, Cancer, 2019.

, Mécanisme de cancérisation -Qu'est-ce qu'un cancer ?, 2019.

, Les cancers du sein, 2013.

, Anatomie du sein -Cancer du sein, 2019.

, Cancers du sein, 2019.

M. Akram, M. Iqbal, M. Daniyal, and A. U. Khan, Awareness and current knowledge of breast cancer, Biol Res, vol.50, issue.1, p.33, 2017.

, Cancer inflammatoire -Les maladies du sein, 2019.

, Formes rares -Les maladies du sein, 2019.

A. Fondation, Qu'est-ce qu'un cancer hormono dépendant ?, 2019.

, Hormonothérapie -Cancer du sein, 2019.

F. Bray, J. Ferlay, I. Soerjomataram, R. L. Siegel, L. A. Torre et al., Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA: A Cancer Journal for Clinicians, vol.68, issue.6, pp.394-424, 2018.

F. Binder-foucard, A. Belot, P. Delafosse, L. Remontet, A. Woronoff et al., Estimation nationale de l'incidence et de la mortalité par cancer en France entre 1980 et 2012 -Partie 1 -Tumeurs solides, 2013.

F. Binder-foucard, N. Bossard, P. Delafosse, A. Belot, A. Woronoff et al., Cancer incidence and mortality in France over the 1980-2012 period: solid tumors. Rev Epidemiol Sante Publique, vol.62, pp.95-108, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01915012

, Les cancers en France, 2017.

G. Plu-bureau, P. Touraine, and F. Kuttenn, Sein et hormones. EMC -Gynécologie, pp.1-19, 2002.

M. Espié, A. Hamy, S. Eskenazy, C. Cuvier, and S. Giacchetti, Épidémiologie du cancer du sein. EMC -Gynécologie, vol.7, pp.1-17, 2012.

. Inserm, Cancer et environnement. Les éditions Inserm, p.50, 2008.

J. G. Brody, R. A. Rudel, K. B. Michels, K. B. Moysich, L. Bernstein et al., Environmental pollutants, diet, physical activity, body size, and breast cancer: where do we stand in research to identify opportunities for prevention? Cancer, vol.109, pp.2627-2661, 2007.

R. A. Rudel, J. M. Ackerman, K. R. Attfield, and J. G. Brody, New exposure biomarkers as tools for breast cancer epidemiology, biomonitoring, and prevention: a systematic approach based on animal evidence. Environ Health Perspect, vol.122, pp.881-95, 2014.

. Ocde, Le coût de la pollution de l'air : Impacts sanitaires du transport routier, Editions OCDE, 2014.

M. Pascal, P. De-crouy-chanel, V. Wagner, M. Corso, C. Tillier et al., Analyse des gains en santé de plusieurs scénarios d'amélioration de la qualité de l'air en France conti-nentale, Bull Epidémiol Hebd, pp.430-437, 2016.

S. Medina, M. Pascal, and C. Tillier, Impacts de l'exposition chronique aux particules fines sur la mortalité en France continentale et analyse des gains en santé de plusieurs scénarios de réduction de la pollution atmosphérique, 2016.

. Oms, Qualité de l'air ambiant et santé

J. Lelieveld, K. Klingmüller, A. Pozzer, U. Pöschl, M. Fnais et al., Cardiovascular disease burden from ambient air pollution in Europe reassessed using novel hazard ratio functions, Eur Heart J, vol.40, issue.20, pp.1590-1596, 2019.

D. Loomis, Y. Grosse, B. Lauby-secretan, F. E. Ghissassi, V. Bouvard et al., The carcinogenicity of outdoor air pollution. The Lancet Oncology, vol.14, pp.1262-1265, 2013.

, IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. Outdoor air pollution. Lyon: International Agency for Research on Cancer, 2015.

, Les cancers attribuables au mode de vie et à l'environnement en France métropolitaine. Lyon: International Agency for Research on Cancer, 2018.

, Cancer et environnement. (page consultée le 05/06/2019). Particules dans l'air et risque de cancer, Cancer et environnement, 2016.

, INERIS. Données technico-économiques sur les substances chimiques en France : Les PolyChloroBiphenyles (PCB), 2011.

A. Nationale, Rapport d'information n° 998

. Cnrtl,

. Aasqa-rhône-alpes, Etat des concentrations de PCB dans l'air et les retombées atmosphériques -Mesures réalisées en 2008 dans départements du Rhône et de l'Isère, 2010.

