Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group, Neurology, vol.54, issue.11, pp.10-15, 2000. ,
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria, Alzheimers Dement, vol.12, issue.3, pp.292-323, 2016. ,
Clinical and biomarker changes in dominantly inherited Alzheimer's disease, N Engl J Med, vol.367, issue.9, pp.795-804, 2012. ,
Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease, Sci Transl Med, vol.6, issue.226, pp.226-256, 2014. ,
The amyloid hypothesis of Alzheimer's disease at 25 years, EMBO Mol Med, vol.8, issue.6, pp.595-608, 2016. ,
Independent information from cerebrospinal fluid amyloid-beta and florbetapir imaging in Alzheimer's disease. Brain, pp.772-83, 2015. ,
Utilization of polysomnography in the assessment of sleep disorders, Med Clin North Am, vol.69, issue.6, pp.1153-67, 1985. ,
How is good and poor sleep in older adults and college students related to daytime sleepiness, fatigue, and ability to concentrate?, J Psychosom Res, vol.49, issue.5, pp.381-90, 2000. ,
Aging-related sleep changes, Clin Geriatr Med, vol.24, issue.1, pp.1-14, 2008. ,
Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan, Sleep, vol.27, issue.7, pp.1255-73, 2004. ,
Circadian rhythms and sleep in human aging, Chronobiol Int, vol.17, issue.3, pp.233-276, 2000. ,
Sleep slow wave changes during the middle years of life, Eur J Neurosci, vol.33, issue.4, pp.758-66, 2011. ,
An examination of evoked K-complex amplitude and frequency of occurrence in the elderly, J Sleep Res, vol.11, issue.2, pp.129-169, 2002. ,
The effects of normal aging on sleep spindle and K-complex production, Clin Neurophysiol, vol.113, issue.10, pp.1615-1637, 2002. ,
Evoked K-complex generation: the impact of sleep spindles and age, Clin Neurophysiol, vol.115, issue.2, pp.471-477, 2004. ,
Buying time: a rationale for examining the use of circadian rhythm and sleep interventions to delay progression of mild cognitive impairment to Alzheimer's disease. Front Aging Neurosci, vol.6, p.325, 2014. ,
Sleep and quantitative EEG in neurodegenerative disorders, J Psychosom Res, vol.56, issue.5, pp.487-96, 2004. ,
, A gerontopsychological pilot study on the sleep of the very elderly--initial experiences with the Nurnberg Gerontopsychologic Inventory
, Z Gerontol, vol.26, issue.6, pp.471-476, 1993.
Sleep in Alzheimer's disease: further considerations on the role of brainstem and forebrain cholinergic populations in sleep-wake mechanisms, Sleep, vol.18, issue.3, pp.145-153, 1995. ,
,
, Psychol Neuropsychiatr Vieil, vol.8, issue.1, pp.15-23, 2010.
Use of wrist activity for monitoring sleep/wake in demented nursing-home patients, Sleep, vol.20, issue.1, pp.24-31, 1997. ,
Circadian rhythms of agitation in institutionalized patients with Alzheimer's disease, Chronobiol Int, vol.17, issue.3, pp.405-423, 2000. ,
Disturbance of endogenous circadian rhythm in aging and Alzheimer disease, Am J Geriatr Psychiatry, vol.13, issue.5, pp.359-68, 2005. ,
Rapid eye movement sleep deprivation in elderly patients with concurrent symptoms of depression and dementia, J Neuropsychiatry Clin Neurosci, vol.4, issue.3, pp.249-56, 1992. ,
Observed sleep/wakefulness and severity of dementia in an Alzheimer's disease special care unit, J Gerontol A Biol Sci Med Sci, vol.50, issue.6, pp.303-309, 1995. ,
Sleep disturbance in mild to moderate Alzheimer's disease, Sleep Med, vol.6, issue.4, pp.347-52, 2005. ,
The relationship between dementia severity and rest/activity circadian rhythms, Neuropsychiatr Dis Treat, vol.1, issue.2, pp.155-63, 2005. ,
Treatment of sleep disturbance in Alzheimer's disease, Sleep Med Rev, vol.4, issue.6, pp.603-628, 2000. ,
Sleep and synaptic homeostasis: a hypothesis, Brain Res Bull, vol.62, issue.2, pp.143-50, 2003. ,
Sleep disturbances in older adults with mild cognitive impairment, Int Psychogeriatr, vol.21, issue.4, pp.654-66, 2009. ,
Polysomnographic and subjective sleep markers of mild cognitive impairment, Sleep, vol.36, issue.9, pp.1327-1361, 2013. ,
,
, Psychiatr Pol, vol.45, issue.6, pp.851-60, 2011.
