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Master Thesis

Impact de l’activation de AhR sur les processus moléculaires au niveau des cellules épithéliales thymiques

Abstract : Autoimmune diseases are a group of 80 pathologies arising from dysfunctional immune central tolerance mechanism. Their feminine prevalence as well as their high incidence in industrialized countries have raised questions and concerns about environmental exposure to xenoestrogens, described as endocrine disruptors, which could play a leading role in the development of autoimmune pathologies. Toxicity of these chemicals is mediated through Aryl Hydrocarbon Receptor (AhR). AhR is known to regulate autoimmunity key genes by binding to DNA or inducing epigenetic modifications. Thus, AhR can disrupt the balance between Th17 and Treg proliferation. In this study, we compared expression profiles of AhR target genes deregulated in patients with myasthenia gravis with thymic cells exposed to different AhR ligands, and we found similarities. Secondly, after showing overexpression of DNA methylatransferases by exposure to AhR ligands, we identified common differentially methylated promoter regions. Two of them were located in KRT5 and GNAS, two genes that are linked to autoimmunity.
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https://dumas.ccsd.cnrs.fr/dumas-02364967
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Submitted on : Friday, November 15, 2019 - 11:22:06 AM
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Bastien Ducreux. Impact de l’activation de AhR sur les processus moléculaires au niveau des cellules épithéliales thymiques. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02364967⟩

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