother, vol.45, issue.11, pp.3262-3268, 2001.

L. I. Kupferwasser, M. R. Yeaman, C. C. Nast, D. Kupferwasser, Y. Xiong et al., Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus, J Clin Invest. 15 juill, vol.112, issue.2, pp.222-255, 2003.

M. Palma, A. Bayer, L. I. Kupferwasser, T. Joska, M. R. Yeaman et al., Salicylic Acid Activates Sigma Factor B by rsbU-Dependent and -Independent Mechanisms, J Bacteriol. août, vol.188, issue.16, pp.5896-903, 2006.

S. Gertz, S. Engelmann, R. Schmid, A. Ziebandt, K. Tischer et al., Characterization of the ?B Regulon in Staphylococcus aureus, J Bacteriol. déc, vol.182, issue.24, pp.6983-91, 2000.

A. Karlsson and S. Arvidson, Variation in extracellular protease production among clinical isolates of Staphylococcus aureus due to different levels of expression of the protease repressor sarA, Infect Immun. août, vol.70, issue.8, pp.4239-4285, 2002.

B. F. Farber and A. G. Wolff, The Use of Nonsteroidal Antiinflammatory Drugs to Prevent Adherence of Staphylococcus epidermidis to Medical Polymers, J Infect Dis, vol.166, issue.4, pp.861-866, 1992.

P. Domenico, S. Schwartz, and B. A. Cunha, Reduction of Capsular Polysaccharide Production in Klebsiella pneumoniae by Sodium Salicylate, INFECT IMMUN, vol.57, p.5, 1989.

L. P. Alvarez, M. S. Barbagelata, M. Gordiola, A. L. Cheung, D. O. Sordelli et al., Salicylic Acid Diminishes Staphylococcus aureus Capsular Polysaccharide Type 5 Expression, Infect Immun. 1 mars, vol.78, issue.3, pp.1339-1383, 2010.

L. I. Kupferwasser, M. R. Yeaman, S. M. Shapiro, C. C. Nast, P. M. Sullam et al., Acetylsalicylic Acid Reduces Vegetation Bacterial Density, Hematogenous Bacterial Dissemination, and Frequency of Embolic Events in Experimental Staphylococcus aureus Endocarditis Through Antiplatelet and Antibacterial Effects, Circulation. juin, vol.99, issue.21, pp.2791-2798, 1999.

C. Dotto, L. Serrat, A. Cattelan, N. Barbagelata, M. S. Yantorno et al., The Active Component of Aspirin, Salicylic Acid, Promotes Staphylococcus aureus Biofilm Formation in a PIAdependent Manner. Front Microbiol, vol.23

A. Chabert, P. Damien, P. O. Verhoeven, F. Grattard, P. Berthelot et al., Acetylsalicylic acid differentially limits the activation and expression of cell death markers in human platelets exposed to Staphylococcus aureus strains, Sci Rep. déc, vol.7, issue.1, p.5610, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01770234

E. Chan, Z. Y. Yee, I. Raja, and J. Yap, Synergistic effect of non-steroidal anti-inflammatory drugs (NSAIDs) on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus, J Glob Antimicrob Resist. sept, vol.10, pp.70-74, 2017.

M. A. Farha, A. Leung, E. W. Sewell, D. 'elia, M. A. et al., Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to ?-Lactams, ACS Chem Biol. 18 janv, vol.8, issue.1, pp.226-259, 2013.

K. F. Alsharif, M. R. Thomas, H. M. Judge, H. Khan, L. R. Prince et al., Ticagrelor potentiates adenosineinduced stimulation of neutrophil chemotaxis and phagocytosis, Vascul Pharmacol. août, vol.71, pp.201-208, 2015.

M. E. Levison, J. Carrizosa, D. Tanphaichitra, P. K. Schick, and W. Rubin, Effect of aspirin on thrombogenesis and on production of experimental aortic valvular Streptococcus viridans endocarditis in rabbits, Blood. avr, vol.49, issue.4, pp.645-50, 1977.

D. P. Nicolau, C. D. Freeman, C. H. Nightingale, R. Quintiliani, C. J. Coe et al., Reduction of bacterial titers by low-dose aspirin in experimental aortic valve endocarditis, Infect Immun. avr, vol.61, issue.4, pp.1593-1598, 1993.

