Skip to Main content Skip to Navigation
Master Thesis

Incidence de la cystite hémorragique à BK virus et déterminants cliniques et virologiques dans la greffe halo-identique de cellules souches hématopoïétiques: étude observationnelle prospective monocentrique

Abstract : Introduction: BK virus hemorrhagic cystitis (BKV-HC) is a common complication of the allogenic hematopoietic stem cell transplantation. Its incidence is increased after haploidentical transplantation (haplo) in retrospective studies but has never been evaluated prospectively. The clinical and biological determinants remain to be defined. Methods: We included 21 patients at Bordeaux University Hospital between 1st July 2016 and 31st December 2017 in a prospective observational study. The primary endpoint was the occurrence of BKV-HC. We performed weekly BK virus quantitative real-time PCR in blood and urine samples from day-6 to day+100 post-transplant. Patients were followed until day+100 post-transplant. Results: The incidence of hemorrhagic cystitis (HC) was 19% (4 patients), with 75% grade 3-4 CH. The median occurrence of HC was 45 days. Only one patient had low platelet level at HC onset. The BK virus PCR (BKV-PCR) urinary had 100% sensitivity and 70% specificity. BKV-PCR in urine were positive at least 1 month before appearance of clinical signs. BKV-PCR in blood were positive only at the time of clinical symptomatology. 5 patients had BKV viruria without clinical signs. The main risk factors for HC were corticosteroids (p = 0.047) and myeloablative conditioning (MAC) (p = 0.087). Survival at day+100 was 81%. Conclusion: We found a low incidence of BKV-HC in haplo and that BKV-PCR in urine could be positive at least 1 month before HC onset in HSC recipients. In our study HC impact on morbidity but not on overall survival. As we found a lower incidence of BKV-HC than expected, a larger multicenter prospective study is needed to corroborate our findings.
Complete list of metadatas

Cited literature [41 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-02384536
Contributor : Médecine Ub <>
Submitted on : Thursday, November 28, 2019 - 2:11:41 PM
Last modification on : Friday, October 23, 2020 - 4:34:50 PM
Long-term archiving on: : Saturday, February 29, 2020 - 3:52:49 PM

File

Med_spe_2018_Debus.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-02384536, version 1

Collections

Citation

Lucile Debus. Incidence de la cystite hémorragique à BK virus et déterminants cliniques et virologiques dans la greffe halo-identique de cellules souches hématopoïétiques: étude observationnelle prospective monocentrique. Sciences du Vivant [q-bio]. 2018. ⟨dumas-02384536⟩

Share

Metrics

Record views

36

Files downloads

53