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Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation, Investig Radiol, vol.49, pp.685-690, 2014. ,
Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent, Radiology, vol.275, pp.783-791, 2015. ,
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Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol, Eur Radiol, vol.26, pp.807-815, 2016. ,
Signal enhancement of the dentate nucleus at unenhanced MR imaging after very high cumulative doses of the macrocyclic gadolinium-based contrast agent gadobutrol: an observational study, Radiology, vol.285, pp.434-444, 2017. ,
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Hepatic gadolinium deposition and reversibility after contrast agent-enhanced MR imaging of pediatric hematopoietic stem cell transplant recipients, Radiology, vol.281, pp.418-426, 2016. ,
High levels of gadolinium deposition in the skin of a patient with normal renal function, Investig Radiol, vol.51, pp.280-289, 2016. ,
Macrocyclic and other non-group 1 gadolinium contrast agents deposit low levels of gadolinium in brain and bone tissue: preliminary results from 9 patients with Normal renal function, Investig Radiol, vol.51, pp.447-453, 2016. ,
Comparison of Gd(DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy, Investig Radiol, vol.41, pp.272-278, 2006. ,
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, CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014, vol.19, pp.1-88, 2017.
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Long-term visual outcomes of optic pathway gliomas in pediatric patients without neurofibromatosis type 1, J Neuro-Oncol, vol.129, pp.173-178, 2016. ,
Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations, Ann Neurol, vol.61, pp.189-198, 2007. ,
, CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States, vol.17, pp.1-62, 2008.
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URL : https://hal.archives-ouvertes.fr/hal-01479018
Optic pathway gliomas in children with and without neurofibromatosis 1, J Child Neurol, vol.18, pp.471-478, 2003. ,
MR imaging of brain pilocytic astrocytoma: beyond the stereotype of benign astrocytoma, Childs Nerv Syst, vol.33, pp.35-54, 2017. ,
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Spontaneous modifications of contrast enhancement in childhood non-cerebellar pilocytic astrocytomas, Neuroradiology, vol.54, pp.989-995, 2012. ,
Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis, Neuro-Oncology, vol.14, pp.790-797, 2012. ,
Longitudinal measures of visual function, tumor volume, and prediction of visual outcomes after treatment of optic pathway gliomas, Ophthalmology, vol.119, pp.1231-1237, 2012. ,
The effect of chemotherapy on optic pathway gliomas and their sub-components: a volumetric MR analysis study, Pediatr Blood Cancer, vol.62, pp.1353-1359, 2015. ,
Radiological classification of optic pathway gliomas: experience of a modified functional classification system, Br J Radiol, vol.81, pp.761-766, 2008. ,
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Can we improve accuracy and reliability of MRI interpretation in children with optic pathway glioma? Proposal for a reproducible imaging classification, Neuroradiology, vol.58, pp.197-208, 2016. ,
Automatic segmentation, internal classification, and follow-up of optic pathway gliomas in MRI, Med Image Anal, vol.16, pp.177-188, 2012. ,
Comparison of diameter and perimeter methods for tumor volume calculation, J Clin Oncol, vol.19, pp.551-557, 2001. ,
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, Eur Radiol, vol.26, issue.11, pp.4080-4088, 2016.
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Intracranial Gadolinium Deposition Following Gadodiamide-Enhanced Magnetic Resonance Imaging in Pediatric Patients: A Case-Control Study, JAMA Pediatr. 1 juill, vol.171, issue.7, 2017. ,
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Group 1 Gadolinium Contrast Agents Deposit Low Levels of Gadolinium in Brain and Bone Tissue: Preliminary Results From 9 Patients With Normal Renal Function, Invest Radiol, vol.51, issue.7, pp.447-53, 2016. ,
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Au moment d'être admis à exercer la médecine, je promets et je jure d'être fidèle aux lois de l'honneur et de la probité. Mon premier souci sera de rétablir, de préserver ou de promouvoir la santé dans tous ses éléments, physiques et mentaux ,
, Je respecterai toutes les personnes, leur autonomie et leur volonté, sans aucune discrimination selon leur état ou leurs convictions. J'interviendrai pour les protéger si elles sont affaiblies, vulnérables ou menacées dans leur intégrité ou leur dignité. Même sous la contrainte
, J'informerai les patients des décisions envisagées, de leurs raisons et de leurs
, Je donnerai mes soins à l'indigent et à quiconque me les demandera. Je ne me laisserai
, Reçu à l'intérieur des maisons, je respecterai les secrets des foyers et ma conduite ne servira pas à corrompre les moeurs
, Je ne prolongerai pas abusivement les agonies. Je ne provoquerai jamais la mort délibérément
, Je préserverai l'indépendance nécessaire à l'accomplissement de ma mission
, J'apporterai mon aide à mes confrères ainsi qu'à leurs familles dans l'adversité
, Que les hommes et mes confrères m'accordent leur estime si je suis fidèle à mes promesses ; que je sois déshonoré et méprisé si j'y manque
La mise en évidence récente de dépôts intracérébraux de gadolinium pourrait modifier cette règle. L'objectif de l'étude a été d'évaluer la performance diagnostique d'une IRM sans injection de contraste (IRMC-) dans le suivi évolutif des GVO chez l'enfant ,
, 25 cas de progression tumorale et 25 cas de stabilité mentionnés dans la conclusion du compterendu IRM (référence) ont été sélectionnés et couplés avec les examens précédents respectifs (50 paires d'examen). Pour l'évaluation de l'évolution tumorale, ces examens ont été analysés en aveugle par 2 radiologues à l'aide de critères quantitatifs et qualitatifs, en excluant la série IRMC+, Cette étude rétrospective a été réalisée dans un centre de référence pédiatrique des GVO en accord avec le comité éthique local. 17 patients suivis par au moins 5 IRMC+ entre 2001 et 2017 ont été inclus (atteints ou non de NF1)
, L'âge moyen au moment du diagnostic était de 5,4 ±3.4 ans. La durée moyenne de suivi était de 6, vol.7
La sensibilité des IRMC-était de 84-88 % (IC 95% : 63,9-97,5%), la spécificité de 91,3-100% (IC 95% : 72-100%), la VPP était de 91,7 % pour le 1 er lecteur, de 100% pour le second, la VPN était de 87,5% pour le 1 er lecteur, de 85,2% pour le second. Il y avait un excellent accord inter-observateur (kappa= 0, vol.87 ,
, La variation du volume tumoral et les critères qualitatifs (dilatation ventriculaire) sont le plus souvent suffisants pour apprécier l'évolutivité tumorale