D. P. Nicolau, M. N. Marangos, C. H. Nightingale, and R. Quintiliani, Influence of aspirin on development and treatment of experimental Staphylococcus aureus endocarditis, Antimicrob Agents Chemother. 1 août, vol.39, issue.8, pp.1748-51, 1995.

D. P. Nicolau, P. R. Tessier, C. H. Nightingale, and R. Quintiliani, Influence of ticlopidine on the development of experimental Staphylococcus aureus endocarditis, Int J Antimicrob Agents, vol.7, issue.4, pp.271-275, 1996.

D. P. Nicolau, P. R. Tessier, C. H. Nightingale, and R. Quintiliani, Influence of adjunctive ticlopidine on the treatment of experimental Staphylococcus aureus endocarditis, Int J Antimicrob Agents. févr, vol.9, issue.4, pp.227-236, 1998.

D. P. Nicolau, P. R. Tessier, and C. H. Nightingale, Beneficial effect of combination antiplatelet therapy on the development of experimental Staphylococcus aureus endocarditis, Int J Antimicrob Agents. févr, vol.11, issue.2, pp.159-61, 1999.

T. R. Veloso, F. Oechslin, Y. Que, P. Moreillon, J. M. Entenza et al., Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus. Oswald E, éditeur. Pathog Dis, vol.73, p.60, 2015.

T. R. Veloso, Y. Que, A. Chaouch, M. Giddey, J. Vouillamoz et al., Prophylaxis of Experimental Endocarditis With Antiplatelet and Antithrombin Agents: A Role for Long-term Prevention of Infective Endocarditis in Humans?, J Infect Dis. 1 janv, vol.211, issue.1, pp.72-81, 2015.

T. Vanassche, J. Verhaegen, W. E. Peetermans, J. V. Ryn, A. Cheng et al., Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulence, J Thromb Haemost, vol.9, issue.12, pp.2436-2482, 2011.

C. J. Lerche, L. J. Christophersen, J. P. Goetze, P. R. Nielsen, K. Thomsen et al., Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis, PLoS ONE, vol.19, issue.2019

T. H. Taha, S. S. Durrant, P. K. Mazeika, P. Nihoyannopoulos, and C. M. Oakley, Aspirin to prevent growth of vegetations and cerebral emboli in infective endocarditis, J Intern Med. mai, vol.231, issue.5, pp.543-549, 1992.

K. Chan, J. G. Dumesnil, B. Cujec, A. J. Sanfilippo, J. Jue et al., A randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis, J Am Coll Cardiol. 3 sept, vol.42, issue.5, pp.775-80, 2003.

K. Chan, J. Tam, J. G. Dumesnil, B. Cujec, A. J. Sanfilippo et al., Effect of Long-Term Aspirin Use on Embolic Events in Infective Endocarditis, Clin Infect Dis. 1 janv, vol.46, issue.1, pp.37-41, 2008.

N. S. Anavekar, I. M. Tleyjeh, N. S. Anavekar, Z. Mirzoyev, J. M. Steckelberg et al., Impact of Prior Antiplatelet Therapy on Risk of Embolism in Infective Endocarditis, Clin Infect Dis. 1 mai, vol.44, issue.9, pp.1180-1186, 2007.

A. D. Michelson, M. Cattaneo, J. W. Eikelboom, P. Gurbel, K. Kottke-marchant et al., Aspirin resistance: position paper of the Working Group on Aspirin Resistance: Aspirin resistance, J Thromb Haemost. 9 juin, vol.3, issue.6, pp.1309-1320, 2005.

M. Sedlacek, J. M. Gemery, A. L. Cheung, A. S. Bayer, and B. D. Remillard, Aspirin Treatment Is Associated With a Significantly Decreased Risk of Staphylococcus aureus Bacteremia in Hemodialysis Patients With Tunneled Catheters, Am J Kidney Dis. 1 mars, vol.49, issue.3, pp.401-409, 2007.

J. Pepin, V. Tremblay, D. Bechard, F. Rodier, C. Walker et al., Chronic antiplatelet therapy and mortality among patients with infective endocarditis, Clin Microbiol Infect. févr, vol.15, issue.2, pp.193-202, 2009.

