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Master Thesis

Infection à CMV chez la femme enceinte : surdité congénitale et rôle de la prévention

Abstract : Congenital cytomegalovirus (CMV) infection is the first cause of congenital deafness of infectious origin. It is also the most common congenital infection, with, among 800 000 pregnancies each year in France, 3500 newborns infected from a CMV primary infection, reactivation or reinfection in the pregnant women. Sequelae can be serious but also moderate. Serological screening of pregnant women and screening for neonatal infection are not recommended until now because all women are at risk. There is no validated treatment during pregnancy and no treatment to be proposed for asymptomatic newborns. In symptomatic newborns with deafness, two antiviral drugs, Valganciclovir and Ganciclovir, can be used with caution in weighing benefit against risk. For children, deafness secondary to a congenital CMV infection can be total. Correct hearing is essential for the child's linguistic, cognitive and psycho-emotional development, but also for schooling and social integration. The cochlear implant is the most effective tool for auditory rehabilitation. The main course of action to prevent infection in pregnant women (and thus the risk of viral transmission to the fetus) is based upon prevention during pregnancy with hygiene counseling. This preventive role goes through various health actors, including the pharmacist in this context.
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Master Thesis
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Morgane Clabé. Infection à CMV chez la femme enceinte : surdité congénitale et rôle de la prévention. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02328328⟩

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