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Master Thesis

Traitement de l'aphtose buccale récidivante et idiopathique de l'adulte par probiotiques : étude interventionnelle randomisée en double aveugle versus placebo

Abstract : Background: Recurrent idiopathic aphtosous stomatitis (RIAS) is a frequent disorder that induces a marked alteration of the quality of life of affected individuals. The objective of this study was to assess the efficacy of probiotics on recurrent aphthous ulcerations in adults.
Patients and Methods: Monocentric randomized parallel group, double blind, placebo-controlled, study was conducted in the Department of Dermatology of Nice University hospital over a two years period. Eligible participants were all adults aged 18 or over with history of recurrent aphthous ulcerations. Treatment was a powder for oral suspension. Probiotic group received Lactobacillus rhamnosus Lcr35. The daily dosage was 4 sachets for each group. Duration of treatment and post-treatment follow-up were 3 months each. The primary endpoint was the number of canker sores’ evolution during the three months of treatment compared to baseline.
Results: 19 patients (9 placebo group; 10 probiotic group) were randomized. 2 patients were excluded from analysis because they didn’t start the treatment, leaving 17 patients (8 placebo group ; 9 probiotic group) for the modified intention to treat analysis. The average decrease of canker sores in placebo group was -3,55 ± 1,80 IC95% [-7,42 ; 0,32] p = 0,0693, versus -0,73 ± 1,69 IC95% [-4,35 ; 2,88] p = 0,67 in probiotic group. There is no significant difference between the 2 groups (-2,81 IC95% [-8,52 ; 2,89] p = 0,3076).
Conclusion: Probiotics do not seem effective in the treatment of recurrent aphthous ulceration in adults.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02386674
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Submitted on : Friday, November 29, 2019 - 2:07:28 PM
Last modification on : Tuesday, May 26, 2020 - 6:50:40 PM

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Pierre-Michel Dugourd. Traitement de l'aphtose buccale récidivante et idiopathique de l'adulte par probiotiques : étude interventionnelle randomisée en double aveugle versus placebo. Médecine humaine et pathologie. 2019. ⟨dumas-02386674⟩

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