, Etudes)exclues)(n=19))

, M)Intervention)mal)définie):)5)

, M)Fertilité)mal)définie):)7)

, Données)manquantes):)4)

, M)Inclusion)de)cancers):)2)

, Données)déjà)publiées):)1)

, Études)incluses)dans)la)synthèse) quantitative)(n=7))

. Tulcinsky, , 2013.

. Bartels, , 2012.

. Jonhson, , 2004.

. Olsen, , 2002.

. Oresland, , p.métaDanalyse, 1994.

E. Risque&relatif,

, Le biais de performance est dû au caractère rétrospectif des études ne permettant pas d'inclure une population exposée uniformément au traitement étudié. S'ajoutent à ces biais systématiques des facteurs confondants tels que les données de fertilité concernant les partenaires masculins qui devraient être recherchées et plus explicitement exposées pour améliorer l'imputabilité de l'AIA dans la survenue d'une infertilité

. Enfin, hétérogénéité des essais inclus dans la méta-analyse limitait l'interprétation des résultats. S'il est difficile de réaliser une méta-analyse d'essais parfaitement homogènes, l'analyse de sensibilité a permis de déterminer l'impact de l'étude d'Olsen dans l'hétérogénéité (42). Cependant, si son retrait de la méta-analyse abaissait légèrement le risque relatif d'infertilité après AIA

, Au mieux, une méta-analyse sur données individuelles, issues d'essais randomisés, permettrait d'étudier l'interaction des différents facteurs pour annuler leur effet. Une analyse sur données publiées permettrait aussi de réaliser des analyses de sous-groupes pour déterminer des facteurs prédictifs d

B. Sjögren and B. Poppen, Sexual life in women after colectomy-proctomucosectomy with

. S-pouch, Acta Obstet Gynecol Scand, vol.74, issue.1, pp.51-56, 1995.

T. Oresland, S. Palmblad, M. Ellström, I. Berndtsson, N. Crona et al., Gynaecological and sexual function related to anatomical changes in the female pelvis after restorative proctocolectomy, Int J Colorectal Dis, vol.9, issue.2, pp.77-81, 1994.

S. G. Rajaratnam, T. W. Eglinton, P. Hider, and N. S. Fearnhead, Impact of ileal pouch-anal anastomosis on female fertility: meta-analysis and systematic review, Int J Colorectal Dis, vol.26, issue.11, pp.1365-74, 2011.

A. Waljee, J. Waljee, A. M. Morris, and P. Higgins, Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis, Gut, vol.55, issue.11, pp.1575-80, 2006.

A. G. Parks and R. J. Nicholls, Proctocolectomy without ileostomy for ulcerative colitis, Br Med J, vol.2, issue.6130, pp.85-93, 1978.

F. Magro, P. Gionchetti, R. Eliakim, S. Ardizzone, A. Armuzzi et al., Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders, J Crohns Colitis, vol.11, issue.6, pp.649-70, 2017.

A. Couchard, Y. Panis, A. Alves, P. Mariani, and P. Valleur, Techniques d'anastomoses iléoanales avec réservoir. EMC -Chir, vol.2, pp.123-162, 2005.

A. Ali, U. Keus, F. Heikens, J. T. Bemelman, W. A. Berdah et al.,

, Open versus laparoscopic (assisted) ileo pouch anal anastomosis for ulcerative colitis and familial adenomatous polyposis. Cochrane Database Syst Rev, p.6267, 2009.

H. S. Tilney, R. E. Lovegrove, A. G. Heriot, S. Purkayastha, V. Constantinides et al., Comparison of short-term outcomes of laparoscopic vs open approaches to ileal pouch surgery, Int J Colorectal Dis, vol.22, issue.5, pp.531-573, 2007.

F. J. Fleming, T. D. Francone, M. J. Kim, D. Gunzler, S. Messing et al., A laparoscopic approach does reduce short-term complications in patients undergoing ileal pouch-anal anastomosis, Dis Colon Rectum, vol.54, issue.2, pp.176-82, 2011.

J. H. Lefevre, F. Bretagnol, M. Ouaïssi, P. Taleb, A. Alves et al., Total laparoscopic ileal pouch-anal anastomosis: prospective series of 82 patients, Surg Endosc, vol.23, issue.1, pp.166-73, 2009.

