Pharmacokinetic and pharmacodynamic properties of tramadol IR and SR in elderly patients: A prospective, age-groupcontrolled study, Clin Ther. déc, vol.28, issue.12, pp.2022-2061, 2006. ,
Tramadol for osteoarthritis, Cochrane Collab, p.33, 2009. ,
Management of Chronic Arthritis Pain in the Elderly, Drugs Aging. juin, vol.27, issue.6, pp.471-90, 2010. ,
Projections of US prevalence of arthritis and associated activity limitations, Arthritis Rheum. janv, vol.54, issue.1, pp.226-235, 2006. ,
Pharmacotherapeutic Management of Pain with a Focus Directed at the Geriatric Patient. Rheum Dis Clin N Am, févr, vol.33, issue.1, pp.1-31, 2007. ,
Du symptôme au syndrome, Douleur Analgésie. mars, vol.1, issue.1, pp.11-18, 1988. ,
Effectiveness of Opioids in the Treatment of Chronic Non-Cancer Pain, Pain Physician, issue.11, 2008. ,
Prise en charge de la douleur des personnes âgées en soins primaires : l'ouverture vers les interventions non médicamenteuses. Analyse qualitative de l'expérience des médecins généralistes, Presse Médicale. déc, vol.45, issue.12, pp.377-87, 2016. ,
The therapeutic management of chronic pain in ambulatory care patients aged 65 and over in France: the S.AGES cohort. Baseline data, J Nutr Health Aging, vol.17, issue.8, pp.681-687, 2013. ,
Etat des lieux de la consommation des antalgiques opioïdes et leurs usages problematiques, févr, 2019. ,
Effets indésirables « graves » du tramadol : bilan 2010-2011 de pharmacovigilance en France, Thérapie. mars, vol.68, issue.2, pp.77-84, 2013. ,
, sept, issue.11, 2009.
Survey of the prescription of step-2 analgesics in persons aged 75 years and older in general practitioners, Gériatrie Psychol Neuropsychiatr Viellissement. déc, issue.4, pp.383-393, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01670497
, Pharmacologie du tramadol. Drugs, vol.53, issue.2, pp.18-24, 1997.
The clinical use of tramadol hydrochloride, Pain Rev. oct, vol.5, issue.3, pp.155-82, 1998. ,
Toward a rational taxonomy of analgesic treatments, Pharmacol Pain IASP Press, pp.27-40, 2010. ,
Cochrane Neuromuscular Group, éditeur. Cochrane Database Syst Rev, 2017. ,
,
Underutilisation of Opioids in Elderly Patients with Chronic Pain: Approaches to Correcting the Problem, Drugs Aging, vol.22, issue.8, pp.641-54, 2005. ,
Impact of CYP2D6 Genetic Polymorphism on ,
, Tramadol Pharmacokinetics and Pharmacodynamics. Mol Diagn Ther. mai, vol.11, issue.3, pp.171-81, 2007.
CYP2D6 genotype can help to predict effectiveness and safety during opioid treatment for chronic low back pain: results from a retrospective study in an Italian cohort, Pharmacogenomics Pers Med. oct, vol.11, pp.179-91, 2018. ,
Pharmacogenomic considerations in opioid analgesia, Pharmacogenomics Pers Med. août, pp.73-87, 2012. ,
Genetic modulation of the pharmacological treatment of pain, Pharmacol Ther, vol.124, pp.168-84, 2009. ,
Consensus multidisciplinaire d'experts en douleur et gériatrie : utilisation des antalgiques dans la prise en charge de la douleur de la personne âgée (hors anesthésie). Douleurs Éval -Diagn -Trait, vol.18, pp.234-281, 2017. ,
Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping, Eur J Clin Pharmacol. 8 mars, vol.63, issue.4, pp.321-354, 2007. ,
A Case of Respiratory Depression in a Child With Ultrarapid CYP2D6 Metabolism After Tramadol, PEDIATRICS. mars, vol.135, issue.3, pp.753-758, 2015. ,
Interactions médicamenteuses et cytochromes P450, Pharma-Flash, vol.29, issue.4, pp.13-19, 2002. ,
Importance des cytochromes P450: pharmacogénétique et intéractions médicamenteuses, Pharma-Flash, vol.37, issue.2, 2010. ,
Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6 substrate metabolism, Xenobiotica. janv, vol.27, issue.4, pp.319-359, 1997. ,
Interactions médicamenteuses et cytochromes, 2017. ,
Prescription of potentially inappropriate medications among older people with intellectual disability: a register study, Disponible sur, vol.18, 2017. ,
Adverse Effects of Analgesics Commonly Used by Older Adults With Osteoarthritis: Focus on Non-Opioid and Opioid Analgesics, Am J Geriatr Pharmacother. déc, vol.10, issue.6, pp.331-373, 2012. ,
Prise en soins de la douleur en EHPAD, NPG Neurol -Psychiatr -Gériatrie. août, vol.18, issue.106, pp.218-243, 2018. ,
Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications: Age-related changes in pharmacokinetics and pharmacodynamics, Br J Clin Pharmacol, vol.57, issue.1, pp.6-14, 2003. ,
Medication prescribing in frail older people, Eur J Clin Pharmacol. mars, vol.69, issue.3, pp.319-345, 2013. ,
Les effets du vieillissement sur la fonction rénale et leurs implications en pratique médicale, Presse Médicale. juill, vol.29, issue.24, pp.1373-1381, 2000. ,
Serum creatinine levels in older adults: relationship with health status and medications, Age Ageing. mars, vol.24, issue.2, pp.142-50, 1995. ,
Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-Release Tablets to Elderly and Young Subjects, Drugs Aging. déc, vol.32, issue.12, pp.1029-1072, 2015. ,
, Consommation Médicamenteuse chez le Sujet Agé, 2005.
Prescribing opioids in older people, Maturitas. févr, vol.74, issue.2, pp.123-132, 2013. ,
Problems of Nonadherence in Cardiology and Proposals to Improve Outcomes, Am J Cardiol. mai, vol.105, issue.10, pp.1495-501, 2010. ,
Potentially Inappropriate Prescribing and Related Hospital Admissions in Geriatric Patients: A Comparative Analysis between the STOPP and START Criteria Versions 1 and 2, J Am Geriatr Soc. sept, vol.36, issue.5, pp.2052-2058, 2017. ,
, American Geriatrics Society. American Geriatrics Society, 2019.
, Potentially Inappropriate Medication Use in Older Adults: 2019 AGS Beers Criteria® Update expert panel, J Am Geriatr Soc, vol.67, issue.4, pp.674-94, 2019.
STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing, vol.44, pp.213-221, 2014. ,
Prevalence of Potentially Inappropriate Medication Use in Older Adults Living in Nursing Homes: A Systematic Review, J Am Med Dir Assoc. sept, vol.17, issue.9, pp.862-863, 2016. ,
Potentially inappropriate medications in the elderly: a French consensus panel list, Eur J Clin Pharmacol. juill, vol.63, issue.8, pp.725-756, 2007. ,
The Norwegian General Practice (NORGEP) criteria for assessing potentially inappropriate prescriptions to elderly patients: A modified Delphi study. Scand J Prim Health Care, janv, vol.27, issue.3, pp.153-162, 2009. ,
Double-Blind, Crossover Comparison of the Efficacy and Safety of Oral Controlled-Release Tramadol and Placebo in Patients with Painful Osteoarthritis, Pain Res Manag, vol.13, issue.2, pp.93-102, 2008. ,
Potentially inappropriate drug use in older people: a nationwide comparison of different explicit criteria for population-based estimates: Comparing different explicit criteria of potentially inappropriate drug use, Br J Clin Pharmacol. août, vol.80, issue.2, pp.315-339, 2015. ,
Apport des essais pré-AMM à la connaissance du risque iatrogène chez la personne âgée, Thérapie. mars, vol.59, issue.2, pp.233-239, 2004. ,
, American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons. Pharmacological Management of Persistent Pain in Older Persons, J Am Geriatr Soc. août, vol.57, issue.8, pp.1331-1377, 2009.