A. , Les polluants organiques persistants (POP)

, Ministère de l'écologie et du développement durable, ADEME. Plan national de décontamination et d'élimination des appareils contenant des PCB et PCT, 2003.

. Larousse,

, Appareils contaminés par PCB/PCT

. Citepa, Polychlorobiphényls -PCB, 2019.

, Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to the presence of non dioxin-like polychlorinated biphenyls (PCB) in feed and food, EFSA Journal, vol.3, issue.11, p.284, 2005.

, INERIS. Fiche de données toxicologiques et environnementales des substances chimiquespolychlorobiphényles, 2005.

, Biphényles chlorés -Fiche toxicologique n°194, INRS, 2007.

L. Leng, J. Li, X. Luo, J. Kim, Y. Li et al., Polychlorinated biphenyls and breast cancer: A congener-specific meta-analysis, Environ Int, vol.88, pp.133-174, 2016.

A. Demers, P. Ayotte, J. Brisson, S. Dodin, J. Robert et al., Risk and aggressiveness of breast cancer in relation to plasma organochlorine concentrations, Cancer Epidemiol Biomarkers Prev, vol.9, issue.2, pp.161-167, 2000.

W. H. Organization and F. Nations, Joint FAO/WHO Expert Committee on Food Additives. Meeting (80th: 2015 R. Evaluation of certain food additives and contaminants: eightieth report of the Joint FAO/WHO Expert Committee on Food Additives, 2016.

A. C. Casey, D. F. Berger, J. P. Lombardo, A. Hunt, and F. Quimby, Aroclor 1242 inhalation and ingestion by Sprague-Dawley rats, J Toxicol Environ Health Part A, vol.56, issue.5, pp.311-353, 1999.

B. Lauby-secretan, D. Loomis, Y. Grosse, E. Ghissassi, F. Bouvard et al., Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls, vol.14, pp.287-295, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01607039

D. Bachelet, M. Verner, M. Neri, C. Duverger, É. Charlier et al., Breast Cancer and Exposure to Organochlorines in the CECILE Study: Associations with Plasma Levels Measured at the Time of Diagnosis and Estimated during Adolescence, Int J Environ Res Public Health, vol.16, issue.2, 2019.

H. Itoh, M. Iwasaki, T. Hanaoka, Y. Kasuga, S. Yokoyama et al., Serum organochlorines and breast cancer risk in Japanese women: a case-control study. Cancer Causes Control, vol.20, pp.567-80, 2009.

N. M. Gatto, M. P. Longnecker, M. F. Press, J. Sullivan-halley, R. Mckean-cowdin et al., Serum organochlorines and breast cancer: a case-control study among African-American women. Cancer Causes Control, vol.18, pp.29-39, 2007.

O. Raaschou-nielsen, M. Pavuk, A. Leblanc, P. Dumas, P. Weber et al., Adipose organochlorine concentrations and risk of breast cancer among postmenopausal Danish women, Cancer Epidemiol Biomarkers Prev, vol.14, issue.1, pp.67-74, 2005.

J. A. Rusiecki, T. R. Holford, S. H. Zahm, and T. Zheng, Polychlorinated biphenyls and breast cancer risk by combined estrogen and progesterone receptor status, Eur J Epidemiol, vol.19, issue.8, pp.793-801, 2004.

A. P. Høyer, T. Jørgensen, F. Rank, and P. Grandjean, Organochlorine exposures influence on breast cancer risk and survival according to estrogen receptor status: a Danish cohort-nested casecontrol study, BMC Cancer, vol.1, p.8, 2001.

K. J. Helzlsouer, A. J. Alberg, H. Y. Huang, S. C. Hoffman, P. T. Strickland et al., Serum concentrations of organochlorine compounds and the subsequent development of breast cancer, Cancer Epidemiol Biomarkers Prev, vol.8, issue.6, pp.525-557, 1999.

G. Liljegren, L. Hardell, G. Lindström, P. Dahl, and A. Magnuson, Case-control study on breast cancer and adipose tissue concentrations of congener specific polychlorinated biphenyls, DDE and hexachlorobenzene, Eur J Cancer Prev, vol.7, issue.2, pp.135-175, 1998.