T. L. Hull, M. R. Joyce, D. P. Geisler, and J. C. Coffey, Adhesions after laparoscopic and open ileal pouch-anal anastomosis surgery for ulcerative colitis, Br J Surg, vol.99, issue.2, pp.270-275, 2012.

F. G. Campos, C. A. Martinez, M. De-camargo, M. G. Cesconetto, D. M. Nahas et al.,

I. Cecconello, Laparoscopic Versus Open Restorative Proctocolectomy for Familial Adenomatous Polyposis, J Laparoendosc Adv Surg Tech A, vol.28, issue.1, pp.47-52, 2018.

Y. Takao, R. Gilliland, J. J. Nogueras, E. G. Weiss, and S. D. Wexner, Is age relevant to functional outcome after restorative proctocolectomy for ulcerative colitis?: prospective assessment of 122 cases, Ann Surg, vol.227, issue.2, pp.187-94, 1998.

C. Benlice, L. Stocchi, M. Costedio, E. Gorgun, T. Hull et al., Laparoscopic IPAA is not associated with decreased rates of incisional hernia and small-bowel obstruction when compared with open technique: long-term follow-up of a case-matched study, Dis Colon Rectum, vol.58, issue.3, pp.314-334, 2015.

L. Beyer-berjot, L. Maggiori, D. Birnbaum, J. H. Lefevre, S. Berdah et al., A total laparoscopic approach reduces the infertility rate after ileal pouch-anal anastomosis: a 2-center study, Ann Surg, vol.258, issue.2, pp.275-82, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00936957

Z. Lakkis, G. Manceau, V. Bridoux, A. Brouquet, S. Kirzin et al., Management of rectal cancer: the 2016 French guidelines, Colorectal Dis Off J Assoc Coloproctology G B Irel, vol.19, issue.2, pp.115-137, 2017.

A. Abdelli, X. Tillou, A. Alves, and B. Menahem, Genito-urinary sequelae after carcinological rectal resection: What to tell patients in 2017, J Visc Surg, vol.154, issue.2, pp.93-104, 2017.

P. Van-duijvendijk, J. F. Slors, C. W. Taat, P. Oosterveld, M. A. Sprangers et al.,

, Quality of life after total colectomy with ileorectal anastomosis or proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis, Br J Surg, vol.87, issue.5, pp.590-596, 2000.

A. C. Von-roon, O. Will, R. F. Man, K. F. Neale, R. Phillips et al.,

, Mucosectomy with handsewn anastomosis reduces the risk of adenoma formation in the anorectal segment after restorative proctocolectomy for familial adenomatous polyposis, Ann Surg, vol.253, issue.2, pp.314-321, 2011.

P. Ganschow, I. Treiber, U. Hinz, C. Leowardi, M. W. Büchler et al., Residual rectal mucosa after stapled vs. handsewn ileal J-pouch-anal anastomosis in patients with familial adenomatous polyposis coli (FAP)--a critical issue, Langenbecks Arch Surg, 2015.

, Feb, vol.400, issue.2, pp.213-222

S. J. Schluender, L. Mei, H. Yang, and P. R. Fleshner, Can a meta-analysis answer the question: is mucosectomy and handsewn or double-stapled anastomosis better in ileal pouch-anal anastomosis?, Am Surg, vol.72, issue.10, pp.912-918, 2006.

R. E. Lovegrove, V. A. Constantinides, A. G. Heriot, T. Athanasiou, A. Darzi et al.,

, A comparison of hand-sewn versus stapled ileal pouch anal anastomosis (IPAA) following proctocolectomy: a meta-analysis of 4183 patients, Ann Surg, vol.244, issue.1, pp.18-26, 2006.

H. T. Kirat, F. H. Remzi, R. P. Kiran, and V. W. Fazio, Comparison of outcomes after hand-sewn versus stapled ileal pouch-anal anastomosis in 3,109 patients, Surgery, vol.146, issue.4, p.723, 2009.

M. Harbord, R. Eliakim, D. Bettenworth, K. Karmiris, K. Katsanos et al., Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management, J Crohns Colitis, vol.11, issue.7, pp.769-84, 2017.

F. H. Remzi, V. W. Fazio, E. Gorgun, B. S. Ooi, J. Hammel et al., The outcome after restorative proctocolectomy with or without defunctioning ileostomy, Dis Colon Rectum, 2006.

