, Alzheimer Annexe n°7 : Test de l'évaluation in vitro de l'activité inhibitrice de MT5-MMP et MT1-MMP des composés synthétisés au CERMN Annexe n°8 : Les Zinc Binding Groups (ZBG) les plus fréquemment retrouvés Annexe n°9 : Choix d'une conformation de MT5-MMP et MT1-MMP Annexe n°10 : Poster Annexe n°1 : Nomenclature des Enzymes Document issu de l' « ENZYME nomenclature database, Rôles des MMP dans les maladies neurodégénératives Annexe n°4 : Mini Mental State Examination Annexe n°5 : Voies de signalisation liées à la Maladie d, vol.3
,
, Rôles des MMP dans les maladies neurodégénératives Document issu de la publication de Brkic et Al. 2015 « Friends or Foes Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases, vol.3
Les Métalloprotéases de la matrice et leurs inhibiteurs , des modulateurs des interactions neuro-immunes et des processus physiopathologiques dans le système nerveux, vol.197, pp.133-144, 2003. ,
Implication des métalloprotéases matricielles en obstétrique: De la nidation a l'accouchement, Rev. Med. Liege, vol.69, pp.46-50, 2014. ,
, Collagenolytic Activity in Amphibian Tissues: a Tissue Culture Assay. Proc. Natl. Acad. Sci, vol.48, pp.1014-1022, 1962.
Quantitation and Immunocytochemichal Localization of Human Skin Collagenase in Basal Cell Carcinoma, J. Invest. Dermatol, vol.69, pp.363-367, 1977. ,
ExPASy: SIB bioinformatics resource portal, Nucleic Acids Res, vol.40, pp.597-603, 2012. ,
, J. Biol. Chem, vol.274, pp.21491-21494, 1999.
, Métalloprotéases matricielles et athérosclérose. Perspectives thérapeutiques
, Ann. Biol. Clin, vol.61, pp.147-158, 2003.
, Une cible thérapeutique de l'athérosclérose? Sang Thromb. Vaiss, vol.18, pp.247-256, 2006.
Protéomique fonctionnelle des Métalloprotéases Matricielles (MMPs) dédié à la détection des formes acitves de MMPs dans des protéomes complexes, 2007. ,
Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases, Mediators Inflamm, 2015. ,
Snapshots of the reaction mechanism of matrix metalloproteinases, Angew. Chemie -Int. Ed, vol.45, pp.7952-7955, 2006. ,
, , 2015.
Membrane-type matrix metalloproteinases: Their functions and regulations, Matrix Biol. 44, vol.46, pp.207-223, 2015. ,
Structure and function of matrix metalloproteinases and TIMPs, Cardiovasc. Res, vol.69, pp.562-573, 2006. ,
Fluorogenic MMP activity assay for plasma including MMPs complexed to ?2-macroglobulin, Ann. N. Y. Acad. Sci, vol.878, pp.150-158, 1999. ,
Crystal structures of MMPs in complex with physiological and pharmacological inhibitors, Biochimie, vol.87, pp.249-263, 2005. ,
The role of TIMPs in regulation of Extracellular Matrix Proteolysis, Matrix Biol, vol.44, pp.247-254, 2015. ,
Les Métalloprotéases de la matrice et leurs inhibiteurs , des modulateurs des interactions neuro-immunes et des processus physiopathologiques dans le système nerveux, J. Soc. Biol, vol.197, pp.133-144, 2003. ,
Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer ,
, Crit. Rev. Oncol. Hematol, vol.137, pp.57-83, 2019.
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases, Nat. Rev. Drug Discov, vol.6, pp.480-498, 2007. ,
Third generation of matrix metalloprotease inhibitors: Gain in selectivity by targeting the depth of the S1' cavity, Biochimie, vol.92, pp.1501-1508, 2010. ,
Sulphonamides: Deserving class as MMP inhibitors?, Eur. J. Med. Chem, vol.60, pp.89-100, 2013. ,
Third generation of matrix metalloprotease inhibitors: Gain in selectivity by targeting the depth of the S1' cavity, Biochimie, vol.92, pp.1501-1508, 2010. ,
Selective non zinc binding inhibitors of MMP13, Bioorganic Med. Chem. Lett, vol.21, pp.4215-4219, 2011. ,
Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2, Bioorganic Med. Chem. Lett, vol.22, pp.271-277, 2012. ,
Inhibition of MMPs and ADAM / ADAMTS, Biochem. Pharmacol, 2019. ,
Matrix metalloproteinases and their multiple roles in Alzheimer's disease, Biomed Res Int, 2014. ,
Gene Expression Profiling of Aging in Multiple Mouse Strains: Identification of Aging Biomarkers and Impact of Dietary Antioxidants, Aging Cell, vol.8, pp.484-495, 2009. ,
Advanced Glycation End Products, Oxidative Stress and Metalloproteinases are altered in the Cerebral Microvasculature during Aging ,
, Curr. Neurovasc. Res, vol.4, pp.228-234, 2007.