T. Zheng, T. R. Holford, J. Tessari, S. T. Mayne, P. H. Owens et al., Breast cancer risk associated with congeners of polychlorinated biphenyls, Am J Epidemiol, vol.152, issue.1, pp.50-58, 2000.

R. Recio-vega, V. Velazco-rodriguez, G. Ocampo-gómez, S. Hernandez-gonzalez, P. Ruiz-flores et al., Serum levels of polychlorinated biphenyls in Mexican women and breast cancer risk, J Appl Toxicol, vol.31, issue.3, pp.270-278, 2011.

A. Demers, P. Ayotte, J. Brisson, S. Dodin, J. Robert et al., Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer: a congener-specific analysis, Am J Epidemiol, vol.155, issue.7, pp.629-664, 2002.

K. J. Aronson, A. B. Miller, C. G. Woolcott, E. E. Sterns, D. R. Mccready et al., Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk, Cancer Epidemiol Biomarkers Prev, vol.9, issue.1, pp.55-63, 2000.

M. Wielsøe, P. Kern, and E. C. Bonefeld-jørgensen, Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study. Environ Health, vol.13, p.56, 2017.

R. Millikan, E. Devoto, E. J. Duell, C. K. Tse, D. A. Savitz et al., Dichlorodiphenyldichloroethene, polychlorinated biphenyls, and breast cancer among African-American and white women in North Carolina, Cancer Epidemiol Biomarkers Prev, vol.9, issue.11, pp.1233-1273, 2000.

C. H. Rubin, A. Lanier, S. Kieszak, J. W. Brock, K. R. Koller et al., Breast cancer among Alaska Native women potentially exposed to environmental organochlorine chemicals, Int J Circumpolar Health, vol.65, issue.1, pp.18-27, 2006.

M. Pavuk, J. R. Cerhan, C. F. Lynch, A. Kocan, J. Petrik et al., Case-control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia, J Expo Anal Environ Epidemiol, vol.13, issue.4, pp.267-75, 2003.

F. Laden, S. E. Hankinson, M. S. Wolff, G. A. Colditz, W. C. Willett et al., Plasma organochlorine levels and the risk of breast cancer: an extended follow-up in the Nurses' Health Study, Int J Cancer, vol.91, issue.4, pp.568-74, 2001.

S. D. Stellman, M. V. Djordjevic, J. A. Britton, J. E. Muscat, M. L. Citron et al., Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, Cancer Epidemiol Biomarkers Prev, vol.9, issue.11, pp.1241-1250, 2000.

J. F. Dorgan, J. W. Brock, N. Rothman, L. L. Needham, R. Miller et al., Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA). Cancer Causes Control, vol.10, pp.1-11, 1999.

K. B. Moysich, R. J. Menezes, J. A. Baker, and K. L. Falkner, Environmental exposure to polychlorinated biphenyls and breast cancer risk, Rev Environ Health, vol.17, issue.4, pp.263-77, 2002.

D. J. Hunter, S. E. Hankinson, F. Laden, G. A. Colditz, J. E. Manson et al., Plasma organochlorine levels and the risk of breast cancer, N Engl J Med, vol.337, issue.18, pp.1253-1261, 1997.

A. P. Høyer, T. Jørgensen, P. Grandjean, and H. B. Hartvig, Repeated measurements of organochlorine exposure and breast cancer risk (Denmark). Cancer Causes Control, vol.11, pp.177-84, 2000.

E. M. Ward, P. Schulte, B. Grajewski, A. Andersen, D. G. Patterson et al., Serum organochlorine levels and breast cancer: a nested case-control study of Norwegian women, Cancer Epidemiol Biomarkers Prev, vol.9, issue.12, pp.1357-67, 2000.

E. C. Bonefeld-jorgensen, M. Long, R. Bossi, P. Ayotte, G. Asmund et al., Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study. Environ Health, vol.10, p.88, 2011.

A. P. Høyer, P. Grandjean, T. Jørgensen, J. W. Brock, and H. B. Hartvig, Organochlorine exposure and risk of breast cancer, Lancet, vol.352, issue.9143, pp.1816-1836, 1998.

T. R. Holford, T. Zheng, S. T. Mayne, S. H. Zahm, J. D. Tessari et al., Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk, Int J Epidemiol, vol.29, issue.6, pp.975-82, 2000.