Disrupted daytime activity and altered sleep-wake patterns may predict transition to mild cognitive impairment or dementia: a critically appraised topic, Neurologist, vol.18, issue.6, pp.426-435, 2012. ,
Cognitive impairment, and Alzheimer's disease: A Systematic Review and Meta-Analysis, Sleep, issue.1, p.40, 2017. ,
Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis, Sleep Med Rev, vol.40, pp.4-16, 2018. ,
Sleep quality and preclinical Alzheimer disease, JAMA Neurol, vol.70, issue.5, pp.587-93, 2013. ,
The interaction of sleep and amyloid deposition on cognitive performance, J Sleep Res, vol.26, issue.3, pp.288-292, 2017. ,
Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults, Neurology, vol.89, issue.5, pp.445-453, 2017. ,
Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy, Cereb Cortex, vol.28, issue.8, pp.2775-2785, 2018. ,
Self-reported sleep disturbance is associated with Alzheimer's disease risk in men, Alzheimers Dement, vol.11, issue.9, pp.1090-1097, 2015. ,
Sleep deficits in mild cognitive impairment are related to increased levels of plasma amyloid-beta and cortical thinning, Neuroimage, vol.98, pp.395-404, 2014. ,
Plasma amyloid beta measurementsa desired but elusive Alzheimer's disease biomarker, Alzheimers Res Ther, vol.5, issue.2, p.8, 2013. ,
Chronic sleep fragmentation exacerbates amyloid beta deposition in Alzheimer's disease model mice, Neurosci Lett, vol.653, pp.362-369, 2017. ,
Self-reported sleep and beta-amyloid deposition in communitydwelling older adults, JAMA Neurol, vol.70, issue.12, pp.1537-1580, 2013. ,
, The Relationship between Sleep Quality and Brain Amyloid Burden. Sleep, vol.39, pp.1063-1071, 2016.
Relationships between sleep quality and brain volume, metabolism, and amyloid deposition in late adulthood, Neurobiol Aging, vol.41, pp.107-114, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-01295793
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle, Science, vol.326, issue.5955, pp.1005-1012, 2009. ,
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo, Neuron, vol.48, issue.6, pp.913-935, 2005. ,
Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila, Science, vol.324, issue.5923, pp.109-121, 2009. ,
Decoupling of the brain's default mode network during deep sleep, Proc Natl Acad Sci, vol.106, issue.27, pp.11376-81, 2009. ,
Development of a large-scale functional brain network during human non-rapid eye movement sleep, J Neurosci, vol.30, issue.34, pp.11379-87, 2010. ,
Variations in connectivity in the sensorimotor and default-mode networks during the first nocturnal sleep cycle, Brain Connect, vol.2, issue.4, pp.177-90, 2012. ,
Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo, Nat Med, vol.12, issue.7, pp.856-61, 2006. ,
beta-amyloid dynamics in human plasma, Arch Neurol, vol.69, issue.12, pp.1591-1598, 2012. ,
Proteolytic degradation of amyloid beta-protein. Cold Spring Harb Perspect Med, vol.2, p.6379, 2012. ,
Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease, Exp Neurol, vol.149, issue.2, pp.329-369, 1998. ,
Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease, Acta Neuropathol, vol.118, issue.1, pp.103-116, 2009. ,
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta, Sci Transl Med, vol.4, issue.147, pp.147-111, 2012. ,
Sleep drives metabolite clearance from the adult brain, Science, vol.342, issue.6156, pp.373-380, 2013. ,
Candidate mechanisms underlying the association between sleepwake disruptions and Alzheimer's disease, Sleep Med Rev, vol.31, pp.102-111, 2017. ,
Release of hypocretin (orexin) during waking and sleep states, J Neurosci, vol.22, issue.13, pp.5282-5288, 2002. ,
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease, J Exp Med, vol.211, issue.13, pp.2487-96, 2014. ,
CSF beta-amyloid levels are altered in narcolepsy: a link with the inflammatory hypothesis?, J Sleep Res, vol.23, issue.4, pp.420-424, 2014. ,
Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process, Neurobiol Aging, vol.53, pp.59-66, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01781465
Altered CSF orexin and alpha-synuclein levels in dementia patients, J Alzheimers Dis, vol.29, issue.1, pp.125-157, 2012. ,
Sleep deprivation induces brain region-specific decreases in glutathione levels, Neuroreport, vol.9, issue.12, pp.2853-2859, 1998. ,
Effect of REM sleep deprivation on the antioxidant status in the brain of Wistar rats, Ann Neurosci, vol.19, issue.4, pp.161-165, 2012. ,
, Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem, vol.13, pp.1387-90, 2002.
