, Comparaison des patients à l'inclusion (M0) selon leur amélioration du CSS La synthèse des résultats est présentée dans les tableaux 27 et 28

, Dix-sept patients (31,48%) présentaient une amélioration du CSS de plus de 4,9 points lors de la réévaluation à M8 (« diminution CSS > 4,9 points »). Dans ce groupe « diminution CSS > 4,9 points » on notait 11 femmes et 6 hommes soit 64,7% de femmes. Le groupe « diminution CSS < 4,9 points

, On notait dans le groupe « diminution CSS > 4,9 points » et le groupe « diminution CSS < 4,9 points » respectivement 17,6% et 32,4% d'antécédent de syndrome dépressif, vol.0, p.0

, d'infarctus du myocarde dans les deux groupes (p=1), 0% et 5,4% d'antécédent de diabète (p=1), vol.35

, Il existait significativement plus de patients ayant un antécédent d'accident vasculaire cérébral dans le groupe « diminution CSS > 4,9 points » avec respectivement 17

C. Masson, Algodystrophie : syndrome douloureux régional complexe de type I. EMC -Appareil locomoteur, janv, vol.6, issue.2, pp.1-16, 2011.

J. Berthelot, Actualités dans le traitement des algodystrophies (syndrome douloureux régional complexe de type I). Revue du Rhumatisme, vol.73, pp.881-887, 2006.

B. Blum and J. Estebe, Anesthésie locorégionale et anesthésie locorégionale intraveineuse dans la prise en charge du syndrome douloureux régional complexe (algoneurodystrophie) chez l'adulte. Douleur et Analgésie

D. Sur,

P. Doury and . Algodystrophy, Reflex sympathetic dystrophy syndrome, Clinical Rheumatology. juin, vol.7, issue.2, pp.173-80, 1988.

F. Kozin, L. M. Ryan, G. F. Carerra, J. S. Soin, and R. L. Wortmann, The reflex sympathetic dystrophy syndrome (RSDS), The American Journal of Medicine. janv, vol.70, issue.1, pp.23-30, 1981.

S. Bruehl, N. R. Harden, B. S. Galer, S. Saltz, M. Bertram et al., External validation of IASP diagnostic criteria for Complex Regional Pain Syndrome and proposed research diagnostic criteria, Pain. mai, vol.81, issue.1, pp.147-54, 1999.

N. R. Harden, S. Bruehl, R. Perez, F. Birklein, J. Marinus et al., Validation of proposed diagnostic criteria (the "Budapest Criteria") for Complex Regional Pain Syndrome, Pain. août, vol.150, issue.2, pp.268-74, 2010.

C. Spicher, J. Estebe, E. Létourneau, T. L. Packham, P. Rossier et al., Critères diagnostiques du syndrome douloureux régional complexe (SDRC), Douleur et Analgésie. mars, vol.27, issue.1, pp.62-66, 2014.

R. N. Harden, S. Bruehl, M. Stanton-hicks, and P. R. Wilson, Proposed New Diagnostic Criteria for Complex Regional Pain Syndrome, Pain Medicine. mai, vol.8, issue.4, pp.326-357, 2007.

P. Sandroni, L. M. Benrud-larson, R. L. Mcclelland, and P. A. Low, Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study, Pain. mai, vol.103, issue.1, pp.199-207, 2003.

M. De-mos, A. De-bruijn, F. Huygen, J. P. Dieleman, S. Chbh et al., The incidence of complex regional pain syndrome: A population-based study, Pain. mai, vol.129, issue.1, pp.12-20, 2007.

A. Kuttikat, M. Shaikh, A. Oomatia, R. Parker, and N. Shenker, Novel Signs and Their Clinical Utility in Diagnosing Complex Regional Pain Syndrome (CRPS): A Prospective Observational Cohort Study, The Clinical Journal of Pain. juin, vol.33, issue.6, pp.496-502, 2017.

