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Master Thesis

Évaluation d'une nouvelle technique laser de dé-tatouage par succession ultra-rapide d'impulsions : étude prospective de phase I-II

Abstract : Background: Current technologies for removing tattoos have shown their limitations in term of efficiency, pain and side-effects. We propose a new approach to avoid the energy levels used today and responsible of such side-effects.
Objective: To study the efficacy and the tolerance in tattoo removal of a laser providing an ultrafast burst of pulses.
Methods: A preclinical followed by a phase 1-2 prospective studies were performed on ex-vivo skin explants and on healthy subjects with black tattoos, respectively, using an ultrafast burst of pulses laser (35ps, 4MHz, 1064nm). Efficacy was assessed on standardized pictures by two independent physicians. Pain during treatment was evaluated using a visual analogical scale. Histological examinations were performed immediately after the laser session and at two months.
Results: We included 10 patients from skin type II to IV. The fluences of 10 and 50 J/cm2 have reduced the intensity of the pigment in 6 patients with a better decrease at 50 J/cm2. The average pain ranged from 0.4 to 2.75/10 depending on the fluences. Side effects were mild and only at the highest fluencies. Conclusion: Laser emitting ultrafast burst of pulses showed very good tolerance and promising efficacy for removing tattoos in this proof of concept study.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02382533
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Submitted on : Wednesday, November 27, 2019 - 11:25:22 AM
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Aurélie Lorgeou. Évaluation d'une nouvelle technique laser de dé-tatouage par succession ultra-rapide d'impulsions : étude prospective de phase I-II. Médecine humaine et pathologie. 2018. ⟨dumas-02382533⟩

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