REM sleep loss and recovery regulates blood-brain barrier function, Curr Neurovasc Res, vol.10, issue.3, pp.197-207, 2013. ,
Sleep restriction impairs blood-brain barrier function, J Neurosci, vol.34, issue.44, pp.14697-706, 2014. ,
Abeta, oxidative stress in Alzheimer disease: evidence based on proteomics studies, Biochim Biophys Acta, vol.1842, issue.8, pp.1248-57, 2014. ,
Breakdown of the Cerebrovasculature and Blood-Brain Barrier: A Mechanistic Link Between Diabetes Mellitus and Alzheimer's Disease, J Alzheimers Dis, vol.54, issue.2, pp.445-56, 2016. ,
Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons, J Neurosci, vol.34, issue.12, pp.4418-4449, 2014. ,
Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice, Neuropharmacology, vol.46, issue.6, pp.895-903, 2004. ,
, Sleep deprivation and cellular responses to oxidative stress. Sleep, vol.27, pp.27-35, 2004.
The pericyte: a forgotten cell type with important implications for Alzheimer's disease?, Brain Pathol, vol.24, issue.4, pp.371-86, 2014. ,
Effects of age and amyloid deposition on Abeta dynamics in the human central nervous system, Arch Neurol, vol.69, issue.1, pp.51-59, 2012. ,
Are new neurons formed in the brains of adult mammals? Science, vol.135, pp.1127-1135, 1962. ,
Regulation and function of adult neurogenesis: from genes to cognition, Physiol Rev, vol.94, issue.4, pp.991-1026, 2014. ,
Functional integration of adult-born neurons, Curr Biol, vol.12, issue.7, pp.606-614, 2002. ,
Functional neurogenesis in the adult hippocampus, Nature, vol.415, issue.6875, pp.1030-1034, 2002. ,
The circadian clock and cell cycle: interconnected biological circuits, Curr Opin Cell Biol, vol.25, issue.6, pp.730-734, 2013. ,
Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation, Sleep, vol.28, issue.4, pp.395-409, 2005. ,
The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit, Cell Rep, vol.5, issue.4, pp.961-73, 2013. ,
Survival of adult generated hippocampal neurons is altered in circadian arrhythmic mice, PLoS One, vol.9, issue.6, p.99527, 2014. ,
Premature aging of the hippocampal neurogenic niche in adult Bmal1-deficient mice, Aging (Albany NY), issue.7, pp.435-484, 2015. ,
Sleep and hippocampal neurogenesis: Implications for Alzheimer's disease. Front Neuroendocrinol, vol.45, pp.35-52, 2017. ,
Sleep deprivation suppresses neurogenesis in the adult hippocampus of rats, Eur J Neurosci, vol.22, issue.8, pp.2111-2117, 2005. ,
Hippocampal neurogenesis is reduced by sleep fragmentation in the adult rat, Neuroscience, vol.148, issue.1, pp.325-358, 2007. ,
Sleep restriction alters the hypothalamic-pituitary-adrenal response to stress, J Neuroendocrinol, vol.14, issue.5, pp.397-402, 2002. ,
URL : https://hal.archives-ouvertes.fr/hal-02326238
Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning, J Neurophysiol, vol.94, issue.6, pp.4224-4257, 2005. ,
Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids, Proc Natl Acad Sci, vol.103, issue.50, pp.19170-19175, 2006. ,
Sleep deprivation can inhibit adult hippocampal neurogenesis independent of adrenal stress hormones, Am J Physiol Regul Integr Comp Physiol, vol.294, issue.5, pp.1693-703, 2008. ,
Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to sleep deprivation in laboratory rats, Am J Physiol Regul Integr Comp Physiol, vol.289, issue.4, pp.1054-63, 2005. ,
Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation, Arch Intern Med, vol.166, issue.16, pp.1756-62, 2006. ,
Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers, Sleep, vol.30, issue.9, pp.1145-52, 2007. ,
REM sleep deprivation in rats results in inflammation and interleukin-17 elevation, J Interferon Cytokine Res, vol.29, issue.7, pp.393-401, 2009. ,
Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6, J Neurosci, vol.22, issue.2, pp.486-92, 2002. ,
Inflammatory blockade restores adult hippocampal neurogenesis, Science, vol.302, issue.5651, pp.1760-1765, 2003. ,
