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Master Thesis

Anatomie du nerf terminal chez l’homme

Abstract : A century ago, the terminal nerve (TN) was clearly identified as an additional cranial nerve. In animal models, it is supposed to play a role in the detection of pheromones. Nevertheless, in the Human adult, his anatomy and physiology remain unknown. The objective of our study was to characterize the endonasal path of the TN, and to study the connections with the structures of nasal mucosa, particularly with the vomeronasal organ. We have included a total of 18 corpses. They were analyzed through to 3 axes of research: dissection, anatomopathological and radiological. The TN is composed of an average of 3±0.86 [2-5] plexiform lymph node fibers over its entire course. Its passage in the skull base is done exclusively by the ethmoidal slot. Then, branches of the TN travel downwards and forwards of the nasal septum over a length of 40.5mm±2,5 [37-45], ending at about 13mm±4.5 [8-24] from the floor of the nasal cavity, onwards of the vomeronasal organ. In histology, the TN cytoskeleton is composed of heavy neurofilament heavy (SMI31), some of which contain GnRH and a neurotransmitter of neuropeptide Y. The TN does not seem to be structured with others elements of the olfactive area of the nose. On the other hand, an important neuronal network composes the vomeronasal organ, with the presence of mature olfactory neurons as well as a peri-neuronal network (WFA). This study allowed us to deepen our knowledge of the terminal nerve in Human, by specifying its extra-cranial anatomy and anatomopathological characteristics, along with objectify a neuronal impregnation of the vomeronasal organ.
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https://dumas.ccsd.cnrs.fr/dumas-02329808
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Submitted on : Wednesday, October 23, 2019 - 4:51:28 PM
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Maxime Humbert. Anatomie du nerf terminal chez l’homme. Médecine humaine et pathologie. 2019. ⟨dumas-02329808⟩

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