Association of matrix metalloproteinases with MRI indices of brain ischemia and aging, Neurobiol. Aging, vol.31, pp.2128-2135, 2010. ,
Matrix metalloproteinase-12 contributes to neuroinflammation in the aged brain, Neurobiol. Aging, vol.34, pp.1231-1239, 2013. ,
APP processing in Alzheimer's disease, Mol. Brain, vol.4, pp.1-13, 2011. ,
?-Secretase processing of APP inhibits neuronal activity in the hippocampus, Nature, vol.526, pp.443-447, 2015. ,
Cleavage of Amyloid-Precursor Protein (APP) by Membrane-Type Matrix Metalloproteinases, J. Biochem, vol.139, pp.517-526, 2006. ,
Hippocampe et mémoire autobiographique: une étude en IRM volumétrique dans la maladie d'Alzheimer, Rev. Neurol, vol.168, p.24, 2012. ,
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease, Cell. Mol. Life Sci, vol.73, pp.217-236, 2016. ,
just a new APP processing proteinase in Alzheimer's disease?, J. Neuroinflammation, vol.13, p.167, 2016. ,
MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro, Front. Mol. Neurosci, vol.9, pp.1-17, 2017. ,
Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP, J. Biol. Chem, vol.274, pp.8925-8932, 1999. ,
Identification and Characterization of Human MT5-MMP, a New Membrane-bound Activator of Progelatinase A Overexpressed in Brain Tumors 1, Cancer Res, vol.59, pp.2570-2576, 1999. ,
Évolution temporelle des démences : état des lieux en France et à l'international. Bull. épidémiologique Hebd, pp.467-473, 2016. ,
Les conceptions de la mémoire déclarative d'Endel Tulving et leurs conséquences actuelles, Rev. Neuropsychol, vol.3, pp.94-103, 2011. ,
Alzheimer's disease, Lancet, vol.349, pp.1906-1909, 1997. ,
, JAMA, vol.313, p.1488, 2015.
Mental State, un incontournable de la neuropsychologie, Sci. Soc. Sante, vol.32, pp.71-77, 2014. ,
Un test rudimentaire mais pratique. Enquête sur le succès du Mini-Mental State Examination, Sci. Soc. Sante, vol.32, pp.43-70, 2014. ,
Multi-target-directed ligands to combat neurodegenerative diseases, J. Med. Chem, vol.51, pp.347-372, 2008. ,
The role of microbial amyloid in neurodegeneration, PLoS Pathog, vol.13, pp.1-12, 2017. ,
Genetic diagnosis and prognosis of Alzheimer's disease: Challenges and opportunities, Expert Rev. Mol. Diagn, vol.15, pp.339-348, 2015. ,
Alzheimer Disease: Pharmacologic and Nonpharmacologic Therapies for Cognitive and Functional Symptoms ,
, Fam. Physician, vol.95, pp.771-778, 2017.
Recent therapeutic strategies targeting beta amyloid and tauopathies in Alzheimer's disease, Brain Res. Bull, vol.146, pp.171-184, 2019. ,
Drug candidates in clinical trials for Alzheimer's disease, J. Biomed. Sci, vol.24, pp.1-12, 2017. ,
Serotonin: A New Hope in Alzheimer's Disease?, ACS Chem. Neurosci, vol.6, pp.940-943, 2015. ,
Neuronal histamine and cognitive symptoms in Alzheimer's disease, Neuropharmacology, vol.106, pp.135-145, 2016. ,
Dysregulation of neuronal calcium homeostasis in Alzheimer's disease -a therapeutic opportunity?, Biochem. Biophys. Res. Commun, vol.483, pp.998-1004, 2017. ,
Alzheimer's disease: The right drug, the right time, vol.362, pp.1250-1252, 2018. ,
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease, Nat. Med, vol.25, pp.277-283, 2019. ,
Méthodes de criblage in silico de chimiothèques, Tech. l'Ingénieur, vol.33, 2014. ,
Compendium of Chemical Terminology ,
, Blackwell Sci. Publ. Oxford, vol.1670, 2014.