Population Pharmacokinetic/Pharmacodynamic Modeling of O-Desmethyltramadol in Young and Elderly Healthy Volunteers, Drugs Aging, pp.1-12, 2019. ,
Tramadol buvable avec compte-gouttes: pourquoi un carton jaune? Prescrire, vol.37, p.390, 2017. ,
Réunion du Comité technique de Pharmacovigilance, 2016. ,
,
Pharmacokinetics of Therapeutic and Supratherapeutic Doses of Tramadol Hydrochloride in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Multiple-Ascending-Dose Study, Clin Pharmacol Drug Dev, vol.00, issue.0, pp.592-603, 2017. ,
Tolérance et sécurité d'emploi du tramadol -Résultats des études internationales et données de la pharmacovigilance, Drugs, vol.53, issue.2, pp.50-62, 1997. ,
The elderly patient and postoperative pain treatment, Best Pract Res Clin Anaesthesiol. mars, vol.21, issue.1, pp.109-136, 2007. ,
Slowing the titration rate of tramadol HCl reduces the incidence of discontinuation due to nausea and/or vomiting: a double-blind randomized trial, J Clin Pharm Ther. avr, vol.24, issue.2, pp.115-138, 1999. ,
Effect of a Simple Dose-Escalation Schedule on Tramadol Tolerability: Assessment in the Clinical Setting, Clin Drug Investig, vol.25, issue.1, pp.23-31, 2005. ,
Slowing the Initial Titration Rate of Tramadol Improves Tolerability, Pharmacotherapy. janv, vol.19, issue.1, pp.88-93, 1999. ,
The Role of Opioid Analgesics in Geriatric Pain Management, Clin Geriatr Med. nov, vol.32, issue.4, pp.725-760, 2016. ,
La nutrition des personnes âgées : place et pièges du bilan biologique, Ann Biol Clin (Paris). août, vol.59, issue.4, pp.445-52, 2001. ,
, Stratégie de prise en charge en cas de dénutrition protéino-énergétique chez la personne âgée, Serv Recomm Prof. avr, 2007.
, Évaluation diagnostique de la dénutrition protéino-énergétique des adultes hospitalisés, Serv Recomm Prof. sept, 2003.
Evaluer la fonction rénale, Rev Prat Médecine Générale. sept, vol.29, issue.945, pp.2-4, 2015. ,
Mesurer la polymédication chez les personnes âgées : impact de la méthode sur la prévalence et les classes thérapeutiques. Quest D'économie Santé, 8. 67. ANSM. Thesaurus des intéractions médicamenteuses, 2015. ,
État de santé et dépendance des personnes âgées en institution ou à domicile, Etudes Résultats. déc, issue.0988, 2016. ,
728 000 résidents en établissements d'hébergement pour personnes âgées en 2015. Premiers résultats de l'enquête EHPA 2015, Etudes Résultats. juill, 1015. ,
Épidémiologie des démences, Gérontologie Société. févr, vol.24, issue.97, pp.75-90, 2001. ,
Global prevalence of dementia: a Delphi consensus study, The Lancet. déc, vol.366, issue.9503, pp.2112-2119, 2005. ,
Prevalence of dementia in the oldest old: The Monzino 80-plus population based study, Alzheimers Dement. mars, vol.11, issue.3, pp.258-70, 2015. ,
Prevalence of polypharmacy in a Scottish primary care population, Eur J Clin Pharmacol. mai, vol.70, issue.5, pp.575-81, 2014. ,
Cognitive decline after hospitalization in a community population of older persons, Neurology. mars, vol.78, pp.950-956, 2012. ,
Swimming Against the Tide: Primary Care Physicians' Views on Deprescribing in Everyday Practice, Ann Fam Med. juill, vol.15, issue.4, pp.341-347, 2017. ,
Tramadol for Noncancer Pain and the Risk of Hyponatremia, Am J Med. avr, vol.128, issue.4, pp.418-443, 2015. ,
Tramadol Use and the Risk of Hospitalization for Hypoglycemia in Patients With Noncancer Pain, JAMA Intern Med. févr, vol.175, issue.2, pp.186-93, 2015. ,
Concurrent use of tramadol and oral vitamin K antagonists and the risk of excessive anticoagulation: a registerbased nested case-control study, Eur J Clin Pharmacol. mars, vol.69, issue.3, pp.641-647, 2013. ,
, « Par délibération de son Conseil en date du 10 Novembre 1972