M. Varenna, S. Adami, M. Rossini, D. Gatti, L. Idolassi et al., Treatment of complex regional pain syndrome type I with neridronate : a randomized, double-blind, placebo-controlled study, Rheumatology (Oxford). mars, vol.52, issue.3, pp.534-576, 2013.

J. N. Robinson, J. Sandom, and P. T. Chapman, Efficacy of pamidronate in complex regional pain syndrome type I, Pain Med. sept, vol.5, issue.3, pp.276-80, 2004.

D. H. Manicourt, J. P. Brasseur, Y. Boutsen, G. Depreseux, and J. P. Devogelaer, Role of alendronate in therapy for posttraumatic complex regional pain syndrome type I of the lower extremity, Arthritis Rheum, vol.50, issue.11, pp.3690-3697, 2004.

S. Adami, V. Fossaluzza, D. Gatti, E. Fracassi, and V. Braga, Bisphosphonate therapy of reflex sympathetic dystrophy syndrome, Ann Rheum Dis. mars, vol.56, issue.3, pp.201-205, 1997.

A. T. Borchers and M. E. Gershwin, Complex regional pain syndrome: A comprehensive and critical review, Autoimmunity Reviews. mars, vol.13, issue.3, pp.242-65, 2014.

S. Bruehl, An Update on the Pathophysiology of Complex Regional Pain Syndrome, Anesthesiology. août, vol.1, 2010.

C. Maihöfner, F. Seifert, and K. Markovic, Complex regional pain syndromes: new pathophysiological concepts and therapies: CRPS -new aspects, European Journal of Neurology. mai, vol.17, issue.5, pp.649-60, 2010.

G. Wasner, Vasomotor Disturbances in Complex Regional Pain Syndrome-A Review, Pain Medicine. août, vol.11, issue.8, pp.1267-73, 2010.

R. Baron, J. Schattschneider, A. Binder, D. Siebrecht, and G. Wasner, Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study, The Lancet. mai, vol.359, issue.9318, pp.1655-60, 2002.

D. F. Bandyk, B. L. Johnson, A. F. Kirkpatrick, M. L. Novotney, M. R. Back et al., Surgical sympathectomy for reflex sympathetic dystrophy syndromes, Journal of Vascular Surgery. févr, vol.35, issue.2, pp.269-77, 2002.

T. J. Coderre, D. N. Xanthos, L. Francis, and G. J. Bennett, Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-Type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat: Pain, vol.112, pp.94-105, 2004.

F. Birklein, M. Weber, and B. Neundorfer, Increased skin lactate in complex regional pain syndrome: Evidence for tissue hypoxia? Neurology, vol.55, pp.1213-1218, 2000.

P. J. Albrecht, S. Hines, E. Eisenberg, D. Pud, D. R. Finlay et al., Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome, Pain. févr, vol.120, issue.3, pp.244-66, 2006.

L. Van-der-laan, H. J. Ter-laak, A. Gabreëls-festen, F. Gabreël, and R. J. Goris, Complex regional pain syndrome type I (RSD): pathology of skeletal muscle and peripheral nerve, Neurology, vol.51, issue.1, pp.20-25, 1998.

A. M. Rooij, M. Mos, M. Sturkenboom, J. Marinus, A. Maagdenberg et al., Familial occurrence of complex regional pain syndrome, European Journal of Pain. févr, vol.13, issue.2, pp.171-178, 2009.

M. A. Kemler, A. C. Van-de-vusse, E. M. Van-den-berg-loonen, G. A. Barendse, M. Van-kleef et al., HLA-DQ1 associated with reflex sympathetic dystrophy, Neurology, vol.53, issue.6, pp.1350-1351, 1999.

J. J. Van-hilten, W. J. Van-de-beek, and B. O. Roep, Multifocal or generalized tonic dystonia of complex regional pain syndrome. A distinct clinical entity associated with HLA-DR13, Ann Neurol, vol.48, issue.1, pp.113-119, 2000.