Inflammation is detrimental for neurogenesis in adult brain, Proc Natl Acad Sci, vol.100, issue.23, pp.13632-13639, 2003. ,
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination, J Neurosci, vol.32, issue.25, pp.8696-702, 2012. ,
Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus, J Neurosci, vol.15, issue.6, pp.4687-92, 1995. ,
Sleep interacts with abeta to modulate intrinsic neuronal excitability, Curr Biol, vol.25, issue.6, pp.702-712, 2015. ,
Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit, Cell, vol.165, issue.6, pp.1347-1360, 2016. ,
Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep, Nat Neurosci, vol.11, issue.2, pp.200-208, 2008. ,
Alzheimer's disease, beta-amyloid, glutamate, NMDA receptors and memantine--searching for the connections, Br J Pharmacol, vol.167, issue.2, pp.324-52, 2012. ,
A practical method for grading the cognitive state of patients for the clinician, J Psychiatr Res, vol.12, issue.3, pp.189-98, 1975. ,
Validity of the Mini-Mental State examination as a screening instrument for cognitive impairment and dementia in French elderly community residents, Neuroepidemiology, vol.9, issue.3, pp.143-50, 1990. ,
Calibration of the Computer Science and Applications, Inc. accelerometer, Med Sci Sports Exerc, vol.30, issue.5, pp.777-81, 1998. ,
Automatic sleep/wake identification from wrist activity, Sleep, vol.15, issue.5, pp.461-470, 1992. ,
Actigraphy-based sleep estimation in adolescents and adults: a comparison with polysomnography using two scoring algorithms, Nat Sci Sleep, vol.10, pp.13-20, 2018. ,
Direct comparison of two actigraphy devices with polysomnographically recorded naps in healthy young adults, Chronobiol Int, vol.30, issue.5, pp.691-699, 2013. ,
What is segmented sleep? Actigraphy field validation for daytime sleep and nighttime wake, Sleep Health, vol.2, issue.4, pp.341-347, 2016. ,
Actigraphy for the assessment of sleep measures in Parkinson's disease. Sleep, vol.36, pp.1209-1226, 2013. ,
Unified segmentation, Neuroimage, vol.26, issue.3, pp.839-51, 2005. ,
Automatic segmentation of the hippocampus and the amygdala driven by hybrid constraints: method and validation, Neuroimage, vol.46, issue.3, pp.749-61, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00805390
Anatomically constrained region deformation for the automated segmentation of the hippocampus and the amygdala: Method and validation on controls and patients with Alzheimer's disease. Neuroimage, vol.34, pp.996-1019, 2007. ,
Cognitive and neuroimaging features and brain beta-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study, Lancet Neurol, vol.17, issue.4, pp.335-346, 2018. ,
Use of florbetapir-PET for imaging beta-amyloid pathology, JAMA, vol.305, issue.3, pp.275-83, 2011. ,
Low Cognitive Awareness, but Not Complaint, is a Good Marker of Preclinical Alzheimer's Disease, J Alzheimers Dis, vol.59, issue.2, pp.753-762, 2017. ,
Cognitive and Brain Profiles Associated with Current Neuroimaging Biomarkers of Preclinical Alzheimer's Disease, J Neurosci, vol.35, issue.29, pp.10402-10413, 2015. ,
Amyloid PET imaging in Alzheimer's disease: a comparison of three radiotracers, Eur J Nucl Med Mol Imaging, vol.41, issue.7, pp.1398-407, 2014. ,
Phases of A beta-deposition in the human brain and its relevance for the development of AD, Neurology, vol.58, issue.12, pp.1791-800, 2002. ,
Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults, Neurobiol Aging, vol.36, issue.9, pp.2568-76, 2015. ,
Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease. Brain, pp.844-58, 2013. ,
Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia, Ann Neurol, vol.64, issue.4, pp.388-401, 2008. ,
Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study, Neurology, vol.42, issue.1, pp.115-124, 1992. ,
Insomnia and total sleep time in France: prevalence and associated socio-demographic factors in a general population survey ,
, Rev Neurol (Paris), issue.169, pp.956-64, 2013.
