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Master Thesis

Les perturbateurs endocriniens et fertilité trans-générationnelle

Abstract : Introduction: Endocrine disruptors are present ubiquitously in our environment and expose us to risks. Pregnant women and their fetus are obviously exposed to these substances. Endocrine disruptors can have a significant impact on the reproductive system and impair the future fertility of unborn children. Objective: To identify the effects of exposure to endocrine disruptors in utero on genital development. Materials and methods: A review of the literature was conducted on 3 databases (PubMed, ScienceDirect, EM Premium), using the following keywords "endocrine disruptor", "endocrine disruptors AND intrauterine exposure", "endocrine disrptor and infertility ». 26 items were selected. Results: Bisphenol A, Distilbene, phthalates, parabens and mild analgesics are the main incriminated substances. External genital malformations such as cryptorchidism, hypospadias in the male newborn, or reproductive disorders, endometriosis in the girl were found. In the end, it is the future fertility of these children that would seem to be disturbed. Conclusion: The suspected effects are considerable. The reproductive system seems to be very sensitive to these kinds of substances, especially at the time of its formation. However, it would be necessary to take stock of the self-medication of pregnant women with mild analgesics given their likely consequences.
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https://dumas.ccsd.cnrs.fr/dumas-02376410
Contributor : École Universitaire de Maïeutique Marseille Méditerranée (eu3m) <>
Submitted on : Friday, November 22, 2019 - 3:39:25 PM
Last modification on : Monday, July 6, 2020 - 4:04:38 PM

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  • HAL Id : dumas-02376410, version 1

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Élodie Galtier. Les perturbateurs endocriniens et fertilité trans-générationnelle. Gynécologie et obstétrique. 2019. ⟨dumas-02376410⟩

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