D. P. Eisen, G. R. Corey, E. S. Mcbryde, V. G. Fowler, J. M. Miro et al., Reduced valve replacement surgery and complication rate in Staphylococcus aureus endocarditis patients receiving acetyl-salicylic acid, J Infect. mai, vol.58, issue.5, pp.332-340, 2009.

N. S. Anavekar, J. C. Schultz, D. Sa, D. Thomas, J. M. Lahr et al., Modifiers of Symptomatic Embolic Risk in Infective Endocarditis, Mayo Clin Proc, vol.86, issue.11, pp.1068-74, 2011.

V. L. Serebruany, M. Miller, A. N. Pokov, A. I. Malinin, D. R. Lowry et al., Effect of Statins on Platelet PAR-1 Thrombin Receptor in Patients With the Metabolic Syndrome (From the PAR-1 Inhibition by Statins [PARIS] Study), Am J Cardiol. mai, vol.97, issue.9, pp.1332-1338, 2006.

I. M. Tleyjeh, T. Kashour, F. A. Hakim, V. A. Zimmerman, P. J. Erwin et al., Statins for the Prevention and Treatment of Infections: A Systematic Review and Meta-analysis, Arch Intern Med, vol.169, issue.18, pp.1658-67, 2009.

D. Pruefer, J. Makowski, M. Schnell, U. Buerke, M. Dahm et al., Simvastatin Inhibits Inflammatory Properties of Staphylococcus aureus ?-Toxin, Circulation, vol.106, issue.16, pp.2104-2114, 2002.

U. Laufs and J. K. Liao, Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase, J Biol Chem. 11 sept, vol.273, issue.37, pp.24266-71, 1998.

M. Tsai, S. Ou, C. Shih, P. Chao, L. Wang et al., Association of prior antiplatelet agents with mortality in sepsis patients: a nationwide population-based cohort study, Intensive Care Med. 1 mai, vol.41, issue.5, pp.806-819, 2015.

M. Cattaneo, C. Cerletti, P. Harrison, C. Hayward, D. Kenny et al., Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH, J Thromb Haemost. juin, vol.11, issue.6, pp.1183-1192, 2013.

P. Seng, J. Rolain, P. E. Fournier, L. Scola, B. Drancourt et al., MALDI-TOF-mass spectrometry applications in clinical microbiology, Future Microbiol, vol.5, issue.11, pp.1733-54, 2010.

I. Ford, C. Douglas, F. E. Preston, A. Lawless, and K. K. Hampton, Mechanisms of platelet aggregation by Streptococcus sanguis, a causative organism in infective endocarditis, Br J Haematol. mai, vol.84, issue.1, pp.95-100, 1993.

A. E. Laudy, A. Mrowka, J. Krajewska, and S. Tyski, The Influence of Efflux Pump Inhibitors on the Activity of Non-Antibiotic NSAIDS against Gram-Negative Rods, PLoS ONE, vol.15, issue.2016

F. Söderlund, A. Asztély, A. Jeppsson, S. Nylander, A. Berggren et al., In vitro anti-platelet potency of ticagrelor in blood samples from infants and children, Thromb Res. sept, vol.136, issue.3, pp.620-624, 2015.

M. Ciborowski, M. Tomasiak, T. Rusak, K. Winnicka, and S. Dobrzycki, The in-vitro effect of tirofiban, glycoprotein IIb/IIIa antagonist, on various responses of porcine blood platelets, Blood Coagul Fibrinolysis. sept, vol.19, issue.6, pp.557-67, 2008.

J. Chia, Y. Lin, H. Lien, and J. Chen, Platelet Aggregation Induced by Serotype Polysaccharides from Streptococcus mutans, Infect Immun. mai, vol.72, issue.5, pp.2605-2622, 2004.

A. R. Spaulding, E. A. Satterwhite, Y. Lin, C. On, K. L. Frank et al., Comparison of Staphylococcus aureus strains for ability to cause infective endocarditis and lethal sepsis in rabbits. Front Cell Infect Microbiol

, , vol.2, 2012.

M. J. Huseby, A. C. Kruse, J. Digre, P. L. Kohler, J. A. Vocke et al., Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms, Proc Natl Acad Sci, vol.107, issue.32, pp.14407-14419, 2010.

A. L. Cheung and S. J. Projan, Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr, J Bacteriol. juill, vol.176, issue.13, pp.4168-72, 1994.