U. A. Heuschen, U. Hinz, E. H. Allemeyer, M. Lucas, G. Heuschen et al., One-or twostage procedure for restorative proctocolectomy: rationale for a surgical strategy in ulcerative colitis, Ann Surg, vol.234, issue.6, pp.788-94, 2001.

R. Mennigen, N. Senninger, M. Bruwer, and E. Rijcken, Impact of defunctioning loop ileostomy on outcome after restorative proctocolectomy for ulcerative colitis, Int J Colorectal Dis, vol.26, issue.5, pp.627-660, 2011.

H. L. Van-westreenen, A. Visser, P. J. Tanis, and W. A. Bemelman, Morbidity related to defunctioning ileostomy closure after ileal pouch-anal anastomosis and low colonic anastomosis, Int J Colorectal Dis, vol.27, issue.1, pp.49-54, 2012.

J. J. Tjandra, V. W. Fazio, J. W. Milsom, I. C. Lavery, J. R. Oakley et al., Omission of temporary diversion in restorative proctocolectomy--is it safe? Dis Colon Rectum, 1993.

G. K. Weston-petrides, R. E. Lovegrove, H. S. Tilney, and A. G. Heriot,

. Njm, Comparison of outcomes after restorative proctocolectomy with or without defunctioning ileostomy, Arch Surg Chic Ill, vol.143, issue.4, pp.406-418, 1960.

T. Hor, J. H. Lefevre, C. Shields, N. Chafai, E. Tiret et al., Female sexual function and fertility after ileal pouch-anal anastomosis, Int J Colorectal Dis, vol.31, issue.3, pp.593-601, 2016.

P. Galiatsatos and W. D. Foulkes, Familial adenomatous polyposis, Am J Gastroenterol, 2006.

, Feb, vol.101, issue.2, pp.385-98

D. Herzig, K. Hardiman, M. Weiser, N. You, I. Paquette et al., The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes, Church JM, McGannon E, vol.60, pp.887-896, 2002.

R. W. Burt, M. F. Leppert, M. L. Slattery, W. S. Samowitz, L. N. Spirio et al.,

, Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis, Gastroenterology, vol.127, issue.2, pp.444-51, 2004.

H. Vasen, G. Möslein, A. Alonso, S. Aretz, I. Bernstein et al., Guidelines for the clinical management of familial adenomatous polyposis (FAP), 2008.

H. Kobayashi, H. Ishida, H. Ueno, T. Hinoi, Y. Inoue et al., Childbirth after surgery for familial adenomatous polyposis in Japan. Surg Today, vol.47, pp.233-240, 2017.

S. Strong, S. R. Steele, M. Boutrous, L. Bordineau, J. Chun et al., Clinical Practice Guideline for the Surgical Management of Crohn's Disease, Dis Colon Rectum, 2015.

O. Aziz, T. Athanasiou, V. W. Fazio, R. J. Nicholls, A. W. Darzi et al., Meta-analysis of observational studies of ileorectal versus ileal pouch-anal anastomosis for familial adenomatous polyposis, Br J Surg, vol.93, issue.4, pp.407-424, 2006.

S. Bülow, Results of national registration of familial adenomatous polyposis, Gut, 2003.

K. Ø. Olsen, S. Juul, S. Bülow, H. J. Järvinen, A. Bakka et al., Female fecundity before and after operation for familial adenomatous polyposis, Br J Surg, vol.90, issue.2, pp.227-258, 2003.

R. Ungaro, S. Mehandru, P. B. Allen, L. Peyrin-biroulet, and J. Colombel,

, Lancet Lond Engl, vol.389, pp.1756-70, 10080.

J. A. Eaden, K. R. Abrams, and J. F. Mayberry, The risk of colorectal cancer in ulcerative colitis: a meta-analysis, Gut, vol.48, issue.4, pp.526-561, 2001.

M. D. Rutter, B. P. Saunders, K. H. Wilkinson, S. Rumbles, G. Schofield et al.,

, Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk, Gut, vol.53, issue.12, pp.1813-1819, 2004.

T. Jess, J. Simonsen, K. T. Jørgensen, B. V. Pedersen, N. M. Nielsen et al.,

, Gastroenterology, vol.143, issue.2, pp.375-81, 2012.