A. Beerthuizen, A. Van-?t-spijker, F. Huygen, J. Klein, and R. De-wit, Is there an association between psychological factors and the Complex Regional Pain Syndrome type 1 (CRPS1) in adults? A systematic review, Pain. sept, vol.145, issue.1, pp.52-61, 2009.

B. Dilek, B. Yemez, R. Kizil, E. Kartal, S. Gulbahar et al., Anxious personality is a risk factor for developing complex regional pain syndrome type I, Rheumatology International. avr, vol.32, issue.4, pp.915-935, 2012.

R. N. Harden, A. L. Oaklander, A. W. Burton, R. Perez, K. Richardson et al., Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, Pain Medicine. févr, vol.14, issue.2, pp.180-229, 2013.

H. Mussawy, Evaluation of bone microstructure in CRPS-affected upper limbs by HR-pQCT. Clinical Cases in Mineral and Bone Metabolism, vol.14, p.54, 2017.

M. F. Basle, A. Rebel, and J. C. Renier, Bone tissue in reflex sympathetic dystrophy syndrome-Sudeck's atrophy: Structural and ultrastructural studies. Metabolic Bone Disease and Related Research, janv, vol.4, issue.5, pp.305-316, 1983.

A. Giusti and G. Bianchi, Treatment of complex regional pain syndrome type I with bisphosphonates, RMD Open, vol.7, 2014.

M. Russo, P. Georgius, and D. M. Santarelli, A new hypothesis for the pathophysiology of complex regional pain syndrome, Medical Hypotheses. oct, vol.119, pp.41-53, 2018.

A. Lauwers, M. Koenig, M. Navez, and P. Cathébras, Algodystrophie ou syndrome douloureux régional complexe de type I : mise au point, vol.12, p.9, 2019.

B. Vincent and C. Wood, Les syndromes douloureux régionaux complexes (SDRC) de type I et II. Douleurs : Evaluation -Diagnostic -Traitement, févr, vol.9, issue.1, pp.11-20, 2008.

P. Veldman, H. M. Reynen, I. E. Arntz, and R. Goris, Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. The Lancet, vol.342, pp.1012-1018, 1993.

H. Kocabas, F. Levendoglu, O. M. Ozerbil, and B. Yuruten, Complex regional pain syndrome in stroke patients, International Journal of Rehabilitation Research. mars, vol.30, issue.1, pp.33-41, 2007.

L. Falcou, E. Bayen, A. Potet, A. Peskine, and P. P. Diehl, Pre´valence et facteurs associe´s au syndrome douloureux re´gional complexe de type 1 du membre supe´rieur chez le patient he´miple´gique, p.1

M. Sellami, F. Frikha, H. Fourati, M. Ezzedine, N. Hdiji et al., Algodystrophie des membres inférieurs au cours de la grossesse, vol.49, pp.178-86, 2006.

S. U. Ahmed, Complex Regional Pain Syndrome Type I After myocardial infarction treated with spinal cord stimulation, Reg Anesth Pain Med. mai, vol.28, issue.3, pp.245-252, 2003.

J. C. Crispin and J. Alcocer-varela, Rheumatologic manifestations of diabetes mellitus, The American Journal of Medicine. juin, vol.114, issue.9, pp.753-760, 2003.

M. Prowse, C. M. Higgs, C. Forrester-wood, and N. Mchugh, Reflex sympathetic dystrophy associated with squamous cell carcinoma of the lung, Annals of the Rheumatic Diseases. 1 avr, vol.48, issue.4, pp.339-380, 1989.

M. De-mos, F. Huygen, S. Chbh, J. P. Dieleman, and M. Sturkenboom, The association between ACE inhibitors and the complex regional pain syndrome: Suggestions for a neuro-inflammatory pathogenesis of, CRPS: Pain. avr, vol.142, issue.3, pp.218-242, 2009.

