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Master Thesis

Le comparateur dans l'évaluation technologique du médicament : deux évaluations, deux approches ?

Abstract : In France, in a context of growing innovation and by the same time, reduction of health expenditures, market access of drugs with marketing authorization is based on their technology assessment by the French National Authority for Health (HAS). For drugs claiming a significant therapeutic progress and a significant impact on national health insurance expenditures, the assessment is two-fold : medical by the Transparency Committee (CT) and medico-economic by the Economic and Public Health Committee (CEESP) aiming in common to support public decision-making. The basis of this assessment is supported by a comparison with existing alternatives. Therefore, the choice of the comparator is decisive for market access of medicinal products and can have a significant impact on pricing decision by the Economic Committee for Health Products (CEPS). This choice is guided by recommendations and criteria drawn up by each committee. A retrospective study of the comparators selected by the two committees was conducted, based on their respective opinions for drugs that benefit from a twofold assessment between 2014 and 2018. The aim was to highlight the effective selection method of the relevant comparators chosen by each committee and, if possible, identify criteria and reasons for these choices. This study revealed significant differences in the type of comparators selected by the two committees. Thus, according to the type of assessment, medical or medico-economic, the concept of comparator and its definition is partly different.
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Master Thesis
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Submitted on : Tuesday, October 29, 2019 - 1:34:38 PM
Last modification on : Friday, October 23, 2020 - 4:56:46 PM
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  • HAL Id : dumas-02337268, version 1



Alexia Bove. Le comparateur dans l'évaluation technologique du médicament : deux évaluations, deux approches ?. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02337268⟩



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