T. Delaunoit, P. J. Limburg, R. M. Goldberg, J. F. Lymp, and E. V. Loftus, Colorectal cancer prognosis among patients with inflammatory bowel disease, Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc, vol.4, issue.3, pp.335-377, 2006.

A. Dignass, R. Eliakim, F. Magro, C. Maaser, Y. Chowers et al., Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 1: definitions and diagnosis, J Crohns Colitis, vol.6, issue.10, pp.965-90, 2012.

H. Tulchinsky, F. Averboukh, N. Horowitz, M. Rabau, J. M. Klausner et al.,

, Restorative proctocolectomy impairs fertility and pregnancy outcomes in women with ulcerative colitis, Colorectal Dis Off J Assoc Coloproctology G B Irel, vol.15, issue.7, pp.842-849, 2013.

A. Foulon, J. Dupas, C. Sabbagh, J. Chevreau, L. Rebibo et al., Defining the Most Appropriate Delivery Mode in Women with Inflammatory Bowel Disease: A Systematic Review, Inflamm Bowel Dis, vol.23, issue.5, pp.712-732, 2017.

D. Hahnloser, J. H. Pemberton, B. G. Wolff, D. Larson, J. Harrington et al.,

, Pregnancy and delivery before and after ileal pouch-anal anastomosis for inflammatory bowel disease: immediate and long-term consequences and outcomes, Dis Colon Rectum, 2004.

S. W. Polle, M. S. Vlug, J. Slors, A. H. Zwinderman, A. G. Van-der-hoop et al.,

, Effect of vaginal delivery on long-term pouch function, Br J Surg, vol.93, issue.11, pp.1394-401, 2006.

A. Ilnyckyji, J. F. Blanchard, P. Rawsthorne, and C. N. Bernstein, Perianal Crohn's disease and pregnancy: role of the mode of delivery, Am J Gastroenterol, vol.94, issue.11, pp.3274-3282, 1999.

S. Bartels, A. D?hoore, M. A. Cuesta, A. J. Bensdorp, C. Lucas et al.,

, Significantly increased pregnancy rates after laparoscopic restorative proctocolectomy: a crosssectional study, Ann Surg, vol.256, issue.6, pp.1045-1053, 2012.

, The american fertility society. The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, Müllerian anomalies and intrauterine adhesions, Fertil Steril, vol.49, issue.6, pp.944-55, 1988.

A. Liberati, D. G. Altman, J. Tetzlaff, C. Mulrow, P. C. Gøtzsche et al., The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration, J Clin Epidemiol, vol.62, issue.10, pp.1-34, 2009.

A. R. Jadad, R. A. Moore, D. Carroll, C. Jenkinson, D. J. Reynolds et al.,

, Assessing the quality of reports of randomized clinical trials: is blinding necessary?, Control Clin Trials, vol.17, issue.1, pp.1-12, 1996.

F. Zegers-hochschild, G. D. Adamson, J. De-mouzon, O. Ishihara, R. Mansour et al., The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) Revised Glossary on ART Terminology, Hum Reprod Oxf Engl, vol.24, issue.11, pp.2683-2690, 2009.

P. Mortier, L. Gambiez, M. Karoui, A. Cortot, J. Paris et al., Colectomy with ileorectal anastomosis preserves female fertility in ulcerative colitis, Gastroenterol Clin Biol, vol.30, issue.4, pp.594-601, 2006.

S. Friedman, P. V. Larsen, J. Fedder, and B. M. Nørgård, The Efficacy of Assisted Reproduction in Women with Inflammatory Bowel Disease and the Impact of Surgery-A Nationwide Cohort Study, Inflamm Bowel Dis, vol.23, issue.2, pp.208-225, 2017.

M. H. Nieuwenhuis, K. F. Douma, E. M. Bleiker, W. A. Bemelman, N. K. Aaronson et al.,

, Female fertility after colorectal surgery for familial adenomatous polyposis: a nationwide crosssectional study, Ann Surg, vol.252, issue.2, pp.341-345, 2010.

M. Hudson, G. Flett, T. S. Sinclair, P. W. Brunt, A. Templeton et al., Fertility and pregnancy in inflammatory bowel disease, Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet, vol.58, issue.2, pp.229-266, 1997.

M. Wikland, I. Jansson, M. Asztély, I. Palselius, G. Svaninger et al.,

, Gynaecological problems related to anatomical changes after conventional proctocolectomy and ileostomy, Int J Colorectal Dis, vol.5, issue.1, pp.49-52, 1990.