A. K. Ndao, N. S. Diagne, M. Ndiaye, L. B. Seck, M. S. Diop-sene et al., Algodystrophie gardénalique : présentation de huit nouveaux cas africains et revue de la littérature, juin, vol.32, issue.2, pp.66-75, 2012.

R. Boerl, J. Marinusl, J. J. Hiltenl, F. J. Huygenl, F. Eijsl et al., Distribution of signs and symptoms of Complex Regional Pain Syndrome type I in patients meeting the diagnostic criteria of the International Association for the Study of Pain, European Journal of Pain. sept, vol.15, issue.8, 2011.

. Damiano, Algodystrophie (syndrome douloureux régional complexe de type I) du pied et de la cheville, EMC -podologie. janv, vol.15, issue.1, pp.1-13, 2019.

M. Stanton-hicks, W. Jänig, S. Hassenbusch, J. D. Haddox, R. Boas et al., Reflex sympathetic dystrophy: changing concepts and taxonomy: Pain, vol.63, pp.127-160, 1995.

M. Schürmann, J. Zaspel, P. Löhr, I. Wizgall, M. Tutic et al., Imaging in Early Posttraumatic Complex Regional pain syndrome: a comparison of diagnostic mathods, Clin J Pain, vol.23, issue.5, pp.449-57, 2007.

Z. J. Cappello, M. L. Kasdan, and D. S. Louis, Meta-analysis of Imaging Techniques for the Diagnosis of Complex Regional Pain Syndrome Type I. The Journal of Hand Surgery, févr, vol.37, issue.2, pp.288-96, 2012.

F. Crozier, P. Champsaur, T. Pham, J. Bartoli, M. Kasbarian et al., Magnetic resonance imaging in reflex sympathetic dystrophy syndrome of the foot, Joint Bone Spine. déc, vol.70, issue.6, pp.503-511, 2003.

B. A. Howard, L. Roy, A. D. Kaye, and S. Pyati, Utility of Radionuclide Bone Scintigraphy in Complex Regional Pain Syndrome, Current Pain and Headache Reports. janv, vol.22, issue.1, p.7, 2018.

A. Goebel, C. H. Barker, and L. Turner-stokes, Complex regional pain syndrome: UK guidelines for diagnosis, referral and management in primary and secondary care. London: Royal College of Physicians, British Orthopaedic Association, 2012.

M. D. Stanton-hicks, A. W. Burton, S. P. Bruehl, D. B. Carr, R. N. Harden et al., An Updated Interdisciplinary Clinical Pathway for CRPS: Report of an Expert Panel, Pain Practice. mars, vol.2, issue.1, pp.1-16, 2002.

F. Debiais, Bone targeting agents: bisphosphonates, Bulletin du Cancer, vol.100, issue.11, pp.1199-206, 2013.

F. Debiais, Biomarkers of bone remodelling, Bulletin du Cancer, vol.100, issue.11, pp.1093-100, 2013.

A. Bonabello, M. R. Galmozzi, T. Bruzzese, and G. P. Zara, Analgesic effect of bisphosphonates in mice, Pain. avr, vol.91, issue.3, pp.269-75, 2001.

R. K. Wong and P. J. Wiffen, Bisphosphonates for the relief of pain secondary to bone metastases. Cochrane Pain, Palliative and Supportive Care Group, éditeur. Cochrane Database of Systematic Reviews, vol.22

D. Sur,

R. M. Javier and S. Perrot, Les bisphosphonates sont-ils des antalgiques ? Perspectives futures, de la métastase osseuse à l'arthrose -Are bisphosphonates antalgics? Perspectives for the future

M. Chevreau, X. Romand, P. Gaudin, R. Juvin, and A. Baillet, Bisphosphonates pour le traitement du syndrome douloureux régional complexe de type 1 : revue systématique de la littérature et métaanalyse des essais randomisés versus placebo, Revue du Rhumatisme. déc, vol.84, issue.6, pp.492-499, 2017.

