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Master Thesis

Biopsies de prostate ciblées pour le diagnostic du cancer de la prostate : évaluation au fil du temps et des outils technologiques au CHU de Grenoble

Abstract : INTRODUCTION. The main objective was to evaluate the results of targeted prostate biopsies combined with systematics biopsies for the early diagnosis of prostate cancer. METHODS. This is a single-center retrospective study conducted from 2011 to 2019. All included patients had a positive MRI (PI-RADS≥3) followed by randomized and targeted prostatic biopsies with software fusion. Clinically significant prostate cancer (csCaP) was defined as ISUP ≥ 2. FINDINGS. 327 patients were analyzed, 302 transrectal biopsies (149 with Urostation® device, and 153 with Trinity®), 25 transperineal biopsies. CsCaP was more frequently detected with combined biopsies than with systematic biopsies alone (142 (47%) vs 129 (40.4%), p <0.0001). The PI-RADS score increased the detection rate of csCaP, respectively 20%, 44.3% and 80% for PI-RADS 3, 4 and 5. The use of one or the other image fusion device did not vary the detection rate of csCaP (40% - Urostation®, vs 44% - Trinity® (p = 0.46), the operating time was shorter with the Trinity device (21 vs 19min, p <0.05). There were no significant differences between the operators, whether experienced or not, 16 (5.3%) patients presented with prostatitis, and the transperineal targeted biopsies appeared to be of interest for the anterior lesions with reducing the septic risk. The delay between MRI and the targeted biopsies increased during the study period (77 vs 29 days). CONCLUSION. Targeted transrectal biopsies increase the detection rate of csCaP, correlated with the PI-RADS score.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02324051
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Submitted on : Tuesday, October 22, 2019 - 9:14:41 AM
Last modification on : Wednesday, July 15, 2020 - 8:58:04 AM
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Jean-Benjamin Lefrancq. Biopsies de prostate ciblées pour le diagnostic du cancer de la prostate : évaluation au fil du temps et des outils technologiques au CHU de Grenoble. Médecine humaine et pathologie. 2019. ⟨dumas-02324051⟩

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