J. Zhang, Y. Huang, X. Wang, K. Lin, and K. Wu, Environmental Polychlorinated Biphenyl Exposure and Breast Cancer Risk: A Meta-Analysis of Observational Studies, PLoS ONE, vol.10, issue.11, p.142513, 2015.

T. Zheng, T. R. Holford, S. T. Mayne, J. Tessari, B. Ward et al., Risk of female breast cancer associated with serum polychlorinated biphenyls and 1,1-dichloro-2,2'-bis(pchlorophenyl)ethylene, Cancer Epidemiol Biomarkers Prev, vol.9, issue.2, pp.167-74, 2000.

T. He, A. Zuo, J. Wang, and P. Zhao, Organochlorine pesticides accumulation and breast cancer: A hospital-based case-control study, Tumour Biol, vol.39, issue.5, p.1010428317699114, 2017.

B. A. Cohn, M. B. Terry, M. Plumb, and P. M. Cirillo, Exposure to polychlorinated biphenyl (PCB) congeners measured shortly after giving birth and subsequent risk of maternal breast cancer before age 50, Breast Cancer Res Treat, vol.136, issue.1, pp.267-75, 2012.

F. Clavel-chapelon and . Study-group, Cohort Profile: The French E3N Cohort Study, Int J Epidemiol, vol.44, issue.3, pp.801-810, 2015.

B. Binachon, L. Dossus, A. Danjou, F. Clavel-chapelon, and B. Fervers, Life in urban areas and breast cancer risk in the French E3N cohort, European Journal of Epidemiology, vol.29, issue.10, pp.743-51, 2014.

M. His, L. Guélennec, M. Mesrine, S. Boutron-ruault, M. Clavel-chapelon et al., Life course evolution of body size and breast cancer survival in the E3N cohort, Int J Cancer, vol.142, issue.8, pp.1542-53, 201815.

E. Faure, A. Danjou, F. Clavel-chapelon, M. Boutron-ruault, L. Dossus et al., Accuracy of two geocoding methods for geographic information system-based exposure assessment in epidemiological studies, Environ Health Glob Access Sci Source, vol.16, issue.1, p.15, 201724.

. Inra,

J. Bryere, O. Dejardin, L. Launay, M. Colonna, P. Grosclaude et al., Environnement socioéconomique et incidence des cancers en France, Bull Epidémiol Hebd, issue.4, pp.68-77, 2017.

M. Touvier, N. Druesne-pecollo, P. Galan, S. Hercberg, and P. Latino-martel, Déterminants de la consommation de boissons alcoolisées dans l'Étude NutriNet, pp.199-204, 2013.

. Inserm, . Usage, and F. Tabac-en, Tabac : Comprendre la dépendance pour agir. Les éditions Inserm, pp.1-10, 2004.

. Inserm, Inégalités sociales de santé en lien avec l'alimentation et l'activité physique. Les éditions Inserm, 2015.

D. E. , Un premier enfant à 28 ans. INSEE Première, p.4, 1419.

. Inserm, Déterminants sociaux de l'allaitement. In: Inégalités sociales de santé en lien avec l'alimentation et l'activité physique. Les éditions Inserm, pp.267-307, 2015.

H. Leridon, J. Sardon, P. Collomb, and Y. Charbit, La contraception en France en 1978, Population, vol.34, issue.1, pp.1349-90, 1979.

A. Auvergne-rhône-alpes, Activités physiques et qualité de l'air : bien respirer pour bien bouger, 2019.

S. Garcia-acosta and F. Clavel-chapelon, Dealing with missing, abnormal and incoherent data in E3N cohort study, vol.47, pp.515-538, 1999.
URL : https://hal.archives-ouvertes.fr/inserm-00176590

C. J. Charlier, A. I. Albert, L. Zhang, N. G. Dubois, and G. J. Plomteux, Polychlorinated biphenyls contamination in women with breast cancer, Clin Chim Acta, vol.347, issue.1-2, pp.177-81, 2004.

M. Morgan, A. Deoraj, Q. Felty, and D. Roy, Environmental estrogen-like endocrine disrupting chemicals and breast cancer, Mol Cell Endocrinol, vol.457, pp.89-102, 2017.

J. P. Arrebola, M. Fernández-rodríguez, F. Artacho-cordón, C. Garde, F. Perez-carrascosa et al., Associations of persistent organic pollutants in serum and adipose tissue with breast cancer prognostic markers, Sci Total Environ, pp.41-50, 2016.