Insomnia in young men and subsequent depression. The Johns Hopkins Precursors Study, Am J Epidemiol, vol.146, issue.2, pp.105-119, 1997. ,
Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis, Arch Gen Psychiatry, vol.63, issue.5, pp.530-538, 2006. ,
Source modeling sleep slow waves, Proc Natl Acad Sci, vol.106, issue.5, pp.1608-1621, 2009. ,
Hemodynamic cerebral correlates of sleep spindles during human non-rapid eye movement sleep, Proc Natl Acad Sci, vol.104, issue.32, pp.13164-13173, 2007. ,
, Vascular cognitive impairment. Lancet Neurol, vol.2, issue.2, pp.89-98, 2003.
Sleep disturbance correlates with white matter hyperintensity in patients with subcortical ischemic vascular dementia, J Geriatr Psychiatry Neurol, vol.26, issue.3, pp.158-64, 2013. ,
,
Association between Benzodiazepine Use and Dementia: A Meta-Analysis, PLoS One, vol.10, issue.5, p.127836, 2015. ,
Benzodiazepine, psychotropic medication, and dementia: A population-based cohort study, Alzheimers Dement, vol.12, issue.5, pp.604-617, 2016. ,
Effects of olanzapine, risperidone and haloperidol on sleep after a single oral morning dose in healthy volunteers, Psychopharmacology (Berl), vol.190, issue.4, pp.507-523, 2007. ,
The role of apolipoprotein E in Alzheimer's disease. Neuron, vol.63, pp.287-303, 2009. ,
, Orexin-A is Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects. Sleep, vol.39, issue.6, pp.1253-60, 2016.
Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea, Sleep Med, vol.25, pp.87-92, 2016. ,
YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease, Biol Psychiatry, vol.68, issue.10, pp.903-915, 2010. ,
beta-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation, Nat Neurosci, vol.18, issue.7, pp.1051-1058, 2015. ,
Sleep and Alzheimer disease pathology--a bidirectional relationship, Nat Rev Neurol, vol.10, issue.2, pp.115-124, 2014. ,
Bidirectional relationships between sleep and amyloid-beta in the hippocampus, Neurobiol Learn Mem, 2018. ,
beta-Amyloid accumulation in the human brain after one night of sleep deprivation, Proc Natl Acad Sci U S A, vol.115, issue.17, pp.4483-4488, 2018. ,
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease, Neurobiol Dis, vol.35, issue.3, pp.426-458, 2009. ,
Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition, Arch Neurol, vol.69, issue.5, pp.636-679, 2012. ,
Résumé : Les troubles du sommeil sont associés à une augmentation du risque de développer des troubles cognitifs tels que les troubles cognitifs légers et la maladie d'Alzheimer. De nombreuses études récentes suggèrent que l'accumulation du peptide bêta-amyloïde (Aß), Sleep Biol Rythms, vol.13, pp.172-180, 2015. ,
, Cependant, les mécanismes liant le sommeil et les modifications cérébrales sous-jacentes au déclin cognitif ne sont pas encore clairement élucidées
Analyser objectivement les perturbations du cycle veille-sommeil chez les personnes âgées présentant des troubles cognitifs subjectifs avec (A+) ou sans (A-) dépôt amyloïde cérébral significatif ,
, Méthode: Les participants (68 individus cognitivement sains avec une plainte subjective issus de la cohorte INSIGHT-preAD) ont été invités à enregistrer leur qualité de sommeil pendant sept nuit à domicile par l'intermédiaire d'un accéléromètre, et ont été divisés en deux sousgroupes (A+ et A-) en fonction de la présence d'un dépôt cérébral amyloïde significatif. Les participants ont également passé une imagerie par résonance magnétique afin de mesurer la trophicité hippocampique
, Résultats: Plusieurs paramètres du sommeil étaient significativement différents entre les deux sous-groupes
, Une latence du sommeil plus longue, des éveils nocturnes plus longs et plus nombreux ainsi qu'une plus mauvaise efficacité du sommeil étaient associés à une charge amyloïde cérébrale plus importante. Cependant, le dépôt d'Aß n'était pas associé à une région cérébrale spécifique
, De plus, aucune association n'a été retrouvée entre la qualité du sommeil et la trophicité hippocampique
, Conclusion: Conformément aux données de la littérature, la qualité du sommeil évaluée objectivement était associée à un niveau plus élevé de dépôt amyloïde cérébral. Ces résultats confirment l'importance de la qualité du sommeil chez les personnes âgées
, Mot clés : Sommeil, amyloïde, Maladie d'Alzheimer, florbetapir