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, Étude de l'Association entre la Concentration plasmatique, la Tolérance et l'Efficacité du sorafénib, chez les patients débutant un traitement palliatif pour carcinome hépatocellulaire

. Le, Le recueil des EI était réalisé aux consultations de suivi à S4, S8 et S16. Résultats : Parmi les 60 patients, 36 (60%) ont eu au moins un effet indésirable de grade ? II et 9 (15%) de grade III. La valeur moyenne de la concentration plasmatique était de 4725,28ng/mL avec une forte variabilité interindividuelle. La concentration plasmatique moyenne chez les patients ayant présenté un effet indésirable de grade III était significativement supérieure que chez les autres patients (p=0,0218), CHC) avancé. L'impact sur la survie des patients est faible et les effets secondaires invalidants fréquents conduisant à de nombreuses interruptions thérapeutiques