Glossary of Terms Used in Medicinal Chemistry, Pure Appl. Chem, vol.70, pp.1129-1143, 1998. ,
Chimie médicinale -Structure et activité du médicament, Tech. l'Ingénieur, vol.33, 2007. ,
, J. Applied Chemoinformatics : Achievements and Future Opportunities, 2018.
Homology modeling: An important tool for the drug discovery ,
, J. Biomol. Struct. Dyn, vol.33, pp.1780-1793, 2015.
Gene Help: Integrated Access to Genes of Genomes in the Reference Sequence Collection, 2006. ,
, Nucleic Acids Res, vol.46, pp.754-761, 2018.
The Protein Data Bank, Nucleic Acids Res, vol.28, pp.235-242, 2000. ,
UniProt: The universal protein knowledgebase, Nucleic Acids Res, vol.32, pp.115-119, 2006. ,
The Reactome Pathway Knowledgebase, Nucleic Acids Res, vol.46, pp.649-655, 2018. ,
WikiPathways: A multifaceted pathway database bridging metabolomics to other omics research, Nucleic Acids Res, vol.46, pp.661-667, 2018. ,
Pathway Commons, a web resource for biological pathway data, Nucleic Acids Res, vol.39, pp.685-690, 2011. ,
New approach for understanding genome variations in KEGG, Nucleic Acids Res, pp.1-6, 2018. ,
Open Targets Platform: new developments and updates two years on, Nucleic Acids Res. 1, p.10, 2018. ,
The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog), Nucleic Acids Res, vol.45, pp.896-901, 2017. ,
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity, Nature, vol.483, pp.603-607, 2012. ,
Online Mendelian Inheritance in Man (OMIM®), an Online catalog of human genes and genetic disorders, Nucleic Acids Res, vol.43, pp.789-798, 2015. ,
Intent to Share Individual Participant Data as Disclosed at ClinicalTrials.gov, JAMA -J. Am. Med. Assoc, vol.319, pp.406-408, 2018. ,
Defining a Cancer Dependency Map, Cell, vol.170, pp.564-576, 2017. ,
CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network, Database, vol.2017, pp.1-10, 2017. ,
ChEMBL: A large-scale bioactivity database for drug discovery, Nucleic Acids Res, vol.40, pp.1100-1107, 2012. ,
PubChem substance and compound databases, Nucleic Acids Res, vol.44, pp.1202-1213, 2015. ,
Identification of 'known unknowns' utilizing accurate mass data and chemspider, J. Am. Soc. Mass Spectrom, vol.23, pp.179-185, 2012. ,
ZINC 15 -Ligand Discovery for Everyone, J. Chem. Inf. Model, vol.55, pp.2324-2337, 2015. ,
DrugBank 5.0: A major update to the DrugBank database for 2018, Nucleic Acids Res, vol.46, pp.1074-1082, 2018. ,
PASS : prediction of activity spectra for biologically active substances, Bioinforma. Appl. Note, vol.16, pp.747-748, 2000. ,
The Process of Structure-Based Drug Design, Chem. Biol, vol.10, pp.787-797, 2003. ,
Structure-based drug design, Nature, vol.384, pp.23-26, 1996. ,
Active-site zinc ligands and activated H2O of zinc enzymes, Proc. Natl. Acad. Sci, vol.87, pp.220-224, 1990. ,
Insight into the structural determinants for selective inhibition of matrix metalloproteinases, Drug Discov. Today, vol.12, pp.640-646, 2007. ,
Crystal Structures of MMP-9 Complexes with Five Inhibitors: Contribution of the Flexible Arg424 Side-chain to Selectivity, J. Mol. Biol, vol.371, pp.989-1006, 2007. ,
Targeting matrix metalloproteinases: Exploring the dynamics of the S1? pocket in the design of selective, small molecule inhibitors, J. Med. Chem, vol.57, pp.10205-10219, 2014. ,
Metal-ligand interactions: An analysis of zinc binding groups using the Protein Data Bank, Eur. J. Med. Chem, vol.51, pp.271-276, 2012. ,
Protease inhibitors: Current status and future prospects, J. Med. Chem, vol.43, pp.305-341, 2000. ,
Seesaw of matrix metalloproteinases (MMPs), J. Cancer Res. Ther, vol.12, pp.28-35, 2016. ,