F. R. Pachler, S. B. Brandsborg, and S. Laurberg, Paradoxical Impact of Ileal Pouch-Anal Anastomosis on Male and Female Fertility in Patients With Ulcerative Colitis, Dis Colon Rectum, vol.60, issue.6, pp.603-610, 2017.

A. Ravid, C. S. Richard, L. M. Spencer, B. I. O'connor, E. D. Kennedy et al.,

, Pregnancy, delivery, and pouch function after ileal pouch-anal anastomosis for ulcerative colitis, Dis Colon Rectum, vol.45, issue.10, pp.1283-1291, 2002.

H. J. Scott, R. S. Mcleod, J. Blair, B. O'connor, and Z. Cohen, Ileal pouch-anal anastomosis: pregnancy, delivery and pouch function, Int J Colorectal Dis, vol.11, issue.2, pp.84-91, 1996.

J. Tiainen, M. Matikainen, and K. M. Hiltunen, Ileal J-pouch--anal anastomosis, sexual dysfunction, and fertility, Scand J Gastroenterol, vol.34, issue.2, pp.185-193, 1999.

C. Johansen, M. Bitsch, and S. Bülow, Fertility and pregnancy in women with familial adenomatous polyposis, Int J Colorectal Dis, vol.5, issue.4, pp.203-209, 1990.

T. C. Counihan, P. L. Roberts, D. J. Schoetz, J. A. Coller, J. J. Murray et al.,

, Fertility and sexual and gynecologic function after ileal pouch-anal anastomosis, Dis Colon Rectum, vol.37, issue.11, pp.1126-1135, 1994.

J. A. Cornish, E. Tan, B. Singh, H. Bundock, N. Mortensen et al., Female infertility following restorative proctocolectomy, Colorectal Dis Off J Assoc Coloproctology G B Irel, vol.13, issue.10, pp.339-383, 2011.

K. O. Olsen, M. Joelsson, S. Laurberg, and T. Oresland, Fertility after ileal pouch-anal anastomosis in women with ulcerative colitis, Br J Surg, vol.86, issue.4, pp.493-498, 1999.

A. Lepistö, S. Sarna, A. Tiitinen, and H. J. Järvinen, Female fertility and childbirth after ileal pouch-anal anastomosis for ulcerative colitis, Br J Surg, vol.94, issue.4, pp.478-82, 2007.

E. Gorgun, F. H. Remzi, J. M. Goldberg, J. Thornton, J. Bast et al., Fertility is reduced after restorative proctocolectomy with ileal pouch anal anastomosis: a study of 300 patients, Surgery, vol.136, issue.4, pp.795-803, 2004.

P. Johnson, C. Richard, A. Ravid, L. Spencer, E. Pinto et al., Female infertility after ileal pouch-anal anastomosis for ulcerative colitis, Dis Colon Rectum, 2004.

Ø. Olsen, K. Juul, S. Berndtsson, I. Oresland, T. Laurberg et al., Ulcerative colitis: female fecundity before diagnosis, during disease, and after surgery compared with a population sample, Gastroenterology, vol.122, issue.1, pp.15-24, 2002.

M. Asztély, S. Palmblad, M. Wikland, L. Hultén, K. A. Van-balkom et al., Long-term results after restorative proctocolectomy with ileal pouch-anal anastomosis at a young age, Int J Colorectal Dis, vol.6, issue.2, pp.939-986, 1991.

A. Timmer, A. Bauer, A. Dignass, and G. Rogler, Sexual function in persons with inflammatory bowel disease: a survey with matched controls, Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc, vol.5, issue.1, pp.87-94, 2007.

J. W. Ogilvie, L. Goetz, N. N. Baxter, J. Park, S. Minami et al., Female sexual dysfunction after ileal pouch-anal anastomosis, Br J Surg, vol.95, issue.7, pp.887-92, 2008.

S. Baek, A. L. Lightner, S. Y. Boostrom, K. L. Mathis, R. R. Cima et al.,

, Functional Outcomes Following Laparoscopic Ileal Pouch-Anal Anastomosis in Patients with Chronic Ulcerative Colitis: Long-Term Follow-up of a Case-Matched Study, J Gastrointest Surg Off J Soc Surg Aliment Tract, vol.21, issue.8, pp.1304-1312, 2017.