A. K. Holmes, K. R. Koller, S. M. Kieszak, A. Sjodin, A. M. Calafat et al., Case-control study of breast cancer and exposure to synthetic environmental chemicals among Alaska Native women, Int J Circumpolar Health, vol.73, issue.1, p.25760, 2014.

M. D. Gammon, M. S. Wolff, A. I. Neugut, S. M. Eng, S. L. Teitelbaum et al., Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood, Cancer Epidemiol Biomarkers Prev, vol.11, issue.8, pp.686-97, 2002.

M. T. Smith, K. Z. Guyton, C. F. Gibbons, J. M. Fritz, C. J. Portier et al., Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis, Environ Health Perspect, vol.124, issue.6, pp.713-734, 2016.

G. G. Oakley, U. Devanaboyina, L. W. Robertson, and R. C. Gupta, Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): implications for PCB-induced oxidative stress in breast cancer, Chem Res Toxicol, vol.9, issue.8, pp.1285-92, 1996.

Y. Liu, K. Hu, H. Jia, J. G. Glatt, H. Jiang et al., Potent mutagenicity of some non-planar tri-and tetrachlorinated biphenyls in mammalian cells, human CYP2E1 being a major activating enzyme, Arch Toxicol, vol.91, issue.7, pp.2663-76, 2017.

L. W. Robertson and G. Ludewig, Polychlorinated Biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs, Gefahrst Reinhalt Luft, vol.71, issue.1-2, pp.25-32, 2011.

K. P?n?íková, L. Svr?ková, S. Strapá?ová, J. Ne?a, I. Barto?ková et al., In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion, Environ Pollut, vol.237, pp.473-86, 2018.

P. L. Andersson, A. Blom, A. Johannisson, M. Pesonen, M. Tysklind et al., Assessment of PCBs and hydroxylated PCBs as potential xenoestrogens: In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes, Arch Environ Contam Toxicol, vol.37, issue.2, pp.145-50, 1999.

W. D. Dupont and W. D. Plummer, Power and sample size calculations. A review and computer program, Control Clin Trials, vol.11, issue.2, pp.116-144, 1990.

A. Amadou, D. Praud, T. Coudon, A. Danjou, E. Faure et al., Chronic long-term exposure to cadmium air pollution and breast cancer risk in the French E3N cohort, Int J Cancer, 2009.

F. Couvidat, B. Bessagnet, M. Garcia-vivanco, E. Real, L. Menut et al., Development of an inorganic and organic aerosol model (CHIMERE 2017? v1.0): seasonal and spatial evaluation over, Europe. Geosci Model Dev, vol.11, issue.1, pp.165-94, 2018.
URL : https://hal.archives-ouvertes.fr/ineris-01863249

, Facteurs de risques du cancer du sein, Cancer et environnement, 2019.

T. Gabrio, I. Piechotowski, T. Wallenhorst, M. Klett, L. Cott et al., PCB-blood levels in teachers, working in PCB-contaminated schools, Chemosphere, vol.40, issue.9, pp.1055-62, 2000.

B. Liebl, T. Schettgen, G. Kerscher, H. Broding, A. Otto et al., Evidence for increased internal exposure to lower chlorinated polychlorinated biphenyls (PCB) in pupils attending a contaminated school, Int J Hyg Environ Health, vol.207, issue.4, pp.315-339, 2004.

R. F. Herrick, J. D. Meeker, and L. Altshul, Serum PCB levels and congener profiles among teachers in PCB-containing schools: a pilot study. Environ Health, vol.10, p.56, 2011.

A. M. Roveda, L. Veronesi, R. Zoni, M. E. Colucci, and G. Sansebastiano, Exposure to polychlorinated biphenyls (PCBs) in food and cancer risk: recent advances

, Ig Sanita Pubbl, vol.62, issue.6, pp.677-96, 2006.

L. Zhang, L. Dong, W. Yang, L. Zhou, S. Shi et al., Passive air sampling of organochlorine pesticides and polychlorinated biphenyls in the Yangtze River Delta, China: concentrations, distributions, and cancer risk assessment, Environ Pollut, vol.181, pp.159-66, 2013.

C. Donat-vargas, A. Åkesson, M. Berglund, A. Glynn, A. Wolk et al., Dietary exposure to polychlorinated biphenyls and risk of breast, endometrial and ovarian cancer in a prospective cohort, Br J Cancer, vol.115, issue.9, pp.1113-1134, 2016.