V. Chauvineau, P. Codine, C. Hérisson, F. Pellas, and J. Pélissier, Quelle est la place des biphosphonates dans le traitement de l'algodystrophie sympathique réflexe ? Annales de Réadaptation et de Médecine Physique, avr, vol.48, issue.3, pp.150-157, 2005.

H. Harke, P. Gretenkort, H. U. Ladleif, S. Rahman, and O. Harke, The Response of Neuropathic Pain and Pain in Complex Regional Pain Syndrome I to Carbamazepine and Sustained-Release Morphine in Patients Pretreated with Spinal Cord Stimulation: A Double-Blinded Randomized Study, ANESTH ANALG, issue.8

A. C. Van-de-vusse, S. G. Stomp-van-den-berg, A. H. Kessels, and W. E. Weber, Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1, BMC Neurol. déc, vol.4, issue.1, p.13, 2004.

I. Gilron, R. R. Holden, and R. L. Houlden, Morphine, Gabapentin, or Their Combination for Neuropathic Pain, The New England Journal of Medicine, p.11, 2005.

F. Aïm, S. Klouche, A. Frison, T. Bauer, and P. Hardy, Efficacité de la vitamine C en prévention du syndrome douloureux régional complexe de type 1 après fracture du poignet : revue systématique et métaanalyse, Revue de Chirurgie Orthopédique et Traumatologique. mai, vol.103, issue.3, pp.324-333, 2017.

M. J. Sigtermans, J. J. Van-hilten, M. Bauer, S. M. Arbous, J. Marinus et al., Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1: Pain, vol.145, pp.304-315, 2009.

S. Derry, R. Lloyd, R. A. Moore, and H. J. Mcquay, Topical capsaicin for chronic neuropathic pain in adults, vol.36, 2009.

D. Tran, S. Duong, P. Bertini, and R. J. Finlayson, Treatment of complex regional pain syndrome: a review of the evidence, Can J Anesth/J Can Anesth. févr, vol.57, issue.2, pp.149-66, 2010.

S. Kharkar, P. Ambady, Y. Venkatesh, and R. J. Schwartzman, Intramuscular Botulinum Toxin in Complex Regional Pain Syndrome: Case Series and Literature Review, Pain Physician, p.6

S. Straube, S. Derry, R. A. Moore, and P. Cole, Cervico-thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome. Cochrane Pain, Palliative and Supportive Care Group, éditeur. Cochrane Database of Systematic Reviews, 2013.

D. Sur,

R. S. Perez, P. E. Zollinger, P. U. Dijkstra, I. L. Thomassen-hilgersom, W. W. Zuurmond et al., ERevseiadrcheanrticclee based guidelines for complex regional pain syndrome type, p.14, 2010.

A. Mailis-gagnon and A. D. Furlan, The Cochrane Collaboration, éditeur. Cochrane Database of Systematic Reviews

U. K. Chichester, , 2002.

.. C. Disponible,

A. A. Der-plas, J. Marinus, S. Eldabe, E. Buchser, and J. J. Van-hilten, The Lack of Efficacy of Different Infusion Rates of Intrathecal Baclofen in Complex Regional Pain Syndrome: A Randomized, Double-Blind, Crossover Study, Pain Med. mars, vol.12, issue.3, pp.459-65, 2011.

C. Palazzo and S. Poiraudeau, Actualités dans le diagnostic et les traitements du SDRC. Developments in the diagnosis and treatment of CRPS, Lett Méd Phys Réadapt, issue.28, pp.64-69, 2012.

R. S. Perez, P. E. Zollinger, P. U. Dijkstra, I. L. Thomassen-hilgersom, W. W. Zuurmond et al., Evidence based guidelines for complex regional pain syndrome type 1, BMC Neurol. Mars, vol.10, p.20, 2010.