M. S. Wolff, D. Camann, M. Gammon, and S. D. Stellman, Proposed PCB Congener Groupings for Epidemiological Studies, vol.105, p.13, 1997.

N. Hamajima, K. Hirose, K. Tajima, T. Rohan, E. E. Calle et al., Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease, Br J Cancer, vol.87, issue.11, pp.1234-1279, 2002.

H. K. Seitz, C. Pelucchi, V. Bagnardi, L. Vecchia, and C. , Epidemiology and pathophysiology of alcohol and breast cancer: Update, Alcohol Alcohol, vol.47, issue.3, pp.204-216, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01262951

G. Fagherazzi, A. Vilier, M. Boutron-ruault, S. Mesrine, and F. Clavel-chapelon, Alcohol consumption and breast cancer risk subtypes in the E3N-EPIC cohort, Eur J Cancer Prev, vol.24, issue.3, pp.209-223, 2015.

L. Dossus, M. Boutron-ruault, R. Kaaks, I. T. Gram, A. Vilier et al., Active and passive cigarette smoking and breast cancer risk: results from the EPIC cohort, Int J Cancer, vol.134, issue.8, pp.1871-88, 2014.

K. C. Johnson, Accumulating evidence on passive and active smoking and breast cancer risk, Int J Cancer, vol.117, issue.4, pp.619-647, 2005.

Y. Wu, D. Zhang, and S. Kang, Physical activity and risk of breast cancer: a meta-analysis of prospective studies, Breast Cancer Res Treat, vol.137, issue.3, pp.869-82, 2013.

B. Tehard, C. M. Friedenreich, J. Oppert, and F. Clavel-chapelon, Effect of physical activity on women at increased risk of breast cancer: results from the E3N cohort study, Cancer Epidemiol Biomarkers Prev, vol.15, issue.1, pp.57-64, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00107119

A. G. Renehan, M. Tyson, M. Egger, R. F. Heller, and M. Zwahlen, Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies, Lancet, vol.371, issue.9612, pp.569-78, 2008.

, Annexes

, Annexe 1 -Présentation de la structure d'accueil

, Annexe 2 -Taux d'incidence et de mortalité du cancer du sein dans le monde

, Annexe 3 -Principaux facteurs de risque du cancer du sein, p.61

, Annexe 4 -Classification

, Annexe

, Annexe 8 -Graph orienté acyclique

, Annexe 9 -Caractéristiques des sujets en fonction des quintiles d'exposition aux PCB, p.74

, Annexe 10 -Evolution des concentrations en PCB 153 au cours du temps

, Dans la cohorte E3N, les femmes consommant plus de deux verres d'alcool par jour ont risque plus élevé d'avoir un cancer du sein que les femmes ne consommant pas d'alcool

, Cette association n'est retrouvée que pour les cancers post-ménopausiques (HR = 1, p.24

, IC95% : 1,07 -1,44), elle n'est pas significative pour les cancers pré-ménopausiques

, Tabac Si le tabac est reconnu comme cancérogène certain pour l'homme (groupe 1) par le

, CIRC, les résultats des études s'intéressant au lien entre le tabagisme et le cancer du sein sont contradictoires (16). La méta-analyse de 2002 n'a pas mis en évidence d'association statistiquement significative entre le tabagisme et le risque de cancer du sein

, Néanmoins, des études plus récentes ont montré des associations positives, vol.134

, Activité physique Une méta-analyse de 2013 a montré une association inverse entre l'activité physique et le risque de cancer du sein avec un RR combiné de 0, vol.88

, Cette méta-analyse conclue que l'activité physique pourrait réduire considérablement le risque de cancer du sein, IC95% : 0,97-0,99)

, une diminution linéaire statistiquement significative du risque de cinq heures par semaines des activités rigoureuses avaient un RR de 0,62 (IC95% : 0,49-0,78) par rapport à celles n'en pratiquant pas

, IMC) et le risque de cancer du sein diffère selon le statut ménopausique. Pour une augmentation de 5kg/m 2 , une méta-analyse de 2008 a montré des tendances opposées avec un RR de 0,89 (IC95% : 0,84-0,94) chez les femmes pré-ménopausiques et un RR de, vol.1, p.9