R. N. Harden, M. Swan, A. King, B. Costa, and J. Barthel, Treatment of Complex Regional Pain Syndrome, Clin J Pain, vol.22, issue.5, p.5, 2006.

H. K. Watson and L. Carlson, Treatment of reflex sympathetic dystrophy of the hand with an active "stress loading" program, J Hand Surg Am. sept, vol.12, issue.5, pp.779-85, 1987.

A. Berquin, B. Leroy, D. Mouraux, and P. Voodecker, Mirrors for treating pain, Why?, vol.16, pp.124-130, 2015.

, Haute Autorité de santé -Evaluation des appareils de neurostimulation electrique transcutanee

F. J. Robainai, J. L. Rodriguez, J. A. De-vera, and M. A. Martin, Transcutaneous eletrical nerve stimulation and spinal cord stimulation for pain relief in reflex sympathetic dystrophy, Stereotact Funct Neurosurg, vol.52, issue.1, pp.53-62, 1989.

N. Vaserman, D. Vesvard, J. Edan, J. Estèbe, D. Roy et al., Thérapie cognitivocomportementale de huit cas de syndrome douloureux régional complexe rebelle (SDRC), juin, vol.8, issue.3, pp.160-72, 2007.

A. Bera-louville, V. Barfety-servignat, and A. Berquin, Recommandations diagnostiques et prise en charge thérapeutique du syndrome douloureux régional complexe. Conférence. 30e congrès Francais de rhumatologie, 2017.

N. R. Harden, S. Bruehl, R. Perez, F. Birklein, J. Marinus et al., Development of a severity score for, CRPS: Pain. déc, vol.151, issue.3, pp.870-876, 2010.

M. Rehman, A. D. Clayson, D. Marsh, J. Adams, J. Cantrill et al., Treatment of reflex sympathetic dystrophy witch intravenous pamidronate. Bone Diseases Research, Avril, vol.36, 1991.

. Inserm--dépression,

F. Eulry, D. Lechevalier, B. Pats, C. Alliaume, P. Crozes et al., Regional intravenous guanethidine blocks in algodystrophy, Clin Rheumatol, vol.10, issue.4, pp.377-83, 1991.

, Ministère des solidarités et de la Santé

, Disponible sur

D. Bouhassira, N. Attal, J. Fermanian, H. Alchaar, M. Gautron et al., Development and validation of the Neuropathic pain symptom inventory, vol.108, pp.248-57, 2004.

, Haute Autorité de santé -Polyarthrite rhumatoïde. Diagnostic et prise en charge initiale, 2009.

, Disponible sur

, Disponible sur

Y. Yao, Y. Tan, A. R. Light, J. Mao, A. Yu et al., Alendronate Attenuates Spinal Microglial Activation and Neuropathic Pain, The Journal of Pain. août, vol.17, issue.8, pp.889-903, 2016.

M. Caraglia, L. Luongo, G. Salzano, S. Zappavigna, M. Marra et al., Stealth Liposomes Encapsulating Zoledronic Acid: A New Opportunity To Treat Neuropathic Pain, Mol Pharmaceutics. 4 mars, vol.10, issue.3, pp.1111-1119, 2013.

N. Yildiz, O. Topuz, G. O. Gungen, S. Deniz, H. Alkan et al., Health-related quality of life (Nottingham Health Profile) in knee osteoarthritis: correlation with clinical variables and self-reported disability, Rheumatol Int, vol.30, issue.12, pp.1595-600, 2010.

A. Llewellyn, C. S. Mccabe, Y. Hibberd, P. White, L. Davies et al., Are you better? A multi-centre study of patient-defined recovery from Complex Regional Pain Syndrome, Eur J Pain. mars, vol.22, issue.3, pp.551-64, 2018.

D. J. Bean, M. H. Johnson, W. Heiss-dunlop, and R. R. Kydd, Factors associated with disability and sick leave in early complex regional pain syndrome type 1, Clin J Pain. fev, vol.32, issue.2, pp.130-138, 2016.